Hyperbaric medicine, also known as hyperbaric oxygen therapy (HBOT), is the medical use of oxygen at a level higher than atmospheric pressure.

Therapeutic principles

Several therapeutic principles are made use of in HBOT: The increased overall pressure is of therapeutic value when HBOT is used in the treatment of decompression sickness and air embolism;

For many other conditions, the therapeutic principle of HBOT lies in its ability to drastically increase partial pressure of oxygen in the tissues of the body. The oxygen partial pressures achievable using HBOT are much higher than those achievable while breathing pure oxygen at conditions (i.e. at normal atmospheric pressure);

A related effect is the increased oxygen transport capacity of the blood. Under normal atmospheric pressure, oxygen transport is limited by the oxygen binding capacity of hemoglobin in red blood cells and very little oxygen is transported by blood plasma. Because the hemoglobin of the red blood cells is almost saturated with oxygen under atmospheric pressure, this route of transport cannot be exploited any further. Oxygen transport by plasma, however is significantly increased using HBOT as the stimulus.

Indications

Not long ago, HBOT was controversial and health policy regarding its uses was politically charged. Both sides of the issue of the effectiveness of HBOT for pathological and non-pathological use is available in the form of Cochrane Library reviews. As of January, 2010, times have changed and HBOT is even being proposed to treat U.S. service men and women suffering with PTSD. HBOT, both in the hard chambers and the soft chambers, is now seeing widespread use throughout the world for a number of acute and chronic conditions.

In the United States the Undersea and Hyperbaric Medical Society, known as UHMS, lists approvals for reimbursement for certain diagnoses in hospitals and clinics. The following indications are approved (for reimbursement) uses of hyperbaric oxygen therapy as defined by the UHMS Hyperbaric Oxygen Therapy Committee: However, these are reimbursement decisions based on cost of medical treatments vs HBOT at the average U.S. hospital charge of $1,800.00 per 90 minute HBOT treatment. China and Russia treat more than 80 maladies, conditions and trauma with HBOT, since dollar costs are insignificant in those countries. Air or gas embolism; Carbon monoxide poisoning;

Carbon monoxide poisoning complicated by cyanide poisoning;

Clostridal myositis and myonecrosis (gas gangrene); Crush injury, compartment syndrome, and other acute traumatic ischemias; Decompression sickness; Enhancement of healing in selected problem wounds;

Diabetically derived illness, such as diabetic foot, diabetic retinopathy, diabetic nephropathy;

Exceptional blood loss (anemia); Intracranial abscess; Necrotizing soft tissue infections (necrotizing fasciitis); Osteomyelitis (refractory); Delayed radiation injury (soft tissue and bony necrosis); Skin grafts and flaps (compromised); Thermal burns.

HBOT is recognized by Medicare in the United States as a reimbursable treatment for 14 UHMS "approved" conditions. A 1-hour HBOT session may cost between $108 and $250 in private clinics, and over $1,000 in hospitals. U.S. physicians (either M.D. or D.O.) may lawfully prescribe HBOT for "off-label" conditions such as Lyme Disease, stroke, and migraines. Such patients are treated in outpatient clinics. In the United Kingdom most chambers are financed by the National Health Service, although some, such as those run by Multiple Sclerosis Therapy Centres, are non-profit.

Other reported applications include: Autism. A small 2009 double-blind study of autistic children found that 40 hourly treatments of 24% oxygen at 1.3 atm provided significant improvement in the children's behavior immediately after treatment sessions. The study has not been independently confirmed; further studies are planned or in progress; Epidural abscesses; Certain kind of hearing loss; Radiation-induced hemorrhagic cystitis; Inflammatory bowel disease.

The toxicology of the treatment has recently been reviewed by Ustundag et al. and its risk management is discussed by Christian R. Mortensen.

Structure

Construction

In the past, the traditional type of hyperbaric chamber used for HBOT was a hard shelled pressure vessel. Such chambers can be run at absolute pressures up to . Navies, diving organizations and hospitals typically operate these. They range in size from semi-portable, one-patient units to great fast units that can treat eight or more patients. Recent advances in materials technology have resulted in the manufacture of portable, "soft" chambers that can operate at between above atmospheric pressure. Hard chambers and soft chambers should not be considered equivalent in regards to efficacy and safety as they are different in many aspects.

