The Republic of Macedonia produces wine on some 22,400 hectares (55,000 acres) of vineyards, and the production was 108,100 tonnes in 2008. There are also some additional 30,000 hectares (74,000 acres) of vineyards dedicated to table grapes.

The production of red wine dominates the Macedonian wine production, with around 80 per cent.

Within the European Union, "Macedonia" (Μακεδονία) is a protected geographical indication (PGI) for wine from the Greek region of Macedonia.

In the culture of Ancient Macedonia, which covered a larger geographical area than today's Republic of Macedonia, wine played an important role.

While part of Yugoslavia, Macedonia was a major producer of wine. In the 1980s, it accounted for around two-thirds of the Yugoslav wine production. After the breakup of Yugoslavia, the Macedonian wine production decreased dramatically, from 1.8 million hectoliters in the mid-1990s to 447,000 hl in 2002.

Macedonia has three wine-growing regions:

The grape varieties common in cultivation includes a large proportion of indigenous varieties and varieties common to Central Europe and the Balkans, as well as some international varieties. Red varieties include Vranec (the most common variety of Macedonia), Kratosija, Cabernet Sauvignon and Merlot. White varieties include Smederevka, Welschriesling (usually referred to as Laški Rizling), Chardonnay, Sauvignon Blanc and Žilavka