Diabetes mellitus
Classification and external resources
Universal blue circle symbol for diabetes.[1]
ICD-10	E10–E14
ICD-9	250
MedlinePlus	001214
eMedicine	med/546 emerg/134
MeSH	C18.452.394.750

Diabetes mellitus, often simply referred to as diabetes, is a group of metabolic diseases in which a person has high blood sugar, either because the body does not produce enough insulin, or because cells do not respond to the insulin that is produced.^[2] This high blood sugar produces the classical symptoms of polyuria (frequent urination), polydipsia (increased thirst) and polyphagia (increased hunger).

The three main types of diabetes mellitus (DM) are:

• Type 1 DM results from the body's failure to produce insulin, and presently requires the person to inject insulin. (Also referred to as insulin-dependent diabetes mellitus (IDDM) or "juvenile" diabetes)
• Type 2 DM results from insulin resistance, a condition in which cells fail to use insulin properly, sometimes combined with an absolute insulin deficiency. (Formerly referred to as noninsulin-dependent diabetes mellitus (NIDDM) or "adult-onset" diabetes)
• Gestational diabetes is when pregnant women, who have never had diabetes before, have a high blood glucose level during pregnancy. It may precede development of type 2 DM.

Other forms of diabetes mellitus include congenital diabetes, which is due to genetic defects of insulin secretion, cystic fibrosis-related diabetes, steroid diabetes induced by high doses of glucocorticoids, and several forms of monogenic diabetes.

All forms of diabetes have been treatable since insulin became available in 1921, and type 2 diabetes may be controlled with medications. Both types 1 and 2 are chronic conditions that usually cannot be cured. Pancreas transplants have been tried with limited success in type 1 DM; gastric bypass surgery has been successful in many with morbid obesity and type 2 DM. Gestational diabetes usually resolves after delivery. Diabetes without proper treatments can cause many complications. Acute complications include hypoglycemia, diabetic ketoacidosis, or nonketotic hyperosmolar coma. Serious long-term complications include cardiovascular disease, chronic renal failure, and diabetic retinopathy (retinal damage). Adequate treatment of diabetes is thus important, as well as blood pressure control and lifestyle factors such as smoking cessation and maintaining a healthy body weight.

Globally, as of 2010^[update], an estimated 285 million people have type 2 diabetes, making up about 90 percent of all diabetes cases.^[3]

Classification[link]

Diabetes mellitus is classified into four broad categories: type 1, type 2, gestational diabetes and "other specific types".^[2] The "other specific types" are a collection of a few dozen individual causes.^[2] The term "diabetes", without qualification, usually refers to diabetes mellitus. The rare disease diabetes insipidus has similar symptoms as diabetes mellitus, but without disturbances in the sugar metabolism (insipidus means "without taste" in Latin).

The term "type 1 diabetes" has replaced several former terms, including childhood-onset diabetes, juvenile diabetes, and insulin-dependent diabetes mellitus (IDDM). Likewise, the term "type 2 diabetes" has replaced several former terms, including adult-onset diabetes, obesity-related diabetes, and noninsulin-dependent diabetes mellitus (NIDDM). Beyond these two types, there is no agreed-upon standard nomenclature.

Type 1 diabetes[link]

Type 1 diabetes mellitus is characterized by loss of the insulin-producing beta cells of the islets of Langerhans in the pancreas, leading to insulin deficiency. This type can be further classified as immune-mediated or idiopathic. The majority of type 1 diabetes is of the immune-mediated nature, in which beta cell loss is a T-cell-mediated autoimmune attack.^[5] There is no known preventive measure against type 1 diabetes, which causes approximately 10% of diabetes mellitus cases in North America and Europe. Most affected people are otherwise healthy and of a healthy weight when onset occurs. Sensitivity and responsiveness to insulin are usually normal, especially in the early stages. Type 1 diabetes can affect children or adults, but was traditionally termed "juvenile diabetes" because a majority of these diabetes cases were in children.

