Look up IPS in Wiktionary, the free dictionary.

IPS or ips may refer to:

Computing[link]

• Image Packaging System, OpenSolaris software
• In-Plane Switching, an LCD display technology
• Instructions per second, a measure of a computer's processor speed
• Internet Provider Security
• Interpreter for Process Structures, used in AMSAT satellites
• Intrusion prevention system, a network security appliance
• .IPS, the International Patching System file extension

Entertainment[link]

• In Plain Sight

Medicine[link]

• IPS Supported Employment, an approach to vocational rehabilitation in psychiatry
• Induced pluripotent stem cell
• Intermittent photic stimulation, a neuroimaging technique
• Intraparietal sulcus, a region of the brain

Organizations[link]

International[link]

• Industrial and provident society, in the United Kingdom, the Republic of Ireland, and New Zealand
• Industrial Promotion Services, the industrial development arm of the Aga Khan Fund for Economic Development
• Institute of Professional Sound
• Inter Press Service, a global news agency
• International Parliamentary Scholarship
• International Planetarium Society
• International Primatological Society
• International Professional Surfers
• International Pyrotechnics Society

India[link]

• Indian Police Service

Iraq[link]

• Iraqi Police Service

Israel[link]

• Israel Prison Service

Japan[link]

• Insectivorous Plant Society

Lebanon[link]

• Institute for Palestine Studies

United Kingdom[link]

• Identity and Passport Service
• Institute of Professional Sound

United States[link]

• Ford Dorsey Program in International Policy Studies
• Indianapolis Public Schools
• Inner Perimeter Security, a specialized team of the Massachusetts Department of Correction
• Institute for Policy Studies
• Invision Power Services

Science and technology[link]

• IPS panel (in-plane switching), a type of liquid crystal display
• IPS/UPS, an electric power transmission grid of the Commonwealth of Independent States
• Indoor positioning system, a network of devices used to wirelessly locate objects or people
• Interplanetary Superhighway
• Introductory Physical Science, an American high school science education class
• Institute of Professional Sound

Other uses[link]

• Ips (beetle), a genus of bark beetle
• Inch per second
• Investment Policy Statement
• Iron pipe size
• International Parcel Service, a fictional company (based loosely on UPS) in the TV sitcom The King of Queens

This disambiguation page lists articles associated with the same title. If an internal link led you here, you may wish to change the link to point directly to the intended article.

Shinya Yamanaka
Born	(1962-09-04) September 4, 1962 (age 49) Higashiōsaka, Osaka, Japan
Nationality	Japanese
Fields	stem cell research[1][2][3]
Institutions	Kyoto University, Gladstone Institute of Cardiovascular Disease
Alma mater	Kobe University Osaka City University Gladstone Institute of Cardiovascular Disease
Known for	Induced Pluripotent Stem Cell
Notable awards	Robert Koch Prize (2008) Shaw Prize (2008) Gairdner Foundation International Award (2009) Albert Lasker Basic Medical Research Award (2009) BBVA Foundation Frontiers of Knowledge Award (2010) Wolf Prize (2011) Fellow of the National Academy of Sciences[4] (2012)

Shinya Yamanaka (山中 伸弥, Yamanaka Shin'ya^?, born September 4, 1962 in Higashiōsaka) is a Japanese physician and adult stem cell researcher.^[1][2][3] He serves as the director of Center for iPS Cell Research and Application and a professor at the Institute for Frontier Medical Sciences at Kyoto University, as a senior investigator at the UCSF-affiliated J. David Gladstone Institutes in San Francisco, California, and as a professor of anatomy at University of California, San Francisco (UCSF). He was recently awarded the Wolf Prize in Medicine. Yamanaka has been listed as one of the 15 Asian Scientists To Watch by Asian Scientist Magazine on 15 May 2011.^[5][6]

Biography[link]

He received his M.D. at Kobe University in 1987 and his Ph.D. at Osaka City University Graduate School in 1993. After this he went through a residency in orthopedic surgery at National Osaka Hospital and a postdoctoral fellowship at the Gladstone Institute of Cardiovascular Disease, San Francisco.

Professional career[link]

From 1987-1989, Yamanaka was a Resident in orthopedic surgery at the National Osaka Hospital. From 1993-1995, he was a Postdoctoral Fellow at the Gladstone Institute of Cardiovascular Disease, which is affiliated with the University of California, San Francisco. From 1995-1996, he was a staff research investigator at the UCSF-affililated Gladstone Institute of Cardiovascular Disease. From 1996-1999, he was an assistant professor at Osaka City University Medical School. From 1999-2003, he was an associate professor at the Nara Institute of Science and Technology. From 2003-2005, he was a professor at the Nara Institute of Science and Technology. From 2004–2010, Shinya Yamanaka was a professor at the Institute for Frontier Medical Sciences.^[7] Currently Yamanaka is the director and a professor at the Center for iPS Cell Research and Application in Kyoto university, Japan.

In 2006, he and his team generated Induced Pluripotent Stem Cells - pluripotent stem cells from adult mouse fibroblasts. In 2007, he and his team were able to generate Induced Pluripotent Stem Cells from human adult fibroblasts. ^[1][2][3]

Recognitions[link]

In 2007, Shinya Yamanaka was recognized as a "Person Who Mattered" in the Time Person of the Year edition of Time Magazine.^[8] Shinya Yamanaka was also nominated as a 2008 Time 100 Finalist.^[9] In June 2010, Yamanaka was awarded the Kyoto Prize for reprogramming adult skin cells to pluripotential precursors. Yamanaka developed the method as an alternative to embryonic stem cells, thus circumventing an approach in which embryos would be destroyed.^[10] In September 2010 he was awarded the Balzan Prize for his work on biology and stem cells.^[11]

Awards[link]

