Angoche is a city of Nampula Province in Mozambique. The city was named António Enes until 1976, after the 19th century Portuguese journalist and colonial administrator, António José Enes. In administrative terms, since 1998, the city is also a municipality.

Angoche is an old Muslim trading centre, which local tradition states was founded in the 1490s by refugees from the Kilwa Sultanate. Xosa, the son of one of the leaders of the refugees, was made the first sultan. One of the earliest settlements in Mozambique and an important gold and ivory trading post, it posed a serious rival to the Portuguese settlement in Mozambigue until the mid-16th century, when Angoche was eclipsed by Quelimane as an entry port to the interior. However, Angoche continued to play a role in coastal trade and was an important economic and political centre in the region, with close ties to Ilha de Moçambique. In the 19th century, Angoche became the focus of the clandestine slave trade, which continued until the 1860s when the town was attacked by the Portuguese. While effective Portuguese administration was not established until several decades later, the attack marked the beginning of Angoche's downfall, and the town never regained its former status.