- published: 01 Jul 2016
- views: 5
The melanocortin 1 receptor (MC1R), also known as melanocyte-stimulating hormone receptor (MSHR), melanin-activating peptide receptor, or melanotropin receptor, is a G protein–coupled receptor that binds to a class of pituitary peptide hormones known as the melanocortins, which include adrenocorticotropic hormone (ACTH) and the different forms of melanocyte-stimulating hormone (MSH). MC1R is one of the key proteins involved in regulating mammalian skin and hair color. It is located on the plasma membrane of specialized cells known as melanocytes, which produce the pigment melanin through the process of melanogenesis. It works by controlling the type of melanin being produced, and its activation causes the melanocyte to switch from generating the yellow or red phaeomelanin by default to the brown or black eumelanin in replacement.
The MC1R protein lies within the cell membrane, and is signalled by melanocyte-stimulating hormone (MSH) released by the pituitary gland. When activated by one of the variants of MSH, typically α-MSH, MC1R initiates a complex signaling cascade that leads to the production of the brown or black pigment eumelanin. In contrast, the receptor can also be antagonized by agouti signalling peptide (ASIP), which reverts the cell back to producing the yellow or red phaeomelanin.
Going to the city........
Run to the city with your own contraption
Run to the city for a new reaction
To the city for your own advantage
To the city for a sidewalk attraction
Hmm.......
See the light that you hold now in our times
Sole single light
Sole single light
See the light that you hold out in our times
Sole single light
Sole single light
So, get ready for what the lights intended
Stay in the city for the love of attention
In the city that is most intensive
In the city where the light will protect you now
Up for the looks and the outboasts
Side street crowds and the kids on the lampposts
Catch a glimpse of the light from the street show
Hopes there'll be a sign
See the light that you hold now in our times
Sole single light
Sole single light
See the light that you hold out in our times
Sole single light
Sole single light
So, get ready for what the lights intended
Stay in the city for the love of attention
In the city that is most inventive
In the city where the light will protect you now