IUPAC-recommended ring-lettering (left) and atom-numbering (right) of cholestane, a prototypical steroid skeleton.^[1] The four rings A-D form the gonane nucleus of the steroid.

Stick model of the steroid lanosterol. The total number of carbons (30) reflects its triterpenoid origin.

A steroid is a type of organic compound that contains a characteristic arrangement of four cycloalkane rings that are joined to each other. Examples of steroids include the dietary fat cholesterol, the sex hormones estradiol and testosterone, and the anti-inflammatory drug dexamethasone. The core of steroids is composed of twenty carbon atoms bonded together that take the form of four fused rings: three cyclohexane rings (designated as rings A, B, and C in the figure to the right) and one cyclopentane ring (the D ring). The steroids vary by the functional groups attached to this four-ring core and by the oxidation state of the rings. Sterols are special forms of steroids, with a hydroxyl group at position-3 and a skeleton derived from cholestane.^[1]

Hundreds of distinct steroids are found in plants, animals, and fungi. All steroids are made in cells either from the sterols lanosterol (animals and fungi) or from cycloartenol (plants). Both lanosterol and cycloartenol are derived from the cyclization of the triterpene squalene.^[2]

Structure[link]

Steroids are a class of organic compounds with a chemical structure that contains the core of gonane or a skeleton derived therefrom. Usually, methyl groups are present at the carbons C-10 and C-13. At carbon C-17 an alkyl side chain may also be present.

The basic skeleton of a steroid, with standard stereo orientations. R is a side-chain.

Cholestane, a typical steroid

Numbering of carbon atoms in gonane

Gonane is the simplest possible steroid and is composed of seventeen carbon atoms, bonded together to form four fused rings. The three cyclohexane rings (designated as rings A, B, and C in the figure above right) form the skeleton of phenanthrene; ring D has a cyclopentane structure. Hence, together they are called cyclopentaphenanthrene.^[3]

Commonly, steroids have a methyl group at the carbons C-10 and C-13 and an alkyl side chain at carbon C-17. Further, they vary by the configuration of the side chain, the number of additional methyl groups and the functional groups attached to the rings. For example the hydroxyl group at position C-3 in sterols.

Cholesterol

Cholic acid

Medrogestone

Classification[link]

Taxonomical/Functional[link]

Some of the common categories of steroids:

• Animal
  • Insect
    • Ecdysteroids such as ecdysterone
  • Vertebrate
    • Steroid hormones
      • Sex steroids are a subset of sex hormones that produce sex differences or support reproduction. They include androgens, estrogens, and progestagens.
      • Corticosteroids include glucocorticoids and mineralocorticoids. Glucocorticoids regulate many aspects of metabolism and immune function, whereas mineralocorticoids help maintain blood volume and control renal excretion of electrolytes. Most medical 'steroid' drugs are corticosteroids.
      • Anabolic steroids are a class of steroids that interact with androgen receptors to increase muscle and bone synthesis. There are natural and synthetic anabolic steroids. In popular language, the word "steroids" usually refers to anabolic steroids.
    • Cholesterol, which modulates the fluidity of cell membranes and is the principal constituent of the plaques implicated in atherosclerosis.
• Plant
  • Phytosterols
  • Brassinosteroids
• Fungus
  • Ergosterols

Structural[link]

It is also possible to classify steroids based upon their chemical composition. One example of how MeSH performs this classification is available at the Wikipedia MeSH catalog. Examples from this classification include:

Gonane (or steroid nucleus) is the parent (17-carbon tetracyclic) hydrocarbon molecule without any alkyl sidechains.^[4]

Biosynthesis[link]

Simplified version of latter part of steroid synthesis pathway, where the intermediates isopentenyl pyrophosphate (IPP) and dimethylallyl pyrophosphate (DMAPP) form geranyl pyrophosphate (GPP), squalene and, finally, lanosterol, the first steroid in the pathways. Some intermediates are omitted for clarity.

Steroid biosynthesis is an anabolic metabolic pathway that produces steroids from simple precursors. A unique biosynthetic pathway is followed in animals compared to many other organisms, making the pathway a common target for antibiotics and other anti-infective drugs. In addition, steroid metabolism in humans is the target of cholesterol-lowering drugs such as statins.

In humans and other animals, the biosynthesis of steroids follows the mevalonate pathway that uses acetyl-CoA as building-blocks to form dimethylallyl pyrophosphate (DMAPP) and isopentenyl pyrophosphate (IPP).^[5] In subsequent steps, DMAPP and IPP are joined to form geranyl pyrophosphate (GPP), which in turn is used to synthesize the steroid lanosterol. Further modifications of lanosterol into other steroids are classified steroidogenesis transformations.

Mevalonate pathway[link]

Mevalonate pathway

The mevalonate pathway or HMG-CoA reductase pathway starts with and ends with dimethylallyl pyrophosphate (DMAPP) and isopentenyl pyrophosphate (IPP).

Pharmacology[link]

A number of drugs target the mevalonate pathway:

• Statins (used for elevated cholesterol levels)
• Bisphosphonates (used in treatment of various bone-degenerative diseases)

DMAPP to lanosterol[link]

Isopentenyl pyrophosphate and dimethylallyl pyrophosphate donate isoprene units, which are assembled and modified to form terpenes and isoprenoids,^[6] which are a large class of lipids that include the carotenoids, and form the largest class of plant natural products.^[7]

Here, the isoprene units are joined together to make squalene and then folded up and formed into a set of rings to make lanosterol.^[8] Lanosterol can then be converted into other steroids such as cholesterol and ergosterol.^[8][9]

Human Steroidogenesis

Steroidogenesis[link]

Steroidogenesis is the biological process by which steroids are generated from cholesterol and transformed into other steroids. The pathways of steroidogenesis differ between different species, but the pathways of human steroidogenesis are shown in the figure.

Products of steroidogenesis include:

• androgens
  • testosterone
• estrogens and progesterone
• corticoids
  • cortisol
  • aldosterone

Steroids include estrogen, cortisol, progesterone, and testosterone. Estrogen and progesterone are made primarily in the ovary and in the placenta during pregnancy, and testosterone in the testes. Testosterone is also converted into estrogen to regulate the supply of each, in the bodies of both females and males. Certain neurons and glia in the central nervous system (CNS) express the enzymes that are required for the local synthesis of pregnane neurosteroids, either de novo or from peripherally-derived sources. The rate-limiting step of steroid synthesis is the conversion of cholesterol to pregnenolone, which occurs inside the mitochondrion.^[10]

Regulation[link]

Several key enzymes can be activated through DNA transcriptional regulation on activation of SREBP (Sterol Regulatory Element-Binding Protein-1 and -2). This intracellular sensor detects low cholesterol levels and stimulates endogenous production by the HMG-CoA reductase pathway, as well as increasing lipoprotein uptake by up-regulating the LDL receptor. Regulation of this pathway is also achieved by controlling the rate of translation of the mRNA, degradation of reductase and phosphorylation.