• 2007 Osaka Science Prize
• 2007 Inoue Prize for Science
• 2007 Asahi Prize
• 2007 Meyenburg Cancer Research Award ^[12][13]
• 2008 Yamazaki-Teiichi Prize in Biological Science & Technology
• 2008 Robert Koch Prize
• 2008 Medals of Honor (Japan) (Medal with Purple Ribbon)
• 2008 Shaw Prize in Life Science & Medicine^[14][15][16]
• 2008 Sankyo Takamine Memorial Award^[17]
• 2009 Lewis S. Rosenstiel Award for Distinguished Work in Basic Medical Research^[18]
• 2009 Gairdner Foundation International Award^[19]
• 2009 Albert Lasker Award for Basic Medical Research
• 2010 March of Dimes Prize in Developmental Biology
• 2010 Kyoto Prize in Biotechnology and medical technology
• 2010 Balzan Prize in biology
• 2010 Person of Cultural Merit
• 2010 BBVA Foundation Frontiers of Knowledge Award in the Biomedicine Category^[20]
• 2011 Albany Medical Center Prize in biomedicine
• 2011 Wolf Prize in medicine
• 2011 King Faisal International Prize
• 2012 Millennium Technology Prize
• 2012 Fellow of the National Academy of Sciences^[4]

References[link]

External links[link]

• The Shinya Yamanaka Lab, CiRA, Kyoto University
• Center for iPS Cell Research and Application, Kyoto University
• Shinya Yamanaka on Charlie Rose
• Fackler, Martin (2007-12-11). "Risk Taking Is in His Genes". The New York Times. http://www.nytimes.com/2007/12/11/science/11prof.html?pagewanted=all. Retrieved 2007-12-11. 
• The Discovery and Future of Induced Pluripotent Stem (iPS)

Sir Ian Wilmut, OBE FRS FMedSci FRSE^[3] (born 7 July 1944) is an English embryologist and is currently Director of the Medical Research Council Centre for Regenerative Medicine at the University of Edinburgh^[4]. He is best known as the leader of the research group that in 1996 first cloned a mammal from an adult somatic cell, a Finnish Dorset lamb named Dolly.^[5][6][7][8] He was granted an OBE in 1999 for services to embryo development.^[9] In December 2007 it was announced that he would be knighted in the 2008 New Year Honours.^[10]

Early life and career[link]

Wilmut was born in Hampton Lucy, Warwickshire, England.^[11] Wilmut's father, Leonard Wilmut, was a mathematics teacher who suffered from diabetes for fifty years eventually causing blindness.^[12] He was a student of the former Boys' High School, in Scarborough, where his father taught.^[13] Wilmut's early desire was to embark on a naval career, but he was unable to do so due to his colour blindness.^[14] As a school boy, Wilmut worked as a farm hand on weekends, which inspired him to study Agriculture at the University of Nottingham.^[13][15]

In 1966 Wilmut spent 8 weeks working in the laboratory of Christopher Polge, who is credited with developing the technique of cryopreservation in 1949.^[16] The following year, Wilmut joined Polge's laboratory to undertake a research PhD, from which he graduated in 1971. Wilmut has since been involved in research focusing on gametes and embryogenesis including working at the Roslin Institute.^[13] In 1998 he received the Lord Lloyd of Kilgerran Award.

Wilmut was the leader of the research group that in 1996 first cloned a mammal, a lamb named Dolly.^[7][8] Dolly died of a respiratory disease in 2003. However, in 2008 Wilmut announced that he is to abandon the technique of somatic cell nuclear transfer^[17] by which Dolly was created in favour of an alternative technique developed by Shinya Yamanaka. This method has been used in mice to derive pluripotent stem cells from differentiated adult skin cells, thus circumventing the need to generate embryonic stem cells. Wilmut believes that this method holds greater potential for the treatment of degenerative conditions such as Parkinson's disease and to treat stroke and heart attack patients.^[18]

Wilmut has been accused of accepting disproportionate credit for his contribution to the development of Dolly. Former employees of the Roslin Institute claim that Wilmut is “self-confessed charlatan” who “apparently lacks adequate scientific understanding”.^[19] These employees, who were not directly involved in the creation of Dolly, have signed a petition for the Queen to withdraw Wilmut's knighthood.^[20] Indeed, Wilmut admits to having played only a supervisory role in the creation of Dolly, crediting his colleague Keith Campbell with "66 per cent" of the work.^[21] This supervisory role however is consistent with the post of principal investigator held by Wilmut at the time of Dolly's creation.

Wilmut currently holds the post of Chair of Reproductive Biology at the Medical Research Council Centre for Regenerative Medicine in Edinburgh and in 2008 was knighted in the New Year Honours for "services to science".^[14]

References[link]

Wikiquote has a collection of quotations related to: Ian Wilmut

Prophet Muhammad Prophet, Messenger, Apostle, Witness, Bearer of Good Tidings, Warner, Reminder, Caller, Announcer.
Common calligraphic representation of Muhammad's name
Born	Muḥammad ibn `Abd Allāh c. (570-04-26)26 April 570 Mecca (Makkah), Arabia (now Saudi Arabia)
Died	8 June 632(632-06-08) (aged 62) Yathrib, Arabia (present-day Medina, Hejaz, Saudi Arabia)
Cause of death	Illness (high fever)
Resting place	Tomb under the Green Dome of Al-Masjid al-Nabawi in Medina, Hejaz, Saudi Arabia
Other names	See Names of Muhammad
Ethnicity	Arab
Religion	Islam
Spouse	Wives: Khadijah bint Khuwaylid (595-619) Sawda bint Zamʿa (619-632) Aisha bint Abi Bakr (619-632) Hafsa bint Umar (624-632) Zaynab bint Khuzayma (625-627) Hind bint Abi Umayya (629-632) Zaynab bint Jahsh (627-632) Juwayriya bint al-Harith (628-632) Ramlah bint Abi Sufyan (628-632) Rayhana bint Zayd (629-631) Safiyya bint Huyayy (629-632) Maymuna bint al-Harith (630-632) Maria al-Qibtiyya (630-632)
Children	Sons: al-Qasim, `Abd-Allah, Ibrahim Daughters: Zainab, Ruqayyah, Umm Kulthoom, Fatimah Zahra
Parents	Father: `Abd Allah ibn `Abd al-Muttalib Mother: Aminah bint Wahb
Relatives	Ahl al-Bayt
Further articles from Category:Muhammad Life In Mecca · Hijra · In Medina · Conquest of Mecca · Wives · Family tree Career Qur'an · Hadith · Early reforms under Islam · Diplomacy · Military · Persecution by Meccans · Migration to Abyssinia · Farewell pilgrimage Miracles Isra and Mi'raj · Relics · Splitting of the moon · Al-Masjid al-Nabawi Views by subject Jewish · Christian · Slavery Succession Farewell sermon · Saqifah · Pen and paper · Family · Companions · History Praise Durood · Na'at · Mawlid · Haḍra · Madih nabawi · Ya Muhammad Perspectives Islamic · Jewish · Bible · Medieval Christian · Historicity · Criticism · Prophetic biography · Depictions · Films · Depictions in film v t e