"Brittle" diabetes, also known as unstable diabetes or labile diabetes, is a term that was traditionally used to describe to dramatic and recurrent swings in glucose levels, often occurring for no apparent reason in insulin-dependent diabetes. This term, however, has no biologic basis and should not be used.^[6] There are many different reasons for type 1 diabetes to be accompanied by irregular and unpredictable hyperglycemias, frequently with ketosis, and sometimes serious hypoglycemias, including an impaired counterregulatory response to hypoglycemia, occult infection, gastroparesis (which leads to erratic absorption of dietary carbohydrates), and endocrinopathies (e.g., Addison's disease).^[6] These phenomena are believed to occur no more frequently than in 1% to 2% of persons with type 1 diabetes.^[7]

Type 2 diabetes[link]

Type 2 diabetes mellitus is characterized by insulin resistance, which may be combined with relatively reduced insulin secretion.^[2] The defective responsiveness of body tissues to insulin is believed to involve the insulin receptor. However, the specific defects are not known. Diabetes mellitus cases due to a known defect are classified separately. Type 2 diabetes is the most common type.

In the early stage of type 2, the predominant abnormality is reduced insulin sensitivity. At this stage, hyperglycemia can be reversed by a variety of measures and medications that improve insulin sensitivity or reduce glucose production by the liver.

Gestational diabetes[link]

Gestational diabetes mellitus (GDM) resembles type 2 diabetes in several respects, involving a combination of relatively inadequate insulin secretion and responsiveness. It occurs in about 2%–5% of all pregnancies and may improve or disappear after delivery. Gestational diabetes is fully treatable, but requires careful medical supervision throughout the pregnancy. About 20%–50% of affected women develop type 2 diabetes later in life.

Though it may be transient, untreated gestational diabetes can damage the health of the fetus or mother. Risks to the baby include macrosomia (high birth weight), congenital cardiac and central nervous system anomalies, and skeletal muscle malformations. Increased fetal insulin may inhibit fetal surfactant production and cause respiratory distress syndrome. Hyperbilirubinemia may result from red blood cell destruction. In severe cases, perinatal death may occur, most commonly as a result of poor placental perfusion due to vascular impairment. Labor induction may be indicated with decreased placental function. A Caesarean section may be performed if there is marked fetal distress or an increased risk of injury associated with macrosomia, such as shoulder dystocia.

A 2008 study completed in the U.S. found the number of American women entering pregnancy with pre-existing diabetes is increasing. In fact, the rate of diabetes in expectant mothers has more than doubled in the past six years.^[8] This is particularly problematic as diabetes raises the risk of complications during pregnancy, as well as increasing the potential for the children of diabetic mothers to become diabetic in the future.

Other types[link]

Prediabetes indicates a condition that occurs when a person's blood glucose levels are higher than normal but not high enough for a diagnosis of type 2 DM. Many people destined to develop type 2 DM spend many years in a state of prediabetes which has been termed "America's largest healthcare epidemic."^[9]:10–11

Latent autoimmune diabetes of adults (LADA) is a condition in which type 1 DM develops in adults. Adults with LADA are frequently initially misdiagnosed as having type 2 DM, based on age rather than etiology.

Some cases of diabetes are caused by the body's tissue receptors not responding to insulin (even when insulin levels are normal, which is what separates it from type 2 diabetes); this form is very uncommon. Genetic mutations (autosomal or mitochondrial) can lead to defects in beta cell function. Abnormal insulin action may also have been genetically determined in some cases. Any disease that causes extensive damage to the pancreas may lead to diabetes (for example, chronic pancreatitis and cystic fibrosis). Diseases associated with excessive secretion of insulin-antagonistic hormones can cause diabetes (which is typically resolved once the hormone excess is removed). Many drugs impair insulin secretion and some toxins damage pancreatic beta cells. The ICD-10 (1992) diagnostic entity, malnutrition-related diabetes mellitus (MRDM or MMDM, ICD-10 code E12), was deprecated by the World Health Organization when the current taxonomy was introduced in 1999.^[10]

Signs and symptoms[link]

Overview of the most significant symptoms of diabetes

The classical symptoms of untreated diabetes are loss of weight, polyuria (frequent urination), polydipsia (increased thirst) and polyphagia (increased hunger).^[11] Symptoms may develop rapidly (weeks or months) in type 1 diabetes, while they usually develop much more slowly and may be subtle or absent in type 2 diabetes.