Alternative pathways[link]

In plants and bacteria, the non-mevalonate pathway uses pyruvate and glyceraldehyde 3-phosphate as substrates.^[11][6]

Metabolism[link]

Steroids are oxidized mainly by cytochrome P450 oxidase enzymes, such as CYP3A4. These reactions introduce oxygen into the steroid ring and allows the structure to be broken up by other enzymes, to form bile acids as final products.^[12] These bile acids can then be eliminated through secretion from the liver in the bile.^[13] The expression of this oxidase gene can be upregulated by the steroid sensor PXR when there is a high blood concentration of steroids.^[14]

Use[link]

Medical use[link]

Misuse[link]

See also[link]

pharmacology portal

• Batrachotoxin
• List of steroid abbreviations
• Steroid hormone
• Corticosteroid
• Sex steroid
• Steroid sulfatase
• Steroid hydroxylases
• Steroidogenic acute regulatory protein

References[link]

External links[link]

• Nomenclature of Steroids Home Page at Queen Mary University of London.
• The Science of Steroids (Documentary)
• Steroidogenesis

Lance Armstrong

Armstrong at the Tour de France 2010
Personal information
Full name	Lance Edward Armstrong
Nickname	The Boss, Juan Pelota, Big Tex, The Texan,[1] Mellow Johnny (from maillot jaune, French for yellow jersey)[2]
Born	(1971-09-18) September 18, 1971 (age 40) Plano, Texas, United States
Height	1.77 m (5 ft 9 1⁄2 in)[3]
Weight	71 kg (157 lb)[3]
Team information
Current team	Livestrong
Discipline	Road
Role	Rider
Rider type	All-Rounder
Amateur team(s)
1990–1991 1991	Subaru-Montgomery US National Team
Professional team(s)
1992–1996 1997 1998–2004 2005 2006–2008 2009 2010–2011 2012–	Motorola Cofidis US Postal Discovery Channel Livestrong Astana Team RadioShack Livestrong
Major wins
Grand Tours Tour de France General Classification (1999, 2000, 2001, 2002, 2003, 2004, 2005) 22 Individual Stages Stage Races Critérium du Dauphiné Libéré General Classification (2002, 2003) Points classification (2005) Tour de Suisse General classification (2001) Tour de Luxembourg General classification (1998) Single-Day Races and Classics Cycling World Champion (1993) US National Cycling Champion (1993) Clásica de San Sebastián (1995) La Flèche Wallonne (1996)
Medal record Competitor for USA Men's Cycling World Championships Gold 1993 Oslo Elite Men's Road Race Olympic Games Bronze 2000 Sydney Men's Time Trial
Infobox last updated on July 26, 2008

Lance Edward Armstrong (born Lance Edward Gunderson on September 18, 1971) is an American former professional road racing cyclist who won the Tour de France a record seven consecutive times after having survived testicular cancer. He is also the founder and chairman of the Lance Armstrong Foundation for cancer research and support. He last rode for UCI ProTeam Team RadioShack, a team he helped found.

In October 1996 he was diagnosed as having testicular cancer with a tumor that had metastasized to his brain and lungs. His cancer treatments included brain and testicular surgery and extensive chemotherapy, and his prognosis was originally poor. He went on to win the Tour de France each year from 1999 to 2005, and is the only person to win seven times having broken the previous record of five wins shared by Miguel Indurain, Bernard Hinault, Eddy Merckx, and Jacques Anquetil.

In 1999, he was named the ABC Wide World of Sports Athlete of the Year. In 2000 he won the Prince of Asturias Award in Sports.^[4] In 2002, Sports Illustrated magazine named him Sportsman of the Year. He was also named Associated Press Male Athlete of the Year for the years 2002–2005. He received ESPN's ESPY Award for Best Male Athlete in 2003, 2004, 2005, and 2006, and won the BBC Sports Personality of the Year Overseas Personality Award in 2003. Armstrong announced his retirement from racing on July 24, 2005, at the end of the 2005 Tour de France but returned to competitive cycling in January 2009 and finished third in the 2009 Tour de France. He confirmed he had retired from competitive cycling for good on February 16, 2011.^[5]

Career[link]

Early career[link]

This biographical section of an article needs additional citations for verification. Please help by adding reliable sources. Contentious material about living persons that is unsourced or poorly sourced must be removed immediately, especially if potentially libelous or harmful. (July 2011)

Armstrong was born on September 18, 1971, at Methodist Hospital in Plano, Texas in the southern sector of Dallas.^[6] At the age of 12, he began his sporting career as a swimmer at the City of Plano Swim Club and finished fourth in Texas state 1,500-meter freestyle. He abandoned swimming-only competition after seeing a poster for a junior triathlon called the Iron Kids Triathlon, which he entered and won at age 13.^[7]

In the 1987–1988 Tri-Fed/Texas ("Tri-Fed" was the former name of USA Triathlon), Armstrong was the number one ranked triathlete in the 19-and-under group; second place was Chann McRae, who became a US Postal Service cycling teammate and the 2002 USPRO national champion. Armstrong's points total for 1987 as an amateur was better than the five professionals ranked that year. At 16, Armstrong became a professional triathlete and became national sprint-course triathlon champion in 1989 and 1990 at 18 and 19, respectively.^[8]

It became clear that his greatest talent was for bicycle racing after he won the U.S. Amateur Championship in 1991. Representing the U.S., he finished 14th in the 1992 Summer Olympics. This performance earned him his first professional contract with Motorola. He won his first race with Motorola, the Trophee Laigueglia in Italy, beating the favourite Moreno Argentin.

In 1993, Armstrong won 10 one-day events and stage races. He stunned the cycling world when at age 21 he became one of the youngest riders to ever win the UCI Road World Championship, held in pouring rain in Norway that year. Prior to his World's win, he took his first stage win at the Tour de France, in the stage from Châlons-sur-Marne to Verdun. He was in 97th place overall when he abandoned the 1993 race in the Alps after the 12th stage.

He also collected the Thrift Drug Triple Crown of Cycling: the Thrift Drug Classic in Pittsburgh, the K-Mart West Virginia Classic, and the CoreStates USPRO national championship in Philadelphia. Thrift Drug said it would award $1 million to a rider winning all three races, a feat previously unachieved. At the USPRO championship, Armstrong sat up on his bicycle on the final lap, took out a comb, combed his hair and smiled for the cameras.