Muhammad (c. 26 April 570 – 8 June 632;^[1] also transliterated as Mohammad, Mohammed, or Muhammed; Arabic: محمد‎), full name: Muhammad Ibn `Abd Allāh Ibn `Abd al-Muttalib (Arabic: محمد بن عبدالله بن عبد المطلب ‎) was a leader from Mecca who unified the tribes of Arabia into a single religious polity under Islam. He is believed by Muslims and Bahá'ís to be a messenger and prophet of God. Muslims believe that Islam was not his own invention but was revealed by God,^[2][3] and most consider him to be the last prophet of God^{[4][n 1]} Muslims thus consider him the restorer of an uncorrupted original monotheistic faith (islām) of Adam, Noah, Abraham, Moses, Jesus and other prophets.^[5][6][7]

Born in 570 CE in the Arabian city of Mecca,^[8][9] he was orphaned at an early age and brought up under the care of his uncle Abu Talib. He later worked mostly as a merchant, as well as a shepherd, and was first married by age 25.^[10] Being in the habit of periodically retreating to a cave in the surrounding mountains for several nights of meditation and prayer, he later reported that it was there, at age 40,^[8][11] that he received his first revelation from God. Three years after this event Muhammad started preaching these revelations publicly, proclaiming that "God is One", that complete "surrender" to Him (lit. islām) is the only way (dīn)^{[n 2]} acceptable to God, and that he himself was a prophet and messenger of God, in the same vein as other Islamic prophets.^[7][12][13]

Muhammad gained few followers early on,^[14] and was met with hostility from some Meccan tribes; he and his followers were treated harshly. To escape persecution, Muhammad sent some of his followers to Abyssinia^[15] before he and his remaining followers in Mecca migrated to Medina (then known as Yathrib) in the year 622.^[16] This event, the Hijra, marks the beginning of the Islamic calendar, which is also known as the Hijri Calendar. In Medina, Muhammad united the tribes under the Constitution of Medina,.^[16] After eight years of fighting with the Meccan tribes, his followers, who by then had grown to 10,000, conquered Mecca. Muhammad destroyed the symbols of paganism in Mecca^[17] and then sent his followers out to destroy all of the remaining pagan temples throughout Eastern Arabia.^[18][19]

In 632, a few months after returning to Medina from The Farewell Pilgrimage, Muhammad fell ill and died. By the time of his death, most of the Arabian Peninsula had converted to Islam, and he had united the tribes of Arabia into a single Muslim religious polity.^[20][21]

The revelations (or Ayah, lit. "Signs [of God]")—which Muhammad reported receiving until his death—form the verses of the Quran, regarded by Muslims as the “Word of God” and around which the religion is based. Besides the Quran, Muhammad’s life (sira) and traditions (sunnah) are also upheld by Muslims. They discuss Muhammad and other prophets of Islam with reverence, adding the phrase peace be upon him whenever their names are mentioned.^[22] While conceptions of Muhammad in medieval Christendom and premodern times were largely negative, appraisals in modern history have been far less so.^[13][23]

Names and appellations in the Quran[link]

The name Muhammad written in Thuluth, a script variety of Islamic calligraphy.

The name Muhammad means "Praiseworthy" and occurs four times in the Quran.^[24] The Quran addresses Muhammad in the second person not by his name but by the appellations prophet, messenger, servant of God ('abd), announcer (bashir)^{[Quran 2:119]}, witness (shahid),^{[Quran 33:45]} bearer of good tidings (mubashshir), warner (nathir),^{[Quran 11:2]} reminder (mudhakkir),^{[Quran 88:21]} one who calls [unto God] (dā‘ī),^{[Quran 12:108]} light personified (noor)^{[Quran 05:15]}, and the light-giving lamp (siraj munir)^{[Quran 73:1]}. Muhammad is sometimes addressed by designations deriving from his state at the time of the address: thus he is referred to as the enwrapped (al-muzzammil) in Quran 73:1 and the shrouded (al-muddaththir) in Quran 74:1.^[25] In the Quran, believers are not to distinguish between the messengers of God and are to believe in all of them (Sura Al-Baqara 2:285). God has caused some messengers to excel above others 2:253 and in Sura Al-Ahzab 33:40 He singles out Muhammad as the "Seal of the Prophets".^[26] The Quran also refers to Muhammad as Aḥmad "more praiseworthy" (Arabic: أحمد‎, Sura As-Saff 61:6).

Sources for Muhammad's life[link]

Quran[link]

A folio from an early Quran, written in Kufic script (Abbasid period, 8th–9th century).

The Quran is the central religious text of Islam and Muslims believe that it represents the words of God revealed to Muhammad through the archangel Gabriel.^[27][28][29] Although it mentions Muhammad directly only four times,^[30] there are verses which can be interpreted as allusions to Muhammad's life.^{[13][n 3]} The Quran however provides little assistance for a chronological biography of Muhammad, and many of the utterances recorded in it lack historical context.^[31][32]

Early biographies[link]

Next in importance are historical works by writers of the 3rd and 4th centuries of the Muslim era.^[33] These include the traditional Muslim biographies of Muhammad (the sira literature), which provide further information on Muhammad's life.^[34]

The earliest surviving written sira (biographies of Muhammad and quotes attributed to him) is Ibn Ishaq's Life of God's Messenger written ca. 767 (150 AH). The work is lost, but was used verbatim at great length by Ibn Hisham and Al-Tabari.^[35][36] Another early source is the history of Muhammad's campaigns by al-Waqidi (death 207 of Muslim era), and the work of his secretary Ibn Sa'd al-Baghdadi (death 230 of Muslim era).^[33]

Many scholars accept the accuracy of the earliest biographies, though their accuracy is unascertainable.^[35] Recent studies have led scholars to distinguish between the traditions touching legal matters and the purely historical ones. In the former sphere, traditions could have been subject to invention while in the latter sphere, aside from exceptional cases, the material may have been only subject to "tendential shaping".^[37]

Hadith[link]

In addition, the hadith collections are accounts of the verbal and physical traditions of Muhammad that date from several generations after his death.^[38]

