potassium ← calcium → scandium Mg ↑ Ca ↓ Sr 20Ca Periodic table
Appearance
Dull gray, silver Spectral lines of Calcium
General properties
Name, symbol, number	calcium, Ca, 20
Pronunciation	/ˈkælsiəm/ KAL-see-əm
Element category	alkaline earth metal
Group, period, block	2, 4, s
Standard atomic weight	40.078(4)
Electron configuration	[Ar] 4s2
Electrons per shell	2, 8, 8, 2 (Image)
Physical properties
Phase	solid
Density (near r.t.)	1.55 g·cm−3
Liquid density at m.p.	1.378 g·cm−3
Melting point	1115 K, 842 °C, 1548 °F
Boiling point	1757 K, 1484 °C, 2703 °F
Heat of fusion	8.54 kJ·mol−1
Heat of vaporization	154.7 kJ·mol−1
Molar heat capacity	25.929 J·mol−1·K−1
Vapor pressure
P (Pa) 1 10 100 1 k 10 k 100 k at T (K) 864 956 1071 1227 1443 1755
Atomic properties
Oxidation states	+2, +1[1] (strongly basic oxide)
Electronegativity	1.00 (Pauling scale)
Ionization energies (more)	1st: 589.8 kJ·mol−1
	2nd: 1145.4 kJ·mol−1
	3rd: 4912.4 kJ·mol−1
Atomic radius	197 pm
Covalent radius	176±10 pm
Van der Waals radius	231 pm
Miscellanea
Crystal structure	face-centered cubic
Magnetic ordering	diamagnetic
Electrical resistivity	(20 °C) 33.6 nΩ·m
Thermal conductivity	201 W·m−1·K−1
Thermal expansion	(25 °C) 22.3 µm·m−1·K−1
Speed of sound (thin rod)	(20 °C) 3810 m·s−1
Young's modulus	20 GPa
Shear modulus	7.4 GPa
Bulk modulus	17 GPa
Poisson ratio	0.31
Mohs hardness	1.75
Brinell hardness	167 MPa
CAS registry number	7440-70-2
Most stable isotopes
Main article: Isotopes of calcium
iso NA half-life DM DE (MeV) DP 40Ca 96.941% 40Ca is stable with 20 neutrons 41Ca trace 1.03×105 y ε - 41K 42Ca 0.647% 42Ca is stable with 22 neutrons 43Ca 0.135% 43Ca is stable with 23 neutrons 44Ca 2.086% 44Ca is stable with 24 neutrons 45Ca syn 162.7 d β− 0.258 45Sc 46Ca 0.004% >2.8×1015 y β−β−  ? 46Ti 47Ca syn 4.536 d β− 0.694, 1.99 47Sc γ 1.297 - 48Ca 0.187% >4×1019 y β−β−  ? 48Ti
v t e · r

Calcium ( /ˈkælsiəm/ KAL-see-əm) is the chemical element with the symbol Ca and atomic number 20. It has an atomic mass of 40.078 amu. Calcium is a soft gray alkaline earth metal, and is the fifth-most-abundant element by mass in the Earth's crust. Calcium is also the fifth-most-abundant dissolved ion in seawater by both molarity and mass, after sodium, chloride, magnesium, and sulfate.^[2]

Calcium is essential for living organisms, in particular in cell physiology, where movement of the calcium ion Ca²⁺ into and out of the cytoplasm functions as a signal for many cellular processes. As a major material used in mineralization of bones and shells, calcium is the most abundant metal by mass in many animals.

Notable characteristics[link]

Flame test. Brick-red color originates from calcium.

In chemical terms, calcium is reactive and soft for a metal (though harder than lead, it can be cut with a knife with difficulty). It is a silvery metallic element that must be extracted by electrolysis from a fused salt like calcium chloride.^[3] Once produced, it rapidly forms a gray-white oxide and nitride coating when exposed to air. In bulk form (typically as chips or "turnings"), the metal is somewhat difficult to ignite, more so even than magnesium chips; but, when lit, the metal burns in air with a brilliant high-intensity orange-red light. Calcium metal reacts with water, evolving hydrogen gas at a rate rapid enough to be noticeable, but not fast enough at room temperature to generate much heat. In powdered form, however, the reaction with water is extremely rapid, as the increased surface area of the powder accelerates the reaction with the water. Part of the slowness of the calcium-water reaction results from the metal being partly protected by insoluble white calcium hydroxide. In water solutions of acids, where this salt is soluble, calcium reacts vigorously.

