Airframe is a novel by American writer Michael Crichton, first published in hardcover in 1996 by Knopf and as a paperback in 1997 by Ballantine Books. The plot follows Casey Singleton, a quality assurance vice-president at the fictional aerospace manufacturer Norton Aircraft, as she investigates an in-flight accident aboard a Norton-manufactured airliner that leaves three passengers dead and fifty-six injured.

Airframe remains one of Crichton's few novels to be unadapted to film (and the only such novel written in the twentieth century). Crichton stated this to be due to the great expenses needed to make such a film.

The novel opens aboard Hong Kong-based Transpacific Airlines Flight 545, a Norton Aircraft-manufactured N-22 wide-body aircraft, flying from Hong Kong to Denver. An incident occurs on board the plane about a half-hour west of the California coast and the pilot requests an emergency landing at Los Angeles International Airport, stating that the plane encountered "severe turbulence" in flight. The pilot gives air traffic control conflicting information regarding the type and severity of injuries, but does inform them that crew members were hurt and "three passengers are dead."

A novel is a book of long narrative in literary prose. The genre has historical roots both in the fields of the medieval and early modern romance and in the tradition of the novella. The latter supplied the present generic term in the late 18th century.

Further definition of the genre is historically difficult. The construction of the narrative, the plot, the way reality is created in the works of fiction, the fascination of the character study, and the use of language are usually discussed to show a novel's artistic merits. Most of these requirements were introduced in the 16th and 17th centuries, in order to give fiction a justification outside the field of factual history.

The fictional narrative, the novel's distinct "literary" prose, specific media requirements (the use of paper and print), a characteristic subject matter that creates both intimacy and a typical epic depth can be seen as features that developed with the Western (and modern) market of fiction. The separation of a field of histories from a field of literary fiction fueled the evolution of these features in the last 400 years.

John Michael Crichton ( /ˈkraɪtən/; rhymes with frighten; October 23, 1942 – November 4, 2008), best known as Michael Crichton, was an American best-selling author, producer, director, and screenwriter, best known for his work in the science fiction, medical fiction, and thriller genres. His books have sold over 200 million copies worldwide, and many have been adapted into films. In 1994, Crichton became the only creative artist ever to have works simultaneously charting at #1 in television, film, and book sales (with ER, Jurassic Park, and Disclosure, respectively).

His literary works are usually based on the action genre and heavily feature technology. His novels epitomize the techno-thriller genre of literature, often exploring technology and failures of human interaction with it, especially resulting in catastrophes with biotechnology. Many of his future history novels have medical or scientific underpinnings, reflecting his medical training and science background. He was the author of, among others, Jurassic Park, The Andromeda Strain, Congo, Travels, Sphere, Rising Sun, Disclosure, The Lost World, Airframe, Timeline, Prey, State of Fear, Next (the final book published before his death), Pirate Latitudes (published November 24, 2009), and a final unfinished techno-thriller, Micro, which was published in November 2011.