- Order:
- Duration: 4:03
- Updated: 30 Dec 2012
- published: 19 Oct 2012
- views: 11006071
- author: littlemixVEVO
Messenger of generations, I can change you, you can change me.
Following your winding staircase, doors are opened, doors are
closed behind.
Codes are broken, we can re-program.
Dark New Age
Protein synthesis, replication, cell repairing.
Dark New Age
We are blessed with the Midas touch.
Dark New Age
We are golden, we are sulphur, we are water.
Dark New Age
everybody says that i'm getting older
i can't stop aging, it's on my shoulders
to get sober every time i see the state i'm in
so what's so strange, i'm only human
oh god help us, we're only human (x2)
on this summer's night i'm glad to be alive
everybody says it's time to live my life
it's a state of mind but it feels just right
i get reborn as the night moves on
oh god help us, we're only human (x2)
you waste your time working 9 to 5
you play along, you can't decide
you know what's wrong, you feel what's right
you toss and turn, you can't sleep at night
satellite up high, flying through the sky
i spy i spy with my little eye
wave the truth goodbye believe your lies are they watching me, ccctv
oh god help us......
everybody says that i'm getting older
i can't stop aging, it's on my shoulders
to get sober every time i see the state i'm in
so what's so strange, i'm only human
oh god help us, we're only human (x2)
on this summer's night i'm glad to be alive
everybody says it's time to live my life
it's a state of mind but it feels just right
i get reborn as the night moves on
oh god help us, we're only human (x2)
you waste your time working 9 to 5
you play along, you can't decide
you know what's wrong, you feel what's right
you toss and turn, you can't sleep at night
satellite up high, flying through the sky
i spy i spy with my little eye
wave the truth goodbye believe your lies are they watching me, ccctv
oh god help us......
my DNA is not for sale.......
Feel the music son, we got you programmed like a beat
When I press snare, yo, guard your grill
Press kick, you move your feet, you can?t compete
I got my hydrants parked on every street
I?m federal nigga, son of sun, come close and feel the heat
I am the streets, the white lines only separate me from me
You hydroplane in false gods name and still crash into me
Sign and tree, mountainside, guardrail into the sea
They thought they stole you from my arms then carried you to me
Here?s the key, DNA encoded in a beat
White rocks in a vial, nigga, ain?t got nuthin? on me
Bitch I?m free, ask these editors at MTV
Far as they know they?re publishing some new school poetry
Let it be ?cause even that will do to turn the key
Doorways into other worlds, the truth shall set you free
You are me, I am you, but also I?m he
Shepherd of a bastard flock that grazes in the streets
Feel the beat nod your head lean back, yo, touch your feet
Let me see you pop that thang right there girl in your seat
Feel the heat, count this page amongst your whitest sheets
Comfort in my every word slide under countless sheep
Hail Mary, Mother of God
Got the whole host of angels shuffling in my iPod
Niggas learned to raise their voices when I lowered my rod
Staff of Moses, Pharaoh knows it, son, my word is my bond
Tune my heart with mind, speak my nature, divine
Callin' shit into existence back in '79
With the future in my pocket tightly gripped like a 9
Keep my finger on the trigger waiting for the right time
Ancient niggas align, path of cosmic design
Blood of kings ?cause Saturn?s rings don?t need no diamonds to shine
Yes, the reason for the season, ornamented divine
Coded Language of the mystics with my fist in the sky
Keep your head up, we represent the real, my nigga dead up
Book of the dead, history bled, this nigga fed up
Led us to despair, some into prayer and they won?t let up
Until they got us worshiping them false gods instead of the realness
God of the streets, my niggas feel this
We nod our heads and worship through beats
Go ahead and kneel
It?s the love that makes the cipher complete
And it?d displayed through the way the bass line marries the beat
Hail Mary, Mother of God
Got the whole host of angels shuffling in my iPod
Niggas learned to raise their voices when I lowered my rod
Staff of Moses, Pharaoh knows it, son, my word is my bond
Tune my heart with mind, speak my nature, divine
Callin' shit into existence back in '79
With the future in my pocket tightly gripped like a 9
Keep my finger on the trigger waiting for the right time
Ancient niggas align, path of cosmic design
Blood of kings ?cause Saturn?s rings don?t need no diamonds to shine
Yes, the reason for the season, ornamented divine
Coded language of the mystics with my fist in the sky
When it came to pass,
Loaded, pass me by
Fate, with a single blow,
Has clustered by me now
True, I had my chance,
True, true, true I had those wild charms for you
Oh, oh...
My fire burned them out
But we will not be moved by it(2x)
Your mind would never ache,
When you were young and sound
The way your heart aches now,
You feel you sent them onto ground
Love, love, love til you got enough,
Dance, dance, dance, if you got no love around you Love, love, love, til' you got enough,
Dance, dance, dance, til' there's noone left to hound you
We will not be moved by it(2x)
Oh, oh...
Love, love, love til you got enough,
Dance, dance, dance, if you got no love around you Love, love, love, til you got enough,
Dance, dance, dance, til' there's noone left to hound you
D - N - A
(instrumental)
DNA, welcome to my DNA
Stupidly who wants to stay
With my DNA
DNA, you cannot fix what you get
Things that I try to forget
In my DNA
Can you forgive me?