Calcium, with a density of 1.55 g/cm³, is the lightest of the alkaline earth metals; magnesium (specific gravity 1.74) and beryllium (1.84) are more dense, although lighter in atomic mass. From strontium onward, the alkali earth metals become more dense with increasing atomic mass.

It has two allotropes.^[4]

Calcium has a higher electrical resistivity than copper or aluminium, yet weight-for-weight, due to its much lower density, it is a rather better conductor than either. However, its use in terrestrial applications is usually limited by its high reactivity with air.

Calcium salts are colorless from any contribution of the calcium, and ionic solutions of calcium (Ca²⁺) are colorless as well. As with magnesium salts and other alkaline earth metal salts, calcium salts are often quite soluble in water. Notable exceptions include the hydroxide, the sulfate (unusual for sulfate salts), the carbonate and the phosphates. With the exception of the sulfate, even the insoluble ones listed are in general more soluble than its transition metal counterparts. When in solution, the calcium ion to the human taste varies remarkably, being reported as mildly salty, sour, "mineral like" or even "soothing." It is apparent that many animals can taste, or develop a taste, for calcium, and use this sense to detect the mineral in salt licks or other sources.^[5] In human nutrition, soluble calcium salts may be added to tart juices without much effect to the average palate.

Calcium is the fifth-most-abundant element by mass in the human body, where it is a common cellular ionic messenger with many functions, and serves also as a structural element in bone. It is the relatively high-atomic-number calcium in the skeleton that causes bone to be radio-opaque. Of the human body's solid components after drying and burning of organics (as for example, after cremation), about a third of the total "mineral" mass remaining, is the approximately one kilogram of calcium that composes the average skeleton (the remainder being mostly phosphorus and oxygen).

H and K lines[link]

Visible spectra of many stars, including the Sun, exhibit strong absorption lines of singly ionized calcium. Prominent among these are the H-line at 3968.5 Å and the K line at 3933.7 Å of singly ionized calcium, or Ca II. For the Sun and stars with low temperatures, the prominence of the H and K lines can be an indication of strong magnetic activity in the chromosphere. Measurement of periodic variations of these active regions can also be used to deduce the rotation periods of these stars.^[6]

Compounds[link]

Calcium, combined with phosphate to form hydroxylapatite, is the mineral portion of human and animal bones and teeth. The mineral portion of some corals can also be transformed into hydroxylapatite.

Calcium hydroxide (slaked lime) is used in many chemical refinery processes and is made by heating limestone at high temperature (above 825 °C) and then carefully adding water to it. When lime is mixed with sand, it hardens into a mortar and is turned into plaster by carbon dioxide uptake. Mixed with other compounds, lime forms an important part of Portland cement.

Calcium carbonate (CaCO₃) is one of the common compounds of calcium. It is heated to form quicklime (CaO), which is then added to water (H₂O). This forms another material known as slaked lime (Ca(OH)₂), which is an inexpensive base material used throughout the chemical industry. Chalk, marble, and limestone are all forms of calcium carbonate.

When water percolates through limestone or other soluble carbonate rocks, it partially dissolves the rock and causes cave formation and characteristic stalactites and stalagmites and also forms hard water. Other important calcium compounds are calcium nitrate, calcium sulfide, calcium chloride, calcium carbide, calcium cyanamide and calcium hypochlorite.

A few calcium compounds in the oxidation state +1 have also been investigated recently.^[1]

Nucleosynthesis[link]

This section requires expansion with: information on other calcium isotopes.

