A molecular assembler, as defined by K. Eric Drexler, is a "proposed device able to guide chemical reactions by positioning reactive molecules with atomic precision". Some biological molecules such as ribosomes fit this definition. This is because they receive instructions from messenger RNA and then assemble specific sequences of amino acids to construct protein molecules. However, the term "molecular assembler" usually refers to theoretical human-made devices.

Beginning in 2007, the British Engineering and Physical Sciences Research Council funds development of ribosome-like molecular assemblers. Clearly, molecular assemblers are possible in this limited sense. A technology roadmap project, led by the Battelle Memorial Institute and hosted by several U.S. National Laboratories has explored a range of atomically precise fabrication technologies, including both early-generation and longer-term prospects for programmable molecular assembly; the report was released in December, 2007.^[1] In 2008 the Engineering and Physical Sciences Research Council provided funding of 1.5 million pounds over six years for research working towards mechanized mechanosynthesis, in partnership with the Institute for Molecular Manufacturing, amongst others. [1]

Likewise, the term "molecular assembler" has been used in science fiction and popular culture to refer to a wide range of fantastic atom-manipulating nanomachines, many of which may be physically impossible in reality. Much of the controversy regarding "molecular assemblers" results from the confusion in the use of the name for both technical concepts and popular fantasies. In 1992, Drexler introduced the related but better-understood term "molecular manufacturing," which he defined as the programmed "chemical synthesis of complex structures by mechanically positioning reactive molecules, not by manipulating individual atoms."^[2]

This article mostly discusses "molecular assemblers" in the popular sense. These include hypothetical machines that manipulate individual atoms and machines with organism-like self-replicating abilities, mobility, ability to consume food, and so forth. These are quite different from devices that merely (as defined above) "guide chemical reactions by positioning reactive molecules with atomic precision".

Because synthetic molecular assemblers have never been constructed and because of the confusion regarding the meaning of the term, there has been much controversy as to whether "molecular assemblers" are possible or simply science fiction. Confusion and controversy also stem from their classification as nanotechnology, which is an active area of laboratory research which has already been applied to the production of real products; however, there had been, until recently, no research efforts into the actual construction of "molecular assemblers". A primary criticism of the computational research into products of advanced "molecular assemblers" is that the structures investigated are impossible to make today.

Nanofactories[link]

A nanofactory is a proposed system in which nanomachines (resembling molecular assemblers, or industrial robot arms) would combine reactive molecules via mechanosynthesis to build larger atomically precise parts. These, in turn, would be assembled by positioning mechanisms of assorted sizes to build macroscopic (visible) but still atomically-precise products.

A typical nanofactory would fit in a desktop box, in the vision of K. Eric Drexler published in Nanosystems: Molecular Machinery, Manufacturing and Computation (1992), a notable work of "exploratory engineering". During the last decade, others have extended the nanofactory concept, including an analysis of nanofactory convergent assembly by Ralph Merkle, a systems design of a replicating nanofactory architecture by J. Storrs Hall, Forrest Bishop's "Universal Assembler", the patented exponential assembly process by Zyvex, and a top-level systems design for a 'primitive nanofactory' by Chris Phoenix (Director of Research at the Center for Responsible Nanotechnology). All of these nanofactory designs (and more) are summarized in Chapter 4 of Kinematic Self-Replicating Machines (2004) by Robert Freitas and Ralph Merkle. The Nanofactory Collaboration,^[3] founded by Freitas and Merkle in 2000, is a focused ongoing effort involving 23 researchers from 10 organizations and 4 countries that is developing a practical research agenda^[4] specifically aimed at positionally-controlled diamond mechanosynthesis and diamondoid nanofactory development.

In 2005, a computer-animated short film of the nanofactory concept was produced by John Burch, in collaboration with Drexler. Such visions have been the subject of much debate, on several intellectual levels. No one has discovered an insurmountable problem with the underlying theories and no one has proved that the theories can be translated into practice. However, the debate continues, with some of it being summarized in the Molecular nanotechnology article.

If nanofactories could be built, severe disruption to the world economy would be one of many possible negative impacts, though it could be argued that this disruption would have little negative effect if everyone had such nanofactories. Great benefits also would be anticipated. Various works of science fiction have explored these and similar concepts. The potential for such devices was part of the mandate of a major UK study led by mechanical engineering professor Dame Ann Dowling. The report is now complete.

