Addiction

Addiction is a state characterized by compulsive engagement in rewarding stimuli, despite adverse consequences. It can be thought of as a disease or biological process leading to such behaviors. The two properties that characterize all addictive stimuli are that they are reinforcing (i.e., they increase the likelihood that a person will seek repeated exposure to them) and intrinsically rewarding (i.e., something perceived as being positive or desirable).

Addiction is a disorder of the brain's reward system which arises through transcriptional and epigenetic mechanisms and occurs over time from chronically high levels of exposure to an addictive stimulus (e.g., morphine, cocaine, sexual intercourse, gambling, etc.).ΔFosB, a gene transcription factor, is a critical component and common factor in the development of virtually all forms of behavioral and drug addictions; two decades of research into ΔFosB's role in addiction have demonstrated that addiction arises, and the associated compulsive behavior intensifies or attenuates, along with the genetic overexpression of ΔFosB in the D1-type medium spiny neurons of the nucleus accumbens; due to the causal relationship between ΔFosB expression and addictions, it is used preclinically as an addiction biomarker. ΔFosB expression in these neurons directly and positively regulates drug self-administration and reward sensitization through positive reinforcement, while decreasing sensitivity to aversion.

Addiction (Skinny Puppy song)

"Addiction" is a song by the band Skinny Puppy, taken from their 1987 album Cleanse Fold and Manipulate. It was released on vinyl in 1987 and released on CD in 1991 (Canada) and 1997 (United States). The lyrics of the song quote the 19th century Gothic novel Melmoth the Wanderer by Charles Maturin.

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Addiction (journal)

Addiction is a monthly peer-reviewed scientific journal established in 1884 by the Society for the Study of Addiction to Alcohol and other Drugs. It covers original research relating to alcohol, illicit drugs, tobacco, and behavioural addictions.

Impact

According to the Journal Citation Reports, the journal has a 2010 impact factor of 4.145, ranking it second out of 14 journals in the category "Substance Abuse" and 24th out of 126 journals in the category of "Psychiatry". It is also ranked 1st out of 29 journals in the Social Sciences category "Substance Abuse" and 12th out of 107 journals in the Social Sciences category "Psychiatry".

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Slam (soundtrack)

Slam: The Soundtrack is the soundtrack to the 1998 film, Slam. It was released on October 13, 1998 through Epic Records and consisted entirely of hip hop music. The soundtrack was a minor success, making it to 84 on the Billboard 200 and 24 on the Top R&B/Hip-Hop Albums.

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Slam (band)

Slam is a producer/DJ duo from Glasgow, consisting of Stuart MacMillan (born 1966, Glasgow) and Orde Meikle (born 1964, Oxford). They are co-founders of Soma Quality Recordings. Their music style consists of house and techno.

History

McMillan and Meikle's first club event was a weekly Thursday night called Black Market, in the Glasgow club, Fury Murrys. They played a mix of house, funk and rap. In early 1988, they were approached by Steven Sleepman (aka Steven Workman), after he heard his first acid house track on DJ Segun's late night show on Radio Clyde. During a brief stint PRing for Club Eden, Sleepman secured a Saturday night at Glasgow's Tin Pan Alley, which was to become the home of Slam. Prior to the launch of her musical career Dot Allison (future musical collaborator) worked with the PR team, and DJ Harri was a regular guest on the turntables.

Slam then launched a Friday night at the Sub Club called Joy. Black Market still kept its own musical identity throughout the Summer of Love, playing an eclectic mix of musical genres.

Slam 100.5

Slamm 100.5 is a radio station in Trinidad and Tobago.

Bass

Bass or Basses may refer to:

Fish

Music