A-412,997 is a drug which acts as a dopamine agonist that is used in scientific research. It is the first drug developed that is a highly selective agonist for the D₄ subtype, with significantly improved selectivity over older D₄-preferring compounds such as PD-168,077 and CP-226,269. In animal tests it improved cognitive performance in rats to a similar extent as methylphenidate, but without producing place preference or other signs of abuse liability. Also unlike other dopamine agonists, selective D₄ agonists do not cause side effects such as sedation and nausea, and so might have advantages over older dopamine agonist drugs.

William Martin "Billy" Joel (born May 9, 1949) is an American pianist, singer-songwriter, and composer. Since releasing his first hit song, "Piano Man," in 1973, Joel has become the sixth best-selling recording artist and the third best-selling solo artist in the United States, according to the RIAA.

Joel had Top 40 hits in the 1970s, 1980s, and 1990s, achieving 33 Top 40 hits in the United States, all of which he wrote himself. He is also a six-time Grammy Award winner, a 23-time Grammy nominee and has sold over 150 million records worldwide. He was inducted into the Songwriter's Hall of Fame (1992), the Rock and Roll Hall of Fame (1999), the Long Island Music Hall of Fame (2006), and the Hit Parade Hall of Fame (2009). In 2008, Billboard magazine released a list of the Hot 100 All-Time Top Artists to celebrate the US singles chart's 50th anniversary, with Billy Joel positioned at No. 23. With the exception of the 2007 songs "All My Life" and "Christmas in Fallujah," Joel stopped recording pop/rock material after 1993's River of Dreams, but he continued to tour extensively until 2010.

Ashley Fuller Olsen (born June 13, 1986) is an American actress, fashion designer, producer, author, and businesswoman.

Olsen and her fraternal twin sister Mary-Kate Olsen were born in Sherman Oaks, California to David Olsen (born 1953) and Jarnette "Jarnie" Fuller (born 1954). Despite being very similar in appearance, they are not identical. They have an older brother, Trent, a little sister, Elizabeth Olsen, and two younger half siblings Taylor and Jake from their father's second marriage. Mary-Kate and Ashley's parents divorced in 1995.

Along with Mary-Kate, Olsen was cast at the age of nine months to share the role of Michelle Tanner on the ABC sitcom Full House. The Olsens portrayed Michelle throughout the series' 1987–1995 run. In the early 1990s, the sisters established a company, Dualstar, which produced a long string of TV movies and direct-to-video releases featuring the girls. The Olsens continued to release direct-to-video films up to the early 2000s, along with starring in the 1995 feature film It Takes Two. After Full House, the sisters starred in two other sitcoms (Two of a Kind and So Little Time) and an animated series (Mary-Kate and Ashley in Action!), each of which lasted only one season. These ventures, combined with a massive array of licensing deals for their names and likenesses, made the twins phenomenally wealthy at a young age. They became co-presidents of Dualstar upon their eighteenth birthday. Following a second feature film, 2004's New York Minute, Ashley gave up acting because she didn't feel a connection to being an actress anymore. In 2009 when asked about acting again Ashley said, "Never say never." Ashley contemplated giving up fashion and going back to acting in 2009. Ashley changed her mind in 2012 as she and Mary-Kate decided to retire from acting to focus on fashion. In 2007 Mary-Kate and Ashley expressed an interest in producing movies together.