A hard chamber may consist of

a pressure vessel that is generally made of steel, aluminium with the view ports (windows) made of acrylic;

one or more human entry hatches—small and circular or wheel-in type hatches for patients on gurneys;

the airlock that allows human entry—a separate chamber with two hatches, one to the outside and one to the main chamber, which can be independently pressurized to allow patients to enter or exit the main chamber while it is still pressurized and a small airlock for medicines, instruments, and food;

glass ports or closed-circuit television that allows technicians and medical staff outside the chamber to monitor the patient inside the chamber;

an intercom or walkie-talkie allowing two-way communication;

a carbon dioxide scrubber—consisting of a fan that passes the gas inside the chamber through a soda lime canister;

a control panel outside the chamber to open and close valves that control air flow to and from the chamber, and regulate oxygen to helmets or masks.

A soft chamber may consist of

a urethane-coated, nylon-bonded flexible acrylic pressure vessel with steel-weld technology;

a full-length dual zipper sealed opening;

an over-pressure valve, as the oxygen is fed into a small mask and expired gas has to be circulated toward the end of the chamber and out through the pressure regulators.

Oxygen supply

In today's larger "multiplace" chambers, both patients and medical staff inside the chamber breathe from "oxygen helmets", flexible, transparent soft plastic helmets with a seal around the neck similar to a space suit helmet, or tightly fitting aviator's oxygen masks, which supply pure oxygen and remove the exhaled gas from the chamber. During treatment patients breathe 100% oxygen most of the time but have periodic air breaks to minimize the risk of oxygen toxicity. The exhaled gas must be removed from the chamber to prevent the build up of oxygen, which could present a fire risk. Medical staff may also breathe oxygen to reduce the risk of decompression sickness. Administration of 96% to 100% oxygen maximizes the patient's treatment. The pressure inside a hard chamber is increased by opening valves allowing high-pressure air to enter from storage cylinders, similar to diving cylinders. An air compressor is used to fill these cylinders. A soft chamber may be pressurised directly from a compressor.

Smaller "monoplace" chambers can only accommodate the patient. No medical staff can enter. The chamber is flooded with pure oxygen or compressed air. The cost of using pure oxygen in a monoplace chamber is much higher than using compressed air. If pure oxygen is used, no oxygen breathing mask or helmet is needed. If compressed air is used then an oxygen mask or helmet is needed as in a multiplace, hard chamber. In monoplace chambers that are compressed with pure oxygen a mask is available to provide the patient with "air breaks," periods of breathing normal air, in order to reduce the risk of hyperoxic seizures. In soft chambers, using compressed air and a mask supplying 96% oxygen, no air breaks are necessary as there is no risk of oxygen toxicity because of relatively low oxygen partial pressures and short durations of treatment.

Treatments

Initially, HBOT was developed as a treatment for diving disorders involving bubbles of gas in the tissues, such as decompression sickness and gas embolism. The chamber cures decompression sickness and gas embolism by increasing pressure, reducing the size of the gas bubbles and improving the transport of blood to downstream tissues. The high concentrations of oxygen in the tissues are beneficial in keeping oxygen-starved tissues alive, and have the effect of removing the nitrogen from the bubble, making it smaller until it consists only of oxygen, which is re-absorbed into the body. After elimination of bubbles, the pressure is gradually reduced back to atmospheric levels.

Protocol

The slang term, at some facilities, for a cycle of pressurization inside the HBOT chamber is "a dive". An HBOT treatment for longer-term conditions is often a series of 20 to 40 dives, or compressions. Again, these dives last for about an hour and can be administered via a hard, high-pressure chamber or a soft, low-pressure chamber - the major difference being per-dive "dose" of oxygen. Many conditions do quite well with the lower dose, lower cost-per-hour, soft chambers.

Emergency HBOT for decompression illness follows treatment schedules laid out in treatment tables. Most cases employ a recompression to absolute, the equivalent of of water, for 4.5 to 5.5 hours with the casualty breathing pure oxygen, but taking air breaks every 20 minutes to reduce oxygen toxicity. For extremely serious cases resulting from very deep dives, the treatment may require a chamber capable of a maximum pressure of , the equivalent of of water, and the ability to supply heliox as a breathing gas.