Prolonged high blood glucose can cause glucose absorption in the lens of the eye, which leads to changes in its shape, resulting in vision changes. Blurred vision is a common complaint leading to a diabetes diagnosis; type 1 should always be suspected in cases of rapid vision change, whereas with type 2 change is generally more gradual, but should still be suspected^{[citation needed]}. A number of skin rashes that can occur in diabetes are collectively known as diabetic dermadromes.

Diabetic emergencies[link]

People (usually with type 1 diabetes) may also present with diabetic ketoacidosis, a state of metabolic dysregulation characterized by the smell of acetone, a rapid, deep breathing known as Kussmaul breathing, nausea, vomiting and abdominal pain, and altered states of consciousness.

A rare but equally severe possibility is hyperosmolar nonketotic state, which is more common in type 2 diabetes and is mainly the result of dehydration.

Complications[link]

All forms of diabetes increase the risk of long-term complications. These typically develop after many years (10–20), but may be the first symptom in those who have otherwise not received a diagnosis before that time. The major long-term complications relate to damage to blood vessels. Diabetes doubles the risk of cardiovascular disease.^[12] The main "macrovascular" diseases (related to atherosclerosis of larger arteries) are ischemic heart disease (angina and myocardial infarction), stroke and peripheral vascular disease.

Diabetes also causes "microvascular" complications—damage to the small blood vessels.^[13] Diabetic retinopathy, which affects blood vessel formation in the retina of the eye, can lead to visual symptoms, reduced vision, and potentially blindness. Diabetic nephropathy, the impact of diabetes on the kidneys, can lead to scarring changes in the kidney tissue, loss of small or progressively larger amounts of protein in the urine, and eventually chronic kidney disease requiring dialysis. Diabetic neuropathy is the impact of diabetes on the nervous system, most commonly causing numbness, tingling and pain in the feet and also increasing the risk of skin damage due to altered sensation. Together with vascular disease in the legs, neuropathy contributes to the risk of diabetes-related foot problems (such as diabetic foot ulcers) that can be difficult to treat and occasionally require amputation.

Causes[link]

The cause of diabetes depends on the type.

Type 1 diabetes is partly inherited, and then triggered by certain infections, with some evidence pointing at Coxsackie B4 virus. A genetic element in individual susceptibility to some of these triggers has been traced to particular HLA genotypes (i.e., the genetic "self" identifiers relied upon by the immune system). However, even in those who have inherited the susceptibility, type 1 DM seems to require an environmental trigger.

Type 2 diabetes is due primarily to lifestyle factors and genetics.^[14]

The following is a comprehensive list of other causes of diabetes:^[15]

Pathophysiology[link]

This unreferenced section requires citations to ensure verifiability.

Mechanism of insulin release in normal pancreatic beta cells - insulin production is more or less constant within the beta cells. Its release is triggered by food, chiefly food containing absorbable glucose.

Insulin is the principal hormone that regulates uptake of glucose from the blood into most cells (primarily muscle and fat cells, but not central nervous system cells). Therefore, deficiency of insulin or the insensitivity of its receptors plays a central role in all forms of diabetes mellitus.

Humans are capable of digesting some carbohydrates, in particular those most common in food; starch, and some disaccharides such as sucrose, are converted within a few hours to simpler forms, most notably the monosaccharide glucose, the principal carbohydrate energy source used by the body. The rest are passed on for processing by gut flora largely in the colon. Insulin is released into the blood by beta cells (β-cells), found in the islets of Langerhans in the pancreas, in response to rising levels of blood glucose, typically after eating. Insulin is used by about two-thirds of the body's cells to absorb glucose from the blood for use as fuel, for conversion to other needed molecules, or for storage.

Insulin is also the principal control signal for conversion of glucose to glycogen for internal storage in liver and muscle cells. Lowered glucose levels result both in the reduced release of insulin from the β-cells and in the reverse conversion of glycogen to glucose when glucose levels fall. This is mainly controlled by the hormone glucagon, which acts in the opposite manner to insulin. Glucose thus forcibly produced from internal liver cell stores (as glycogen) re-enters the bloodstream; muscle cells lack the necessary export mechanism. Normally, liver cells do this when the level of insulin is low (which normally correlates with low levels of blood glucose).