For things that I've said
Things that I've done
Go now and never come back
DNA, we all got expiring dates
Trust me there's no get away
From my DNA
DNA, Wires of sadness and pain
Always remaining the same, my DNA
Disarmed by the music, there's bombs in my head
You'll always get burned
Go now and never get back
My deadly venom, Soon I'll be dead
Go now my lover
[Hook: Danny Brown]
It's in my, D.N.A
Cause my pops like to get fucked up the same way
It's in my, D.N.A
Cause my moms like to get fucked up the same way
D.N.A., D.N.A
Cause my fam like to get fucked up the same way
D.N.A., D.N.A
Cause my fam like to get fucked up the same way
[Verse 1:]
Waking up, drooling on Versace pillowcases
And I'm smoking eight a day, I might end up a mental
patient
Terrycloth bathrobes, blunts and ashtrays
White wine in flute glass, early morning Saturdays
Food plates and grade A, crepes and OJ
Bitches swimming topless in Chlorine off morphine
Emails on iPads don't answer when phone rings
Text message full coming down on four beans
Every night like a bachelor party in Sin City
Bitches sniffing coke off each other titties with
rolled 50s
Life I live like Charlie Sheen and Rick James
Goin' hard until it ain't a dollar to my name
This that triple X shit nigga how ya feel
Groupies like glam rock poison logo pills
Sniffing molly off amps with blond haired tramps
When I'm on my way to the stage every night I rage
[Hook:]
It's in my, D.N.A
Cause my pops like to get fucked up the same way
It's in my, D.N.A
Cause my moms like to get fucked up the same way
D.N.A., D.N.A
Cause my fam like to get fucked up the same way
D.N.A., D.N.A
Cause my fam like to get fucked up the same way
[Verse 2:]
Warhols all on the wall of the villa
Adderall popping got me jumping to ceiling
Perceived as a villain no sentiment in my sentence
For instance in instants they'll be calling forensics
If incidents occur remember these ain't just words
Go from talking shit to organs preserved
You soft serve rappers just hide behind your reverb
And even with effects you'll just end you dessert
I research and homework, make you dig ya own dirt
On beats buried alive, ratting wiseguys
I'm with a Latin bitch fat ass and well proportioned
thighs
And love to see it cumming so I squirt it in her eyes
I'm hopping out that new shit like narcs on Tuesday
The grill on it shiny like LL Cool J's
What's on my waist could make a nigga meet his doomsday
To describe your mixtape that shit was like a toothache
[Hook:]
It's in my, D.N.A
Cause my pops like to get fucked up the same way
It's in my, D.N.A
Cause my moms like to get fucked up the same way
D.N.A., D.N.A
Cause my fam like to get fucked up the same way
D.N.A., D.N.A
my dna is running out i am not the guy who makes you
smile now
and when we talk it's not the same but i already lost the
gene for feeling pain
so i won't cry i will just pretend i'm still the one and
that we are in love again
but when i call you are never home and i am down to six
or seven chromosomes
but you don't care or understand how it feels to be a
single double strand
(chorus)
all these molecules don't make me who i am, you did
i'm still the one
(chorus)
Latly somethings messing with my head YEah it's hard to know what's real and whats pretend
the way i feel i don't have the cure of cure of but the one thing that i'm sure of sure of
i am the one and only no one is exactly like me
iam the one and only
who turned out this way it's all in my D.N.A
Do not attempt to copy i'm on this ride and there ain't no stoping me
It's in my DNA-ehay-ehay-ehay (that's okay)
So let the music play-ehay-ehay (let it, let it)
It's in my DNA-ehay-ehay-ehay (rock wid it)
I was born to shut it down
Rye Rye
Eh, It's natural
I don't need no Adderall
And just let the beat bump
And Imma make yo bodies jump
All my chickas reports to the dance floor
Or, better yet, sweat our your dance pores
Pull out cho weaves
Done for
These niggas run the world, I rep fo um
We get stupid, we get dumb
Party all night
Till we numb
I got shades on, forget a hater
And don't be throwing no ass in tha... ?
That's right, that's right
We can keep this... till they turn on the lights
Let's go, Let's go
Cause a party ain't a party till you put on a show
Natural killah-killah
Now my body move realer-realer
Up in the club, screamin' we don't give a fuck
... ?
It's in my DNA-ehay-ehay-ehay
So let the music play-ehay-ehay
It's in my DNA-ehay-ehay-ehay
I was born to shut it down
It's in my DNA-ehay-ehay-ehay
So let the music play-ehay-ehay
It's in my DNA-ehay-ehay-ehay
I was born to shut it down
D-N-N-N-A D-N-N-N-A D-N-N-N-A
It's in my
D-N-N-N-A D-N-N-N-A D-N-N-N-A
It's in my
D-N-N-N-A D-N-N-N-A D-N-N-N-A
It's in my
D-N-N-N-A D-N-N-N-A D-N-N-N-A
D-N-N-N-A D-N-N-N-A D-N-N-N-A
This is a party anthem
Hand in tha air
You can talk that shit
But truly, we don't really care
And tonight, you came to party
Hands in tha air
And you're feelin' yourself getting zoned out
Say hell yeah
I said, put me on the dance floor
And you can catch me freakin' on a bad boy
Workin' my body-yoddie-ah
And I'm feeling so naughty-oddie-oddia-ah
Now when the DJ spin that record
We be goin' reckless
We be throwin' shades, party rockin', and two-steppin'
It's in my DNA-ehay-ehay-ehay
So let the music play-ehay-ehay
It's in my DNA-ehay-ehay-ehay
I was born to shut it down
It's in my DNA-ehay-ehay-ehay
So let the music play-ehay-ehay
It's in my DNA-ehay-ehay-ehay
I was born to shut it down
I said it's in my DNA
We just came to rock and play
From the window to the wall-all-ah-ah-all
Show some skin, put on a show
Getcho boodies on the flo
From the window to the wall-all-ah-ah-all
I said it's in my DNA
We just came to rock and play
From the window to the wall-all-ah-ah-all
Show some skin, put on a show
Getcho boodies on the flo
From the window to the wall-all-ah-ah-all
D-N-N-N-A D-N-N-N-A D-N-N-N-A
It's in my
D-N-N-N-A D-N-N-N-A D-N-N-N-A
It's in my
D-N-N-N-A D-N-N-N-A D-N-N-N-A
Get down
It's in my DNA-ehay-ehay-ehay
So let the music play-ehay-ehay
It's in my DNA-ehay-ehay-ehay
I was born to shut it down
It's in my DNA-ehay-ehay-ehay
Let the music play-ehay-ehay
It's in my DNA-ehay-ehay-ehay
I'd rather be blind than have two evil eyes.
A backward boy can see from behind.
Abortion is advocated,
Only by those who have themselves been born.
They're taking away our D.N.A.
They're taking away our D.N.A.
Are you going to breed retarded children?
Are you going to breed retarded children?
Everybody is ignorant, only on different subjects.
Drunks and children tell the truth,
Insanity is a kinda innocence.
They're taking away our D.N.A.
They're taking away our D.N.A.
Are you going to breed retarded children?
Are you going to breed retarded children?
I wanna live (whisper)
Birds stop singing when you shoot them down.
Holes in my wings will show me the ground.
A creature born is a creature that's dying.
Statistics can breathe, our numbers are sighing.
Are they going to breed retarded children?
Are they going to breed retarded children?
They're taking away our D.N.A.
They're taking away our D.N.A.
They're taking away our D.N.A.
Taking away, away, away
They're taking away our D.N.A.
