Andrea Pazienza (May 23, 1956 - June 16, 1988), was an Italian comics artist and painter.

Pazienza was born in San Benedetto del Tronto, province of Ascoli Piceno (Marche), in 1956.

Growing up in his father's town of San Severo, in Apulia, he enrolled in 1973 at the DAMS (Dipartimento di Arte, Musica e Spettacolo; Department of Arts, Music and Entertainment) of the University in Bologna.

He made his debut in the spring of 1977 in the magazine Alteralter with his first comic story, "Le straordinarie avventure di Pentothal" (Pentothal's extraordinary adventures), the surrealistic and psychedelic story of an alter ego named from a sedative (Penthothal). He later participated to such editorial experiences as Cannibale, Il Male and Frigidaire, where he created hundreds of comics with his unique and unmatched style, grown out of American underground comics (as represented by visionaries like Rick Griffin and Victor Moscoso), Italian Renaissance art and Walt Disney comics. He was especially fond of the character of Goofy, which he appropriated for a humorous spoof on Italian hippiedom of the 1970s entitled Perché Pippo sembra uno sballato ("Why Goofy Looks Like A Pothead"), and a later, unfinished story entitled La leggenda di Italianino Liberatore ("The Legend Of Italianino Liberatore", referring to his old friend Tanino Liberatore); he also said in an interview that Carl Barks, the creator of Uncle Scrooge, Magica De Spell and other characters of the "duck's family", was a model for his art.