- published: 21 Nov 2013
- views: 737
Medium spiny neurons (MSNs), also known as spiny projection neurons, are a special type of GABA-ergic inhibitory cell representing 95% of neurons within the human striatum, a structure located in the basal ganglia. Medium spiny neurons have two primary phenotypes (i.e., characteristic types): D1-type MSNs of the "direct pathway" and D2-type MSNs of the "indirect pathway".
Direct pathway MSNs excite their ultimate basal ganglia output structure (e.g., the thalamus) and promote associated behaviors; these neurons express D1-type dopamine receptors, adenosine A1 receptors, dynorphin peptides, and substance P peptides. Indirect pathway MSNs inhibit their output structure and in turn inhibit associated behaviors; these neurons express D2-type dopamine receptors, adenosine A2A receptors (A2A), DRD2–A2A heterotetramers, and enkephalin. Both types express glutamate receptors (NMDAR and AMPAR) and CB1 receptors. A subpopulation of MSNs contain both D1-type and D2-type receptors, with approximately 40% of striatal MSNs expressing both DRD1 and DRD2 mRNA. In the nucleus accumbens (NAcc), these mixed-type MSNs that contain both D1-type and D2-type receptors are mostly contained in the NAcc shell.
The mouse in this video expresses channelrhodopsin-2 in the indirect pathway striatal medium spiny neurons. When the word "LASER" appears in this video, these cells are stimulated and movement is inhibited.
Follow us at: https://plus.google.com/+tutorvista/ Check us out at http://www.tutorvista.com/content/biology/biology-iii/animal-histology/nervous-tissue.php Structure Of Neuron Most neurons can be anatomically characterized as: Unipolar or pseudounipolar: dendrite and axon emerging from same process. Bipolar: axon and single dendrite on opposite ends of the soma. Multipolar: more than two dendrites: Golgi I: neurons with long-projecting axonal processes; examples are pyramidal cells, Purkinje cells, and anterior horn cells. Golgi II: neurons whose axonal process projects locally; the best example is the granule cell. Furthermore, we can see some unique types of neurons that can be identified according to their location in the nervous system and distinct shape. Some examples are...
Learning with the Illumianti: Part 16. Introduction to the Basal Ganglia Keywords: Basal ganglia, GABA works Inhibitory, Glutamate works Excitatory, Dopamine works inhibitory via D2 receptors, and excitatory via D1 receptors, direct pathway of the basal ganglia, indirect pathway of the basal ganglia, Caudate, Putamen, Striatum, Globus pallidus internal, Globus pallidus external, Substantia nigra pars reticulata, Pallidum, Ventral lateral nucleus, Ventral anterior nucleus, Subthalamic nucleus, spiny neurons, MSPs, Huntingtons disease, association areas, insular and cingulate cortex, corticostriatal pathway, dendritic spines, disinhibition, the prefrontal loop, the limbic loop, Parkinson's disease, L DOPA, Alpha-synuclein, Lewy bodies.
Human skin cells can be converted into medium spiny neurons. Subscribe this channel to watch more motivational, inspirational, valuable and informative videos to soothe, cleanse and inspire your health, mind, body and spirit. Stay tuned and keep watching. Disclaimer:-- Any medical information published on this video is NOT intended as a substitute for informed medical advice and you should not take any action before consulting with a health care professional. Copyright notice:-- "Copyright Disclaimer Under Section 107 of the Copyright Act 1976, allowance is made for "fair use" for purposes such as criticism, comment, news reporting, teaching, scholarship, and research. Fair use is a use permitted by copyright statute that might otherwise be infringing. Non-profit, educational or persona...
This image was collected with a Zeiss LSM510 Meta Confocal using a 63X NA1.4 oil immersion lens with a 3.3X optical zoom. I used a 488nm Laser for excitation. The Z stacks were 0.3 microns. The image was deconvolved using Autoquant X3 software with spherical aberration correction. Movie was made with Imaris software.
Thomas Südhof and colleagues reveal that neuroligin-3 mutations enhance repetitive behaviors similar to those seen in autism spectrum disorders by selectively affecting one type of medium spiny neuron in a specific brain region.
