Isesaki (伊勢崎市, Isesaki-shi^?) is a city located in Gunma, Japan. The current population is 211,021, with 80,638 households. (As of June 2011)

A small city located near the geographic center of Japan's main island of Honshū, Isesaki is the fourth largest city in Gunma Prefecture and it is one of the growing cities within Gunma Prefecture. The center of the city is 15km (9mi) away from central Maebashi, 95km (59mi) from Central Tokyo, and it is located in the northwestern portion of the Kantō region and is next door neighbor to Saitama Prefecture across the Tone River.

On January 1, 2005 the towns of Akabori and Sakai and the village of Azuma from Sawa District merged with the city.

The city was founded on September 13, 1940.

Isesaki is the birthplace of Mitsuru Adachi, the creator of the baseball manga Touch, as well as several others. It is also the location of J-List, a retailer of anime goods, visual novels and related products from Japan.

Isesaki is famous for silk fabrics (along with neighboring Kiryu). This craft is known as Isesaki Meisen. It has been made since the late 17th century, and became popular during the Meiji and Taishō periods. Now, however, due to the ubiquity of Western-style clothes, its popularity is decreasing.