Epinephrine (adrenaline), a catecholamine-type hormone

A hormone (from Greek ὁρμή, "impetus") is a chemical released by a cell or a gland in one part of the body that sends out messages that affect cells in other parts of the organism. Only a small amount of hormone is required to alter cell metabolism. In essence, it is a chemical messenger that transports a signal from one cell to another.^[1] All multicellular organisms produce hormones; plant hormones are also called phytohormones. Hormones in animals are often transported in the blood. Cells respond to a hormone when they express a specific receptor for that hormone. The hormone binds to the receptor protein, resulting in the activation of a signal transduction mechanism that ultimately leads to cell type-specific responses.

Endocrine hormone molecules are secreted (released) directly into the bloodstream, whereas exocrine hormones (or ectohormones) are secreted directly into a duct, and, from the duct, they flow either into the bloodstream or from cell to cell by diffusion in a process known as paracrine signalling.

Recently it has been found that a variety of exogenous modern chemical compounds have hormone-like effects on both humans and wildlife. Their interference with the synthesis, secretion, transport, binding, action, or elimination of natural hormones in the body can change the homeostasis, reproduction, development, and/or behavior, just as endogenously produced hormones do."^[2]

Hormones as signals[link]

Hormonal signaling involves the following:^{[citation needed]}

1. Biosynthesis of a particular hormone in a particular tissue
2. Storage and secretion of the hormone
3. Transport of the hormone to the target cell(s)
4. Recognition of the hormone by an associated cell membrane or intracellular receptor protein
5. Relay and amplification of the received hormonal signal via a signal transduction process: This then leads to a cellular response. The reaction of the target cells may then be recognized by the original hormone-producing cells, leading to a down-regulation in hormone production. This is an example of a homeostatic negative feedback loop.
6. Degradation of the hormone.

Hormone cells are typically of a specialized cell type, residing within a particular endocrine gland, such as thyroid gland, ovaries, and testes. Hormones exit their cell of origin via exocytosis or another means of membrane transport. The hierarchical model is an oversimplification of the hormonal signaling process. Cellular recipients of a particular hormonal signal may be one of several cell types that reside within a number of different tissues, as is the case for insulin, which triggers a diverse range of systemic physiological effects. Different tissue types may also respond differently to the same hormonal signal. Because of this, hormonal signaling is elaborate and hard to dissect.^{[citation needed]}

Interactions with receptors[link]

Most hormones initiate a cellular response by initially combining with either a specific intracellular or cell membrane associated receptor protein. A cell may have several different receptors that recognize the same hormone and activate different signal transduction pathways, or a cell may have several different receptors that recognize different hormones and activate the same biochemical pathway.

For many hormones, including most protein hormones, the receptor is membrane-associated and embedded in the plasma membrane at the surface of the cell. The interaction of hormone and receptor typically triggers a cascade of secondary effects within the cytoplasm of the cell, often involving phosphorylation or dephosphorylation of various other cytoplasmic proteins, changes in ion channel permeability, or increased concentrations of intracellular molecules that may act as secondary messengers (e.g., cyclic AMP). Some protein hormones also interact with intracellular receptors located in the cytoplasm or nucleus by an intracrine mechanism.

For hormones such as steroid or thyroid hormones, their receptors are located intracellularly within the cytoplasm of their target cell. To bind their receptors, these hormones must cross the cell membrane. They can do so because they are lipid-soluble. The combined hormone-receptor complex then moves across the nuclear membrane into the nucleus of the cell, where it binds to specific DNA sequences, effectively amplifying or suppressing the action of certain genes, and affecting protein synthesis.^[3] However, it has been shown that not all steroid receptors are located intracellularly. Some are associated with the plasma membrane.^[4]

An important consideration, dictating the level at which cellular signal transduction pathways are activated in response to a hormonal signal, is the effective concentration of hormone-receptor complexes that are formed. Hormone-receptor complex concentrations are effectively determined by three factors:

1. The number of hormone molecules available for complex formation
2. The number of receptor molecules available for complex formation
3. The binding affinity between hormone and receptor.