Western academics view the hadith collections with caution as accurate historical sources.^[38] Scholars such as Madelung do not reject the narrations which have been compiled in later periods, but judge them in the context of history and on the basis of their compatibility with the events and figures.^[39]

Non-Arabic sources[link]

The earliest documented Christian knowledge of Muhammad stems from Byzantine sources. They indicate that both Jews and Christians saw Muhammad as a "false prophet". In the Doctrina Jacobi nuper baptizati of 634, Muhammad is portrayed as being "deceiving[,] for do prophets come with sword and chariot?, [...] you will discover nothing true from the said prophet except human bloodshed."^[40] Another Greek source for Muhammad is the 9th-century writer Theophanes. The earliest Syriac source is the 7th-century writer John bar Penkaye.^[41]

Pre-Islamic Arabia[link]

Main tribes and settlements of Arabia in Muhammad's lifetime

The Arabian Peninsula was largely arid and volcanic, making agriculture difficult except near oases or springs. The landscape was thus dotted with towns and cities, two prominent ones being Mecca and Medina. Medina was a large flourishing agricultural settlement, while Mecca was an important financial center for many surrounding tribes.^[42] Communal life was essential for survival in the desert conditions, as people needed support against the harsh environment and lifestyle. Tribal grouping was encouraged by the need to act as a unit, this unity being based on the bond of kinship by blood.^[43] Indigenous Arabs were either nomadic or sedentary, the former constantly travelling from one place to another seeking water and pasture for their flocks, while the latter settled and focused on trade and agriculture. Nomadic survival was also dependent on raiding caravans or oases, the nomads not viewing this as a crime.^[44][45]

In pre-Islamic Arabia, gods or goddesses were viewed as protectors of individual tribes, their spirits being associated with sacred trees, stones, springs and wells. As well as being the site of an annual pilgrimage, the Kaaba shrine in Mecca housed 360 idol statues of tribal patron deities. Aside from these gods, the Arabs shared a common belief in a supreme deity called Allah^{[citation needed]} (literally "the god"), who was remote from their everyday concerns and thus not the object of cult or ritual.^{[citation needed]} Three goddesses were associated with Allah as his daughters: Allāt, Manāt and al-‘Uzzá. Monotheistic communities existed in Arabia, including Christians and Jews.^[46] Hanifs – native pre-Islamic Arab monotheists – are also sometimes listed alongside Jews and Christians in pre-Islamic Arabia, although their historicity is disputed amongst scholars.^[47][48] According to Muslim tradition, Muhammad himself was a Hanif and one of the descendants of Ishmael, son of Abraham.^[49]

Life[link]

Life in Mecca[link]

Muhammad was born and lived in Mecca for the first 52 years of his life (570–622). This period is generally divided into two phases, before and after declaring the prophecy.

Childhood and early life[link]

Muhammad was born in the month of Rabi' al-awwal in 570. He belonged to the Banu Hashim clan, one of the prominent families of Mecca, although it seems not to have been prosperous during Muhammad's early lifetime.^[13][50] The Banu Hashim clan was part of the Quraysh tribe. Tradition places the year of Muhammad's birth as corresponding with the Year of the Elephant, which is named after the failed destruction of Mecca that year by the Aksumite king Abraha who had in his army a number of elephants. 20th-century scholarship has suggested alternative dates for this event, such as 568 or 569.^[51]

Miniature from Rashid-al-Din Hamadani's Jami al-Tawarikh, c. 1315, illustrating the story of Muhammad's role in re-setting the Black Stone in 605.^[52]

His father, Abdullah, died almost six months before Muhammad was born.^[53] According to Islamic tradition, soon after Muhammad's birth he was sent to live with a Bedouin family in the desert, as the desert life was considered healthier for infants. Muhammad stayed with his foster-mother, Halimah bint Abi Dhuayb, and her husband until he was two years old.^[10] Some western scholars of Islam have rejected the historicity of this tradition.^{[54][not in citation given]} At the age of six, Muhammad lost his biological mother Amina to illness and he became fully orphaned.^[10][55] For the next two years, he was under the guardianship of his paternal grandfather Abd al-Muttalib, of the Banu Hashim clan, but when Muhammad was eight, his grandfather also died. He then came under the care of his uncle Abu Talib, the new leader of Banu Hashim.^[10][51] According to William Montgomery Watt, because of the general disregard of the guardians in taking care of weak members of the tribes in Mecca in the 6th century, "Muhammad's guardians saw that he did not starve to death, but it was hard for them to do more for him, especially as the fortunes of the clan of Hashim seem to have been declining at that time."^[56]

While still in his teens, Muhammad accompanied his uncle on trading journeys to Syria gaining experience in commercial trade, the only career open to Muhammad as an orphan.^[10][56] Islamic tradition states that when Muhammad was either nine or twelve while accompanying the Meccans' caravan to Syria, he met a Christian monk or hermit named Bahira who is said to have foreseen Muhammed's career as a prophet of God.^[57]

Little is known of Muhammad during his later youth, and from the fragmentary information that is available, it is difficult to separate history from legend.^[10][56] It is known that he became a merchant and "was involved in trade between the Indian ocean and the Mediterranean Sea."^[58] Due to his upright character he acquired the nickname "al-Amin" (Arabic: الامين), meaning "faithful, trustworthy" and "al-Sadiq" meaning "truthful"^[59] and was sought out as an impartial arbitrator.^[9][13][60] His reputation attracted a proposal in 595 from Khadijah, a 40-year-old widow who was 15 years older than he. Muhammad consented to the marriage, which by all accounts was a happy one.^[10][58]

Several years later, according to a narration collected by Ibn Ishaq, Muhammad was involved with a well-known story about setting the Black Stone in place in the wall of the Kaaba in 605 C.E. The Black Stone, a sacred object, had been removed to facilitate renovations to the Kaaba. The leaders of Mecca could not agree on which clan should have the honour of setting the Black Stone back in its place. They agreed to wait for the next man to come through the gate and ask him to choose. That man was the 35-year-old Muhammad, five years before his first revelation. He asked for a cloth and put the Black Stone in its centre. The clan leaders held the corners of the cloth and together carried the Black Stone to the right spot, then Muhammad set the stone in place, satisfying the honour of all.^[61]

Beginnings of the Quran[link]

The cave Hira in the mountain Jabal al-Nour where, according to Muslim belief, Muhammad received his first revelation.

