Nord-du-Québec (French pronunciation: [nɔʁ dy kebɛk]; English: Northern Quebec) is the largest of the seventeen administrative regions of Quebec, Canada. With nearly 750,000 square kilometres (290,000 sq mi) of land area, and very extensive lakes and rivers, it covers much of the Labrador Peninsula and about 55% of the total land surface area of Quebec.

Before 1912, the northernmost part of this region was known as the Ungava District of the Northwest Territories, and until 1987 it was referred to as Nouveau-Québec, or New Quebec. It is bordered by Hudson Bay and James Bay in the west, Hudson Strait and Ungava Bay in the north, Labrador in the northeast, and the administrative regions of Abitibi-Témiscamingue, Mauricie, Saguenay–Lac-Saint-Jean, and Côte-Nord in the south and southeast.

The Nord-du-Québec region is part of the territory covered by the James Bay and Northern Quebec Agreement of 1975; other regions covered (in part) by this Agreement include Côte-Nord, Mauricie and Abitibi-Témiscamingue administrative regions.