Lobeline

Lobeline is an alkaloid found in "Indian tobacco" (Lobelia inflata), "Devil's tobacco" (Lobelia tupa), "cardinal flower" (Lobelia cardinalis), "great lobelia" (Lobelia siphilitica), and Hippobroma longiflora. Additionally, it is also found in Lobelia chinensis. In its pure form it is a white amorphous powder which is freely soluble in water.

Potential uses

Lobeline has been sold, in tablet form, for use as a smoking cessation aid, and may have application in the treatment of other drug addictions such as addiction to amphetamines, cocaine, or alcohol.

Pharmacology

Lobeline has multiple mechanisms of action, acting as a VMAT2 ligand, which stimulates dopamine release to a moderate extent when administered alone, but reduces the dopamine release caused by methamphetamine. It also inhibits the reuptake of dopamine and serotonin, and acts as a mixed agonist–antagonist at nicotinic acetylcholine receptors to which it binds at the subunit interfaces of the extracellular domain. It is also an antagonist at μ-opioid receptors.

George Michael

Georgios Kyriacos Panayiotou (born 25 June 1963), better known by his stage name George Michael, is an English singer, songwriter and record producer. Michael rose to fame during the 1980s and 1990s with his style of post-disco dance-pop. He has also been characterised as a blue-eyed soul singer, although his material draws more from middle-of-the-road pop than soul music.

As one of the world's best-selling music artists, Michael has sold more than 80 million records worldwide. His 1987 debut solo album, Faith, has on its own sold more than 20 million copies worldwide. Michael has garnered seven number one singles in the UK and eight number one hits on the Billboard Hot 100 in the US. In 2008, Billboard magazine ranked Michael the 40th most successful artist on the Billboard Hot 100 Top All-Time Artists list.

Michael has won numerous music awards throughout his 30-year career, including three Brit Awards—winning Best British Male twice, four MTV Video Music Awards, four Ivor Novello Awards, three American Music Awards, and two Grammy Awards from eight nominations.

Tony Robbins

Tony Robbins (born Anthony J. Mahavoric; February 29, 1960) is an American motivational speaker, personal finance instructor, and self-help author. He became well known from his infomercials and self-help books: Unlimited Power, Unleash the Power Within and Awaken the Giant Within.

In 2007, he was named in Forbes magazine's "Celebrity 100" list.Forbes estimated that Robbins earned approximately US$30 million in that year.

Early life

Robbins was born Anthony J. Mahavoric in North Hollywood, California, on February 29, 1960. Robbins is the eldest of three children and his parents divorced when he was 7. His mother then had a series of husbands, including Jim Robbins, a former semiprofessional baseball player who legally adopted Anthony when he was 12.

His father could not provide for their family, so he left them. His mother started abusing alcohol and prescription drugs sometime after. While growing up, Robbins was a primary care-giver, and helped provide for his siblings. Robbins was raised in Azusa and Glendora, California, and attended Glendora High School. He was elected student body president in his senior year, and grew 10 inches in high school, a growth spurt later attributed to a pituitary tumor. He has said his home life was "chaotic" and "abusive". When he was 17 years old, Robbins' mother chased him out of the house with a knife, and he never returned. Robbins later worked as a janitor, and did not attend college.

I Love Lucy

I Love Lucy is an American television sitcom starring Lucille Ball, Desi Arnaz, Vivian Vance, and William Frawley. The black-and-white series originally ran from October 15, 1951, to May 6, 1957, on CBS. After the series ended in 1957, however, a modified version continued for three more seasons with 13 one-hour specials, running from 1957 to 1960, known first as The Lucille Ball-Desi Arnaz Show and later in reruns as The Lucy–Desi Comedy Hour.

The show, which was the first scripted television program to be shot on 35 mm film in front of a studio audience, won five Emmy Awards and received numerous nominations. Another award that the show won was the coveted Peabody Award for "recognition of distinguished achievement in television."

I Love Lucy was the most watched show in the United States in four of its six seasons, and was the first to end its run at the top of the Nielsen ratings (an accomplishment later matched only by The Andy Griffith Show in 1968 and Seinfeld in 1998). The show is still syndicated in dozens of languages across the world, and remains popular, with an American audience of 40 million each year. A colorized version of its Christmas episode attracted more than 8 million viewers when CBS aired it in prime time in 2013 – 62 years after the show premiered. A second colorized special, featuring the "L.A. At Last!" and "Lucy and Superman" episodes, aired on May 17, 2015, attracting 6.4 million viewers.