Muhammad adopted the practice of meditating alone for several weeks every year in a cave on Mount Hira near Mecca.^[62][63] Islamic tradition holds that during one of his visits to Mount Hira, the angel Gabriel appeared to him in the year 610 and commanded Muhammad to recite the following verses:^[64]

Proclaim! (or read!) in the name of thy Lord and Cherisher, Who created-
Created man, out of a (mere) clot of congealed blood:
Proclaim! And thy Lord is Most Bountiful,-
He Who taught (the use of) the pen,-
Taught man that which he knew not.

—Quran, sura 96 (Al-Alaq), ayat 1-5^[65]

After returning home, Muhammad was consoled and reassured by Khadijah and her Christian cousin, Waraqah ibn Nawfal. Upon receiving his first revelations, he was deeply distressed and resolved to commit suicide.^[45] He also feared that others would dismiss his claims as being possessed.^[45] Shi'a tradition maintains that Muhammad was neither surprised nor frightened at the appearance of Gabriel but rather welcomed him as if he had been expecting him.^[66] The initial revelation was followed by a pause of three years during which Muhammad further gave himself to prayers and spiritual practices. When the revelations resumed he was reassured and commanded to begin preaching: "Thy Guardian-Lord hath not forsaken thee, nor is He displeased."^[67][68][69]

A depiction of Muhammad receiving his first revelation from the angel Gabriel. From the manuscript Jami' al-tawarikh by Rashid-al-Din Hamadani, 1307, Ilkhanate period.

Sahih Bukhari narrates Muhammad describing the revelations as, "Sometimes it is (revealed) like the ringing of a bell" and Aisha reported, "I saw the Prophet being inspired Divinely on a very cold day and noticed the sweat dropping from his forehead (as the Inspiration was over)".^[70] According to Welch these revelations were accompanied by mysterious seizures, and the reports are unlikely to have been forged by later Muslims.^[13] Muhammad was confident that he could distinguish his own thoughts from these messages.^[71] According to the Quran, one of the main roles of Muhammad is to warn the unbelievers of their eschatological punishment (Quran 38:70, Quran 6:19). Sometimes the Quran does not explicitly refer to the Judgment day but provides examples from the history of some extinct communities and warns Muhammad's contemporaries of similar calamities (Quran 41:13–16).^[25] Muhammad is not only a warner to those who reject God's revelation, but also a bearer of good news for those who abandon evil, listen to the divine word and serve God.^[72] Muhammad's mission also involves preaching monotheism: The Quran commands Muhammad to proclaim and praise the name of his Lord and instructs him not to worship idols or associate other deities with God.^[15][25]

The key themes of the early Quranic verses included the responsibility of man towards his creator; the resurrection of dead, God's final judgment followed by vivid descriptions of the tortures in hell and pleasures in Paradise; and the signs of God in all aspects of life. Religious duties required of the believers at this time were few: belief in God, asking for forgiveness of sins, offering frequent prayers, assisting others particularly those in need, rejecting cheating and the love of wealth (considered to be significant in the commercial life of Mecca), being chaste and not to kill newborn girls.^[13]

Opposition[link]

According to Muslim tradition, Muhammad's wife Khadija was the first to believe he was a prophet.^[73] She was soon followed by Muhammad's ten-year-old cousin Ali ibn Abi Talib, close friend Abu Bakr, and adopted son Zaid.^[11][73] Around 613, Muhammad began his public preaching (Quran 26:214).^[74] Most Meccans ignored him and mocked him,^[15] while a few others became his followers. There were three main groups of early converts to Islam: younger brothers and sons of great merchants; people who had fallen out of the first rank in their tribe or failed to attain it; and the weak, mostly unprotected foreigners.^[75]

The last ayah from the sura An-Najm in the Quran: "So prostrate to Allah and worship [Him]." Muhammad's message of monotheism (one God) challenged the traditional order.

According to Ibn Sad, the opposition in Mecca started when Muhammad delivered verses that condemned idol worship and the Meccan forefathers who engaged in polytheism.^[15][76] However, the Quranic exegesis maintains that it began as soon as Muhammad started public preaching.^[77] As the number of followers increased, he became a threat to the local tribes and the rulers of the city, whose wealth rested upon the Kaaba, the focal point of Meccan religious life, which Muhammad threatened to overthrow. Muhammad’s denunciation of the Meccan traditional religion was especially offensive to his own tribe, the Quraysh, as they were the guardians of the Ka'aba.^[75] The powerful merchants tried to convince Muhammad to abandon his preaching by offering him admission into the inner circle of merchants, and establishing his position therein by an advantageous marriage. However, he refused.^[75]

Tradition records at great length the persecution and ill-treatment of Muhammad and his followers.^[13][15] Sumayyah bint Khabbab, a slave of a prominent Meccan leader Abu Jahl, is famous as the first martyr of Islam, having been killed with a spear by her master when she refused to give up her faith. Bilal, another Muslim slave, was tortured by Umayyah ibn Khalaf who placed a heavy rock on his chest to force his conversion.^[78][79] Apart from insults, Muhammad was protected from physical harm as he belonged to the Banu Hashim clan.^[15][80][81]

In 615, some of Muhammad's followers emigrated to the Ethiopian Aksumite Empire and founded a small colony there under the protection of the Christian Ethiopian emperor Aṣḥama ibn Abjar.^[13][15]

Muhammad desperately hoping for an accommodation with his tribe, either from fear or in the hope of succeeding more readily in this way, pronounced a verse acknowledging the existence of three Meccan goddesses considered to be the daughters of Allah, and appealing for their intercession. Muhammad later retracted the verses at the behest of Gabriel, claiming that the verses were whispered by the devil himself.^{[15][82][n 4]} This episode known as "The Story of the Cranes" (translation: قصة الغرانيق, transliteration: Qissat al Gharaneeq) is also known as "Satanic Verses". Some scholars argued against its historicity on various grounds.^[83] While this incident got widespread acceptance by early Muslims, strong objections to it were raised starting from the tenth century, on theological grounds. The objections continued to be raised to the point where the rejection of the historicity of the incident eventually became the only acceptable orthodox Muslim position.^[84]

In 617, the leaders of Makhzum and Banu Abd-Shams, two important Quraysh clans, declared a public boycott against Banu Hashim, their commercial rival, to pressure it into withdrawing its protection of Muhammad. The boycott lasted three years but eventually collapsed as it failed in its objective.^[85][86] During this, Muhammad was only able to preach during the holy pilgrimage months in which all hostilities between Arabs were suspended.^[87]

