- published: 01 Nov 2012
- views: 14789400
The Urokinase receptor, also known as uPA receptor or uPAR or CD87 (Cluster of Differentiation 87), is multidomain glycoprotein tethered to the cell membrane with a glycosylphosphotidylinositol (GPI) anchor. uPAR was originally identified as a saturable binding site for urokinase on the cell surface.
uPAR consists of three different domains of the Ly-6/uPAR/alpha-neurotoxin family. All three domains are necessary for high affinity binding of the primary ligand, urokinase. It has been possible to express uPAR recombinantly in CHO-cells and S2 cells from Drosophila melanogaster. 4 out of 5 of the possible glycosylation sites are used in vivo giving the protein a molecular weight of 50-60 kDA. Recently the structure of uPAR was solved by X-ray crystallography in complex with an peptide antagonist and with its native ligand, urokinase.
Besides the primary ligand urokinase, uPAR interacts with several other proteins, among others: vitronectin, the uPAR associated protein (uPARAP) and the integrin family of membrane proteins.
You run for cover
Stick your head in the sand
You deny you're wrong
Say you don't understand
The ways and means
Don't mean a thing with no green
And your, body of work
Ain't nobody to be seen
The only choice to make is
Paper or plastic
So ya, do something drastic
And ya make it fantastic
You keep on fishin' for
A way to succeed
It's the, only way
For the big dogs to eat
Just ride the wave
Everybody rave
Don't be a slave
To the things you crave
Temptation make you
Want the things you don't need
Buy them, boogie shoes
And spend to
Feed the greed
You spin the wheel
And play the numbers you feel
Bet them double zeroes
And you'll, be a hero
Just ride the wave
Everybody rave
Don't be a slave
To the things that you crave
Feeble
Evil
Boring
People
Sneaky
Freaky
Lonely
Schemers
Fowling
Scowling
Bottom
Feeders
Musing
Amusing
In
Betweeners
Just ride the wave
Everybody rave
Don't be a slave
To the things you crave