In 1994, he again won the Thrift Drug Classic and came second in the Tour DuPont in the United States. His successes in Europe were second placings in Liège–Bastogne–Liège and the Clásica de San Sebastián, where just two years before, he finished in last place as his first all-pro event in Europe.

He won the Clásica de San Sebastián in 1995, and this time won the Tour DuPont and took a handful of stage victories in Europe, including the stage to Limoges in the Tour De France. He dedicated the win to teammate Fabio Casartelli who died in a crash on the descent of the Col de Portet d'Aspet on the 15th stage, two days before.

Armstrong's successes were much the same in 1996. He became the first American to win the La Flèche Wallonne and again won the Tour DuPont. However, his performances began to suffer and he was only able to compete for five days in the Tour De France. At Atlanta he was only able to finish 6th in the time trial and 12th in the road race in the 1996 Olympic Games.

Cancer[link]

On October 2, 1996, then aged 25, Armstrong was diagnosed as having developed stage three testicular cancer (Embryonal carcinoma).^[9] The cancer spread to his lungs, abdomen and brain. On that first visit to a urologist in Austin, Texas, for his cancer symptoms he was coughing up blood and had a large, painful testicular tumor. Immediate surgery and chemotherapy were required to save his life. Armstrong had an orchiectomy to remove his diseased testicle. After his surgery, his doctor stated that he had less than a 40% survival chance.^[10]

The standard chemotherapeutic regimen for the treatment of this type of cancer is a cocktail of the drugs bleomycin, etoposide, and cisplatin (or Platinol) (BEP). Armstrong, however, chose an alternative, etoposide, ifosfamide, and cisplatin (VIP), to avoid the lung toxicity associated with the drug bleomycin.^[10] This decision may have saved his cycling career. His primary treatment was received at the Indiana University (IU), Indianapolis, Medical Center, where Dr. Lawrence Einhorn had pioneered the use of cisplatinum to treat testicular cancer. His primary oncologist there was Dr. Craig Nichols.^[10] His brain tumors were surgically removed by Scott A. Shapiro, MD, Professor of Neurosurgery at Indiana University and Resident Director, and were found to contain extensive necrosis.^[11] According to Armstrong's first book, Dr. Shapiro convinced him that he was the right neurosurgeon for him by saying: "You'll have to convince me you know what you're doing," said Armstrong. "Look, I've done a large number of these," Shapiro said, "I've never had anyone die, and I've never made anyone worse." "Yeah, but why should you be the person who operates on my head?" Armstrong responded. "Because as good as you are at cycling"-he paused-"I'm a lot better at brain surgery".^[10] His last chemotherapy treatment was received on December 13, 1996.

His cancer went into complete remission, and by January 1998 he was already engaged in serious training for racing, moving to Europe to race for the U.S. Postal team. A pivotal week (April 1998) in his comeback was one he spent training in the very challenging Appalachian terrain around Boone, North Carolina, with his racing friend Bob Roll.^[10]

Tour de France success[link]

Before his cancer treatment, Armstrong had won two Tour de France stages. In 1993, he won the 8th stage and in 1995 he took stage 18 in honor of teammate Fabio Casartelli who crashed and died on stage 15. Armstrong dropped out of the 1996 Tour on the 7th stage after becoming ill, a few months before his diagnosis.

Armstrong finishing 3rd in Sète, taking over the Yellow Jersey at Grand Prix Midi Libre

Armstrong's cycling comeback began in 1998 when he finished fourth in the Vuelta a España. In 1999 he won the Tour de France, including four stages. He beat the second rider, Alex Zülle, by 7 minutes 37 seconds. However, the absence of Jan Ullrich (injury) and Marco Pantani (drug allegations) meant Armstrong had not yet proven himself against the biggest names. Stage wins included the prologue, stage eight, an individual time trial in Metz, an Alpine stage on stage nine, and the second individual time trial on stage 19.

In 2000, Ullrich and Pantani returned to challenge Armstrong. The race that began a six-year rivalry between Ullrich and Armstrong ended in victory for Armstrong by 6 minutes 2 seconds over Ullrich. Armstrong took one stage in the 2000 Tour, the second individual time trial on stage 19. In 2001, Armstrong again took top honors, beating Ullrich by 6 minutes 44 seconds. In 2002, Ullrich did not participate due to suspension, and Armstrong won by seven minutes over Joseba Beloki.

The pattern returned in 2003, Armstrong taking first place and Ullrich second. Only 1 minute 1 second separated the two at the end of the final day in Paris. U.S. Postal won the team time trial on stage four, while Armstrong took stage 15, despite being knocked off on the ascent to Luz Ardiden, the final climb, when a spectator's bag caught his right handlebar. Ullrich waited for him, which brought Ullrich fair-play honors.^[12]

In 2004, Armstrong finished first, 6 minutes 19 seconds ahead of German Andreas Klöden. Ullrich was fourth, a further 2 minutes 31 seconds behind. Armstrong won a personal best five individual stages, plus the team time trial. He became the first since Gino Bartali in 1948 to win three consecutive mountain stages; 15, 16, and 17. The individual time trial on stage 16 up Alpe d'Huez was won in style by Armstrong as he passed Ivan Basso on the way despite setting out two minutes after the Italian. He won sprint finishes from Basso in stages 13 and 15 and made up a significant gap in the last 250 m to nip Klöden at the line in stage 17. He won the final individual time trial, stage 19, to complete his personal record of stage wins.

In 2005, Armstrong was beaten by David Zabriskie in the Stage 1 time trial by 2 seconds, despite passing Ullrich on the road. His Discovery Channel team won the team time trial, while Armstrong won the final individual time trial. In the mountain stages, Armstrong was attacked multiple times mostly by Ivan Basso, but also by T-mobile leaders Jan Ullrich, Andreas Kloden and Alexandre Vinokourov and former teammate Levi Leipheimer. But still, the American champion handled them well, maintained his lead and, on some occasions, increased it. To complete his record-breaking feat, Armstrong crossed the line on the Champs-Élysées on July 24 to win his 7th consecutive Tour, finishing 4m 40s ahead of Basso, with Ullrich third. Another record achieved that year, was that Armstrong completed the tour at the highest pace in the race's history: his average speed over the whole tour being 41.7 km/h(26 mph).^[13][14]

On July 24, 2005, Armstrong officially announced his retirement from professional cycling after his 7th consecutive Tour de France win.^[15]

Comeback[link]

Astana: 2009[link]

Armstrong announced on September 9, 2008 that he would return to pro cycling with the express goal of participating in the 2009 Tour de France.^[16] "After talking with my children, my family and my closest friends, I have decided to return to professional cycling in order to raise awareness of the global cancer burden", Armstrong said on his livestrong.org website.^[17] VeloNews reported that Armstrong would race for no salary or bonuses and would post his internally tested blood results online.^[18]

Armstrong on November 11, 2008 at an informal time trial near New Braunfels, Texas

The announcement ended speculation that he would return with Astana in the Tour of California, Paris–Nice, the Tour de Georgia and the Dauphiné-Libéré. Astana missed the 2008 Tour de France after Alexandre Vinokourov was ejected from the 2007 Tour for blood doping.

