Priest Anthony Holmes (born October 7, 1973 in Fort Smith, Arkansas) is a former American football running back of the National Football League. He was originally signed by the Baltimore Ravens as an undrafted free agent in 1997. He played college football at Texas.

Holmes earned a Super Bowl ring with the Ravens in Super Bowl XXXV. After rushing for just over 2,000 yards in four seasons in Baltimore, Holmes experienced breakout success after signing with the Kansas City Chiefs as a free agent in 2001. During his seven-year stint with the Chiefs, Holmes was a three-time All-Pro, three-time Pro Bowl selection and was named NFL Offensive Player of the Year in 2002. Holmes sat out the 2006 season with a neck injury, and after a brief comeback attempt in 2007 retired from the NFL. Holmes was also inducted into the University of Texas Hall of Honor, and the Texas High School Sports Hall of Fame in 2007.

Priest Anthony Holmes was born in Fort Smith, Arkansas. Although he carries the last name of his biological father, he never met the man, only seeing him for the first time at his funeral. He was raised in San Antonio, Texas by his mother Norma, and stepfather Herman Morris. When he was thirteen years old, Holmes spent a summer in Detroit, Michigan, working for his grandfather's lawn care service. Working with much older men for twelve hours a day, six days a week, Holmes learned the work ethic that later shaped him as a football player.