They're taking away, away, away
They're taking away our D.N.A.
They're taking away our D.N.A.
They're taking away our D.N.A yeah!
Taking away our D.N.A.
D.N.A,
D.N.A,
D.N.A,
D.N.A,
D.N.A,
D.N.A,
D.N.A,
D.N.A.
WEAK13 - D.N.A.
Words & music by Nick J.Townsend
Song info:
Deoxyribonucleic acid (i/diˌɒksiˌraɪbɵ.njuːˌkleɪ.ɨk ˈæsɪd/; DNA) is a nucleic acid containing the genetic instructions used in the development and functioning of all known living organisms (with the exception of RNA viruses). The DNA segments carrying this genetic information are called genes. Likewise, other DNA sequences have structural purposes, or are involved in regulating the use of this genetic information. Along with RNA and proteins, DNA is one of the three major macromolecules that are essential for all known forms of life.
DNA consists of two long polymers of simple units called nucleotides, with backbones made of sugars and phosphate groups joined by ester bonds. These two strands run in opposite directions to each other and are therefore anti-parallel. Attached to each sugar is one of four types of molecules called nucleobases (informally, bases). It is the sequence of these four nucleobases along the backbone that encodes information. This information is read using the genetic code, which specifies the sequence of the amino acids within proteins. The code is read by copying stretches of DNA into the related nucleic acid RNA in a process called transcription.
Within cells DNA is organized into long structures called chromosomes. During cell division these chromosomes are duplicated in the process of DNA replication, providing each cell its own complete set of chromosomes. Eukaryotic organisms (animals, plants, fungi, and protists) store most of their DNA inside the cell nucleus and some of their DNA in organelles, such as mitochondria or chloroplasts.[1] In contrast, prokaryotes (bacteria and archaea) store their DNA only in the cytoplasm. Within the chromosomes, chromatin proteins such as histones compact and organize DNA. These compact structures guide the interactions between DNA and other proteins, helping control which parts of the DNA are transcribed.
Contents |
DNA is a long polymer made from repeating units called nucleotides.[2][3][4] As first discovered by James D. Watson and Francis Crick, the structure of DNA of all species comprises two helical chains each coiled round the same axis, and each with a pitch of 34 Ångströms (3.4 nanometres) and a radius of 10 Ångströms (1.0 nanometres).[5] According to another study, when measured in a particular solution, the DNA chain measured 22 to 26 Ångströms wide (2.2 to 2.6 nanometres), and one nucleotide unit measured 3.3 Å (0.33 nm) long.[6] Although each individual repeating unit is very small, DNA polymers can be very large molecules containing millions of nucleotides. For instance, the largest human chromosome, chromosome number 1, is approximately 220 million base pairs long.[7]
In living organisms DNA does not usually exist as a single molecule, but instead as a pair of molecules that are held tightly together.[5][8] These two long strands entwine like vines, in the shape of a double helix. The nucleotide repeats contain both the segment of the backbone of the molecule, which holds the chain together, and a nucleobase, which interacts with the other DNA strand in the helix. A nucleobase linked to a sugar is called a nucleoside and a base linked to a sugar and one or more phosphate groups is called a nucleotide. Polymers comprising multiple linked nucleotides (as in DNA) are called a polynucleotide.[9]
The backbone of the DNA strand is made from alternating phosphate and sugar residues.[10] The sugar in DNA is 2-deoxyribose, which is a pentose (five-carbon) sugar. The sugars are joined together by phosphate groups that form phosphodiester bonds between the third and fifth carbon atoms of adjacent sugar rings. These asymmetric bonds mean a strand of DNA has a direction. In a double helix the direction of the nucleotides in one strand is opposite to their direction in the other strand: the strands are antiparallel. The asymmetric ends of DNA strands are called the 5′ (five prime) and 3′ (three prime) ends, with the 5' end having a terminal phosphate group and the 3' end a terminal hydroxyl group. One major difference between DNA and RNA is the sugar, with the 2-deoxyribose in DNA being replaced by the alternative pentose sugar ribose in RNA.[8]
The DNA double helix is stabilized primarily by two forces: hydrogen bonds between nucleotides and base-stacking interactions among the aromatic nucleobases.[12] In the aqueous environment of the cell, the conjugated π bonds of nucleotide bases align perpendicular to the axis of the DNA molecule, minimizing their interaction with the solvation shell and therefore, the Gibbs free energy. The four bases found in DNA are adenine (abbreviated A), cytosine (C), guanine (G) and thymine (T). These four bases are attached to the sugar/phosphate to form the complete nucleotide, as shown for adenosine monophosphate.
The nucleobases are classified into two types: the purines, A and G, being fused five- and six-membered heterocyclic compounds, and the pyrimidines, the six-membered rings C and T.[8] A fifth pyrimidine nucleobase, uracil (U), usually takes the place of thymine in RNA and differs from thymine by lacking a methyl group on its ring. Uracil is not usually found in DNA, occurring only as a breakdown product of cytosine. In addition to RNA and DNA a large number of artificial nucleic acid analogues have also been created to study the proprieties of nucleic acids, or for use in biotechnology.[13]
Twin helical strands form the DNA backbone. Another double helix may be found by tracing the spaces, or grooves, between the strands. These voids are adjacent to the base pairs and may provide a binding site. As the strands are not directly opposite each other, the grooves are unequally sized. One groove, the major groove, is 22 Å wide and the other, the minor groove, is 12 Å wide.[14] The narrowness of the minor groove means that the edges of the bases are more accessible in the major groove. As a result, proteins like transcription factors that can bind to specific sequences in double-stranded DNA usually make contacts to the sides of the bases exposed in the major groove.[15] This situation varies in unusual conformations of DNA within the cell (see below), but the major and minor grooves are always named to reflect the differences in size that would be seen if the DNA is twisted back into the ordinary B form.
In a DNA double helix, each type of nucleobase on one strand normally interacts with just one type of nucleobase on the other strand. This is called complementary base pairing. Here, purines form hydrogen bonds to pyrimidines, with A bonding only to T, and C bonding only to G. This arrangement of two nucleotides binding together across the double helix is called a base pair. As hydrogen bonds are not covalent, they can be broken and rejoined relatively easily. The two strands of DNA in a double helix can therefore be pulled apart like a zipper, either by a mechanical force or high temperature.[16] As a result of this complementarity, all the information in the double-stranded sequence of a DNA helix is duplicated on each strand, which is vital in DNA replication. Indeed, this reversible and specific interaction between complementary base pairs is critical for all the functions of DNA in living organisms.[3]
The two types of base pairs form different numbers of hydrogen bonds, AT forming two hydrogen bonds, and GC forming three hydrogen bonds (see figures, right). DNA with high GC-content is more stable than DNA with low GC-content.