U.S. Navy treatment charts are used in Canada and the United States to determine the duration, pressure, and breathing gas of the therapy. The most frequently used tables are Table 5 and Table 6. In the UK the Royal Navy 62 and 67 tables are used.

The Undersea and Hyperbaric Medical Society (UHMS) publishes a report that compiles the latest research findings and contains information regarding the recommended duration and pressure of the longer-term conditions.

Home and out-patient clinic treatment

There are several sizes of portable HBOT chambers, which are used for home treatment. These are usually referred to as "mild personal hyperbaric chambers", which is a reference to the lower pressure (compared to hard chambers) of soft-sided chambers. Food and Drug Administration (FDA) approved chambers available in the USA go up to 4.4 pounds per square inch (psi) above atmospheric pressure, which equals 1.4 atmospheres absolute (ATA), equivalent to a depth of 13.2 feet of sea water In the US, these "mild personal hyperbaric chambers" are categorized by the FDA as CLASS II medical devices and requires a prescription in order to purchase one or take treatments. Personal hyperbaric chambers are only FDA approved to reach 1.3 ATA. While hyperbaric chamber distributors and manufacturers cannot supply a chamber in the US with any form of elevated oxygen delivery system, a physician can write a prescription to combine the two modalities, as long as there is a prescription for both hyperbarics and oxygen. The most common option (but not approved by FDA) some patients choose is to acquire an oxygen concentrator which typically delivers 85–96% oxygen as the breathing gas. Due to the high circulation of air through the chamber, the total concentration of oxygen in the chamber never exceeds 25% as this can increase the risk of fire. Oxygen is never fed directly into soft chambers but is rather introduced via a line and mask directly to the patient. FDA approved oxygen concentrators for human consumption in confined areas used for HBOT are regularly monitored for purity (+/- 1%) and flow (10 to 15 liters per minute outflow pressure). An audible alarm will sound if the purity ever drops below 80%. Personal hyperbaric chambers use 120 volt or 220 volt outlets. Ranging in size from 21 inches up to 40 inches in diameter these chambers measure between 84 in (7 ft) to 120 in (10 ft) in length. The soft chambers are approved by the FDA for the treatment of altitude sickness, but are commonly used for other "off-label" purposes.

Possible complications and concerns

There are risks associated with HBOT, similar to some diving disorders. Pressure changes can cause a "squeeze" or barotrauma in the tissues surrounding trapped air inside the body, such as the lungs, behind the eardrum, inside paranasal sinuses, Breathing high-pressure oxygen may cause oxygen toxicity. Temporarily blurred vision can be caused by swelling of the lens, which usually resolves in two to four weeks.

There are reports that cataract may progress following HBOT. Also a rare side effect has been blindness secondary to optic neuritis (inflammation of the optic nerve).

Effects of Pressure

Patients inside the chamber may notice discomfort inside their ears as a pressure difference develops between their middle ear and the chamber atmosphere. This can be relieved by the Valsalva maneuver or by "jaw wiggling". As the pressure increases further, mist may form in the air inside the chamber and the air may become warm. Increased pressure may also cause ear drums to rupture, resulting in severe pain.

To reduce the pressure, a valve is opened to allow air out of the chamber. As the pressure falls, the patient’s ears may "squeak" as the pressure inside the ear equalizes with the chamber. The temperature in the chamber will fall. The speed of pressurization and de-pressurization can be adjusted to each patient's needs.

Contraindications

The only absolute contraindication to hyperbaric oxygen therapy is untreated pneumothorax. Also, the treatment may raise the issue of Occupational health and safety (OHS), which has been encountered by the therapist.

Patients should not undergo HBO therapy if they are taking or have recently taken the following drugs:

Doxorubicin (Adriamycin) – A chemotherapeutic drug.

Cisplatin – Also a chemotherapeutic drug.

Disulfiram (Antabuse) – Used in the treatment of alcoholism.