The number of hormone molecules available for complex formation is usually the key factor in determining the level at which signal transduction pathways are activated, the number of hormone molecules available being determined by the concentration of circulating hormone, which is in turn influenced by the level and rate at which they are secreted by biosynthetic cells. The number of receptors at the cell surface of the receiving cell can also be varied, as can the affinity between the hormone and its receptor.

Physiology of hormones[link]

Most cells are capable of producing one or more molecules, which act as signaling molecules to other cells, altering their growth, function, or metabolism. The classical hormones produced by cells in the endocrine glands mentioned so far in this article are cellular products, specialized to serve as regulators at the overall organism level. However, they may also exert their effects solely within the tissue in which they are produced and originally released.

The rate of hormone biosynthesis and secretion is often regulated by a homeostatic negative feedback control mechanism. Such a mechanism depends on factors that influence the metabolism and excretion of hormones. Thus, higher hormone concentration alone cannot trigger the negative feedback mechanism. Negative feedback must be triggered by overproduction of an "effect" of the hormone.

Hormone secretion can be stimulated and inhibited by:

• Other hormones (stimulating- or releasing -hormones)
• Plasma concentrations of ions or nutrients, as well as binding globulins
• Neurons and mental activity
• Environmental changes, e.g., of light or temperature

One special group of hormones is the tropic hormones that stimulate the hormone production of other endocrine glands. For example, thyroid-stimulating hormone (TSH) causes growth and increased activity of another endocrine gland, the thyroid, which increases output of thyroid hormones.

A recently identified class of hormones is that of the "hunger hormones" - ghrelin, orexin, and PYY 3-36 - and "satiety hormones" - e.g., cholecystokinin, leptin, nesfatin-1, obestatin.

To release active hormones quickly into the circulation, hormone biosynthetic cells may produce and store biologically inactive hormones in the form of pre- or prohormones. These can then be quickly converted into their active hormone form in response to a particular stimulus.

Effects of hormones[link]

Hormones have the following effects on the body:

• stimulation or inhibition of growth
• mood swings
• induction or suppression of apoptosis (programmed cell death)
• activation or inhibition of the immune system
• regulation of metabolism
• preparation of the body for mating, fighting, fleeing, and other activity
• preparation of the body for a new phase of life, such as puberty, parenting, and menopause
• control of the reproductive cycle
• hunger cravings
• sexual arousal

A hormone may also regulate the production and release of other hormones. Hormone signals control the internal environment of the body through homeostasis.

Chemical classes of hormones[link]

Vertebrate hormones fall into three chemical classes:

• Peptide hormones consist of chains of amino acids. Examples of small peptide hormones are TRH and vasopressin. Peptides composed of scores or hundreds of amino acids are referred to as proteins. Examples of protein hormones include insulin and growth hormone. More complex protein hormones bear carbohydrate side-chains and are called glycoprotein hormones. Luteinizing hormone, follicle-stimulating hormone and thyroid-stimulating hormone are glycoprotein hormones. There is also another type of hydrophilic hormone called nonpeptide hormones. Although they don't have peptide connections, they are assimilated as peptide hormones.
• Lipid and phospholipid-derived hormones derive from lipids such as linoleic acid and arachidonic acid and phospholipids. The main classes are the steroid hormones that derive from cholesterol and the eicosanoids. Examples of steroid hormones are testosterone and cortisol. Sterol hormones such as calcitriol are a homologous system. The adrenal cortex and the gonads are primary sources of steroid hormones. Examples of eicosanoids are the widely studied prostaglandins.
• Monoamines derived from aromatic amino acids like phenylalanine, tyrosine, tryptophan by the action of aromatic amino acid decarboxylase enzymes.