As noted above, most DNA molecules are actually two polymer strands, bound together in a helical fashion by noncovalent bonds; this double stranded structure (dsDNA) is maintained largely by the intrastrand base stacking interactions, which are strongest for G,C stacks. The two strands can come apart – a process known as melting – to form two ss DNA molecules. Melting occurs when conditions favor ssDNA; such conditions are high temperature, low salt and high pH (low pH also melts DNA, but since DNA is unstable due to acid depurination, low pH is rarely used).
The stability of the dsDNA form depends not only on the GC-content (% G,C basepairs) but also on sequence (since stacking is sequence specific) and also length (longer molecules are more stable). The stability can be measured in various ways; a common way is the "melting temperature", which is the temperature at which 50% of the ds molecules are converted to ss molecules; melting temperature is dependent on ionic strength and the concentration of DNA. As a result, it is both the percentage of GC base pairs and the overall length of a DNA double helix that determine the strength of the association between the two strands of DNA. Long DNA helices with a high GC-content have stronger-interacting strands, while short helices with high AT content have weaker-interacting strands.[17] In biology, parts of the DNA double helix that need to separate easily, such as the TATAAT Pribnow box in some promoters, tend to have a high AT content, making the strands easier to pull apart.[18]
In the laboratory, the strength of this interaction can be measured by finding the temperature required to break the hydrogen bonds, their melting temperature (also called Tm value). When all the base pairs in a DNA double helix melt, the strands separate and exist in solution as two entirely independent molecules. These single-stranded DNA molecules (ssDNA) have no single common shape, but some conformations are more stable than others.[19]
A DNA sequence is called "sense" if its sequence is the same as that of a messenger RNA copy that is translated into protein.[20] The sequence on the opposite strand is called the "antisense" sequence. Both sense and antisense sequences can exist on different parts of the same strand of DNA (i.e. both strands contain both sense and antisense sequences). In both prokaryotes and eukaryotes, antisense RNA sequences are produced, but the functions of these RNAs are not entirely clear.[21] One proposal is that antisense RNAs are involved in regulating gene expression through RNA-RNA base pairing.[22]
A few DNA sequences in prokaryotes and eukaryotes, and more in plasmids and viruses, blur the distinction between sense and antisense strands by having overlapping genes.[23] In these cases, some DNA sequences do double duty, encoding one protein when read along one strand, and a second protein when read in the opposite direction along the other strand. In bacteria, this overlap may be involved in the regulation of gene transcription,[24] while in viruses, overlapping genes increase the amount of information that can be encoded within the small viral genome.[25]
DNA can be twisted like a rope in a process called DNA supercoiling. With DNA in its "relaxed" state, a strand usually circles the axis of the double helix once every 10.4 base pairs, but if the DNA is twisted the strands become more tightly or more loosely wound.[26] If the DNA is twisted in the direction of the helix, this is positive supercoiling, and the bases are held more tightly together. If they are twisted in the opposite direction, this is negative supercoiling, and the bases come apart more easily. In nature, most DNA has slight negative supercoiling that is introduced by enzymes called topoisomerases.[27] These enzymes are also needed to relieve the twisting stresses introduced into DNA strands during processes such as transcription and DNA replication.[28]
DNA exists in many possible conformations that include A-DNA, B-DNA, and Z-DNA forms, although, only B-DNA and Z-DNA have been directly observed in functional organisms.[10] The conformation that DNA adopts depends on the hydration level, DNA sequence, the amount and direction of supercoiling, chemical modifications of the bases, the type and concentration of metal ions, as well as the presence of polyamines in solution.[29]
The first published reports of A-DNA X-ray diffraction patterns— and also B-DNA used analyses based on Patterson transforms that provided only a limited amount of structural information for oriented fibers of DNA.[30][31] An alternate analysis was then proposed by Wilkins et al., in 1953, for the in vivo B-DNA X-ray diffraction/scattering patterns of highly hydrated DNA fibers in terms of squares of Bessel functions.[32] In the same journal, James D. Watson and Francis Crick presented their molecular modeling analysis of the DNA X-ray diffraction patterns to suggest that the structure was a double-helix.[5]
Although the `B-DNA form' is most common under the conditions found in cells,[33] it is not a well-defined conformation but a family of related DNA conformations[34] that occur at the high hydration levels present in living cells. Their corresponding X-ray diffraction and scattering patterns are characteristic of molecular paracrystals with a significant degree of disorder.[35][36]
Compared to B-DNA, the A-DNA form is a wider right-handed spiral, with a shallow, wide minor groove and a narrower, deeper major groove. The A form occurs under non-physiological conditions in partially dehydrated samples of DNA, while in the cell it may be produced in hybrid pairings of DNA and RNA strands, as well as in enzyme-DNA complexes.[37][38] Segments of DNA where the bases have been chemically modified by methylation may undergo a larger change in conformation and adopt the Z form. Here, the strands turn about the helical axis in a left-handed spiral, the opposite of the more common B form.[39] These unusual structures can be recognized by specific Z-DNA binding proteins and may be involved in the regulation of transcription.[40]
For a number of years exobiologists have proposed the existence of a shadow biosphere, a postulated microbial biosphere of Earth that uses radically different biochemical and molecular processes than currently known life. One of the proposals was the existence of lifeforms that use arsenic instead of phosphorus in DNA.
A December 2010 NASA press conference stated that the bacterium GFAJ-1, which has evolved in an arsenic-rich environment, is the first terrestrial lifeform found which may have this ability. The bacterium was found in Mono Lake, east of Yosemite National Park. GFAJ-1 is a rod-shaped extremophile bacterium in the family Halomonadaceae that, when starved of phosphorus, may be capable of incorporating the usually poisonous element arsenic in its DNA.[41] This discovery may lend weight to the long-standing idea that extraterrestrial life could have a different chemical makeup from life on Earth.[41][42] The research was carried out by a team led by Felisa Wolfe-Simon, a geomicrobiologist and geobiochemist, a Postdoctoral Fellow of the NASA Astrobiology Institute with Arizona State University. This finding has, however, faced strong criticism from the scientific community; scientists have argued that there is no evidence that arsenic is actually incorporated into biomolecules.[42][43] Independent confirmation of this finding has also not yet been possible.