Self-replication[link]

"Molecular assemblers" have been confused with self-replicating machines. To produce a practical quantity of a desired product, the nanoscale size of a typical science fiction universal molecular assembler requires an extremely large number of such devices. However, a single such theoretical molecular assembler might be programmed to self-replicate, constructing many copies of itself. This would allow an exponential rate of production. Then after sufficient quantities of the molecular assemblers were available, they would then be re-programmed for production of the desired product. However, if self-replication of molecular assemblers were not restrained then it might lead to competition with naturally occurring organisms. This has been called ecophagy or the grey goo problem.^[5]

One method to building molecular assemblers is to mimic evolutionary processes employed by biological systems. Biological evolution proceeds by random variation combined with culling of the less-successful variants and reproduction of the more-successful variants. Production of complex molecular assemblers might be evolved from simpler systems since "A complex system that works is invariably found to have evolved from a simple system that worked. . . . A complex system designed from scratch never works and can not be patched up to make it work. You have to start over, beginning with a system that works."^[6] However, most published safety guidelines include "recommendations against developing ... replicator designs which permit surviving mutation or undergoing evolution".^[7]

Most assembler designs keep the "source code" external to the physical assembler. At each step of a manufacturing process, that step is read from an ordinary computer file and "broadcast" to all the assemblers. If any assembler gets out of range of that computer, or when the link between that computer and the assemblers is broken, or when that computer is unplugged, the assemblers stop replicating. Such a "broadcast architecture" is one of the safety features recommended by the "Foresight Guidelines on Molecular Nanotechnology", and a map of the 137-dimensional replicator design space^[8] recently published by Freitas and Merkle provides numerous practical methods by which replicators can be safely controlled by good design.

Drexler and Smalley debate[link]

One of the most outspoken critics of some concepts of "molecular assemblers" was Professor Richard Smalley (1943–2005) who won the Nobel prize for his contributions to the field of nanotechnology. Smalley believed that such assemblers were not physically possible and introduced scientific objections to them. His two principal technical objections were termed the "fat fingers problem" and the "sticky fingers problem". He believed these would exclude the possibility of "molecular assemblers" that worked by precision picking and placing of individual atoms. Drexler and coworkers responded to these two issues^[9] in a 2001 publication.

Smalley also believed that Drexler's speculations about apocalyptic dangers of self-replicating machines that have been equated with "molecular assemblers" would threaten the public support for development of nanotechnology. To address the debate between Drexler and Smalley regarding molecular assemblers Chemical & Engineering News published a point-counterpoint consisting of an exchange of letters that addressed the issues.^[2]

Regulation[link]

Speculation on the power of systems that have been called "molecular assemblers" has sparked a wider political discussion on the implication of nanotechnology. This is in part due to the fact that nanotechnology is a very broad term and could include "molecular assemblers." Discussion of the possible implications of fantastic molecular assemblers has prompted calls for regulation of current and future nanotechnology. There are very real concerns with the potential health and ecological impact of nanotechnology that is being integrated in manufactured products. Greenpeace for instance commissioned a report concerning nanotechnology in which they express concern into the toxicity of nanomaterials that have been introduced in the environment.^[10] However, it makes only passing references to "assembler" technology. The UK Royal Society and UK Royal Academy of Engineering also commissioned a report entitled "Nanoscience and nanotechnologies: opportunities and uncertainties"^[11] regarding the larger social and ecological implications on nanotechnology. This report does not discuss the threat posed by potential so-called "molecular assemblers."

Formal scientific review[link]

In 2006, U.S. National Academy of Sciences released the report of a study of molecular manufacturing as part of a longer report, A Matter of Size: Triennial Review of the National Nanotechnology Initiative^[12] The study committee reviewed the technical content of Nanosystems, and in its conclusion states that no current theoretical analysis can be considered definitive regarding several questions of potential system performance, and that optimal paths for implementing high-performance systems cannot be predicted with confidence. It recommends experimental research to advance knowledge in this area:

"Although theoretical calculations can be made today, the eventually attainable range of chemical reaction cycles, error rates, speed of operation, and thermodynamic efficiencies of such bottom-up manufacturing systems cannot be reliably predicted at this time. Thus, the eventually attainable perfection and complexity of manufactured products, while they can be calculated in theory, cannot be predicted with confidence. Finally, the optimum research paths that might lead to systems which greatly exceed the thermodynamic efficiencies and other capabilities of biological systems cannot be reliably predicted at this time. Research funding that is based on the ability of investigators to produce experimental demonstrations that link to abstract models and guide long-term vision is most appropriate to achieve this goal."