Calcium-40 is created in extremely large and hot (over 2.5 × 10⁹ K) stars, as part of the silicon-burning process in which alpha particles are added to silicon atoms. The process fuses an atom of argon and an atom of helium:

³⁶Ar + ⁴He = ⁴⁰Ca

Isotopes[link]

Calcium has four stable isotopes (⁴⁰Ca, ⁴²Ca, ⁴³Ca and ⁴⁴Ca), plus two more isotopes (⁴⁶Ca and ⁴⁸Ca) that have such long half-lives that for all practical purposes they also can be considered stable. The 20% range in relative mass among naturally occurring calcium isotopes is greater than for any element except hydrogen and helium. Calcium also has a cosmogenic isotope, radioactive ⁴¹Ca, which has a half-life of 103,000 years. Unlike cosmogenic isotopes that are produced in the atmosphere, ⁴¹Ca is produced by neutron activation of ⁴⁰Ca. Most of its production is in the upper metre or so of the soil column, where the cosmogenic neutron flux is still sufficiently strong. ⁴¹Ca has received much attention in stellar studies because it decays to ⁴¹K, a critical indicator of solar-system anomalies.

Ninety-seven percent of naturally occurring calcium is in the form of ⁴⁰Ca. ⁴⁰Ca is one of the daughter products of ⁴⁰K decay, along with ⁴⁰Ar. While K-Ar dating has been used extensively in the geological sciences, the prevalence of ⁴⁰Ca in nature has impeded its use in dating. Techniques using mass spectrometry and a double spike isotope dilution have been used for K-Ca age dating.

The most abundant isotope, ⁴⁰Ca, has a nucleus of 20 protons and 20 neutrons. This is the heaviest stable isotope of any element that has equal numbers of protons and neutrons. In supernova explosions, calcium is formed from the reaction of carbon with various numbers of alpha particles (helium nuclei), until the most common calcium isotope (containing 10 helium nuclei) has been synthesized.^{[citation needed]}

Isotope fractionation[link]

As with the isotopes of other elements, a variety of processes fractionate, or alter the relative abundance of, calcium isotopes.^[7] The best studied of these processes is the mass dependent fractionation of calcium isotopes that accompanies the precipitation of calcium minerals, such as calcite, aragonite and apatite, from solution. Isotopically light calcium is preferentially incorporated into minerals, leaving the solution from which the mineral precipitated enriched in isotopically heavy calcium. At room temperature the magnitude of this fractionation is roughly 0.25‰ (0.025%) per atomic mass unit (AMU). Mass-dependent differences in calcium isotope composition conventionally are expressed the ratio of two isotopes (usually ⁴⁴Ca/⁴⁰Ca) in a sample compared to the same ratio in a standard reference material. ⁴⁴Ca/⁴⁰Ca varies by about 1% among common earth materials.^[8]

Calcium isotope fractionation during mineral formation has led to several applications of calcium isotopes. In particular, the 1997 observation by Skulan and DePaolo^[9] that calcium minerals are isotopically lighter than the solutions from which the minerals precipitate is the basis of analogous applications in medicine and in paleooceanography. In animals with skeletons mineralized with calcium the calcium isotopic composition of soft tissues reflects the relative rate of formation and dissolution of skeletal mineral. In humans changes in the calcium isotopic composition of urine have been shown to be related to changes in bone mineral balance. When the rate of bone formation exceeds the rate of bone resorption, soft tissue ⁴⁴Ca/⁴⁰Ca rises. Soft tissue ⁴⁴Ca/⁴⁰Ca falls when bone resorption exceeds bone formation. Because of this relationship, calcium isotopic measurements of urine or blood may be useful in the early detection of metabolic bone diseases like osteoporosis.^[10]

A similar system exists in the ocean, where seawater ⁴⁴Ca/⁴⁰Ca tends to rise when the rate of removal of Ca²⁺ from seawater by mineral precipitation exceeds the input of new calcium into the ocean, and fall when calcium input exceeds mineral precipitation. It follows that rising ⁴⁴Ca/⁴⁰Ca corresponds to falling seawater Ca²⁺ concentration, and falling ⁴⁴Ca/⁴⁰Ca corresponds to rising seawater Ca²⁺ concentration. In 1997 Skulan and DePaolo presented the first evidence of change in seawater ⁴⁴Ca/⁴⁰Ca over geologic time, along with a theoretical explanation of these changes. More recent papers have confirmed this observation, demonstrating that seawater Ca²⁺ concentration is not constant, and that the ocean probably never is in “steady state” with respect to its calcium input and output.^[11][12] This has important climatological implications, as the marine calcium cycle is closely tied to the carbon cycle (see below).