Higher insulin levels increase some anabolic ("building up") processes, such as cell growth and duplication, protein synthesis, and fat storage. Insulin (or its lack) is the principal signal in converting many of the bidirectional processes of metabolism from a catabolic to an anabolic direction, and vice versa. In particular, a low insulin level is the trigger for entering or leaving ketosis (the fat-burning metabolic phase).

If the amount of insulin available is insufficient, if cells respond poorly to the effects of insulin (insulin insensitivity or resistance), or if the insulin itself is defective, then glucose will not have its usual effect, so it will not be absorbed properly by those body cells that require it, nor will it be stored appropriately in the liver and muscles. The net effect is persistent high levels of blood glucose, poor protein synthesis, and other metabolic derangements, such as acidosis.

When the glucose concentration in the blood is raised beyond its renal threshold (about 10 mmol/L, although this may be altered in certain conditions, such as pregnancy), reabsorption of glucose in the proximal renal tubuli is incomplete, and part of the glucose remains in the urine (glycosuria). This increases the osmotic pressure of the urine and inhibits reabsorption of water by the kidney, resulting in increased urine production (polyuria) and increased fluid loss. Lost blood volume will be replaced osmotically from water held in body cells and other body compartments, causing dehydration and increased thirst.

Diagnosis[link]

Diabetes mellitus is characterized by recurrent or persistent hyperglycemia, and is diagnosed by demonstrating any one of the following:^[10]

• Fasting plasma glucose level ≥ 7.0 mmol/l (126 mg/dl)
• Plasma glucose ≥ 11.1 mmol/l (200 mg/dL) two hours after a 75 g oral glucose load as in a glucose tolerance test
• Symptoms of hyperglycemia and casual plasma glucose ≥ 11.1 mmol/l (200 mg/dl)
• Glycated hemoglobin (Hb A1C) ≥ 6.5%^[19]

A positive result, in the absence of unequivocal hyperglycemia, should be confirmed by a repeat of any of the above methods on a different day. It is preferable to measure a fasting glucose level because of the ease of measurement and the considerable time commitment of formal glucose tolerance testing, which takes two hours to complete and offers no prognostic advantage over the fasting test.^[20] According to the current definition, two fasting glucose measurements above 126 mg/dl (7.0 mmol/l) is considered diagnostic for diabetes mellitus.

People with fasting glucose levels from 110 to 125 mg/dl (6.1 to 6.9 mmol/l) are considered to have impaired fasting glucose.^[21] Patients with plasma glucose at or above 140 mg/dL (7.8 mmol/L), but not over 200 mg/dL (11.1 mmol/L), two hours after a 75 g oral glucose load are considered to have impaired glucose tolerance. Of these two prediabetic states, the latter in particular is a major risk factor for progression to full-blown diabetes mellitus, as well as cardiovascular disease.^[22]

Glycated hemoglobin is better than fasting glucose for determining risks of cardiovascular disease and death from any cause.^[23]

Management[link]

Diabetes mellitus is a chronic disease which cannot be cured except in very specific situations. Management concentrates on keeping blood sugar levels as close to normal ("euglycemia") as possible, without causing hypoglycemia. This can usually be accomplished with diet, exercise, and use of appropriate medications (insulin in the case of type 1 diabetes, oral medications, as well as possibly insulin, in type 2 diabetes).