At the ends of the linear chromosomes are specialized regions of DNA called telomeres. The main function of these regions is to allow the cell to replicate chromosome ends using the enzyme telomerase, as the enzymes that normally replicate DNA cannot copy the extreme 3′ ends of chromosomes.[44] These specialized chromosome caps also help protect the DNA ends, and stop the DNA repair systems in the cell from treating them as damage to be corrected.[45] In human cells, telomeres are usually lengths of single-stranded DNA containing several thousand repeats of a simple TTAGGG sequence.[46]
These guanine-rich sequences may stabilize chromosome ends by forming structures of stacked sets of four-base units, rather than the usual base pairs found in other DNA molecules. Here, four guanine bases form a flat plate and these flat four-base units then stack on top of each other, to form a stable G-quadruplex structure.[48] These structures are stabilized by hydrogen bonding between the edges of the bases and chelation of a metal ion in the centre of each four-base unit.[49] Other structures can also be formed, with the central set of four bases coming from either a single strand folded around the bases, or several different parallel strands, each contributing one base to the central structure.
In addition to these stacked structures, telomeres also form large loop structures called telomere loops, or T-loops. Here, the single-stranded DNA curls around in a long circle stabilized by telomere-binding proteins.[50] At the very end of the T-loop, the single-stranded telomere DNA is held onto a region of double-stranded DNA by the telomere strand disrupting the double-helical DNA and base pairing to one of the two strands. This triple-stranded structure is called a displacement loop or D-loop.[48]
In DNA fraying occurs when non-complementary regions exist at the end of an otherwise complementary double-strand of DNA. However, branched DNA can occur if a third strand of DNA is introduced and contains adjoining regions able to hybridize with the frayed regions of the pre-existing double-strand. Although the simplest example of branched DNA involves only three strands of DNA, complexes involving additional strands and multiple branches are also possible.[51] Branched DNA can be used in nanotechnology to construct geometric shapes, see the section on uses in technology below.
DNA may carry out low-frequency collective motion as observed by the Raman spectroscopy[52][53] and analyzed with a quasi-continuum model.[54][55]
The expression of genes is influenced by how the DNA is packaged in chromosomes, in a structure called chromatin. Base modifications can be involved in packaging, with regions that have low or no gene expression usually containing high levels of methylation of cytosine bases. For example, cytosine methylation, produces 5-methylcytosine, which is important for X-chromosome inactivation.[56] The average level of methylation varies between organisms – the worm Caenorhabditis elegans lacks cytosine methylation, while vertebrates have higher levels, with up to 1% of their DNA containing 5-methylcytosine.[57] Despite the importance of 5-methylcytosine, it can deaminate to leave a thymine base, so methylated cytosines are particularly prone to mutations.[58] Other base modifications include adenine methylation in bacteria, the presence of 5-hydroxymethylcytosine in the brain,[59] and the glycosylation of uracil to produce the "J-base" in kinetoplastids.[60][61]
DNA can be damaged by many sorts of mutagens, which change the DNA sequence. Mutagens include oxidizing agents, alkylating agents and also high-energy electromagnetic radiation such as ultraviolet light and X-rays. The type of DNA damage produced depends on the type of mutagen. For example, UV light can damage DNA by producing thymine dimers, which are cross-links between pyrimidine bases.[63] On the other hand, oxidants such as free radicals or hydrogen peroxide produce multiple forms of damage, including base modifications, particularly of guanosine, and double-strand breaks.[64] A typical human cell contains about 150,000 bases that have suffered oxidative damage.[65] Of these oxidative lesions, the most dangerous are double-strand breaks, as these are difficult to repair and can produce point mutations, insertions and deletions from the DNA sequence, as well as chromosomal translocations.[66]
Many mutagens fit into the space between two adjacent base pairs, this is called intercalation. Most intercalators are aromatic and planar molecules; examples include ethidium bromide, acridines, daunomycin, and doxorubicin. In order for an intercalator to fit between base pairs, the bases must separate, distorting the DNA strands by unwinding of the double helix. This inhibits both transcription and DNA replication, causing toxicity and mutations.[67] As a result, DNA intercalators may be carcinogens, and in the case of thalidomide, a teratogen.[68] Others such as benzo[a]pyrene diol epoxide and aflatoxin form DNA adducts which induce errors in replication.[69] Nevertheless, due to their ability to inhibit DNA transcription and replication, other similar toxins are also used in chemotherapy to inhibit rapidly growing cancer cells.[70]
DNA usually occurs as linear chromosomes in eukaryotes, and circular chromosomes in prokaryotes. The set of chromosomes in a cell makes up its genome; the human genome has approximately 3 billion base pairs of DNA arranged into 46 chromosomes.[71] The information carried by DNA is held in the sequence of pieces of DNA called genes. Transmission of genetic information in genes is achieved via complementary base pairing. For example, in transcription, when a cell uses the information in a gene, the DNA sequence is copied into a complementary RNA sequence through the attraction between the DNA and the correct RNA nucleotides. Usually, this RNA copy is then used to make a matching protein sequence in a process called translation, which depends on the same interaction between RNA nucleotides. In alternative fashion, a cell may simply copy its genetic information in a process called DNA replication. The details of these functions are covered in other articles; here we focus on the interactions between DNA and other molecules that mediate the function of the genome.
Genomic DNA is tightly and orderly packed in the process called DNA condensation to fit the small available volumes of the cell. In eukaryotes, DNA is located in the cell nucleus, as well as small amounts in mitochondria and chloroplasts. In prokaryotes, the DNA is held within an irregularly shaped body in the cytoplasm called the nucleoid.[72] The genetic information in a genome is held within genes, and the complete set of this information in an organism is called its genotype. A gene is a unit of heredity and is a region of DNA that influences a particular characteristic in an organism. Genes contain an open reading frame that can be transcribed, as well as regulatory sequences such as promoters and enhancers, which control the transcription of the open reading frame.
