I. B. Hale

Insall Bailey "I. B." Hale (September 9, 1916 – May 14, 1971) was an American football tackle at Texas Christian University (TCU) who was voted an All-American. He was drafted in the first round of the 1939 NFL Draft by the Washington Redskins, but never played football professionally.

Hale was married to the former Virginia Kingsbery, and the couple had at least three sons (twins Robert Allen Hale and William Hale, and Timothy Hale). Hale became an Federal Bureau of Investigation (FBI) agent in Fort Worth, Texas and was a close associate of J. Edgar Hoover. Later he became chief of security for the Convair aircraft factory and General Dynamics, and was a chairman of ASIS International. Hale died of a heart attack in 1971.

Hale was best friends with Heisman winner Davey O'Brien, who played football with him at Woodrow Wilson High School in Dallas, Texas and also at TCU. They both worked for the FBI.

Hale was inducted into the Texas Sports Hall of Fame in 1985.

References

External links

IB

IB, Ib or ib may refer to:

Places

Companies and organizations

Business and economics

Products and services

Interstate 895 (Maryland)

Interstate 895 (I-895) is an Interstate Highway in the U.S. state of Maryland. Known as the Harbor Tunnel Thruway, the highway runs 14.87 miles (23.93 km) between one junction with I-95 in Elkridge and another interchange with I-95 on the east side of Baltimore. I-895 is a toll road that crosses the Patapsco River estuary via the Baltimore Harbor Tunnel, connecting U.S. Route 1 (US 1), I-695, and the Baltimore–Washington Parkway in the southwestern suburbs of Baltimore with US 40 on the east side of Baltimore. In conjunction with a pair of spurs, unsigned I-895A and I-895B, I-895 provides access to the tunnel from I-97 and Maryland Route 2 (MD 2) in Glen Burnie. The highway is designed for through traffic by having partial interchanges that require vehicles from almost all starting points to pass through the tunnel and the tunnel toll plaza, where a $4 toll is charged to passenger vehicles, before exiting the facility.

NF-κB

NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA, cytokine production and cell survival. NF-κB is found in almost all animal cell types and is involved in cellular responses to stimuli such as stress, cytokines, free radicals, ultraviolet irradiation, oxidized LDL, and bacterial or viral antigens. NF-κB plays a key role in regulating the immune response to infection (κ light chains are critical components of immunoglobulins). Incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection, and improper immune development. NF-κB has also been implicated in processes of synaptic plasticity and memory.

Discovery

NF-κB was discovered by Dr. Ranjan Sen in the lab of Nobel Prize laureate David Baltimore via its interaction with an 11-base pair sequence in the immunoglobulin light-chain enhancer in B cells.

Structure