Australian ABC radio reported on September 24, 2008 that Armstrong would compete in the UCI Tour Down Under through Adelaide and surrounding areas in January 2009. UCI rules say a cyclist has to be in an anti-doping program for six months before an event, but UCI allowed Armstrong to compete.^[19] The Premier of South Australia, Mike Rann, declared that Armstrong's participation would make the tour "the biggest sporting event in South Australian history."^[20]

In October 2008, Armstrong confirmed he would compete in the 2009 Giro d'Italia, his first participation.^[21]

On January 17, Armstrong said at a press conference for the Tour Down Under that his comeback was motivated by spending most of his days spreading the Livestrong message and raising national awareness of cancer.^[22][23] Though his fitness levels had supposedly returned to peak condition,^[24] Armstrong placed 29th in the race.^[25] Armstrong said he considered this a successful result, as the thousands of fans who flocked to Adelaide to see him compete – booking every hotel room in the city^[24] – added A$17 million to the South Australian economy, and the government rewarded his effort by pledging A$4.1 million towards the construction of a centre for cancer research.^[26]

Armstrong's Trek bicycle was stolen while he was in Sacramento, California, for the Amgen Tour of California. This time-trial bike was returned to the Sacramento police by an anonymous citizen on February 18, 2009, four days after it disappeared from the Astana team truck. A police statement read, "The facts surrounding how the person came into possession of the bicycle are not being released at this time due to an ongoing investigation."^[27]

In February 2009, Armstrong was confirmed to compete in the Tour of Ireland from August 19–23, 2009, before then participating in the Livestrong Global Cancer Summit from August 24–26th in Dublin.^[28] The Astana Cycling team confirmed in early March that Armstrong would return to Europe to continue his comeback season with races at Milan – San Remo and the Vuelta a Castilla y León.^[29] He had to retire from the 2009 Vuelta a Castilla y León during the first stage after crashing in a rider pileup in Baltanás, Spain and breaking his collarbone.^[30]

Armstrong flew back to Austin, Texas, for corrective surgery, which was successful, and was back training on a bicycle within four days of his operation.^[31] On April 10, 2009, a controversy emerged between the French anti-doping agency AFLD and Armstrong and his team manager, Johan Bruyneel, stemming from a March 17, 2009 encounter with an AFLD anti-doping official who visited Armstrong after a training ride in Beaulieu-sur-Mer. When the official arrived, Armstrong claims he asked—and was granted—permission to take a shower while Bruyneel checked the official's credentials. In late April, the AFLD cleared Armstrong of any wrongdoing.^[32] Armstrong returned to racing after his collarbone injury at the Tour of the Gila in New Mexico on April 29.^[33]

On July 7, in the fourth stage of the 2009 Tour de France, Armstrong narrowly failed to win the yellow jersey after his Astana team won the team time trial. His Astana team won the 39 km lap of Montpellier but Armstrong ended up just over two tenths of a second (0.22) outside of Fabian Cancellara's overall lead.^[34] Armstrong finished the 2009 Tour de France in third place overall, 5:24 behind the overall winner, his Astana teammate Alberto Contador.

Team RadioShack: 2010–11[link]

On July 21, 2009, Armstrong announced that he would return to the Tour de France in 2010.^[35] RadioShack was named as the main sponsor for Armstrong's 2010 team, named Team RadioShack.^[36][37] Armstrong made his 2010 season debut at the 2010 Tour Down Under where he finished 25th out of the 127 riders that completed the race. He made his European season debut at the 2010 Vuelta a Murcia finishing in 7th place overall. Armstrong was also set to compete in several classics such as the Milan – San Remo, Amstel Gold Race, Liège–Bastogne–Liège, and the Tour of Flanders, but bouts with gastroenteritis forced his withdrawal from three of the four races.^[38] Armstrong returned to the United States in mid-April to compete in the Tour of Gila and May's Amgen Tour of California, both as preparation for the Tour de France. However, he crashed outside Visalia early in stage 5 of the Tour of California and had to withdraw from the race.^[39] He showed fine shape after recovering from the Tour of California crash, placing second in the Tour of Switzerland and third in the Tour of Luxembourg.

On June 28, Armstrong announced via Twitter that the 2010 edition would be his final Tour de France.^[40] Armstrong put in an impressive performance in the Tour de France prologue TT, finishing third, but was plagued by crashes in later stages that put him out of GC contention, especially a serious crash in stage 8. He rallied for the brutal Pyreneean stage 16, working as a key player in a successful break that included teammate Chris Horner. He finished his last tour in 23rd place, 39 minutes 20 seconds behind former winner Alberto Contador.^[41] He was also a key rider in helping Team RadioShack win the team competition, beating Caisse D’Epargne by 9 minutes, 15 seconds.

In October, he announced the end of international career after the Tour Down Under of January 2011. He stated that after January 2011 he will only race in the U.S. with the Radioshack domestic team.^[42]

Armstrong announced his retirement from competitive cycling 'for good' on February 16, 2011, while still facing a US federal investigation into doping allegations.^[5][43]

Physical attributes[link]

Armstrong has recorded an aerobic capacity of 83.8 mL/kg/min (VO₂ max),^[44][45] much higher than the average person (40–50), but lower than some other Tour De France winners, such as Miguel Indurain (88.0, although reports exist that Indurain tested at 92–94) and Greg LeMond (92.5).^[46] At his peak, he had a resting heart rate of 32–34 beats per minute (bpm) with a maximum heart rate of 201 bpm.^[47]

Collaboration of sponsors[link]

Armstrong revolutionized the support behind his well-funded teams, asking sponsors and suppliers to contribute and act as part of the team.^[48] For example, rather than having the frame, handlebars, and tires designed and developed by separate companies with little interaction, his teams adopted a Formula One relationship with sponsors and suppliers named "F-One",^[49] taking full advantage of the combined resources of several organizations working in close communication. The team, Trek, Nike, AMD, Bontrager (a Trek company), Shimano, Sram, Giro and Oakley, collaborated for an array of products.

