Bcl-2 (B-cell lymphoma 2) is the founding member of the Bcl-2 family of apoptosis regulator proteins encoded by the BCL2 gene. Bcl-2 derives its name from B-cell lymphoma 2, as it is the second member of a range of proteins initially described in chromosomal translocations involving chromosomes 14 and 18 in follicular lymphomas. Bcl-2 orthologs have been identified in numerous mammals for which complete genome data are available. The two isoforms of Bcl-2, Isoform 1, also known as 1G5M, and Isoform 2, also known as 1G5O/1GJH, exhibit similar fold. However, results in the ability of these isoforms to bind to the BAD and BAK proteins, as well as in the structural topology and electrostatic potential of the binding groove, suggest differences in antiapoptotic activity for the two isoforms

The Bcl-2 gene has been implicated in a number of cancers, including melanoma, breast, prostate, chronic lymphocytic leukemia, and lung carcinomas, as well as schizophrenia and autoimmunity. It is also thought to be involved in resistance to conventional cancer treatment. This suggests that decreased apoptosis may play a role in the development of cancer.

3-2-1 Contact is an American science educational television show that aired on PBS from 1980 to 1988, and an adjoining children's magazine. The show, a production of the Children's Television Workshop, teaches scientific principles and their applications. Dr. Edward G. Atkins, who was responsible for much of the scientific content of the show, felt that the TV program wouldn't replace a classroom but would open the viewers to ask questions about the scientific purpose of things.

3-2-1 Contact was the brainchild of Samuel Y. Gibbon, Jr., who had been the executive producer of The Electric Company for CTW from 1971 to 1977. (Gibbon actually left CTW before Contact's production began, though he was still credited as "Senior Consultant.")

The first season of 65 programs began airing January 14, 1980 on select PBS member stations; it featured a cast of three college students who discussed science in an on-campus room known as the Workshop. The first season came to an end on April 11, 1980, but funds for more episodes were not sufficient until 1982.