Mafenide acetate (Sulfamylon) – Suppresses bacterial infections in burn wounds

The following are relative contraindications -- meaning that special consideration must be made by specialist physicians before HBO treatments begin:

Upper respiratory infections – These conditions can make it difficult for the patient to clear their ears, which can result in what is termed sinus squeeze.

High fevers – In most cases the fever should be lowered before HBO treatment begins.

Emphysema with CO2 retention – This condition can lead to pneumothorax during HBO treatment.

History of thoracic (chest) surgery – This is rarely a problem and usually not considered a contraindication. However, there is concern that air may be trapped in lesions that were created by surgical scarring. These conditions need to be evaluated prior to considering HBO therapy.

Malignant disease: Cancers thrive in blood rich environments but may be suppressed by high oxygen levels. HBO treatment of individuals who have cancer presents a problem, since HBO both increases blood flow via angiogenesis and also raises oxygen levels. Taking an anti-angiogenic supplement may provide a solution. A study by Feldemier, et al. and recent NIH funded study on Stem Cells by Thom, et al., indicate that HBO is actually beneficial in producing stem/progenitor cells and the malignant process is not accelerated. Middle ear barotrauma (MEBT) is always a consideration in treating both children and adults in a hyperbaric environment, but most children currently being treated with HBOT are being pressurized to 1.3 ATA, which reduces the risks of side effects.

Neuro-rehabilitation

A 2004 systematic review of HBOT in traumatic brain injury identified 2 randomized controlled trials and 5 observational studies that met evaluated functional health outcomes. The studies ranged from fair to poor in quality. None adequately reported adverse events, the most serious reported being seizures, pulmonary symptoms, and neurologic deterioration. The review concluded that was insufficient evidence to prove the effectiveness or ineffectiveness, including risks and benefits of HBOT for TBI. In one RCT, the HBOT group had reduced mortality compared to the control group but much higher levels of disability. Another, smaller, study found no difference in mortality. The observational studies were weak in quality and did not provide enough evidence of clinical improvement following HBOT treatment.

Evidence in a 2005 systematic review of the evidence for HBOT in the treatment of stroke showed no benefit to the treatment, though the generalizability of the finding was limited due to the wide variety in stage and type of stroke, and the treatment given. Good quality studies were recommended to determine if HBOT provides any benefit in stroke. Another review that examined the effectiveness of HBOT in acute stroke. It found no evidence that HBOT improved clinical outcomes at 6 months, but further study was recommended.

A systematic review of HBOT for cerebral palsy was published in 2007. Two randomized controlled trials and four observational studies were identified. Neuropsychological tests also showed no difference between HBOT and room air. Based on caregiver report, those who received room air had significantly better mobility and social functioning.

A review of 12 randomized studies using HBOT with multiple sclerosis suggested that there is no clinically significant benefit from the administration of HBOT. The review proposed that more trials for selected subgroups of MS and for prolonged treatments may be worthwhile, but that routine use of HBOT in the treatment of MS was not recommended.

See also

Undersea and Hyperbaric Medical Society

South Pacific Underwater Medicine Society

Decompression chamber

References

Further reading

External links

Hyperbaric Oxygen Therapy from eMedicine

Conditions treated by Hyperbaric Medicine

Category:Diving medicine Category:Medical equipment Category:Medical treatments Category:Oxygen

Name	Darren Sharper
Width	150
Caption	Darren Sharper during the Vikings 2008 Training Camp.
Currentteam	New Orleans Saints
Currentnumber	42
Currentpositionplain	Safety
Birthdate	November 03, 1975
Birthplace	Richmond, Virginia
Heightft	6
Heightin	2
Weight	210
Debutyear	1997
Debutteam	Green Bay Packers
College	William & Mary
Draftyear	1997
Draftround	2
Draftpick	60
Pastteams
Status	Active
Highlights
Statweek	17
Statseason	2009
Statlabel1	Tackles
Statvalue1	635
Statlabel2	Sacks
Statvalue2	7.5
Statlabel3	INTs
Statvalue3	63
Statlabel4	INT TDs
Statvalue4	11
Nfl	SHA500479

Darren Mallory Sharper (born November 3, 1975 in Richmond, Virginia) is an American football safety who currently plays for the New Orleans Saints. He was drafted by the Green Bay Packers in the second round of the 1997 NFL Draft. He played college football at William & Mary.