Grey goo[link]

One potential scenario that has been envisioned is out-of-control self-replicating molecular assemblers in the form of grey goo which consumes carbon to continue its replication. If unchecked such mechanical replication could potentially consume whole ecoregions or the whole Earth (ecophagy), or it could simply outcompete natural lifeforms for necessary resources such as carbon, ATP, or UV light (which some nanomotor examples run on). It is worth noting that the ecophagy and 'grey goo' scenarios, like synthetic molecular assemblers, are based upon still-theoretical technologies that have not yet been demonstrated experimentally.

In fiction[link]

Molecular assemblers are a popular topic in science fiction, for example, the matter compiler in The Diamond Age and the cornucopia machine in Singularity Sky. The replicator in Star Trek might also be considered a molecular assembler. A molecular assembler is also a key element of the plot of the computer game Deus Ex (called a "universal constructor" in the game).

See also[link]

References[link]

External links[link]

• Nanoengineer-1 free Open-source multi-scale modeling and simulation program for nano-composites with special support for structural DNA nanotechnology
• Nano-Hive: Nanospace Simulator free software for modeling nanotech entities
• Foresight Institute proposes guidelines for responsible development of molecular manufacturing technologies
• Center for Responsible Nanotechnology
• Molecular Assembler website
• Rage Against the (Green) Machine article originally in Wired
• Government launches nano study UK EducationGuardian, 11 June 2003
• "Unraveling the Big Debate over Small Machines"
• Paper on assembly
• http://www.zyvex.com/nanotech/nano4/merklePaper.html
• Kinematic Self-Replicating Machines (http://www.MolecularAssembler.com/KSRM.htm) online technical book: first comprehensive survey of molecular assemblers (2004) by Robert Freitas and Ralph Merkle
• Design of a Primitive Nanofactory
• Video - Nanofactory in Action
• Nanofactory technology
• Review of Molecular Manufacturing

This article contains Japanese text. Without proper rendering support, you may see question marks, boxes, or other symbols instead of kanji and kana.

Michio Kaku (加来 道雄, Kaku Michio^?, born January 24, 1947) is an American theoretical physicist, the Henry Semat Professor of Theoretical Physics in the City College of New York of City University of New York, a co-founder of string field theory,^[1] a futurist, and a "communicator" and "popularizer" of science. He has written several books about physics and related topics; he has made frequent appearances on radio, television, and film; and he writes extensive online blogs and articles. He has written two New York Times best sellers, Physics of the Impossible (2008) and Physics of the Future (2011). He has hosted several TV specials for BBC-TV, the Discovery Channel, and the Science Channel.

Early life and education[link]

Kaku was born in San Jose, California to Japanese immigrant parents. His grandfather came to the United States to take part in the clean-up operation after the 1906 San Francisco Earthquake^{[citation needed]}. His father was born in California but was educated in Japan and spoke little English. Both his parents were put in the Tule Lake War Relocation Center, where they met and where his two brothers were born.

At Cubberley High School in Palo Alto, Kaku assembled an atom smasher in his parents' garage for a science fair project.^[2] At the National Science Fair in Albuquerque, New Mexico, he attracted the attention of physicist Edward Teller, who took Kaku as a protégé, awarding him the Hertz Engineering Scholarship. Kaku graduated summa cum laude from Harvard University in 1968 and was first in his physics class. He attended the Berkeley Radiation Laboratory at the University of California, Berkeley and received a Ph.D. in 1972, and in 1972 he held a lectureship at Princeton University.

During the Vietnam War, Kaku completed his U.S. Army basic training at Fort Benning, Georgia and his advanced individual training at Fort Lewis, Washington.^[3] However, the Vietnam War ended before he was deployed as an infantryman.