Family and personal life[link]

Armstrong was born to Linda Mooneyham, a secretary, and Eddie Charles Gunderson, a route manager for The Dallas Morning News. His great-grandfather was the son of Norwegian immigrants.^[50] He was named after Lance Rentzel, a Dallas Cowboys wide receiver. His father left his mother when Lance was two and has two other children from another relationship. His mother later married Terry Keith Armstrong, a wholesale salesman, who adopted Lance in 1974. Armstrong refuses to meet his birth father.^[51]

Armstrong (center) on the set of College GameDay during the 2006 UT football season

Armstrong met Kristin Richard in June 1997. They married on May 1, 1998 and had three children: Luke David, born October 1999, and twins Isabelle Rose and Grace Elisabeth, born November 2001. The pregnancy was possible through sperm Armstrong banked three years earlier, prior to chemotherapy and surgery.^[52] The couple filed for divorce in September 2003. At Armstrong's request, his children flew in for the Tour de France podium ceremony in 2005, where Luke helped his father hoist the trophy, while his daughters (in yellow dresses) held the stuffed lion mascot and bouquet of yellow flowers.

Armstrong began dating singer-songwriter Sheryl Crow in the autumn of 2003 and revealed their relationship in January 2004. The couple announced their engagement in September 2005 and their split in February 2006.

In December 2008, Armstrong announced that his girlfriend, Anna Hansen, was pregnant with his child. The couple started dating in July 2008 after meeting through Armstrong's charity work. Although it was believed that Armstrong could no longer father children, after having undergone chemotherapy for testicular cancer, this child was conceived naturally.^[53] The baby boy, Maxwell Edward Armstrong, was born on June 4, 2009 in Aspen, Colorado. Armstrong announced the birth via Twitter.^[54] Armstrong has become a popular Twitter user, with precisely 3,385,486 followers on April 10, 2012. ^[55]

In April 2010, Armstrong, using Twitter, announced that Anna Hansen was having his fifth child. Olivia Marie Armstrong was born October 18, 2010.^[56]

Armstrong owns homes in Austin, Texas, and Aspen, Colorado, as well as a ranch in the Texas Hill Country.^[57] Armstrong is a fan of the University of Texas Longhorns college football program and is often seen on the sidelines supporting the team.

With regard to religion, he is agnostic, quoted as saying, "at the end of the day, if there was indeed some body or presence standing there to judge me, I hoped I would be judged on whether I had lived a true life, not on whether I believed in a certain book, or whether I'd been baptized. If there was indeed a god at the end of my days, I hoped he didn't say, 'But you were never a Christian, so you're going the other way from heaven.' If so, I was going to reply, 'You know what? You're right. Fine.' "^[58]

Allegations of doping[link]

For much of the second phase of his career, Armstrong has faced persistent allegations of doping. A number of high-profile cyclists and assorted journalists have alleged that he cheated. However, no allegations have ever been substantiated, and Armstrong retains respect and prestige in many circles.^[59]

In addition, Armstrong has been criticised for his disagreements with outspoken opponents of doping such as Paul Kimmage^[60][61] and Christophe Bassons.^[62][63] Bassons wrote a number of articles for a French newspaper during the 1999 Tour de France which made references to doping in the peloton. Subsequently, Armstrong had an altercation with Bassons during the 1999 Tour De France where Bassons said Armstrong rode up alongside on the Alpe d'Huez stage to tell him "it was a mistake to speak out the way I [Bassons] do and he [Armstrong] asked why I was doing it. I told him that I'm thinking of the next generation of riders. Then he said 'Why don't you leave, then?'"^[64] Armstrong confirmed the story. On the main evening news on TF1, a national television station, Armstrong said: "His accusations aren't good for cycling, for his team, for me, for anybody. If he thinks cycling works like that, he's wrong and he would be better off going home".^[65] Kimmage, a professional cyclist in the 1980s who later became a sports journalist, referred to Armstrong as a "cancer in cycling".^[63] He also asked Armstrong questions in relation to his "admiration for dopers" at a press conference at the Tour of California in 2009, provoking a scathing reaction from Armstrong.^[63] This spat continued and is exemplified by Kimmage's articles in The Sunday Times.^[66]

Armstrong has continually denied using illegal performance-enhancing drugs and has described himself as the most tested athlete in the world.^[67] A 1999 urine sample showed traces of corticosteroid in an amount that was not in the positive range. A medical certificate showed he used an approved cream for saddle sores which contained the substance.^[68]

From his return to cycling in the fall of 2008 through March 2009, Armstrong submitted to 24 unannounced drug tests by various anti-doping authorities. All of the tests were negative for performance-enhancing drugs.^[69][70]

U.S. federal prosecutors pursued allegations of doping by Armstrong from 2010–2012. The effort convened a grand jury to investigate doping charges, including taking statements under oath from Armstrong's former team members and other associates; met with officials from France, Belgium, Spain, and Italy; and requested samples from the French anti-doping agency. The investigation was led by federal agent Jeff Novitzky, who also investigated suspicions of steroid use by baseball players Barry Bonds and Roger Clemens. The probe was terminated on Feb 3, 2012 with no charges filed.^[71]

Specific allegations[link]

Armstrong has been criticized for working with controversial trainer Michele Ferrari. Greg LeMond described himself as "devastated" on hearing of them working together, while Tour de France organizer Jean-Marie Leblanc said, "I am not happy the two names are mixed."^[72] Following Ferrari's later-overturned conviction for "sporting fraud" and "abuse of the medical profession", Armstrong suspended his professional relationship with him, saying that he had "zero tolerance for anyone convicted of using or facilitating the use of performance-enhancing drugs" and denying that Ferrari had ever "suggested, prescribed or provided me with any performance-enhancing drugs."^[73] Ferrari was later absolved of all charges by an Italian appeals court of the sporting fraud charges as well as charges of abusing his medical license to write prescriptions. The court stated that it overturned his conviction "because the facts do not exist" to support the charges.^[74] Ferrari, however, is still banned from practicing medicine with cyclists by the Italian Cycling Federation. According to Italian law enforcement authorities, Armstrong met with Ferrari as recently as 2010 in a country outside of Italy.^[75]

In 2004, reporters Pierre Ballester and David Walsh published a book alleging Armstrong had used performance-enhancing drugs (L. A. Confidentiel – Les secrets de Lance Armstrong). It contains allegations by Armstrong's former masseuse, Emma O'Reilly, who claimed Armstrong once asked her to dispose of used syringes and to give him makeup to conceal needle marks on his arms.^[76] Another figure in the book, Steve Swart, claims he and other riders, including Armstrong, began using drugs in 1995 while members of the Motorola team, a claim denied by other team members.^[77][78] Allegations in the book were reprinted in the UK newspaper The Sunday Times in a story by deputy sports editor Alan English in June 2004. Armstrong sued for libel, and the paper settled out of court after a High Court judge in a pre-trial ruling stated that the article "meant accusation of guilt and not simply reasonable grounds to suspect."^[79] The newspaper's lawyers issued the statement: "The Sunday Times has confirmed to Mr. Armstrong that it never intended to accuse him of being guilty of taking any performance-enhancing drugs and sincerely apologized for any such impression." (See also^[80] in The Guardian). The same authors (Pierre Ballester and David Walsh) subsequently published "L.A. Official" and "Le Sale Tour" (The Dirty Trick), further cementing their claims that Armstrong used performance-enhancing drugs throughout his career.

