OPN5
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| Opsin 5 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | OPN5; GPR136; PGR12; TMEM13 | ||||||||||||
| External IDs | OMIM: 609042 MGI: 2662912 HomoloGene: 72341 IUPHAR: OPN5 GeneCards: OPN5 Gene | ||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 221391 | 353344 | |||||||||||
| Ensembl | ENSG00000124818 | ENSMUSG00000043972 | |||||||||||
| UniProt | Q6U736 | Q6VZZ7 | |||||||||||
| RefSeq (mRNA) | NM_001030051 | NM_181753 | |||||||||||
| RefSeq (protein) | NP_859528 | NP_861418 | |||||||||||
| Location (UCSC) | Chr 6: 47.75 – 47.8 Mb |
Chr 17: 42.56 – 42.61 Mb |
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| PubMed search | [1] | [2] | |||||||||||
Opsin-5 is a protein that in humans is encoded by the OPN5 gene.[1][2][3]
Opsins are members of the guanine nucleotide-binding protein (G protein)-coupled receptor superfamily. This opsin gene is expressed in the eye, brain, testes, and spinal cord. This gene belongs to the seven-exon subfamily of mammalian opsin genes that includes peropsin (RRH) and retinal G protein coupled receptor (RGR). Like these other seven-exon opsin genes, this gene may encode a protein with photoisomerase activity. Alternative splicing results in multiple transcript variants encoding different isoforms.[3]
See also [edit]
References [edit]
- ^ Tarttelin EE, Bellingham J, Hankins MW, Foster RG, Lucas RJ (Nov 2003). "Neuropsin (Opn5): a novel opsin identified in mammalian neural tissue". FEBS Lett 554 (3): 410–6. doi:10.1016/S0014-5793(03)01212-2. PMID 14623103.
- ^ Fredriksson R, Hoglund PJ, Gloriam DE, Lagerstrom MC, Schioth HB (Nov 2003). "Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives". FEBS Lett 554 (3): 381–8. doi:10.1016/S0014-5793(03)01196-7. PMID 14623098.
- ^ a b "Entrez Gene: OPN5 opsin 5".
Further reading [edit]
- Terakita A (2006). "The opsins". Genome Biol. 6 (3): 213. doi:10.1186/gb-2005-6-3-213. PMC 1088937. PMID 15774036.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Vassilatis DK, Hohmann JG, Zeng H, et al. (2003). "The G protein-coupled receptor repertoires of human and mouse". Proc. Natl. Acad. Sci. U.S.A. 100 (8): 4903–8. doi:10.1073/pnas.0230374100. PMC 153653. PMID 12679517.
- Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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