Sharper is a five-time Pro Bowl selection, and was named to the NFL's 2000s All-Decade Team. He has also played for the Minnesota Vikings. He is the younger brother of former NFL linebacker Jamie Sharper.

Early years

Sharper attended Hermitage High School in Richmond, Virginia, graduating in 1993.

College career

Sharper played college football at William & Mary, where he was a teammate of current Pittsburgh Steelers head coach Mike Tomlin and current Philadelphia Eagles defensive coordinator Sean McDermott. In high school Sharper had primarily played quarterback, and he wanted to be a quarterback at William & Mary as well, until his college coach, Jimmye Laycock, told Sharper that he had the potential to make the NFL as a defensive back.

Minnesota Vikings

Sharper signed with the Minnesota Vikings on March 12, 2005. Sharper made an immediate impact for the Vikings intercepting nine passes for a league high 276 interception yards and two defensive touchdowns, in only 14 games. His great play earned him a trip to his third Pro Bowl. During his second season with the Vikings in 2006 he made 67 tackles and four interceptions. On November 11, 2006 in a game against the Miami Dolphins, Sharper bumped a member of the officiating crew, but he was not immediately penalized, later the following week the NFL fined him $15,000 for the infraction.

Sharper made the Pro Bowl for the fourth time in 2007, after totaling 63 tackles and four interceptions. On September 16, 2007, Sharper became the 22nd player in NFL history to intercept 50 passes. In 2008 Sharper recorded 69 tackles and one interception.

He finished his four-year career in Minnesota with 18 interceptions, 250 tackles, 359 interception yards, three touchdowns, and a sack.

New Orleans Saints

2009 season

An unrestricted free agent after the 2008 season, Sharper signed a one year deal with the New Orleans Saints on March 18, 2009.

On October 4, 2009, Sharper returned an interception 99 yards for a touchdown, the longest in Saints history. It was also his second 95+ yard interception return for a touchdown for the season. On October 25, Sharper returned his third interception for a touchdown on the season, a team record. At the end of Week 8, on Monday Night Football, Sharper intercepted a pass from Atlanta's Matt Ryan to help keep the Saints' perfect record. It was his seventh interception of the season. On November 30, once again on Monday Night Football, Sharper intercepted a desperation pass from New England's Tom Brady and returned it 35 yards, which would have left him 4 yards short of the NFL record for interception return yards in a season, set by Baltimore's Ed Reed in 2004, but the interception was called back due to a penalty.

Sharper then broke that record in a December 27 game against Tampa Bay, intercepting Josh Freeman's pass and returning it 21 yards. This gave him 8 interceptions on the year and 376 return yards (including 3 interceptions returned for touchdowns). It was the 63rd interception of Sharper's NFL career, tying him for sixth on the all-time list. His 376 interception return yards broke the NFL single season record of 358 previously held by Ed Reed. Sharper also shares an NFL record with Deion Sanders for most games with 50+ interception return yards (9) and owns the NFL record for most games with 75+ interception return yards (6).

For his performance in 2009, Sharper was selected for his fifth Pro Bowl. On February 7, 2010, Sharper earned his first Super Bowl ring as the Saints defeated Indianapolis in Super Bowl XLIV.

2010 season

Sharper had micro-facture arthroscopic surgery on his left knee during the off-season. On March 5, 2010, Sharper became an unrestricted free agent, allowing him to sign with another team. However, on May 3, Sharper re-signed with the Saints for the 2010 season. On September 3, Sharper was placed on the PUP (Physically Unable to Perform) list, causing him to miss the first six weeks of the 2010 NFL season. He was activated on October 24, but he later missed another two games after a further injury.

References

External links

Green Bay Packers bio

Minnesota Vikings bio

New Orleans Saints bio

Category:1975 births Category:Living people Category:People from Richmond, Virginia Category:American football safeties Category:William & Mary Tribe football players Category:Green Bay Packers players Category:Minnesota Vikings players Category:New Orleans Saints players Category:National Conference Pro Bowl players