A video of mitochondrial movement in the axons of hippocampal neurons.
The mouse in this video expresses channelrhodopsin-2 in the indirect pathway striatal medium spiny neurons. When the word "LASER" appears in this video, these cells are stimulated and movement is inhibited.
Follow us at: https://plus.google.com/+tutorvista/ Check us out at http://www.tutorvista.com/content/biology/biology-iii/animal-histology/nervous-tissue.php Structure Of Neuron Most neurons can be anatomically characterized as: Unipolar or pseudounipolar: dendrite and axon emerging from same process. Bipolar: axon and single dendrite on opposite ends of the soma. Multipolar: more than two dendrites: Golgi I: neurons with long-projecting axonal processes; examples are pyramidal cells, Purkinje cells, and anterior horn cells. Golgi II: neurons whose axonal process projects locally; the best example is the granule cell. Furthermore, we can see some unique types of neurons that can be identified according to their location in the nervous system and distinct shape. Some examples are...
Learning with the Illumianti: Part 16. Introduction to the Basal Ganglia Keywords: Basal ganglia, GABA works Inhibitory, Glutamate works Excitatory, Dopamine works inhibitory via D2 receptors, and excitatory via D1 receptors, direct pathway of the basal ganglia, indirect pathway of the basal ganglia, Caudate, Putamen, Striatum, Globus pallidus internal, Globus pallidus external, Substantia nigra pars reticulata, Pallidum, Ventral lateral nucleus, Ventral anterior nucleus, Subthalamic nucleus, spiny neurons, MSPs, Huntingtons disease, association areas, insular and cingulate cortex, corticostriatal pathway, dendritic spines, disinhibition, the prefrontal loop, the limbic loop, Parkinson's disease, L DOPA, Alpha-synuclein, Lewy bodies.
Human skin cells can be converted into medium spiny neurons. Subscribe this channel to watch more motivational, inspirational, valuable and informative videos to soothe, cleanse and inspire your health, mind, body and spirit. Stay tuned and keep watching. Disclaimer:-- Any medical information published on this video is NOT intended as a substitute for informed medical advice and you should not take any action before consulting with a health care professional. Copyright notice:-- "Copyright Disclaimer Under Section 107 of the Copyright Act 1976, allowance is made for "fair use" for purposes such as criticism, comment, news reporting, teaching, scholarship, and research. Fair use is a use permitted by copyright statute that might otherwise be infringing. Non-profit, educational or persona...
This image was collected with a Zeiss LSM510 Meta Confocal using a 63X NA1.4 oil immersion lens with a 3.3X optical zoom. I used a 488nm Laser for excitation. The Z stacks were 0.3 microns. The image was deconvolved using Autoquant X3 software with spherical aberration correction. Movie was made with Imaris software.
Thomas Südhof and colleagues reveal that neuroligin-3 mutations enhance repetitive behaviors similar to those seen in autism spectrum disorders by selectively affecting one type of medium spiny neuron in a specific brain region.
A video of mitochondrial movement in the axons of hippocampal neurons.
Social behaviors in species as diverse as honey bees and humans promote group survival but often come at some cost to the individual. Although reinforcement of adaptive social interactions is ostensibly required for the evolutionary persistence of these behaviors, the neural mechanisms by which social reward is encoded by the brain are largely unknown. Evidence that in mice oxytocin (OT) acts as a social reinforcement signal within the nucleus accumbens (NAc) core, where it elicits a presynaptically expressed long-term depression of excitatory synaptic transmission in medium spiny neurons will be presented. Although the NAc receives OT receptor-containing inputs from several brain regions, genetic deletion of these receptors specifically from dorsal raphe nucleus, which provides serotonerg...
1 April 2015, SwissTech Convention Center, Lausanne, Switzerland Website: thebrainforum.org Elena Cattaneo (Professor and Director of UniStem, University of Milan, Italy) demonstrates that human embryonic stem cells may fight the effects of degeneration in Parkinson’s and Huntington’s diseases. About speaker: Prof. Elena Cattaneo is the Director of the Laboratory of Stem Cell Biology and Pharmacology of Neurodegenerative Diseases at the Department of Biosciences as well as co-founder and first appointed Director of UniStem, the Centre for Stem Cell Research of the University of Milano. The main research theme of her lab is the molecular pathophysiology of Huntington's disease (HD). In particular, the laboratory aims at exploiting the recent advances in embryonic and induced stem cell b...