Academic career[link]

Kaku became a visiting professor at the Institute for Advanced Study in Princeton,^[4] and New York University.^[5] He currently holds the Henry Semat Chair and Professorship in theoretical physics at the City College of New York.^[6]

Kaku has had over 70 articles published in physics journals such as Physical Review, covering topics such as superstring theory, supergravity, supersymmetry, and hadronic physics.^[7] In 1974, along with Prof. Keiji Kikkawa of Osaka University, he authored the first papers describing string theory in a field form.^[8][9]

Kaku is the author of several textbooks on string theory and quantum field theory.

Popular science[link]

Kaku is most widely known as a popularizer of science.^[10] He has written books and appeared on many television programs as well as film. He also hosts a weekly radio program.

Books[link]

Kaku is the author of various popular science books.

• Hyperspace (1994)
• Beyond Einstein (with Jennifer Thompson) (1995)
• Visions: How Science Will Revolutionize the 21st Century^[11] (1998)
• Einstein's Cosmos (2004)
• Parallel Worlds (2004)
• Physics of the Impossible (2008)
• Physics of the Future (2011)

Hyperspace was a best-seller and was voted one of the best science books of the year by both The New York Times^[10] and The Washington Post. Parallel Worlds was a finalist for the Samuel Johnson Prize for non-fiction in the UK.^[12]

Radio[link]

Kaku is the host of the weekly, one-hour radio program Explorations, produced by the Pacifica Foundation's WBAI in New York. "Explorations" is syndicated to community and independent radio stations and makes previous broadcasts available on the program's website. Kaku defines the show as dealing with the general topics of science, war, peace, and the environment.

In April 2006, Kaku began broadcasting Science Fantastic on 90 commercial radio stations, the only nationally syndicated science program on commercial radio in the United States. It is syndicated by Talk Radio Network and now reaches 130 radio stations and America's Talk on XM. The program is formatted as a live listener call-in show, focusing on "futurology," which he defines as the future of science.^{[citation needed]} Featured guests include Nobel laureates and top researchers on the topics of string theory, time travel, black holes, gene therapy, aging, space travel, artificial intelligence, and SETI. When Kaku is busy filming for television, Science Fantastic goes on hiatus, sometimes for several months. Kaku is also a frequent guest on many programs, where he is outspoken in all areas and issues he considers of importance, such as the program Coast to Coast AM, where on 30 November 2007, he reaffirmed his belief that there is a 100% probability of extraterrestrial life in the universe.^[13]

Kaku has appeared on The Opie and Anthony Show a number of times, discussing popular fiction such as Back to The Future, Lost, and the theories behind time-travel that these and other fictional entertainment focus on.

Television and film[link]

Kaku has appeared in many forms of media and on many programs and networks, including Good Morning America, The Screen Savers, Larry King Live, 60 Minutes, Nightline, 20/20, Naked Science, CNN, ABC News, CBS News, NBC News, Al Jazeera English, Fox News Channel, The History Channel, Conan, The Science Channel, The Discovery Channel, TLC, Countdown with Keith Olbermann, The Colbert Report, The Art Bell Show and its successor, Coast To Coast AM, BBC World News America, The Opie & Anthony Show, The Covino & Rich Show, Head Rush, The Late Show with David Letterman, and Real Time with Bill Maher.

In 1999, Kaku was one of the scientists profiled in the feature-length film Me and Isaac Newton, directed by Michael Apted. It played theatrically in the United States, was later broadcast on national TV, and won several film awards.^{[citation needed]}

In 2005, Kaku appeared in the short documentary Obsessed & Scientific. The film is about the possibility of time travel and the people who dream about it. It screened at the Montreal World Film Festival and a feature film expansion is in development talks. Kaku also appeared in the ABC documentary UFOs: Seeing Is Believing, in which he suggested that while he believes it is extremely unlikely that extraterrestrials have ever actually visited Earth, we must keep our minds open to the possible existence of civilizations a million years ahead of us in technology, where entirely new avenues of physics open up. He also discussed the future of interstellar exploration and alien life in the Discovery Channel special Alien Planet as one of the multiple speakers who co-hosted the show, and Einstein's Theory of Relativity on The History Channel.

