The rise of Macedon, from a small kingdom at the periphery of Classical Greek affairs, to one which came to dominate the entire Hellenic world (and beyond), occurred in the space of just 25 years, between 359–336 BC. This ascendancy is largely attributable to the personality and policies of Philip II.

Intact and relatively detailed histories of Greece cover the period ca. 500–362 BC, in the form of Herodotus's The Histories, Thucydides's History of the Peloponnesian War, and Xenophon's Hellenica. However, no extant history specifically covers the relevant period of Greek history (359-336 BC).

The main source for the period is Diodorus Siculus's Bibliotheca historica, written in the 1st century BC, which is therefore very much a secondary source. Diodorus devotes Book XVI to the period of Philip's reign, but the action is much compressed, and due to the scope of the work, this book also contains details of happenings during the same period elsewhere in the ancient world. Diodorus is often derided by modern historians for his style and inaccuracies, but he preserves many details of the ancient period found nowhere else. Diodorus worked primarily by epitomizing the works of other historians, omitting many details where they did not suit his purpose, which was to illustrate moral lessons from history; his account of the period therefore contains many gaps.

Alexander III of Macedon (20/21 July 356 – 10/11 June 323 BC), commonly known as Alexander the Great (Greek: Ἀλέξανδρος ὁ Μέγας, Aléxandros ho Mégas from the Greek αλέξω alexo "to defend, help" + ανήρ aner "man"), was a king of Macedon, a state in northern ancient Greece. Born in Pella in 356 BC, Alexander was tutored by Aristotle until the age of 16. By the age of thirty, he had created one of the largest empires of the ancient world, stretching from the Ionian Sea to the Himalayas. He was undefeated in battle and is considered one of history's most successful commanders.

Alexander succeeded his father, Philip II of Macedon, to the throne in 336 BC after Philip was assassinated. Upon Philip's death, Alexander inherited a strong kingdom and an experienced army. He was awarded the generalship of Greece and used this authority to launch his father's military expansion plans. In 334 BC, he invaded Persian-ruled Asia Minor and began a series of campaigns that lasted ten years. Alexander broke the power of Persia in a series of decisive battles, most notably the battles of Issus and Gaugamela. He subsequently overthrew the Persian King Darius III and conquered the entirety of the Persian Empire. At that point, his empire stretched from the Adriatic Sea to the Indus River.