Geochemical cycling[link]

Calcium provides an important link between tectonics, climate and the carbon cycle. In the simplest terms, uplift of mountains exposes Ca-bearing rocks to chemical weathering and releases Ca²⁺ into surface water. This Ca²⁺ eventually is transported to the ocean where it reacts with dissolved CO₂ to form limestone. Some of this limestone settles to the sea floor where it is incorporated into new rocks. Dissolved CO₂, along with carbonate and bicarbonate ions, are referred to as dissolved inorganic carbon (DIC).

Travertine terraces Pamukkale, Turkey

The actual reaction is more complicated and involves the bicarbonate ion (HCO₃^-) that forms when CO₂ reacts with water at seawater pH:

Ca²⁺ + 2HCO−
3 → CaCO₃ (limestone) + CO₂ + H₂O

Note that at ocean pH most of the CO₂ produced in this reaction is immediately converted back into HCO3⁻. The reaction results in a net transport of one molecule of CO₂ from the ocean/atmosphere into the lithosphere.^[13]

The result is that each Ca²⁺ ion released by chemical weathering ultimately removes one CO₂ molecule from the surficial system (atmosphere, ocean, soils and living organisms), storing it in carbonate rocks where it is likely to stay for hundreds of millions of years. The weathering of calcium from rocks thus scrubs CO₂ from the ocean and atmosphere, exerting a strong long-term effect on climate.^[14] Analogous cycles involving magnesium, and to a much smaller extent strontium and barium, have the same effect.

As the weathering of limestone (CaCO₃) liberates equimolar amounts of Ca²⁺ and CO₂, it has no net effect on the CO₂ content of the atmosphere and ocean. The weathering of silicate rocks like granite, on the other hand, is a net CO2 sink because it produces abundant Ca²⁺ but very little CO₂.

History[link]

Lime as building material was used since prehistoric times going as far back as 7000 to 14000 BC.^[15] The first dated lime kiln dates back to 2500 BC and was found in Khafajah mesopotamia.^[16][17] Calcium (from Latin calx, genitive calcis, meaning "lime")^[18] was known as early as the first century when the Ancient Romans prepared lime as calcium oxide. Literature dating back to 975 AD notes that plaster of paris (calcium sulfate), is useful for setting broken bones. It was not isolated until 1808 in England when Sir Humphry Davy electrolyzed a mixture of lime and mercuric oxide.^[19] Davy was trying to isolate calcium; when he heard that Swedish chemist Jöns Jakob Berzelius and Pontin prepared calcium amalgam by electrolyzing lime in mercury, he tried it himself. He worked with electrolysis throughout his life and also discovered/isolated sodium, potassium, magnesium, boron and barium. Calcium metal was not available in large scale until the beginning of the 20th century.

Occurrence[link]

Calcium is not naturally found in its elemental state. Calcium occurs most commonly in sedimentary rocks in the minerals calcite, dolomite and gypsum. It also occurs in igneous and metamorphic rocks chiefly in the silicate minerals: plagioclases, amphiboles, pyroxenes and garnets.

Applications[link]

Calcium is used^[20]

• as a reducing agent in the extraction of other metals, such as uranium, zirconium, and thorium.
• as a deoxidizer, desulfurizer, or decarbonizer for various ferrous and nonferrous alloys.
• as an alloying agent used in the production of aluminium, beryllium, copper, lead, and magnesium alloys.
• in the making of cements and mortars to be used in construction.
• in the making of cheese, where calcium ions influence the activity of rennin in bringing about the coagulation of milk.