In February 2006, Kaku appeared as presenter in the BBC-TV four-part documentary Time which seeks to explore the mysterious nature of time. Part one of the series concerns personal time, and how we perceive and measure the passing of time. The second in the series deals with cheating time, exploring possibilities of extending the lifespan of organisms. The geological time covered in part three explores the ages of the earth and the sun. Part four covers the topics of cosmological time, the beginning of time and the events that occurred at the instant of the big bang.

On January 28, 2007, Kaku hosted the Discovery Channel series 2057. This three-hour program discussed how medicine, the city, and energy could change over the next 50 years.

In 2008, Kaku hosted the three-hour BBC-TV documentary Visions of the Future, on the future of computers, medicine, and quantum physics, and he appeared in several episodes of the History Channel's Universe series.

On December 1, 2009, he began hosting a 12-episode weekly TV series for the Science Channel at 10 pm, called Sci Fi Science: Physics of the Impossible, based on his best-selling book. Each 30-minute episode discusses the scientific basis behind imaginative schemes, such as time travel, parallel universes, warp drive, star ships, light sabers, force fields, teleportation, invisibility, death stars, and even superpowers and flying saucers. Each episode includes interviews with the world's top scientists working on prototypes of these technologies, interviews with science fiction fans, clips from science fiction movies, and special effects and computer graphics. Although these inventions are impossible today, the series discusses when these technologies might become feasible in the future.^[14]

In 2010, he began to appear in a series on the website Gametrailers.com called Science of Games, discussing the scientific aspects of various popular video games such as Mass Effect 2 and Star Wars: The Force Unleashed.

Kaku is popular in mainstream media because of his knowledge and his accessible approach to presenting complex subjects in science. While his technical writings are confined to theoretical physics, his public speaking and media appearances cover a broad range of topics, from the Kardashev scale to more esoteric subjects such as wormholes and time travel. In January 2007, Kaku visited Oman. While there, he talked at length to select members of that country's decision makers. In an interview with local media, Dr Kaku elaborated on his vision of mankind's future. Kaku considers climate change and terrorism as serious threats in man's evolution from a Type 0 civilization to Type 1.^[15]

He is pictured in Symphony of Science's newest song (as of September 6, 2011), 'The Quantum World.'

On October 11, 2010, Michio Kaku appeared in the BBC program "What Happened Before the Big Bang" (along with Laura Mersini-Houghton, Andrei Linde, Roger Penrose, Lee Smolin, Neil Turok, and other notable cosmologists and physicists), where he propounded his theory of the universe created out of nothing.^[16]

Social policy advocacy[link]

Kaku has publicly stated his concerns over matters including the anthropogenic cause of global warming, nuclear armament, nuclear power and the general misuse of science.^[17] He was critical of the Cassini–Huygens space probe because of the 72 pounds (33 kg) of plutonium contained in the craft for use by its radioisotope thermoelectric generator. Conscious of the possibility of casualties if the probe's fuel were dispersed into the environment during a malfunction and crash as the probe was making a 'sling-shot' maneuver around earth, Kaku publicly criticized NASA's risk assessment.^[18] He has also spoken on the dangers of space junk and called for more and better monitoring. Kaku is generally a vigorous supporter of the exploration of outer space, believing that the ultimate destiny of the human race may lie in extrasolar planets; but he is critical of some of the cost-ineffective missions and methods of NASA.

Kaku credits his anti-nuclear war position to programs he heard on the Pacifica Radio network, during his student years in California. It was during this period that he made the decision to turn away from a career developing the next generation of nuclear weapons in association with Edward Teller and focused on research, teaching, writing and media.^{[citation needed]} Kaku joined with others such as Helen Caldicott, Jonathan Schell, Peace Action and was instrumental in building a global anti-nuclear weapons movement that arose in the 1980s, during the administration of U.S. President Ronald Reagan.

Kaku was a board member of Peace Action and on the board of radio station WBAI-FM in New York City where he originated his long running program, Explorations, that focused on the issues of science, war, peace and the environment.

His remark from an interview in support of SETI, "We could be in the middle of an intergalactic conversation...and we wouldn't even know.", is used in the third Symphony of Science installment "Our Place in the Cosmos".

Personal life[link]

Kaku is married to Shizue Kaku and has two daughters.^[19]

Bibliography[link]

References[link]

External links[link]

Wikimedia Commons has media related to: Michio Kaku

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