Isra and Mi'raj[link]

The Al-Aqsa Mosque, part of the al-Haram ash-Sharif complex in Jerusalem, is believed to be the "farthest mosque" to which Muhammad travelled in his night journey. The al-Haram ash-Sharif is the third holiest place on earth for Muslims.^[88]

Islamic tradition relates that in 620, Muhammad experienced the Isra and Mi'raj, a miraculous journey said to have occurred with the angel Gabriel in one night. In the first part of the journey, the Isra, he is said to have travelled from Mecca on a winged steed (Buraq) to "the farthest mosque" (in Arabic: masjid al-aqsa), which Muslims usually identify with the Al-Aqsa Mosque in Jerusalem. In the second part, the Mi'raj, Muhammad is said to have toured heaven and hell, and spoken with earlier prophets, such as Abraham, Moses, and Jesus.^[87][89] Ibn Ishaq, author of the first biography of Muhammad, presents this event as a spiritual experience whereas later historians like Al-Tabari and Ibn Kathir present it as a physical journey.^[89]

Quranic inscriptions on the Dome of the Rock, adjacent to the Al-Aqsa Mosque in the al-Haram ash-Sharif. The Dome of the Rock marks the spot from which Muhammad is believed to have ascended to heaven.^[90]

Some western scholars of Islam hold that the oldest Muslim tradition identified the journey as one traveled through the heavens from the sacred enclosure at Mecca to the celestial al-Baytu l-Maʿmur (heavenly prototype of the Kaaba); but later tradition identified Muhammad's journey as having been from Mecca to Jerusalem.^[91]

Last years in Mecca before Hijra[link]

Muhammad's wife Khadijah and his uncle Abu Talib both died in 619, the year thus being known as the "year of sorrow". With the death of Abu Talib, the leadership of the Banu Hashim clan was passed to Abu Lahab, an inveterate enemy of Muhammad. Soon afterwards, Abu Lahab withdrew the clan's protection from Muhammad. This placed Muhammad in danger of death since the withdrawal of clan protection implied that the blood revenge for his killing would not be exacted. Muhammad then visited Ta'if, another important city in Arabia, and tried to find a protector for himself there, but his effort failed and further brought him into physical danger.^[13][86][87] Muhammad was forced to return to Mecca. A Meccan man named Mut'im b. Adi (and the protection of the tribe of Banu Nawfal) made it possible for him safely to re-enter his native city.^[13][86][87]

Many people were visiting Mecca on business or as pilgrims to the Kaaba. Muhammad took this opportunity to look for a new home for himself and his followers. After several unsuccessful negotiations, he found hope with some men from Yathrib (later called Medina).^[13] The Arab population of Yathrib were familiar with monotheism and prepared for the appearance of a prophet because a Jewish community existed there.^[13][16] They also hoped by the means of Muhammad and the new faith to gain supremacy over Mecca, as they were jealous of its importance as the place of pilgrimage.^[16] Converts to Islam came from nearly all Arab tribes in Medina, such that by June of the subsequent year there were seventy-five Muslims coming to Mecca for pilgrimage and to meet Muhammad. Meeting him secretly by night, the group made what was known as the "Second Pledge of al-`Aqaba", or the "Pledge of War"^[16][92] Following the pledges at Aqabah, Muhammad encouraged his followers to emigrate to Yathrib. As with the migration to Abyssinia, the Quraysh attempted to stop the emigration. However, almost all Muslims managed to leave.^[93]

Hijra[link]

The Hijra is the migration of Muhammad and his followers from Mecca to Medina in 622 CE. In September 622, warned of a plot to assassinate him, Muhammad secretly slipped out of Mecca, moving with his followers to Medina,^[16] 320 kilometres (200 mi) north of Mecca. The Hijra is celebrated annually on the first day of the Muslim year.

Migration to Medina[link]

A delegation consisting of the representatives of the twelve important clans of Medina, invited Muhammad as a neutral outsider to Medina to serve as chief arbitrator for the entire community.^[94][95] There was fighting in Yathrib mainly involving its Arab and Jewish inhabitants for around a hundred years before 620.^[94] The recurring slaughters and disagreements over the resulting claims, especially after the Battle of Bu'ath in which all clans were involved, made it obvious to them that the tribal conceptions of blood-feud and an eye for an eye were no longer workable unless there was one man with authority to adjudicate in disputed cases.^[94] The delegation from Medina pledged themselves and their fellow-citizens to accept Muhammad into their community and physically protect him as one of themselves.^[13]

Muhammad instructed his followers to emigrate to Medina until virtually all his followers left Mecca. Being alarmed at the departure of Muslims, according to the tradition, the Meccans plotted to assassinate Muhammad. With the help of Ali, Muhammad fooled the Meccans who were watching him, and secretly slipped away from the town with Abu Bakr.^[16][96] By 622, Muhammad emigrated to Medina, a large agricultural oasis. Those who migrated from Mecca along with Muhammad became known as muhajirun (emigrants).^[13]

Establishment of a new polity[link]

Wikisource has original text related to this article: Medina Charter

Among the first things Muhammad did to settle down the longstanding grievances among the tribes of Medina was drafting a document known as the Constitution of Medina, "establishing a kind of alliance or federation" among the eight Medinan tribes and Muslim emigrants from Mecca, which specified the rights and duties of all citizens and the relationship of the different communities in Medina (including that of the Muslim community to other communities, specifically the Jews and other "Peoples of the Book").^[94][95] The community defined in the Constitution of Medina, Ummah, had a religious outlook but was also shaped by practical considerations and substantially preserved the legal forms of the old Arab tribes.^[13] It effectively established the first Islamic state.