Calcium compounds[link]

• Calcium carbonate (CaCO₃) is used in manufacturing cement and mortar, lime, limestone (usually used in the steel industry) and aids in production in the glass industry. It also has chemical and optical uses as mineral specimens in toothpastes, for example.
• Calcium hydroxide solution (Ca(OH)₂) (also known as limewater) is used to detect the presence of carbon dioxide by being bubbled through a solution. It turns cloudy where CO₂ is present.
• Calcium arsenate (Ca₃(AsO₄)₂) is used in insecticides.
• Calcium carbide (CaC₂) is used to make acetylene gas (for use in acetylene torches for welding) and in the manufacturing of plastics.
• Calcium chloride (CaCl₂) is used in ice removal and dust control on dirt roads, in conditioner for concrete, as an additive in canned tomatoes, and to provide body for automobile tires.
• Calcium cyclamate (Ca(C₆H₁₁NHSO₃)₂) was used as a sweetening agent but is no longer permitted for use because of suspected cancer-causing properties.
• Calcium gluconate (Ca(C₆H₁₁O₇)₂) is used as a food additive and in vitamin pills.
• Calcium hypochlorite (Ca(OCl)₂) is used as a swimming pool disinfectant, as a bleaching agent, as an ingredient in deodorant, and in algaecide and fungicide.
• Calcium permanganate (Ca(MnO₄)₂) is used in liquid rocket propellant, textile production, as a water sterilizing agent and in dental procedures.
• Calcium phosphate (Ca₃(PO₄)₂) is used as a supplement for animal feed, fertilizer, in commercial production for dough and yeast products, in the manufacture of glass, and in dental products.
• Calcium phosphide (Ca₃P₂) is used in fireworks, rodenticide, torpedoes and flares.
• Calcium stearate (Ca(C₁₈H₃₅O₂)₂) is used in the manufacture of wax crayons, cements, certain kinds of plastics and cosmetics, as a food additive, in the production of water resistant materials and in the production of paints.
• Calcium sulfate (CaSO₄·2H₂O) is used as common blackboard chalk, as well as, in its hemihydrate form better known as Plaster of Paris.
• Calcium tungstate (CaWO₄) is used in luminous paints, fluorescent lights and in X-ray studies.
• Hydroxylapatite (Ca₅(PO₄)₃(OH), but is usually written Ca₁₀(PO₄)₆(OH)₂) makes up seventy percent of bone. Also carbonated-calcium deficient hydroxylapatite is the main mineral of which dental enamel and dentin are comprised.

Nutrition[link]

Calcium is an important component of a healthy diet and a mineral necessary for life. The National Osteoporosis Foundation says, "Calcium plays an important role in building stronger, denser bones early in life and keeping bones strong and healthy later in life." Approximately 99 percent of the body's calcium is stored in the bones and teeth.^[23] The rest of the calcium in the body has other important uses, such as some exocytosis, especially neurotransmitter release, and muscle contraction. In the electrical conduction system of the heart, calcium replaces sodium as the mineral that depolarizes the cell, proliferating the action potential. In cardiac muscle, sodium influx commences an action potential, but during potassium efflux, the cardiac myocyte experiences calcium influx, prolonging the action potential and creating a plateau phase of dynamic equilibrium. Long-term calcium deficiency can lead to rickets and poor blood clotting and in case of a menopausal woman, it can lead to osteoporosis, in which the bone deteriorates and there is an increased risk of fractures. While a lifelong deficit can affect bone and tooth formation, over-retention can cause hypercalcemia (elevated levels of calcium in the blood), impaired kidney function and decreased absorption of other minerals.^[24][25] Several sources suggest a correlation between high calcium intake (2000 mg per day, or twice the U.S. recommended daily allowance, equivalent to six or more glasses of milk per day) and prostate cancer.^[26] High calcium intakes or high calcium absorption were previously thought to contribute to the development of kidney stones. However, a high calcium intake has been associated with a lower risk for kidney stones in more recent research.^[27][28][29] Vitamin D is needed to absorb calcium.

Dairy products, such as milk and cheese, are a well-known source of calcium. Some individuals are allergic to dairy products and even more people, in particular those of non Indo-European descent, are lactose-intolerant, leaving them unable to consume non-fermented dairy products in quantities larger than about half a liter per serving. Others, such as vegans, avoid dairy products for ethical and health reasons.

Many good sources of calcium exist, including seaweeds such as kelp, wakame and hijiki; nuts and seeds like almonds, hazelnuts, sesame, pistachio; blackstrap molasses; beans; figs; quinoa; okra; rutabaga; broccoli; dandelion leaves; kale; and fortified products such as orange juice and soy milk.