In many species, only a small fraction of the total sequence of the genome encodes protein. For example, only about 1.5% of the human genome consists of protein-coding exons, with over 50% of human DNA consisting of non-coding repetitive sequences.[73] The reasons for the presence of so much noncoding DNA in eukaryotic genomes and the extraordinary differences in genome size, or C-value, among species represent a long-standing puzzle known as the "C-value enigma".[74] However, DNA sequences that do not code protein may still encode functional non-coding RNA molecules, which are involved in the regulation of gene expression.[75]
Some noncoding DNA sequences play structural roles in chromosomes. Telomeres and centromeres typically contain few genes, but are important for the function and stability of chromosomes.[45][77] An abundant form of noncoding DNA in humans are pseudogenes, which are copies of genes that have been disabled by mutation.[78] These sequences are usually just molecular fossils, although they can occasionally serve as raw genetic material for the creation of new genes through the process of gene duplication and divergence.[79]
A gene is a sequence of DNA that contains genetic information and can influence the phenotype of an organism. Within a gene, the sequence of bases along a DNA strand defines a messenger RNA sequence, which then defines one or more protein sequences. The relationship between the nucleotide sequences of genes and the amino-acid sequences of proteins is determined by the rules of translation, known collectively as the genetic code. The genetic code consists of three-letter 'words' called codons formed from a sequence of three nucleotides (e.g. ACT, CAG, TTT).
In transcription, the codons of a gene are copied into messenger RNA by RNA polymerase. This RNA copy is then decoded by a ribosome that reads the RNA sequence by base-pairing the messenger RNA to transfer RNA, which carries amino acids. Since there are 4 bases in 3-letter combinations, there are 64 possible codons (Failed to parse (Missing texvc executable; please see math/README to configure.): 4^3
combinations). These encode the twenty standard amino acids, giving most amino acids more than one possible codon. There are also three 'stop' or 'nonsense' codons signifying the end of the coding region; these are the TAA, TGA and TAG codons.
Cell division is essential for an organism to grow, but, when a cell divides, it must replicate the DNA in its genome so that the two daughter cells have the same genetic information as their parent. The double-stranded structure of DNA provides a simple mechanism for DNA replication. Here, the two strands are separated and then each strand's complementary DNA sequence is recreated by an enzyme called DNA polymerase. This enzyme makes the complementary strand by finding the correct base through complementary base pairing, and bonding it onto the original strand. As DNA polymerases can only extend a DNA strand in a 5′ to 3′ direction, different mechanisms are used to copy the antiparallel strands of the double helix.[80] In this way, the base on the old strand dictates which base appears on the new strand, and the cell ends up with a perfect copy of its DNA.
All the functions of DNA depend on interactions with proteins. These protein interactions can be non-specific, or the protein can bind specifically to a single DNA sequence. Enzymes can also bind to DNA and of these, the polymerases that copy the DNA base sequence in transcription and DNA replication are particularly important.
Structural proteins that bind DNA are well-understood examples of non-specific DNA-protein interactions. Within chromosomes, DNA is held in complexes with structural proteins. These proteins organize the DNA into a compact structure called chromatin. In eukaryotes this structure involves DNA binding to a complex of small basic proteins called histones, while in prokaryotes multiple types of proteins are involved.[81][82] The histones form a disk-shaped complex called a nucleosome, which contains two complete turns of double-stranded DNA wrapped around its surface. These non-specific interactions are formed through basic residues in the histones making ionic bonds to the acidic sugar-phosphate backbone of the DNA, and are therefore largely independent of the base sequence.[83] Chemical modifications of these basic amino acid residues include methylation, phosphorylation and acetylation.[84] These chemical changes alter the strength of the interaction between the DNA and the histones, making the DNA more or less accessible to transcription factors and changing the rate of transcription.[85] Other non-specific DNA-binding proteins in chromatin include the high-mobility group proteins, which bind to bent or distorted DNA.[86] These proteins are important in bending arrays of nucleosomes and arranging them into the larger structures that make up chromosomes.[87]
A distinct group of DNA-binding proteins are the DNA-binding proteins that specifically bind single-stranded DNA. In humans, replication protein A is the best-understood member of this family and is used in processes where the double helix is separated, including DNA replication, recombination and DNA repair.[88] These binding proteins seem to stabilize single-stranded DNA and protect it from forming stem-loops or being degraded by nucleases.
In contrast, other proteins have evolved to bind to particular DNA sequences. The most intensively studied of these are the various transcription factors, which are proteins that regulate transcription. Each transcription factor binds to one particular set of DNA sequences and activates or inhibits the transcription of genes that have these sequences close to their promoters. The transcription factors do this in two ways. Firstly, they can bind the RNA polymerase responsible for transcription, either directly or through other mediator proteins; this locates the polymerase at the promoter and allows it to begin transcription.[90] Alternatively, transcription factors can bind enzymes that modify the histones at the promoter; this will change the accessibility of the DNA template to the polymerase.[91]
As these DNA targets can occur throughout an organism's genome, changes in the activity of one type of transcription factor can affect thousands of genes.[92] Consequently, these proteins are often the targets of the signal transduction processes that control responses to environmental changes or cellular differentiation and development. The specificity of these transcription factors' interactions with DNA come from the proteins making multiple contacts to the edges of the DNA bases, allowing them to "read" the DNA sequence. Most of these base-interactions are made in the major groove, where the bases are most accessible.[15]
Nucleases are enzymes that cut DNA strands by catalyzing the hydrolysis of the phosphodiester bonds. Nucleases that hydrolyse nucleotides from the ends of DNA strands are called exonucleases, while endonucleases cut within strands. The most frequently used nucleases in molecular biology are the restriction endonucleases, which cut DNA at specific sequences. For instance, the EcoRV enzyme shown to the left recognizes the 6-base sequence 5′-GAT|ATC-3′ and makes a cut at the vertical line. In nature, these enzymes protect bacteria against phage infection by digesting the phage DNA when it enters the bacterial cell, acting as part of the restriction modification system.[94] In technology, these sequence-specific nucleases are used in molecular cloning and DNA fingerprinting.
Enzymes called DNA ligases can rejoin cut or broken DNA strands.[95] Ligases are particularly important in lagging strand DNA replication, as they join together the short segments of DNA produced at the replication fork into a complete copy of the DNA template. They are also used in DNA repair and genetic recombination.[95]
Topoisomerases are enzymes with both nuclease and ligase activity. These proteins change the amount of supercoiling in DNA. Some of these enzymes work by cutting the DNA helix and allowing one section to rotate, thereby reducing its level of supercoiling; the enzyme then seals the DNA break.[27] Other types of these enzymes are capable of cutting one DNA helix and then passing a second strand of DNA through this break, before rejoining the helix.[96] Topoisomerases are required for many processes involving DNA, such as DNA replication and transcription.[28]
Helicases are proteins that are a type of molecular motor. They use the chemical energy in nucleoside triphosphates, predominantly ATP, to break hydrogen bonds between bases and unwind the DNA double helix into single strands.[97] These enzymes are essential for most processes where enzymes need to access the DNA bases.