On March 31, 2005, Mike Anderson filed a brief^[81] in Travis County District Court in Texas, as part of a legal battle following his termination in November 2004 as an employee of Armstrong. Anderson worked for Armstrong for two years as a personal assistant. In the brief, Anderson claimed that he discovered a box of androstenone while cleaning a bathroom in Armstrong's apartment in Girona, Spain.^[82] Androstenone is not on the list of banned drugs. Anderson stated in a subsequent deposition that he had no direct knowledge of Armstrong using a banned substance. Armstrong denied the claim and issued a counter-suit.^[83] The two men reached an out-of-court settlement in November 2005; the terms of the agreement were not disclosed.^[84]

On August 23, 2005, L'Équipe, a major French daily sports newspaper, reported on its front page under the headline "le mensonge Armstrong" ("The Armstrong Lie") that 6 urine samples taken from the cyclist during the prologue and five stages of the 1999 Tour de France, frozen and stored since at "Laboratoire national de dépistage du dopage de Châtenay-Malabry" (LNDD), had tested positive for erythropoietin (EPO) in recent retesting conducted as part of a research project into EPO testing methods.^[85][86] Armstrong immediately replied on his website, saying, "Unfortunately, the witch hunt continues and tomorrow's article is nothing short of tabloid journalism. The paper even admits in its own article that the science in question here is faulty and that I have no way to defend myself. They state: 'There will therefore be no counter-exam nor regulatory prosecutions, in a strict sense, since defendant's rights cannot be respected.' I will simply restate what I have said many times: I have never taken performance enhancing drugs."^[87] In October 2008, the AFLD gave Armstrong the opportunity to have samples taken during the 1998 and 1999 Tours de France retested.^[88] Armstrong immediately refused, saying, "the samples have not been maintained properly." Head of AFLD Pierre Bordry stated: "Scientifically there is no problem to analyze these samples – everything is correct" and "If the analysis is clean it would have been very good for him. But he doesn't want to do it and that's his problem."^[89] However, according to the results of an investigative report by Emile Vrijman (a Dutch lawyer and the former head of the Dutch anti-doping agency, which he headed for ten years), who was appointed by the UCI to head an independent investigations into the LNDD lab’s findings, it was determined that the analysis of the urine samples were conducted improperly and that they “did not satisfy any standard for doping control testing.”^[90][91] Vrijman’s report went on to state that handling and testing of the samples fell so far short of scientific standards, and that “the process that generated those results and the subsequent reports was so deficient” that it was "completely irresponsible" to suggest that the results could "constitute evidence of anything,” and cleared Armstrong of any wrongdoing.^{[91][92][93][94]} But WADA rejected these conclusions stating "The Vrijman report is so lacking in professionalism and objectivity that it borders on farcical.".^[95]

In June 2006, French newspaper Le Monde reported claims by Betsy and Frankie Andreu during a deposition that Armstrong had admitted using performance-enhancing drugs to his physician just after brain surgery in 1996. The Andreus' testimony was related to litigation between Armstrong and SCA Promotions, a Texas company attempting to withhold a $5-million bonus; this was settled out of court with SCA paying Armstrong and Tailwind Sports $7.5 million, to cover the $5-million bonus plus interest and lawyers' fees. The testimony stated "And so the doctor asked him a few questions, not many, and then one of the questions he asked was... have you ever used any performance-enhancing drugs? And Lance said yes. And the doctor asked, what were they? And Lance said, growth hormone, cortisone, EPO, steroids and testosterone."^[96] Armstrong suggested Betsy Andreu may have been confused by possible mention of his post-operative treatment which included steroids and EPO that are taken to counteract wasting and red-blood-cell-destroying effects of intensive chemotherapy.^[97] The Andreus' allegation was not supported by any of the eight other people present, including Armstrong's doctor Craig Nichols,^[98] or his medical history. According to Greg LeMond (who has been embroiled with his own disputes with Armstrong), he (LeMond) had a recorded conversation,^[99] the transcript of which was reviewed by National Public Radio, with Stephanie McIlvain (Armstrong's contact at Oakley Inc.) in which she said of Armstrong's alleged admission 'You know, I was in that room. I heard it.' However, McIlvain has contradicted LeMond allegations on the issue and denied under oath that the incident in question ever occurred in her sworn testimony.^[96]

In July 2006, the Los Angeles Times published a story on the allegations raised in the SCA case.^[100] The report cited evidence at the trial including the results of the LNDD test and an analysis of these results by an expert witness.^[101] From the LA Times article: "The results, Australian researcher Michael Ashenden testified in Dallas, show Armstrong's levels rising and falling, consistent with a series of injections during the Tour. Ashenden, a paid expert retained by SCA Promotions, told arbitrators the results painted a "compelling picture" that the world's most famous cyclist "used EPO in the '99 Tour."^[102] Ashenden's finding were disputed by the Vrijman report, which pointed to procedural and privacy issues in dismissing the LNDD test results. The LA Times article also provided information on testimony given by Armstrong's former teammate, Swart, Andreu and his wife Betsy and instant messaging conversation between Andreu and Jonathan Vaughters regarding blood-doping in the peloton. Vaughters signed a statement disavowing the comments and stating he had: "no personal knowledge that any team in the Tour de France, including Armstrong's Discovery team in 2005, engaged in any prohibited conduct whatsoever." Andreu signed a statement affirming the conversation took place as indicated on the instant messaging logs submitted to the court. The SCA trial was settled out of court, and the LA Times reported: "Though no verdict or finding of facts was rendered, Armstrong called the outcome proof that the doping allegations were baseless." The L.A. Times' article provides a review of the disputed positive EPO test, allegations and sworn testimony against Armstrong, but notes that: "They are filled with conflicting testimony, hearsay and circumstantial evidence admissible in arbitration hearings but questionable in more formal legal proceedings."^[103]