Patient education, understanding, and participation is vital, since the complications of diabetes are far less common and less severe in people who have well-managed blood sugar levels.^[24][25] The goal of treatment is an HbA1C level of 6.5%, but should not be lower than that, and may be set higher.^[26] Attention is also paid to other health problems that may accelerate the deleterious effects of diabetes. These include smoking, elevated cholesterol levels, obesity, high blood pressure, and lack of regular exercise.^[26]

Lifestyle[link]

There are roles for patient education, dietetic support, sensible exercise, with the goal of keeping both short-term and long-term blood glucose levels within acceptable bounds. In addition, given the associated higher risks of cardiovascular disease, lifestyle modifications are recommended to control blood pressure.^[27]

Medications[link]

Oral medications

Metformin is generally recommended as a first line treatment for type 2 diabetes, as there is good evidence that it decreases mortality.^[28] Routine use of aspirin, however, has not been found to improve outcomes in uncomplicated diabetes.^[29]

Insulin

Type 1 diabetes is typically treated with a combinations of regular and NPH insulin, or synthetic insulin analogs. When insulin is used in type 2 diabetes, a long-acting formulation is usually added initially, while continuing oral medications.^[28] Doses of insulin are then increased to effect.^[28]

Support[link]

In countries using a general practitioner system, such as the United Kingdom, care may take place mainly outside hospitals, with hospital-based specialist care used only in case of complications, difficult blood sugar control, or research projects. In other circumstances, general practitioners and specialists share care of a patient in a team approach. Optometrists, podiatrists/chiropodists, dietitians, physiotherapists, nursing specialists (e.g., diabetic specialist nurses), nurse practitioners, or certified diabetes educators, may jointly provide multidisciplinary expertise.^{[citation needed]} Home telehealth support can be an effective management technique.^[30]

Epidemiology[link]

Prevalence of diabetes worldwide in 2000 (per 1,000 inhabitants) - world average was 2.8%.

no data   ≤ 7.5   7.5–15   15–22.5   22.5–30   30–37.5   37.5–45

45–52.5   52.5–60   60–67.5   67.5–75   75–82.5   ≥ 82.5

Disability-adjusted life year for diabetes mellitus per 100,000 inhabitants in 2004

No data   <100   100–200   200–300   300–400   400–500   500–600

600–700   700–800   800–900   900–1,000   1,000–1,500   >1,500

Globally, as of 2010^[update], an estimated 285 million people had diabetes, with type 2 making up about 90% of the cases.^[3] Its incidence is increasing rapidly, and by 2030, this number is estimated to almost double.^[31] Diabetes mellitus occurs throughout the world, but is more common (especially type 2) in the more developed countries. The greatest increase in prevalence is, however, expected to occur in Asia and Africa, where most patients will probably be found by 2030.^[31] The increase in incidence in developing countries follows the trend of urbanization and lifestyle changes, perhaps most importantly a "Western-style" diet. This has suggested an environmental (i.e., dietary) effect, but there is little understanding of the mechanism(s) at present, though there is much speculation, some of it most compellingly presented.^[31]

United States[link]

For at least 20 years, diabetes rates in North America have been increasing substantially. In 2010, nearly 26 million people have diabetes in the United States alone, from those 7 million people remain undiagnosed. Another 57 million people are estimated to have prediabetes.^[32][33]

The Centers for Disease Control and Prevention (CDC) has termed the change an epidemic.^[34] The National Diabetes Information Clearinghouse estimates diabetes costs $132 billion in the United States alone every year. About 5%–10% of diabetes cases in North America are type 1, with the rest being type 2. The fraction of type 1 in other parts of the world differs. Most of this difference is not currently understood. The American Diabetes Association (ADA) cites the 2003 assessment of the National Center for Chronic Disease Prevention and Health Promotion (Centers for Disease Control and Prevention) that one in three Americans born after 2000 will develop diabetes in their lifetimes.^[35][36]

According to the ADA, about 18.3% (8.6 million) of Americans age 60 and older have diabetes.^[37] Diabetes mellitus prevalence increases with age, and the numbers of older persons with diabetes are expected to grow as the elderly population increases in number. The National Health and Nutrition Examination Survey (NHANES III) demonstrated, in the population over 65 years old, 18% to 20% have diabetes, with 40% having either diabetes or its precursor form of impaired glucose tolerance.^[38]

Australia[link]

Indigenous populations in first world countries have a higher prevalence and increasing incidence of diabetes than their corresponding nonindigenous populations. In Australia, the age-standardised prevalence of self-reported diabetes in indigenous Australians is almost four times that of nonindigenous Australians.^[39] Preventative community health programs, such as Sugar Man (diabetes education), are showing some success in tackling this problem.