Polymerases are enzymes that synthesize polynucleotide chains from nucleoside triphosphates. The sequence of their products are copies of existing polynucleotide chains – which are called templates. These enzymes function by adding nucleotides onto the 3′ hydroxyl group of the previous nucleotide in a DNA strand. As a consequence, all polymerases work in a 5′ to 3′ direction.[98] In the active site of these enzymes, the incoming nucleoside triphosphate base-pairs to the template: this allows polymerases to accurately synthesize the complementary strand of their template. Polymerases are classified according to the type of template that they use.
In DNA replication, a DNA-dependent DNA polymerase makes a copy of a DNA sequence. Accuracy is vital in this process, so many of these polymerases have a proofreading activity. Here, the polymerase recognizes the occasional mistakes in the synthesis reaction by the lack of base pairing between the mismatched nucleotides. If a mismatch is detected, a 3′ to 5′ exonuclease activity is activated and the incorrect base removed.[99] In most organisms, DNA polymerases function in a large complex called the replisome that contains multiple accessory subunits, such as the DNA clamp or helicases.[100]
RNA-dependent DNA polymerases are a specialized class of polymerases that copy the sequence of an RNA strand into DNA. They include reverse transcriptase, which is a viral enzyme involved in the infection of cells by retroviruses, and telomerase, which is required for the replication of telomeres.[44][101] Telomerase is an unusual polymerase because it contains its own RNA template as part of its structure.[45]
Transcription is carried out by a DNA-dependent RNA polymerase that copies the sequence of a DNA strand into RNA. To begin transcribing a gene, the RNA polymerase binds to a sequence of DNA called a promoter and separates the DNA strands. It then copies the gene sequence into a messenger RNA transcript until it reaches a region of DNA called the terminator, where it halts and detaches from the DNA. As with human DNA-dependent DNA polymerases, RNA polymerase II, the enzyme that transcribes most of the genes in the human genome, operates as part of a large protein complex with multiple regulatory and accessory subunits.[102]
A DNA helix usually does not interact with other segments of DNA, and in human cells the different chromosomes even occupy separate areas in the nucleus called "chromosome territories".[104] This physical separation of different chromosomes is important for the ability of DNA to function as a stable repository for information, as one of the few times chromosomes interact is during chromosomal crossover when they recombine. Chromosomal crossover is when two DNA helices break, swap a section and then rejoin.
Recombination allows chromosomes to exchange genetic information and produces new combinations of genes, which increases the efficiency of natural selection and can be important in the rapid evolution of new proteins.[105] Genetic recombination can also be involved in DNA repair, particularly in the cell's response to double-strand breaks.[106]
The most common form of chromosomal crossover is homologous recombination, where the two chromosomes involved share very similar sequences. Non-homologous recombination can be damaging to cells, as it can produce chromosomal translocations and genetic abnormalities. The recombination reaction is catalyzed by enzymes known as recombinases, such as RAD51.[107] The first step in recombination is a double-stranded break either caused by an endonuclease or damage to the DNA.[108] A series of steps catalyzed in part by the recombinase then leads to joining of the two helices by at least one Holliday junction, in which a segment of a single strand in each helix is annealed to the complementary strand in the other helix. The Holliday junction is a tetrahedral junction structure that can be moved along the pair of chromosomes, swapping one strand for another. The recombination reaction is then halted by cleavage of the junction and re-ligation of the released DNA.[109]
DNA contains the genetic information that allows all modern living things to function, grow and reproduce. However, it is unclear how long in the 4-billion-year history of life DNA has performed this function, as it has been proposed that the earliest forms of life may have used RNA as their genetic material.[98][110] RNA may have acted as the central part of early cell metabolism as it can both transmit genetic information and carry out catalysis as part of ribozymes.[111] This ancient RNA world where nucleic acid would have been used for both catalysis and genetics may have influenced the evolution of the current genetic code based on four nucleotide bases. This would occur, since the number of different bases in such an organism is a trade-off between a small number of bases increasing replication accuracy and a large number of bases increasing the catalytic efficiency of ribozymes.[112]
However, there is no direct evidence of ancient genetic systems, as recovery of DNA from most fossils is impossible. This is because DNA will survive in the environment for less than one million years and slowly degrades into short fragments in solution.[113] Claims for older DNA have been made, most notably a report of the isolation of a viable bacterium from a salt crystal 250 million years old,[114] but these claims are controversial.[115][116]
On August 8, 2011, a report, based on NASA studies with meteorites found on Earth, was published suggesting building blocks of DNA (adenine, guanine and related organic molecules) may have been formed extraterrestrially in outer space.[117][118][119]
Methods have been developed to purify DNA from organisms, such as phenol-chloroform extraction, and to manipulate it in the laboratory, such as restriction digests and the polymerase chain reaction. Modern biology and biochemistry make intensive use of these techniques in recombinant DNA technology. Recombinant DNA is a man-made DNA sequence that has been assembled from other DNA sequences. They can be transformed into organisms in the form of plasmids or in the appropriate format, by using a viral vector.[120] The genetically modified organisms produced can be used to produce products such as recombinant proteins, used in medical research,[121] or be grown in agriculture.[122][123]
Forensic scientists can use DNA in blood, semen, skin, saliva or hair found at a crime scene to identify a matching DNA of an individual, such as a perpetrator. This process is formally termed DNA profiling, but may also be called "genetic fingerprinting". In DNA profiling, the lengths of variable sections of repetitive DNA, such as short tandem repeats and minisatellites, are compared between people. This method is usually an extremely reliable technique for identifying a matching DNA.[124] However, identification can be complicated if the scene is contaminated with DNA from several people.[125] DNA profiling was developed in 1984 by British geneticist Sir Alec Jeffreys,[126] and first used in forensic science to convict Colin Pitchfork in the 1988 Enderby murders case.[127]
The development of forensic science,and the ability to now obtain genetic matching on minute samples of blood, skin, saliva or hair has led to a re-examination of a number of cases. Evidence can now be uncovered that was not scientifically possible at the time of the original examination. Combined with the removal of the double jeopardy law, this allows cases to be reopened where previous trials have failed to produce sufficient evidence to convince a jury. People charged with serious crimes may be required to provide a sample of DNA for matching purposes. The most obvious defence to DNA matches obtained forensically is to claim that cross-contamination of evidence has taken place. This has resulted in meticulous strict handling procedures with new cases of serious crime. DNA profiling is also be used to identify victims of mass casualty incidents.[128] As well as positively identifying bodies or body parts in serious accidents, DNA profiling is being successfully used to identify individual victims in mass war graves – matching to family members.