On May 20, 2010, former U.S. Postal teammate Floyd Landis accused Armstrong of doping in 2002 and 2003, and claimed that U.S. Postal team director Johan Bruyneel had bribed former UCI president Hein Verbruggen to keep quiet about a positive Armstrong test in 2002.^[104][105] Landis admitted there was no documentation that supports these claims.^[106] However, in July 2010 the president of the UCI, Pat McQuaid, revealed that Armstrong made two donations to the UCI: $25,000 in 2002, used by the juniors anti-doping program, and $100,000 in 2005, to buy a blood testing machine, and documentation of those payments does exist.^[107] Landis also maintains that he witnessed Armstrong receiving multiple blood transfusions, and dispensing testosterone patches to his teammates on the United States Postal Service Team.^[108] On May 25, 2010, The International Cycling Union disputed comments from Floyd Landis, "Due to the controversy following the statements made by Floyd Landis, the International Cycling Union wishes to stress that none of the tests revealed the presence of EPO in the samples taken from riders at the 2001 Tour of Switzerland," the UCI said in a statement. "The UCI has all the documentation to prove this fact." According to ESPN, "Landis claimed that Armstrong tested positive while winning in 2002, a timeline Armstrong himself said left him 'confused,' because he did not compete in the event in 2002."^[109]

On May 19, 2011, former Armstrong teammate Tyler Hamilton told CBS News that he and Armstrong had together taken EPO before and during the 1999, 2000, and 2001 Tours de France. Armstrong's attorney, Mark Fabiani, responded that Hamilton was lying.^[110] The accompanying 60 Minutes investigation alleges that two other former Armstrong teammates, Frankie Andreu and George Hincapie, have told federal investigators that they witnessed Armstrong taking banned substances, including EPO, or supplied Armstrong with such substances.^[111] Fabiani stated in response that, "We have no way of knowing what happened in the grand jury and so can't comment on these anonymously sourced reports."^[112] Hamilton further claimed that Armstrong tested positive for EPO during the 2001 Tour de Suisse; 60 Minutes reported that the Union Cycliste Internationale intervened to conceal those test results, and that donations from Armstrong totaling US$125,000 may have played into said actions.^[113] Martial Saugy, chief of the Swiss anti-doping agency, later confirmed that they found four urine samples suspicious of EPO use at the 2001 race, but said there was no "positive test" and claimed not to know whether the suspicious results belonged to Armstrong. As a result, Armstrong's lawyers demanded an apology from 60 Minutes.^[114] Instead of apologizing, CBS News chairman Jeff Fager said CBS News stands by its report as "truthful, accurate and fair", and added that the suspicious tests which Saugy confirmed to exist have been linked to Armstrong "by a number of international officials".^[115]

On February 2, 2012, U.S. federal prosecutors officially dropped their investigation with no charges.^[116]

Handling of urine tests[link]

In October 2005, in response to calls from the International Olympic Committee and the World Anti-Doping Agency (WADA) for an independent investigation, the UCI appointed Dutch lawyer Emile Vrijman to investigate the handling of urine tests by the French national anti-doping laboratory, LNDD. Vrijman was head of the Dutch anti-doping agency for ten years; since then he has worked as a defense attorney defending high-profile athletes against doping charges.^[90] Vrijman's report cleared Armstrong because of improper handling and testing.^[92][93] The report said tests on urine samples were conducted improperly and fell so short of scientific standards that it was "completely irresponsible" to suggest they "constitute evidence of anything."^[94] The recommendation of the commission's report was no disciplinary action against any rider on the basis of LNDD research. It also called upon the WADA and LNDD to submit themselves to an investigation by an outside independent authority.^[91] The WADA rejected these conclusions stating "The Vrijman report is so lacking in professionalism and objectivity that it borders on farcical.".^[95] The IOC Ethics Commission subsequently censured Dick Pound, the President of WADA and a member of the IOC, for his statements in the media that suggested wrongdoing by Armstrong.

In April 2009, Dr. Michael Ashenden said that "the LNDD absolutely had no way of knowing athlete identity from the sample they're given. They have a number on them, but that's never linked to an athlete's name. The only group that had both the number and the athlete's name is the federation, in this case it was the UCI." He added "There was only two conceivable ways that synthetic EPO could've gotten into those samples. One, is that Lance Armstrong used EPO during the '99 Tour. The other way it could've got in the urine was if, as Lance Armstrong seems to believe, the laboratory spiked those samples. Now, that's an extraordinary claim, and there's never ever been any evidence the laboratory has ever spiked an athlete's sample, even during the Cold War, where you would've thought there was a real political motive to frame an athlete from a different country. There's never been any suggestion that it happened."^[117]

Dr. Michael Ashenden's statements are at odds with the findings of the Vrijman report "According to Mr. Ressiot, the manner in which the LNDD had structured the results table of its report – i.e. listing the sequence of each of the batches, as well as the exact number of urine samples per batch, in the same (chronological) order as the stages of the 1999 Tour de France they were collected at – was already sufficient to allow him to determine the exact stage these urine samples referred to and subsequently the identity of the riders who were tested at that stage." The Vrijman report also says "Le Monde of July 21 and 23, 1999 reveal that the press knew the contents of original doping forms of the 1999 Tour de France".^[91]

Armstrong's work outside of cycling[link]

In 1997, Armstrong founded the Lance Armstrong Foundation, which supports people affected by cancer. The foundation has become one of the top 10 groups funding cancer research in the U.S., raising more than $325 million from the sale of yellow Livestrong bracelets^[118] During his original retirement beginning after the 2005 season, he also maintained other interests. He was the pace car driver of the Chevrolet Corvette Z06 for the 2006 Indianapolis 500.

In 2007, Armstrong with Andre Agassi, Muhammad Ali, Warrick Dunn, Jeff Gordon, Mia Hamm, Tony Hawk, Andrea Jaeger, Jackie Joyner-Kersee, Mario Lemieux, Alonzo Mourning, and Cal Ripken, Jr. founded Athletes for Hope, a charity which helps professional athletes get involved in charitable causes and inspires non-athletes to volunteer and support the community.^[119] In 2008 and 2009 he appeared on the PBS Kids show Arthur as himself. In these two appearances he taught biking skills and helped spread cancer awareness, respectively.

