Archaeogenetics, a term coined by Colin Renfrew, refers to the application of the techniques of molecular population genetics to the study of the human past. This can involve:

The topic has its origins in the study of human blood groups and the realisation that this classical genetic marker provides information about the relationships between linguistic and ethnic groupings. Early work in this field included that of Ludwik and Hanka Hirszfeld, William Boyd and Arthur Mourant. From the 1960s onwards, Luca Cavalli-Sforza used classical genetic markers to examine the prehistoric population of Europe, culminating in the publication of The History and Geography of Human Genes in 1994.

Since then, the genetic history of all of our major domestic plants (e.g., wheat, rice, maize) and animals (e.g., cattle, goats, pigs, horses) has been analysed. Models for the timing and biogeography of their domestication and subsequent husbandry have been put forward, mainly based on mitochondrial DNA variation, though other markers are currently being analysed to supplement the genetic narrative (e.g., the Y chromosome for describing the history of the male lineage).