Several ordinances were proclaimed to win over the numerous and wealthy Jewish population. But these were soon rescinded as the Jews insisted on preserving the entire Mosaic law, and did not recognize him as a prophet because he was not of the race of David.^[16]

The first group of pagan converts to Islam in Medina were the clans who had not produced great leaders for themselves but had suffered from warlike leaders from other clans. This was followed by the general acceptance of Islam by the pagan population of Medina, apart from some exceptions. According to Ibn Ishaq, this was influenced by the conversion of Sa'd ibn Mu'adh (a prominent Medinan leader) to Islam.^[98] Those Medinans who converted to Islam and helped the Muslim emigrants find shelter became known as the ansar (supporters).^[13] Then Muhammad instituted brotherhood between the emigrants and the supporters and he chose Ali as his own brother.^[99]

Beginning of armed conflict[link]

Following the emigration, the Meccans seized the properties of the Muslim emigrants in Mecca.^[100] Economically uprooted and with no available profession, the Muslim migrants turned to raiding Meccan caravans, initiating armed conflict with Mecca.^{[101][102][103]} Muhammad delivered Quranic verses permitting the Muslims to fight the Meccans (see sura Al-Hajj, Quran 22:39–40).^[104] These attacks allowed the migrants to acquire wealth, power and prestige while working towards their ultimate goal of conquering Mecca.^[105][106]

The Masjid al-Qiblatain, where Muhammad established the new Qibla, or direction of prayer

On 11 February 624 according to the traditional account, while praying in the Masjid al-Qiblatain in Medina, Muhammad received a revelation from God that he should be facing Mecca rather than Jerusalem during prayer. As he adjusted himself, so did his companions praying with him, beginning the tradition of facing Mecca during prayer.^[107] According to Watt, the change may have been less sudden and definite than the story suggests – the related Quranic verses (2:136–2:147) appear to have been revealed at different times – and correlates with changes in Muhammad's political support base, symbolizing his turning away from Jews and adopting a more Arabian outlook.^[107]

In March 624, Muhammad led some three hundred warriors in a raid on a Meccan merchant caravan. The Muslims set an ambush for them at Badr.^[108] Aware of the plan, the Meccan caravan eluded the Muslims.^[103] Meanwhile, a force from Mecca was sent to protect the caravan, continuing forward to confront the Muslims upon hearing that the caravan was safe. The Battle of Badr began in March 624.^[109] Though outnumbered more than three to one, the Muslims won the battle, killing at least forty-five Meccans with only fourteen Muslims dead. They also succeeded in killing many Meccan leaders, including Abu Jahl.^[110] Seventy prisoners had been acquired, many of whom were soon ransomed in return for wealth or freed.^{[101][103][111][112]} Muhammad and his followers saw in the victory a confirmation of their faith^[13] as Muhammad ascribed the victory to the assistance of an invisible host of angels.^[113] The Quranic verses of this period, unlike the Meccan ones, dealt with practical problems of government and issues like the distribution of spoils.^[114][115]

The victory strengthened Muhammad's position in Medina and dispelled earlier doubts among his followers.^[116] As a result the opposition to him became less vocal. Pagans who had not yet converted were very bitter about the advance of Islam. Two pagans, Asma bint Marwan and Abu 'Afak, had composed verses taunting and insulting the Muslims. They were killed by people belonging to their own or related clans, and no blood-feud followed.^[117]

Muhammad expelled from Medina the Banu Qaynuqa, one of three main Jewish tribes.^[13] Although Muhammad wanted them executed, Abd-Allah ibn Ubaiy chief of the Khazraj tribe did not agree and they were expelled to Syria but without their property.^[115] Following the Battle of Badr, Muhammad also made mutual-aid alliances with a number of Bedouin tribes to protect his community from attacks from the northern part of Hijaz.^[13]

Conflict with Mecca[link]

The Kaaba in Mecca long held a major economic and religious role for the area. Seventeen months after Muhammad's arrival in Medina, it became the Muslim Qibla, or direction for prayer (Salah). The Kaaba has been rebuilt several times; the present structure, built in 1629, is a reconstruction of an earlier building dating to 683.^[118]

The Meccans were now anxious to avenge their defeat. To maintain their economic prosperity, the Meccans needed to restore their prestige, which had been lost at Badr.^[119] In the ensuing months, the Meccans sent ambush parties on Medina while Muhammad led expeditions on tribes allied with Mecca and sent out a raid on a Meccan caravan.^[120] Abu Sufyan subsequently gathered an army of three thousand men and set out for an attack on Medina.^[115][121]

A scout alerted Muhammad of the Meccan army's presence and numbers a day later. The next morning, at the Muslim conference of war, there was dispute over how best to repel the Meccans. Muhammad and many senior figures suggested that it would be safer to fight within Medina and take advantage of its heavily fortified strongholds. Younger Muslims argued that the Meccans were destroying their crops, and that huddling in the strongholds would destroy Muslim prestige. Muhammad eventually conceded to the wishes of the latter, and readied the Muslim force for battle.^[115] Thus, Muhammad led his force outside to the mountain of Uhud (where the Meccans had camped) and fought the Battle of Uhud on March 23.^[122][123] Although the Muslim army had the best of the early encounters, indiscipline on the part of strategically placed archers led to a Muslim defeat, with 75 Muslims killed including Hamza, Muhammad's uncle and one of the best known martyrs in the Muslim tradition. The Meccans did not pursue the Muslims further, but marched back to Mecca declaring victory. This is probably because Muhammad was wounded and thought to be dead. When they knew this on their way back, they did not return back because of false information about new forces coming to his aid.^[115] They were not entirely successful, however, as they had failed to achieve their aim of completely destroying the Muslims.^[124][125] The Muslims buried the dead, and returned to Medina that evening. Questions accumulated as to the reasons for the loss, and Muhammad subsequently delivered Quranic verses 3:152 which indicated that their defeat was partly a punishment for disobedience and partly a test for steadfastness.^[126]

Abu Sufyan now directed his efforts towards another attack on Medina. He attracted the support of nomadic tribes to the north and east of Medina, using propaganda about Muhammad's weakness, promises of booty, memories of the prestige of the Quraysh and use of bribes.^[127] Muhammad's policy was now to prevent alliances against him as much as he could. Whenever alliances of tribesmen against Medina were formed, he sent out an expedition to break them up.^[127] When Muhammad heard of men massing with hostile intentions against Medina, he reacted with severity.^[128] One example is the assassination of Ka'b ibn al-Ashraf, a chieftain of the Jewish tribe of Banu Nadir who had gone to Mecca and written poems that helped rouse the Meccans' grief, anger and desire for revenge after the Battle of Badr.^[129][130] Around a year later, Muhammad expelled the Banu Nadir from Medina^[131] to Syria allowing them to take some of their possessions because he was unable to subdue them in their strongholds. The rest of their property was claimed by Muhammad in the name of God because it was not gained with bloodshed. Muhammad surprised various Arab tribes, one by one, with overwhelming force which caused his enemies to unite to annihilate him.^[132] Muhammad's attempts to prevent formation of a confederation against him were unsuccessful, though he was able to increase his own forces and stop many potential tribes from joining his enemies.^[133]