Numerous vegetables, notably spinach, chard and rhubarb have a high calcium content, but they may also contain varying amounts of oxalic acid that binds calcium and reduces its absorption. The same problem may to a degree affect the absorption of calcium from amaranth, collard greens, chicory greens. This process may also be related to the generation of calcium oxalate.

An overlooked source of calcium is eggshell, which can be ground into a powder and mixed into food or a glass of water.^[30][31][32]

The calcium content of most foods can be found in the USDA National Nutrient Database.^[33]

Dietary calcium supplements[link]

500 milligram calcium supplements made from calcium carbonate

Calcium supplements are used to prevent and to treat calcium deficiencies. Most experts recommend that supplements be taken with food and that no more than 600 mg should be taken at a time because the percent of calcium absorbed decreases as the amount of calcium in the supplement increases.^[21] It is recommended to spread doses throughout the day. Recommended daily calcium intake for adults ranges from 1000 to 1500 mg. It is recommended to take supplements with food to aid in absorption.

Vitamin D is added to some calcium supplements. Proper vitamin D status is important because vitamin D is converted to a hormone in the body, which then induces the synthesis of intestinal proteins responsible for calcium absorption.^[34]

• The absorption of calcium from most food and commonly used dietary supplements is very similar.^[35] This is contrary to what many calcium supplement manufacturers claim in their promotional materials.
• Milk is an excellent source of dietary calcium for those whose bodies tolerate it because it has a high concentration of calcium and the calcium in milk is excellently absorbed.^[35]
• Soymilk and other vegetable milks are usually sold with calcium added so that their calcium concentration is as high as in milk
• Also different kind of juices boosted with calcium are widely available.
• Calcium carbonate is the most common and least expensive calcium supplement. It should be taken with food. It depends on low pH levels for proper absorption in the intestine.^[36] Some studies suggests that the absorption of calcium from calcium carbonate is similar to the absorption of calcium from milk.^[37][38] While most people digest calcium carbonate very well, some might develop gastrointestinal discomfort or gas. Taking magnesium with it can help to avoid constipation. Calcium carbonate is 40% elemental calcium. 1000 mg will provide 400 mg of calcium. However, supplement labels will usually indicate how much calcium is present in each serving, not how much calcium carbonate is present.
• Antacids frequently contain calcium carbonate, and are a commonly used, inexpensive calcium supplement
• Coral calcium is a salt of calcium derived from fossilized coral reefs. Coral calcium is composed of calcium carbonate and trace minerals.
• Calcium citrate can be taken without food and is the supplement of choice for individuals with achlorhydria or who are taking histamine-2 blockers or proton-pump inhibitors.^[39]Calcium citrate is about 21% elemental calcium. 1000 mg will provide 210 mg of calcium. It is more expensive than calcium carbonate and more of it must be taken to get the same amount of calcium.
• Calcium phosphate costs more than calcium carbonate, but less than calcium citrate. Microcrystalline hydroxyapatite (MH) is one of several forms of calcium phosphate used as a dietary supplement. Hydroxyapatite is about 40% calcium.
• Calcium lactate has similar absorption as calcium carbonate,^[40] but is more expensive. Calcium lactate and calcium gluconate are less concentrated forms of calcium and are not practical oral supplements.^[39]
• Calcium chelates are synthetic calcium compounds, with calcium bound to an organic molecule, such as malate, aspartate, or fumarate. These forms of calcium may be better absorbed on an empty stomach. However, in general they are absorbed similarly to calcium carbonate and other common calcium supplements when taken with food.^[41] The 'chelate' mimics the action that natural food performs by keeping the calcium soluble in the intestine. Thus, on an empty stomach, in some individuals, chelates might, in theory, be absorbed better.