Common forms of short-term synaptic plasticities are associated with non-linear responses to calcium increases in the post-synaptic compartment. Calmodulin, one of the main calcium sensors in eukaryotic cells, is a small protein that carries four calcium binding sites with different affinities. One can explain many properties of calmodulin by allosteric mechanisms, in particular the apparent increasing calcium affinity with fractional occupancy, the activity of non-saturated forms of calmodulin, and the increase in calcium affinity once calmodulin is bound to a target. Because calmodulin can bind several targets with different affinities in its different conformations, an allosteric model can explain how it can modulate different targets at different calcium concentrations. These propertie...
A neuron (/ˈnjʊərɒn/ NYEWR-on or /ˈnʊərɒn/ NEWR-on; also known as a neurone or nerve cell) is an electrically excitable cell that processes and transmits information through electrical and chemical signals. These signals between neurons occur via synapses, specialized connections with other cells. Neurons can connect to each other to form neural networks. Neurons are the core components of the nervous system, which includes the brain, spinal cord and the ganglia of the peripheral nervous system (PNS) which comprises the central nervous system (CNS). Specialized types of neurons include: sensory neurons which respond to touch, sound, light and all other stimuli affecting the cells of the sensory organs, that then send signals to the spinal cord and brain; motor neurons that receive signals ...
Digital images are collections of measurements of photon flux. To display, manipulate, store and make measurements of digital images, you need a basic understanding as provided in this lecture.
basal ganglia anatomy
The cerebral cortex is the outermost layered structure of neural tissue of the cerebrum (brain), in humans and other mammals. It covers the cerebrum, and is divided into two cortices, along the sagittal plane, covering the left and right cerebral hemispheres. The medial longitudinal fissure is a deep groove that separates these two hemispheres. The cerebral cortex plays a key role in memory, attention, perceptual awareness, thought, language, and consciousness. The neocortex which is the major part of the cortex, consists of up to six horizontal layers, each with a different composition in terms of neurons and connectivity. The human cerebral cortex is 2 to 4 millimetres (0.079 to 0.157 in) thick. It is referred to as gray matter as it consists of cell bodies and capillaries and contrasts ...
Self Stimulation—How Positive Feedback Loops Wire the Brain Air date: Wednesday, May 09, 2012, 3:00:00 PM Time displayed is Eastern Time, Washington DC Local Views: Total views: 129, (128 Live, 1 On-demand) Category: Wednesday Afternoon Lectures Description: A great deal of brain development happens after birth. During this period, sensory inputs and patterns of activity within the brain drive the refinement of circuits and the formation of synapses. This is well established for parts of the brain that receive signals from the outside world, such as sensory systems. Much less is known about the function of activity in shaping the development of non-sensory and sub-cortical systems. Dr. Sabatini will show that activity in a recurrent loop between the basal ganglia and c...
The basal ganglia (or basal nuclei) comprise multiple subcortical nuclei, of varied origin, in the brains of vertebrates, which are situated at the base of the forebrain. Basal ganglia are strongly interconnected with the cerebral cortex, thalamus, and brainstem, as well as several other brain areas. The basal ganglia are associated with a variety of functions including: control of voluntary motor movements, procedural learning, routine behaviors or "habits" such as bruxism, eye movements, cognition and emotion. Currently, popular theories implicate the basal ganglia primarily in action selection; that is, it helps determine the decision of which of several possible behaviors to execute at any given time. In more specific terms, the basal ganglia's primary function is likely to control and...
Acetylcholine is an organic molecule that acts as a neurotransmitter in many organisms, including humans. It is an ester of acetic acid and choline, with chemical formula CH 3COO(CH 2)2N+(CH 3)3 and systematic name 2-acetoxy-N,N,N-trimethylethanaminium. This video targeted to blind users. Attribution: Article text available under CC-BY-SA Public domain image source in video