Siege of Medina[link]

With the help of the exiled Banu Nadir, the Quraysh military leader Abu Sufyan had mustered a force of 10,000 men. Muhammad prepared a force of about 3,000 men and adopted a new form of defense unknown in Arabia at that time: the Muslims dug a trench^[132] wherever Medina lay open to cavalry attack. The idea is credited to a Persian convert to Islam, Salman the Persian. The siege of Medina began on March 31 627^[132] and lasted for two weeks.^[134] Abu Sufyan's troops were unprepared for the fortifications they were confronted with, and after an ineffectual siege lasting several weeks, the coalition decided to go home.^[132][135] The Quran discusses this battle in sura Al-Ahzab, ayat (verses) 9-27, 33:9–27.^[77] During the battle, the Jewish tribe of Banu Qurayza, located at the south of Medina, had entered into negotiations with Meccan forces to revolt against Muhammad. Although they were swayed by suggestions that Muhammad was sure to be overwhelmed, they desired reassurance in case the confederacy was unable to destroy him. No agreement was reached after the prolonged negotiations, in part due to sabotage attempts by Muhammad's scouts.^[136] After the coalition's retreat, the Muslims accused the Banu Qurayza of treachery and besieged them in their forts for 25 days. The Banu Qurayza eventually surrendered; according to Ibn Ishaq, all the men apart from a few who converted to Islam were beheaded, while the women and children were enslaved.^{[132][137][138]} Walid N. Arafat and Barakat Ahmad have disputed the accuracy of Ibn Ishaq"s narrative, however.^[139] Arafat believes that Ibn Ishaq's Jewish sources, speaking over 100 years after the event, conflated their account with memories of earlier massacres in Jewish history; he notes that Ibn Ishaq was considered an unreliable historian by his contemporary Malik ibn Anas, and a transmitter of "odd tales" by the later Ibn Hajar.^[140] Ahmad argues that only some of the tribe were killed, while some of the fighters were merely enslaved.^[141][142] Watt finds Arafat's arguments "not entirely convincing", while Meir J. Kister has contradicted^{[clarification needed]} the arguments of Arafat and Ahmad.^[143]

In the siege of Medina, the Meccans exerted their utmost strength towards the destruction of the Muslim community. Their failure resulted in a significant loss of prestige; their trade with Syria was gone.^[144] Following the Battle of the Trench, he made two expeditions to the north which ended without any fighting.^[13][132] While returning from one of these (or some years earlier according to other early accounts), an accusation of adultery was made against Aisha, Muhammad's wife. Aisha was exonerated from the accusations when Muhammad announced that he had received a revelation confirming Aisha's innocence and directing that charges of adultery be supported by four eyewitnesses (sura 24, An-Nur).^[145]

Truce of Hudaybiyyah[link]

Although Muhammad had already delivered Quranic verses commanding the Hajj,^[146] the Muslims had not performed it due to the enmity of the Quraysh. In the month of Shawwal 628,^[132] Muhammad ordered his followers to obtain sacrificial animals and to make preparations for a pilgrimage (umrah) to Mecca, saying that God had promised him the fulfillment of this goal in a vision where he was shaving his head after the completion of the Hajj.^[147] Upon hearing of the approaching 1,400 Muslims, the Quraysh sent out a force of 200 cavalry to halt them. Muhammad evaded them by taking a more difficult route, thereby reaching al-Hudaybiyya, just outside of Mecca.^[148] According to Watt, although Muhammad's decision to make the pilgrimage was based on his dream, he was at the same time demonstrating to the pagan Meccans that Islam does not threaten the prestige of their sanctuary, and that Islam was an Arabian religion.^[148]

Negotiations commenced with emissaries going to and from Mecca. While these continued, rumors spread that one of the Muslim negotiators, Uthman bin al-Affan, had been killed by the Quraysh. Muhammad responded by calling upon the pilgrims to make a pledge not to flee (or to stick with Muhammad, whatever decision he made) if the situation descended into war with Mecca. This pledge became known as the "Pledge of Acceptance" (Arabic: بيعة الرضوان , bay'at al-ridhwān‎) or the "Pledge under the Tree". News of Uthman's safety, however, allowed for negotiations to continue, and a treaty scheduled to last ten years was eventually signed between the Muslims and Quraysh.^[148][149] The main points of the treaty included the cessation of hostilities; the deferral of Muhammad's pilgrimage to the following year;^[150] and an agreement to send back any Meccan who had gone to Medina without the permission of their protector.^[148]

Many Muslims were not satisfied with the terms of the treaty. However, the Quranic sura "Al-Fath" (The Victory) (Quran 48:1–29) assured the Muslims that the expedition from which they were now returning must be considered a victorious one.^[151] It was only later that Muhammad's followers would realise the benefit behind this treaty. These benefits included the inducing of the Meccans to recognise Muhammad as an equal;^[150] a cessation of military activity posing well for the future; and gaining the admiration of Meccans who were impressed by the incorporation of the pilgrimage rituals.^[13]

After signing the truce, Muhammad made an expedition against the Jewish oasis of Khaybar,^[150] known as the Battle of Khaybar. This was possibly due to it housing the Banu Nadir, who were inciting hostilities against Muhammad, or to regain some prestige to deflect from what appeared to some Muslims as the inconclusive result of the truce of Hudaybiyya.^[121][152] According to Muslim tradition, Muhammad also sent letters to many rulers of the world, asking them to convert to Islam (the exact date is given variously in the sources).^{[13][153][154][155]} Hence he sent messengers (with letters) to Heraclius of the Byzantine Empire (the eastern Roman Empire), Khosrau of Persia, the chief of Yemen and to some others.^{[153][154][155]} In the years following the truce of Hudaybiyya, Muhammad sent his forces against the Arabs on Transjordanian Byzantine soil in the Battle of Mu'tah, in which the Muslims were defeated.^[155][156]

Final years[link]

Conquest of Mecca[link]

A depiction of Muhammad (with veiled face) advancing on Mecca from Siyer-i Nebi, a 16th-century Ottoman manuscript. The angels Gabriel, Michael, Israfil and Azrail, are also shown.