In August 2009, Armstrong headlined the inaugural charity ride "Pelotonia" in Columbus, Ohio, riding over 100 miles on Saturday with the large group of cyclists. He personally addressed the riders the Friday evening before the two-day ride and helped the ride raise millions for cancer research.^[120]

Marathon[link]

Armstrong ran the 2006 New York City Marathon with friends Robert McElligott and Lewis Miles. With Nike, he assembled a pace team of Alberto Salazar, Joan Benoit Samuelson, and Hicham El Guerrouj to help him reach 3 hours. He struggled with shin splints and was on pace for a little above 3 hours but pushed through the last 5 miles (8.0 km) to 2h 59m 36s, finishing 856th. He said the race was extremely difficult compared to the Tour de France. "For the level of condition that I have now, that was without a doubt the hardest physical thing I have ever done. I never felt a point where I hit the wall. It was really a gradual progression of fatigue and soreness."^[121] The NYC Marathon had a dedicated camera on Armstrong throughout the event.^[122] This camera, according to Armstrong, pushed him to continue through points in which he would have normally "stopped and stretched". He also helped raise $600,000 for his LiveStrong campaign during the run.

Armstrong ran the 2007 NYC Marathon in 2h 46m 43s finishing 232nd.^[123] On April 21, 2008, he ran the Boston Marathon in 2h 50m 58s, finishing in the top 500.^[124]

Triathlon[link]

Armstrong made his return to triathlon in the inaugural Ironman 70.3 Panama race, on February 12, 2012. He raced in the Professional category, finishing with a time of 3:50:55, 2nd overall to Bevan Docherty.^[125] Armstrong's splits were 19:22 for the 1.2 mile swim, 2:10:18 for the 56 mile bike, and 1:17:01 for the run.^[126] He also entered half-Ironman distance races in Texas (7th^[127]) and St. Croix (3rd^[128]) before breaking through with a victory at Ironman 70.3 Florida in an overall time of 3:45:38^[129]. Armstrong also plans to race in Ironman France in an attempt to qualify for the 2012 World Ironman Championship in Kona, Hawaii.^[130]

Politics[link]

President George W. Bush and Armstrong mountain biking at the president's Prairie Chapel Ranch

In the New York Times, teammate George Hincapie hinted that Armstrong would run for Governor of Texas after cycling. In the July 2005 issue of Outside, Armstrong hinted at running for governor, although "not in '06".^[131] Armstrong and former president George W. Bush, a Republican and fellow Texan, call themselves friends. Bush called Armstrong in France to congratulate him after his 2005 victory, and in August 2005, The Times reported the President had invited Armstrong to his Prairie Chapel Ranch to go mountain biking.^[132] In a 2003 interview with The Observer, Armstrong said: "He's a personal friend, but we've all got the right not to agree with our friends."^[133]

In August 2005, Armstrong hinted he had changed his mind about politics. In an interview with Charlie Rose on PBS on August 1, 2005, Armstrong pointed out that running for governor would require the commitment that led him to retire from cycling. Again, on August 16, 2005, Armstrong told a local Austin CBS affiliate^[134] that he was no longer considering politics:

"The biggest problem with politics or running for the governor—the governor's race here in Austin or in Texas—is that it would mimic exactly what I've done: a ton of stress and a ton of time away from my kids. Why would I want to go from pro cycling, which is stressful and a lot of time away, straight into politics?"^{[citation needed]}

He does intend to be involved in politics as an activist for change in cancer policies, however. In a May 2006 interview with Sports Illustrated, Armstrong is quoted: "I need to run for one office, the presidency of the Cancer Fighters' Union of the World."^{[citation needed]} Sports Illustrated quoted Armstrong that he fears halving his influence with legislators if he chose one side in politics. His foundation lobbies on behalf of cancer patients before United States Congress.

Armstrong is currently co-chair of a California campaign committee to pass the California Cancer Research Act, a ballot measure to be decided by California voters on June 5, 2012.^[135] If passed, the measure is projected to generate over $500 million dollars annually for cancer research by levying a new $1-per-pack tax on tobacco products in California. Revenues will also be spent on smoking-cessation programs, and tobacco law-enforcement.^[136]

Teams and victories[link]

Filmography[link]

• The Road to Paris (himself, 2000 documentary)
• Dodgeball: A True Underdog Story (himself, cameo)

Accolades[link]

• United States Olympic Committee (USOC) SportsMan of the Year (1999, 2001, 2002, 2003)
• Associated Press Male Athlete of the Year (2002, 2003, 2004, 2005)
• World's Most Outstanding Athlete Award, Jesse Owens International Trophy (2000)
• Reuters Sportsman of the Year (2003)
• Prince of Asturias Award in Sports (2000)
• Sports Ethics Fellows by the Institute for International Sport (2003)
• Laureus World Sports Award for Sportsman of the Year (2003)
• Laureus World Sports Award for Comeback of the Year (2000)
• Trophee de L'Academie des Sport [France] (2004)
• Vélo d'Or Award by Velo Magazine in France (1999, 2000, 2001, 2003, 2004)
• Mendrisio d'Or Award in Switzerland (1999)
• Premio Coppi-Bici d'Oro Trophy by the Fausto Coppi foundation in conjunction with La Gazzetta dello Sport (1999, 2000)
• Marca Legend Award by Marca, a Spanish sports daily in Madrid (2004)
• BBC Sports Personality of the Year Overseas Personality Award (2003)
• ESPY Award for Best Male Athlete (2003, 2004, 2005, 2006)
• ESPY Award for GMC Professional Grade Play Award (2005)
• ESPY Award for Best Comeback Athlete (2000)
• ESPN/Intersport's ARETE Award for Courage in Sport (Professional Division) (1999)
• ABC's Wide World of Sports Athlete of the Year (1999)
• Favorite Athlete award at Nickelodeon Kids' Choice Awards (2006)
• Presidential Delegation to the XIX Olympic Winter Games (2002)^[137]
• Sports Illustrated magazine's Sportsman of the Year (2002)
• VeloNews magazine's International Cyclist of the Year (2000, 2001, 2003, 2004)
• VeloNews magazine's North American Male Cyclist of the Year (1993, 1995, 1996, 1998, 1999, 2002, 2005)
• William Hill Sports Book of the Year: It's Not About the Bike: My Journey Back to Life (2000)^[138]
• Union Cycliste Internationale: World Number 1 Ranked Elite Men's Cyclist (1996)
• Triathlon magazine's Rookie of the Year (1988)
• Pace car driver for the Indianapolis 500 (2006)
• An asteroid, 1994 JE₉ was named 12373 Lancearmstrong in honor of him.
• Honorary Doctorate of Humane Letters, Tufts University (2006)
• Mildred "Babe" Didrikson Zaharias Courage Award presented by the United States Sports Academy (1999)

See also[link]

• Cycling records
• List of doping cases in cycling
• List of sportspeople cleared of doping charges

References[link]