- published: 12 Jun 2011
- views: 8132
Azathioprine (AZA) is an immunosuppressive drug used in organ transplantation and autoimmune diseases and belongs to the chemical class of purine analogues. Synthesized originally as a cancer drug and a prodrug for mercaptopurine in 1957, it has been widely used as an immunosuppressant for more than 50 years.
Azathioprine acts as a prodrug for mercaptopurine, inhibiting an enzyme required for the synthesis of DNA. Thus, it most strongly affects proliferating cells, such as the T cells and B cells of the immune system.
The main adverse effect of azathioprine is bone marrow suppression, which can be life-threatening, especially in people with a genetic deficiency of the enzyme thiopurine S-methyltransferase. It is also listed by the International Agency for Research on Cancer as a group 1 carcinogen (carcinogenic to humans).
Azathioprine is produced by a number of manufacturers under different brand names (Azasan by Salix in the U.S., Imuran by GlaxoSmithKline in Canada, the U.S., Australia, Ireland and the United Kingdom, Azamun in Finland, and Imurel in Scandinavia and France, among others). It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system.
A brief video describing the use of azathioprine also known as Imuran for the treatment of the rheumatic diseases such as lupus.
For more information on Mysthenia Gravis, or the Mysthenia Gravis Association of Kansas City, please visit http://mgakc.org/ Dr. John Sand, Neurologist and Director of MD Electrodiagnosis is a long time Board member of the Myasthenia Gravis Association and former Board President. Dr. Sand specializes in neuromuscular disease.
Imuran, also known as azathioprine, suppresses the immune system and helps prevent organ rejection after an organ transplant. Understand the side effects and other uses of Imuran with information from the CEO of a pharmacy company in this free video on medicine.
This is me talking about the process of realizing that imuran was causing what appeared to be a virus, but was actually a reaction to the medicine azathioprine. My dosage was 100mg a day. Symptoms set in for me within 10 days of taking it.
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(When a guy really likes a girl)
[Chorus:]
When a guy really likes a girl
He's gonna let her know
Just what she needs ta hear
Throw away this playa card
Do whatever 2 show her what
What she needs to hear
Ain't no chicks on the side
No finding #'s in his ride
Cause she the only one
When a guy really likes a girl
He's gonna let her know
[Verse 1:]
I know at times it may seem that my heart maybe mean
I don still but I've gotta keep it real u had me from the game
Pretty facin conversationin had me gone...
And all them hints that I get from them chicks don't mean ah thang
Girl immmmm giving you my time and that's the bottom line
I'm lettin u kno that show that your my lady
Seeee
[Chorus:]
When a guy really likes a girl
He's gonna let her know
Just what she needs ta hear
Throw away this playa card
Do whatever 2 show her what
What she needs to hear
Ain't no chicks on the side
No finding #'s in his ride
Cause she the only one
When a guy really likes a girl
He's gonna let her kno
[Verse 2:]
I got ah spot in my heart
It's engraved with cha name permently
And just like ah baby boy with his favorite toy
That's the way that I've been feelin when I'm with u
She said "I'm gon make it last and not gona let u go it for the long call gonna let my feelings show cus that's what it's all aboutjust wanna shout it out"
[Omarion:]
That's what I'm talking bout
I'm tellin you when a guyyyyy
Seeee
[Chorus:]
When a guy really likes a girl
He's gonna let her kno
Juss wha she needs ta hear
Throw away this playa card
Do whatevr 2 show her what
What she needs to hear
Ain't no chicks on the side
No findin #'s in his ride
Cus she the only one
When a guy really likes a girl
He's gonna let her kno
[Verse 3:]
Ain't no chicks on the side
No findin #'s in his ride
Cus she's the only one
When a guy really likes a girl he's gonna let her kno
(He won't let her go for nothin')
(He'll always show her that he cares0
(He'll take u 2 meet his family)
Omarion
All I'm really tryin 2 say is that I'm feeling u
[Chorus:]
When a guy really likes a girl
He's gonna let her kno
Juss wha she needs ta hear
Throw away this playa card
Do whatevr 2 show her what
What she needs to hear
Ain't no chicks on the side
No findin #'s in his ride
Cus she the only one
When a guy really likes a girl