In July 2006, a report citing research from Fred Hutchinson Cancer Research Center in Seattle, Washington claimed that women in their 50s gained 5 pounds (2.3 kg) less in a period of 10 years by taking more than 500 mg of calcium supplements than those who did not. However, the doctor in charge of the study, Dr. Alejandro J. Gonzalez also noted it would be "going out on a limb" to suggest calcium supplements as a weight-limiting aid.^[42]

Prevention of fractures due to osteoporosis[link]

Such studies often do not test calcium alone, but rather combinations of calcium and vitamin D. Randomized controlled trials found both positive^[43][44] and negative^{[45][46][47][48]} effects. The different results may be explained by doses of calcium and underlying rates of calcium supplementation in the control groups.^[49] However, it is clear that increasing the intake of calcium promotes deposition of calcium in the bones, where it is of more benefit in preventing the compression fractures resulting from the osteoporotic thinning of the dendritic web of the bodies of the vertebrae, than it is at preventing the more serious cortical bone fractures that happen at hip and wrist.^{[citation needed]}

Possible cancer prevention[link]

A meta-analysis^[44] by the international Cochrane Collaboration of two randomized controlled trials^[50][51] found that calcium "might contribute to a moderate degree to the prevention of adenomatous colonic polyps".

More recent studies were conflicting, and one that was positive for effect (Lappe, et al.) did control for a possible anti-carcinogenic effect of vitamin D, which was found to be an independent positive influence from calcium-alone on cancer risk (see second study below).^[52]

• A randomized controlled trial found that 1000 mg of elemental calcium and 400 IU of vitamin D₃ had no effect on colorectal cancer^[53]
• A randomized controlled trial found that 1400–1500 mg supplemental calcium and 1100 IU vitamin D₃ reduced aggregated cancers with a relative risk of 0.402.^[54]
• An observational cohort study found that high calcium and vitamin D intake was associated with "lower risk of developing premenopausal breast cancer."^[55]

Hazards and toxicity[link]

Compared with other metals, the calcium ion and most calcium compounds have low toxicity. This is not surprising given the very high natural abundance of calcium compounds in the environment and in organisms. Calcium poses few serious environmental problems, with kidney stones the most common side-effect in clinical studies. Acute calcium poisoning is rare, and difficult to achieve unless calcium compounds are administered intravenously. For example, the oral median lethal dose (LD⁵⁰) for rats for calcium carbonate and calcium chloride are 6.45 ^[56] and 1.4 g/kg,^[57] respectively.

Calcium metal is hazardous because of its sometimes-violent reactions with water and acids. Calcium metal is found in some drain cleaners, where it functions to generate heat and calcium hydroxide that saponifies the fats and liquefies the proteins (e.g., hair) that block drains. When swallowed calcium metal has the same effect on the mouth, esophagus and stomach, and can be fatal.^[58]

Excessive consumption of calcium carbonate antacids/dietary supplements (such as Tums) over a period of weeks or months can cause milk-alkali syndrome, with symptoms ranging from hypercalcemia to potentially fatal renal failure. What constitutes “excessive” consumption is not well known and, it is presumed, varies a great deal from person to person. Persons consuming more than 10 grams/day of CaCO₃ (=4 g Ca) are at risk of developing milk-alkali syndrome,^[59] but the condition has been reported in at least one person consuming only 2.5 grams/day of CaCO₃ (=1 g Ca), an amount usually considered moderate and safe.^[60]

Oral calcium supplements diminish the absorption of thyroxine when taken within four to six hours of each other.^[61] Thus, people taking both calcium and thyroxine run the risk of inadequate thyroid hormone replacement and thence hypothyroidism if they take them simultaneously or near-simultaneously.

See also[link]

Books View or order collections of articles	Calcium Period 4 elements Alkaline earth metals Chemical elements (sorted alphabetically) Chemical elements (sorted by number)
Portals Access related topics	Chemistry portal
Find out more on Wikipedia's Sister projects	Images and media from Commons Definitions from Wiktionary Textbooks from Wikibooks Learning resources from Wikiversity

References[link]

Further reading[link]

• Rebecca J. Donatelle. Health, The Basics. 6th ed. San Francisco: Pearson Education, Inc. 2005.

External links[link]

• WebElements.com — Calcium
• USDA National Nutrient Database, Calcium content of selected foods
• UK Food Standards Agency: Calcium
• Nutrition fact sheet from the National Institutes of Health