Bioinformatics involves the manipulation, searching, and data mining of biological data, and this includes DNA sequence data. The development of techniques to store and search DNA sequences have led to widely applied advances in computer science, especially string searching algorithms, machine learning and database theory.[129] String searching or matching algorithms, which find an occurrence of a sequence of letters inside a larger sequence of letters, were developed to search for specific sequences of nucleotides.[130] The DNA sequence may be aligned with other DNA sequences to identify homologous sequences and locate the specific mutations that make them distinct. These techniques, especially multiple sequence alignment, are used in studying phylogenetic relationships and protein function.[131] Data sets representing entire genomes' worth of DNA sequences, such as those produced by the Human Genome Project, are difficult to use without the annotations that identify the locations of genes and regulatory elements on each chromosome. Regions of DNA sequence that have the characteristic patterns associated with protein- or RNA-coding genes can be identified by gene finding algorithms, which allow researchers to predict the presence of particular gene products and their possible functions in an organism even before they have been isolated experimentally.[132] Entire genomes may also be compared which can shed light on the evolutionary history of particular organism and permit the examination of complex evolutionary events.
DNA nanotechnology uses the unique molecular recognition properties of DNA and other nucleic acids to create self-assembling branched DNA complexes with useful properties.[133] DNA is thus used as a structural material rather than as a carrier of biological information. This has led to the creation of two-dimensional periodic lattices (both tile-based as well as using the "DNA origami" method) as well as three-dimensional structures in the shapes of polyhedra.[134] Nanomechanical devices and algorithmic self-assembly have also been demonstrated,[135] and these DNA structures have been used to template the arrangement of other molecules such as gold nanoparticles and streptavidin proteins.[136]
Because DNA collects mutations over time, which are then inherited, it contains historical information, and, by comparing DNA sequences, geneticists can infer the evolutionary history of organisms, their phylogeny.[137] This field of phylogenetics is a powerful tool in evolutionary biology. If DNA sequences within a species are compared, population geneticists can learn the history of particular populations. This can be used in studies ranging from ecological genetics to anthropology; For example, DNA evidence is being used to try to identify the Ten Lost Tribes of Israel.[138][139]
DNA has also been used to look at modern family relationships, such as establishing family relationships between the descendants of Sally Hemings and Thomas Jefferson. This usage is closely related to the use of DNA in criminal investigations detailed above. Indeed, some criminal investigations have been solved when DNA from crime scenes has matched relatives of the guilty individual.[140]
DNA was first isolated by the Swiss physician Friedrich Miescher who, in 1869, discovered a microscopic substance in the pus of discarded surgical bandages. As it resided in the nuclei of cells, he called it "nuclein".[141] In 1878, Albrecht Kossel isolated the non-protein component of "nuclein", nucleic acid, and later isolated its five primary nucleobases.[142] In 1919, Phoebus Levene identified the base, sugar and phosphate nucleotide unit.[143] Levene suggested that DNA consisted of a string of nucleotide units linked together through the phosphate groups. However, Levene thought the chain was short and the bases repeated in a fixed order. In 1937 William Astbury produced the first X-ray diffraction patterns that showed that DNA had a regular structure.[144]
In 1927 Nikolai Koltsov proposed that inherited traits would be inherited via a "giant hereditary molecule" which would be made up of "two mirror strands that would replicate in a semi-conservative fashion using each strand as a template".[145] In 1928, Frederick Griffith discovered that traits of the "smooth" form of the Pneumococcus could be transferred to the "rough" form of the same bacteria by mixing killed "smooth" bacteria with the live "rough" form.[146] This system provided the first clear suggestion that DNA carries genetic information—the Avery–MacLeod–McCarty experiment—when Oswald Avery, along with coworkers Colin MacLeod and Maclyn McCarty, identified DNA as the transforming principle in 1943.[147] DNA's role in heredity was confirmed in 1952, when Alfred Hershey and Martha Chase in the Hershey–Chase experiment showed that DNA is the genetic material of the T2 phage.[148]
In 1953, James D. Watson and Francis Crick suggested what is now accepted as the first correct double-helix model of DNA structure in the journal Nature.[5] Their double-helix, molecular model of DNA was then based on a single X-ray diffraction image (labeled as "Photo 51")[149] taken by Rosalind Franklin and Raymond Gosling in May 1952, as well as the information that the DNA bases are paired — also obtained through private communications from Erwin Chargaff in the previous years. Chargaff's rules played a very important role in establishing double-helix configurations for B-DNA as well as A-DNA.
Experimental evidence supporting the Watson and Crick model were published in a series of five articles in the same issue of Nature.[150] Of these, Franklin and Gosling's paper was the first publication of their own X-ray diffraction data and original analysis method that partially supported the Watson and Crick model;[31][151] this issue also contained an article on DNA structure by Maurice Wilkins and two of his colleagues, whose analysis and in vivo B-DNA X-ray patterns also supported the presence in vivo of the double-helical DNA configurations as proposed by Crick and Watson for their double-helix molecular model of DNA in the previous two pages of Nature.[32] In 1962, after Franklin's death, Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine.[152] However, Nobel rules of the time allowed only living recipients, but a vigorous debate continues on who should receive credit for the discovery.[153]
In an influential presentation in 1957, Crick laid out the central dogma of molecular biology, which foretold the relationship between DNA, RNA, and proteins, and articulated the "adaptor hypothesis".[154] Final confirmation of the replication mechanism that was implied by the double-helical structure followed in 1958 through the Meselson–Stahl experiment.[155] Further work by Crick and coworkers showed that the genetic code was based on non-overlapping triplets of bases, called codons, allowing Har Gobind Khorana, Robert W. Holley and Marshall Warren Nirenberg to decipher the genetic code.[156] These findings represent the birth of molecular biology.
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