The River Lune is a river in Cumbria and Lancashire, England.

It is formed at Wath, in the parish of Ravenstonedale, Cumbria, at the confluence of Sandwath Beck and Weasdale Beck. The river then passes the remnants of a Roman fort near Low Borrowbridge at the foot of Borrowdale, and flows through south Cumbria, finally meeting the Irish Sea at Plover Scar near Lancaster, after a total journey of about 44 miles (71 km).

The valley of the Lune has three parts. The northern part between its source and Tebay is called Lunesdale. Below this is the spectacular Lune Gorge through which both the M6 motorway and the West Coast Main Railway Line run. Below the gorge, the valley broadens out into Lonsdale.

Bridges over the Lune include the Devil's Bridge near Kirkby Lonsdale and the Lune Millennium Bridge in Lancaster. At Caton, about 5 miles (8.0 km) upstream from Lancaster, there is a cluster of three bridges (one stone road bridge and two disused iron rail bridges now used as foot/cyclepaths) at the Crook o' Lune. Here in a 180 degree right hand bend the Lune turns back on itself; this is followed by a 90 degree left hand bend forming the shape of a shepherd's crook and creating a beauty spot which was painted by J. M. W. Turner.