CHEK2

CHEK2 is the official symbol for the human gene Checkpoint kinase 2. CHEK2 is located on the long (q) arm of chromosome 22. CHEK2 is tumor suppressor gene that encodes the protein CHK2, a serine threonine kinase. CHK2 operates in an intricate network of proteins to elicit DNA repair, cell cycle arrest or apoptosis in response to DNA damage. Mutations to the CHEK2 gene have been linked to a wide range of cancers including breast cancer.

Other names for CHK2 include CDS1, Cds1 kinase, checkpoint-like protein CHK2, CHK2, CHK2 checkpoint homolog, CHK2_HUMAN, Chk2 protein kinase, hCds1 protein, hCHK2, HuCds1, RAD53, serine/threonine-protein kinase CHK2.

Gene location

The CHEK2 gene is located on the long (q) arm of chromosome 22 at position 12.1. In other words, its location of chromosome 22 stretches from base pair 28,687,742 to base pair 28,741,904.

Protein structure

The CHK2 protein encoded by the CHEK2 gene is a serine threonine kinase. The protein consists of 543 amino acids and the following domains:

Scouting Ireland

Scouting Ireland (Irish: Gasóga na hÉireann) is the sole World Organization of the Scout Movement-recognised Scouting association in the Republic of Ireland; in Northern Ireland it operates alongside The Scout Association of the UK. Scouting Ireland is a voluntary, non-formal educational movement for young people. It is independent, non-political, open to all without distinction of origin, race, creed, sexual orientation, spiritual belief or gender, in accordance with the purpose, principles and method conceived by Lord Baden-Powell and as stated by WOSM.

The aim of Scouting Ireland is to encourage the Social, Physical, Intellectual, Character Emotional, and Spiritual development (known as the SPICES) of young people "so that they may achieve their full potential and as responsible citizens, to improve society". Of the 750,000 people between the ages of 6 and 18 in Ireland, approximately 6% are involved in Scouting Ireland. The organisation was founded on 21 June 2003, after a merger between Scouting Ireland C.S.I. and Scouting Ireland S.A.I.. Its headquarters are at Larch Hill, County Dublin.

A Personal Journey

A Personal Journey is the debut album by Australian heavy metal band Lord. This release was designed as a solo outlet for Lord Tim of the Sydney metal band Dungeon to release material he felt was inappropriate for that group.

Overview

The tracks on A Personal Journey are a mixture of instrumentals and songs. Ex-Dungeon bass guitarist Justin Sayers and Dungeon guitarist Stu Marshall also contributed. Track 5, "By George!", is a tribute to Dokken guitarist George Lynch. The album was released in 2003 by Melbourne label Metal Warriors before being remixed and reissued with one extra track, "The Duel" (a reworking of an early Dungeon song), by Modern Invasion in December 2004. When Dungeon split that year, Lord became a complete band and has recorded a second album since.

Track listing

All titles by Tim Grose

Personnel

Lord

with

English language

English is a West Germanic language that was first spoken in early medieval England and is now a global lingua franca. It is an official language of almost 60 sovereign states, the most commonly spoken language in the United Kingdom, the United States, Canada, Australia, Ireland, and New Zealand, and a widely spoken language in countries in the Caribbean, Africa, and South Asia. It is the third most common native language in the world, after Mandarin and Spanish. It is the most widely learned second language and is an official language of the United Nations, of the European Union, and of many other world and regional international organisations.

English has developed over the course of more than 1,400 years. The earliest forms of English, a set of Anglo-Frisian dialects brought to Great Britain by Anglo-Saxon settlers in the fifth century, are called Old English. Middle English began in the late 11th century with the Norman conquest of England.Early Modern English began in the late 15th century with the introduction of the printing press to London and the King James Bible as well as the Great Vowel Shift. Through the worldwide influence of the British Empire, modern English spread around the world from the 17th to mid-20th centuries. Through all types of printed and electronic media, as well as the emergence of the United States as a global superpower, English has become the leading language of international discourse and the lingua franca in many regions and in professional contexts such as science, navigation, and law.