United Kingdom[link]

About 3.8 million people in the United Kingdom have diabetes mellitus, but the charity Diabetes U.K. have made predictions that that could become high as 6.2 million by 2035/2036. Diabetes U.K. have also predicted that the National Health Service could be spending as much as 16.9 billion pounds on diabetes mellitus by 2035, a figure that means that the National Health Service could be spending as much as 17% of its budget on diabetes treatment by 2035.^[40]

History[link]

Diabetes was one of the first diseases described,^[41] with an Egyptian manuscript from c. 1500 BCE mentioning "too great emptying of the urine".^[42] The first described cases are believed to be of type 1 diabetes.^[42] Indian physicians around the same time identified the disease and classified it as madhumeha or "honey urine", noting the urine would attract ants.^[42] The term "diabetes" or "to pass through" was first used in 230 BCE by the Greek Appollonius of Memphis.^[42] The disease was rare during the time of the Roman empire, with Galen commenting he had only seen two cases during his career.^[42] Type 1 and type 2 diabetes where identified as separate conditions for the first time by the Indian physicians Sushruta and Charaka in 400-500 AD with type 1 associated with youth and type 2 with being overweight.^[42] The term "mellitus" or "from honey" was added by the Briton John Rolle in the late 1700s to separate the condition from diabetes insipidus, which is also associated with frequent urination.^[42] While many measure where tried, effective treatment was not developed until the early part of the 20th century, when Canadians Frederick Banting and Charles Herbert Best developed insulin in 1921 and 1922.^[42] This was followed by the development of the long-acting insulin NPH in the 1940s.^[42]

Etymology[link]

The word diabetes ( /ˌdaɪ.əˈbiːtiːz/ or /ˌdaɪ.əˈbiːtɨs/) comes from Latin diabētēs, which in turn comes from Ancient Greek διαβήτης (diabētēs) which literally means "a passer through; a siphon."^[43] Ancient Greek physician Aretaeus of Cappadocia (fl. 1st century CE) used that word, with the intended meaning "excessive discharge of urine", as the name for the disease.^[44][45] Ultimately, the word comes from Greek διαβαίνειν (diabainein), meaning "to pass through,"^[43] which is composed of δια- (dia-), meaning "through" and βαίνειν (bainein), meaning "to go".^[44] The word "diabetes" is first recorded in English, in the form diabete, in a medical text written around 1425.

The word mellitus (/mɨˈlaɪtəs/ or /ˈmɛlɨtəs/) comes from the classical Latin word mellītus, meaning "mellite"^[46] (i.e. sweetened with honey;^[46] honey-sweet^[47]). The Latin word comes from mell-, which comes from mel, meaning "honey";^[46][47] sweetness;^[47] pleasant thing,^[47] and the suffix -ītus,^[46] whose meaning is the same as that of the English suffix "-ite".^[48] It was Thomas Willis who in 1675 added "mellitus" to the word "diabetes" as a designation for the disease, when he noticed the urine of a diabetic had a sweet taste (glycosuria).^[45] This sweet taste had been noticed in urine by the ancient Greeks, Chinese, Egyptians, Indians, and Persians.

Society and culture[link]

The 1990 "St. Vincent Declaration"^[49][50] was the result of international efforts to improve the care accorded to those with diabetes. Doing so is important not only in terms of quality of life and life expectancy, but also economically—expenses due to diabetes have been shown to be a major drain on health- and productivity-related resources for healthcare systems and governments.

