The 1991 NFL Draft was the procedure by which National Football League teams selected amateur college football players. It is officially known as the NFL Annual Player Selection Meeting. The draft was held April 21–22, 1991 at the Marriott Marquis Hotel in Manhattan, New York. On that day, Raghib "Rocket" Ismail from the University of Notre Dame, who was projected as the number one overall pick, signed with the Toronto Argonauts of the Canadian Football League (CFL). No teams elected to claim any players in the supplemental draft that year.

The first six selections of the draft were defensive players. No draft in league history had begun with more than three consecutive defensive picks.

To date, no members of the 1991 NFL Draft has been inducted into the Professional Football Hall of Fame.

The National Football League Draft is an annual event in which the National Football League (NFL) teams select eligible college football players and it is their most common source of player recruitment. The basic design of the draft is that each team is given a position in the drafting order in reverse order relative its record in the previous year—the last place gets positioned first. With this position, the team can either select a player or trade their position to another team for other positions, a player, or players, or any combination thereof. After each team had utilized its position in the drafting order, whether by trading it or selecting a player, a round would be complete. Certain aspects of the draft, including team positioning and the number of rounds in the draft, have seen revisions since its first creation in 1936, but the fundamental methodology has remained the same. The original rationale in creating the draft was to increase the competitive parity between the teams as the worst team would, idealistically, have chosen the best player available.

Brett Lorenzo Favre (born October 10, 1969) is a former American football quarterback who spent the majority of his career with the Green Bay Packers of the National Football League (NFL). He was a 20-year veteran of the NFL, having played quarterback for the Atlanta Falcons (1991), Green Bay Packers (1992–2007), New York Jets (2008) and Minnesota Vikings (2009–2010). Favre is the only quarterback in NFL history to throw for over 70,000 yards, over 500 touchdowns, over 300 interceptions, and over 10,000 pass attempts. He officially retired on January 17, 2011.

Favre started at the quarterback position for the University of Southern Mississippi for four years before being selected in the second round of the 1991 NFL Draft by Atlanta (33rd overall). He was traded to Green Bay on February 10, 1992, for the 19th pick in the 1992 NFL Draft.

Favre became the Packers' starting quarterback in the fourth game of the 1992 season, and started every game through the 2007 season. He was traded to the New York Jets and started at quarterback for the 2008 season before signing with the Vikings on August 18, 2009 as their starting quarterback. He made an NFL record 297 consecutive starts (321 including playoffs).

Terrence Alan "Terry" Crews (born July 30, 1968) is an American actor, comedian, voice artist and a former player in the National Football League. He is perhaps best known for his role as family patriarch Julius on the UPN/CW sitcom Everybody Hates Chris. Currently, he stars in the TBS sitcom Are We There Yet? as Nick Kingston-Persons. Additionally, he stars in the BET reality series The Family Crews, and has appeared in such films as The 6th Day, Friday After Next, White Chicks, Idiocracy and The Expendables.

In 2010 Crews was featured in several Old Spice TV commercials for their "Odor Blocker Body Wash", and in 2012 for their body spray, directed by Tim Heidecker and Eric Wareheim.

Crews was born in Flint, Michigan, the son of Patricia and Terry Crews, Sr. He attended Flint Southwestern Academy. He earned an Art Excellence Scholarship to attend the Interlochen Center for the Arts and then Western Michigan University.

While completing his studies as hop an Art major, Crews was a key member of the WMU football team, where he earned all-conference honors as a defensive end. Crews was drafted by the Los Angeles Rams of the NFL in the 11th round of the 1991 NFL Draft. He carved out a career that lasted seven seasons, including stints with the Rams, San Diego Chargers, the Washington Redskins and the Philadelphia Eagles.

Emmitt James Smith, III (born May 15, 1969) is a retired American football player who was a running back in the National Football League (NFL) for fifteen seasons during the 1990s and 2000s. Smith played college football for the University of Florida, where he was an All-American. A first-round pick in the 1990 NFL Draft, he played professionally for the Dallas Cowboys and Arizona Cardinals of the NFL.

During his long professional career, he became the NFL's all-time rushing leader, breaking the record formerly held by Walter Payton, and played for three Super Bowl-winning Dallas Cowboys teams. Smith is the only running back to ever win a Super Bowl championship, the NFL Most Valuable Player award, the NFL rushing crown, and the Super Bowl Most Valuable Player award all in the same season (1993). He is also one of only four running backs to lead the NFL in rushing three or more consecutive seasons, joining Steve Van Buren, Jim Brown and Earl Campbell. Smith led the league in rushing and won the Super Bowl in the same year three times (1992, 1993, and 1995) when to that point it had never been done. Smith is also one of only two non-kickers in NFL history to score more than 1,000 career points (the other being Jerry Rice). Smith was inducted into the Pro Football Hall of Fame in 2010, and is the first player from the 1990 NFL Draft to be inducted.