Several countries established more and less successful national diabetes programmes to improve treatment of the disease.^[51]

Diabetic patients with neuropathic symptoms such as numbness or tingling in feet or hands are twice as likely to be unemployed as those without the symptoms.^[52]

In other animals[link]

In animals, diabetes is most commonly encountered in dogs and cats. Middle-aged animals are most commonly affected. Female dogs are twice as likely to be affected as males, while according to some sources, male cats are also more prone than females. In both species, all breeds may be affected, but some small dog breeds are particularly likely to develop diabetes, such as Miniature Poodles.^[53] The symptoms may relate to fluid loss and polyuria, but the course may also be insidious. Diabetic animals are more prone to infections. The long-term complications recognised in humans are much rarer in animals. The principles of treatment (weight loss, oral antidiabetics, subcutaneous insulin) and management of emergencies (e.g. ketoacidosis) are similar to those in humans.^[53]

References[link]

External links[link]

Find more about Diabetes mellitus on Wikipedia's sister projects:
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	Learning resources from Wikiversity
	News stories from Wikinews
	Quotations from Wikiquote
	Source texts from Wikisource
	Textbooks from Wikibooks

• Diabetes at the Open Directory Project
• American Diabetes Association
• IDF Diabetes Atlas
• National Diabetes Education Program

Nick Jonas
Nick Jonas in 2011.
Background information
Birth name	Nicholas Jerry Jonas
Born	(1992-09-16) September 16, 1992 (age 19) Dallas, Texas, United States
Origin	Wyckoff, New Jersey, United States
Genres	Teen pop, pop rock
Occupations	Vocalist, musician, actor, singer–songwriter
Instruments	Vocals, guitar, drums, piano, glockenspiel
Years active	2002–present
Labels	Columbia, Hollywood, Jonas
Associated acts	Jonas Brothers, Nick Jonas & The Administration, Demi Lovato
Notable instruments
Gibson SG Fender Telecaster Gibson ES-335

Nicholas Jerry "Nick" Jonas (born September 16, 1992) is an American singer-songwriter, musician and actor best known as one of the Jonas Brothers, a pop-rock band he formed with his brothers Joe and Kevin. The Jonas Brothers originally started as an attempted solo singing career for Nick, but the record producer liked the sound when his brothers sang backup for him. He previously starred in the Disney Channel original series JONAS L.A. as Nick Lucas, alongside his brothers. He also starred in the Disney Channel original movie Camp Rock and Camp Rock 2: The Final Jam. He formed the band Nick Jonas & The Administration, which released its first album in 2010.

Career[link]

Career beginnings: 2000-2005[link]

Jonas's career started when he was discovered at the age of six in a barber shop, while his mother was getting her hair cut and was referred to a professional show business manager.^[1][2] At the age of 7, he began performing on Broadway.^[3][4] He had acted in several plays, including A Christmas Carol (in 2000 as Tiny Tim and Scrooge at eight), Annie Get Your Gun (in 2001 as Little Jake), Beauty and the Beast (in 2002 as Chip), and Les Misérables (in 2003 as Gavroche).^[4][5][6][7] After Les Misérables closed, he performed in The Sound of Music (as Kurt) at the Paper Mill Playhouse.^[8]

In 2002, while performing in Beauty and the Beast, Jonas wrote a song with his father called "Joy to the World (A Christmas Prayer)." With background vocals from the Beauty and the Beast cast, Nick recorded the song on the 2002 annual Broadway "Equity Fights AIDS" album, Broadway's Greatest Gifts: Carols for a Cure, Vol. 4.^[9][10] In November 2003, INO Records received a demo copy of "Joy To The World (A Christmas Prayer)".^[11] The label released the song to Christian radio, where it quickly became popular on Record & Radio's Christian Adult Contemporary Chart.^[10]

By September 2004, an executive at Columbia Records discovered Jonas' song.^[9][10] He was soon jointly signed to INO Records and Columbia Records and released the single "Dear God".^[12][13] A second single, "Joy to the World (A Christmas Prayer)" (a re-recorded version), was released on November 16.^[14] It was supposed to be followed by a December release of a self-titled solo album Nicholas Jonas, but the album was pushed back.^[15] It did, however, get a limited release.^[16] Nick, along with his brothers, Kevin and Joe, co-wrote songs for the album.^[9] In early 2005, Columbia Records' new president, Steve Greenberg, heard Jonas' record. While Greenberg did not like the album, he did like Nick's voice.^[17]

Jonas Brothers: 2005-2010[link]

After meeting with Jonas and hearing the song, "Please Be Mine", written and performed by the brothers, Daylight/Columbia Records decided to sign the three as a group act.^[9][18][19] After being signed to Columbia, the brothers considered naming their group "Sons of Jonas" before settling on the name "Jonas Brothers."^[20] It's About Time, the brothers' first album was released on August 8, 2006.^[21] According to the band's manager, it was only a "limited release" of a little over 50,000 copies. Because Sony was not interested in further promoting the band, the Jonas Brothers considered switching labels. The band was ultimately dropped by Columbia Records in early 2007.

After shortly being without a label, the Jonas Brothers signed with Hollywood Records in February 2007.^[22][23] Around the same time, brothers began appearing in commercials for Baby Bottle Pops, singing the jingle.^[23] Their self-titled second album, Jonas Brothers, was released on August 7, 2007.^[24] It reached number five on the Billboard 200 chart in its first week. It has since sold over three million copies worldwide. On August 17, 2007, Jonas, along with his brothers, guest starred in an episode of Hannah Montana, which aired after the premiere of High School Musical 2 and the Disney Channel show Phineas and Ferb.^[25] The episode broke basic cable records with a record 10.7 million viewers and became basic cable's most watched series telecast ever.^[26]

Jonas performing in July 2009

The reality short series, Jonas Brothers: Living the Dream, premiered on Disney Channel on May 16, 2008. The show, which ran until September 5, 2008, documents the brothers' lives on the Look Me In The Eyes Tour. The name was inspired by the band's hit song "When You Look Me in the Eyes". The series was renewed for a second season, which premiered on March 21, 2010.^[27] The second season follows the band on the European leg of their World Tour 2009. Jonas and his brothers filmed a Disney Channel Original Movie called Camp Rock where they play a band called "Connect Three." Joe plays the lead male role as lead singer "Shane Gray"; Nick plays the role of "Nate," a guitarist; and Kevin plays the role of "Jason," also a guitarist. A soundtrack for the movie was released on June 17, 2008. The movie premiered on June 20, 2008, in the USA on Disney Channel, and Canada on Family. Production began on the sequel, Camp Rock 2: The Final Jam in September 2009 and it premiered during the summer of 2010.

The Jonas Brothers' third studio album, A Little Bit Longer, was released in the United States on August 12, 2008. It sold over 2 million copies worldwide. The Jonas Brothers were listed number 9 on the richest pop acts of 2008. Jonas and his brothers starred in the Disney Channel Original Series JONAS about a pop band trying to live a normal life, which premiered May 2, 2009 and concluded on March 14, 2010. Filming for the second season began in February 2010. The second season was renamed Jonas L.A., and premiered on June 20, 2010. On November 8, 2010, it was announced that the series had been cancelled.^[28] The Jonas Brothers' fourth studio album, Lines, Vines and Trying Times, was released in the United States in June, 2009.

Solo projects: 2010-2011[link]

Jonas performing live as part of the Jonas Brothers in 2010.

Jonas' side project from the Jonas Brothers called Nick Jonas & the Administration released their debut album Who I Am was released February 2, 2010. In January 2010, Jonas embarked on the Who I Am Tour with the Administration.^[29] The tour consisted of 22 dates that began on January 2, 2010, in Dallas, Texas and concluded on January 30, 2010, in Berkeley, California. Jonas also toured with his brothers again in 2010. In September 2011 and October 2011, Nick Jonas & The Administration began touring through South America in support of their debut album, Who I Am.^[30]

On June 21, 2010, Jonas made his West End debut performing in Les Misérables for the second time, but this time as the role of Marius Pontmercy.^[31] Jonas was originally supposed to play the role for only three weeks, but was able to extend his run until July 24, 2010, because of changes in the Jonas Brothers tour schedule.^[32] He also appeared in the 25th Anniversary Concert at The O2 Arena on October 3, 2010, again playing the role of Marius Pontmercy.^[33] From August 5–7, 2011, Jonas performed in the musical Hairspray as Link Larkin at the Hollywood Bowl.^[34] Jonas appeared in the 2011 series Mr. Sunshine; he played Eli White, an up-and-coming singer who wants everything his way before he performs at the Sunshine Center.^[35] He also plays the role of Ryan on the sitcom Last Man Standing.^[36][37]