Pharmacology[link]

Many hormones and their analogues are used as medication. The most commonly prescribed hormones are estrogens and progestagens (as methods of hormonal contraception and as HRT), thyroxine (as levothyroxine, for hypothyroidism) and steroids (for autoimmune diseases and several respiratory disorders). Insulin is used by many diabetics. Local preparations for use in otolaryngology often contain pharmacologic equivalents of adrenaline, while steroid and vitamin D creams are used extensively in dermatological practice.

A "pharmacologic dose" of a hormone is a medical usage referring to an amount of a hormone far greater than naturally occurs in a healthy body. The effects of pharmacologic doses of hormones may be different from responses to naturally occurring amounts and may be therapeutically useful. An example is the ability of pharmacologic doses of glucocorticoid to suppress inflammation.

Important human hormones[link]

See: List of human hormones

See also[link]

References[link]

External links[link]

• The Hormone Foundation
• Article on hormones and their receptors
• HMRbase: A database of hormones and their receptors
• Hormones at the US National Library of Medicine Medical Subject Headings (MeSH)

Suzanne Somers
Suzanne Somers, May 2006
Born	Suzanne Marie Mahoney (1946-10-16) October 16, 1946 (age 65) San Bruno, California, U.S.
Occupation	Actress, author, businesswoman, singer
Years active	1963–present
Spouse	Bruce Somers (1965–1968) Alan Hamel (1977–present)
Website
http://www.suzannesomers.com/

Suzanne Somers (born as Suzanne Marie Mahoney on October 16, 1946) is an American actress, author, singer and businesswoman, known for her television roles as Chrissy Snow on Three's Company and as Carol Lambert on Step by Step.

Somers later became the author of a series of best-selling self-help books, including Ageless: The Naked Truth About Bioidentical Hormones (2006), a book about bioidentical hormone replacement therapy.^[1] She has also released two autobiographies, four diet books, and a book of poetry entitled "Touch Me" (1980). She currently features items of her design on ShopNBC.^{[citation needed]}

She is criticized for her views on some medical subjects and her advocacy of the Wiley Protocol, which has been labelled as "scientifically unproven and dangerous".^[2][3] Her promotion of alternative cancer treatments has received criticism from the American Cancer Society.^[4]

Personal life[link]

Born Suzanne Marie Mahoney in San Bruno, California, Somers was the third of four children in an Irish Catholic family.^[5][6][7] Her mother, Marion Elizabeth (née Turner), was a medical secretary, and her father, Francis Mahoney, was a laborer (loading beer into boxcars) and gardener.^[8] Her family attended church at St. Robert's Catholic Church in San Bruno.

She attended Capuchino High School,^[9][10] then she was accepted at San Francisco College for Women (commonly referred to as "Lone Mountain College") a Catholic school that is now a campus of the University of San Francisco.

She was a contestant on Anniversary Game (1969–70), where she met host Alan Hamel for the first time; they were married in 1977.

In 2001 Somers announced that she had breast cancer, having a lumpectomy to remove the cancer followed by radiation therapy. She decided to forego chemotherapy in favor of alternative treatment.^[11]

On January 9, 2007, the Associated Press reported that a wildfire in Southern California had destroyed Somers' Malibu home.^[12]

Career[link]

Early acting roles[link]

She began acting in small roles during the late 1960s and early 1970s (including on various talk shows promoting her book of poetry, and bit parts in movies such as the "Blonde in the T-Bird" in American Graffiti, and an episode of the American version of the sitcom Lotsa Luck as the femme fatale in the early 1970s). She appeared in The Rockford Files and had an uncredited role as a topless pool girl in Magnum Force, both in 1974. She next guest starred on the 1977 episode "Cheshire Project" on The Six Million Dollar Man. She later landed the role of the ditzy blonde "Chrissy Snow" on the ABC sitcom Three's Company in 1977. And also that year she was a celebrity panelist on Match Game.

[edit] Three's Company

Suzanne Somers on the USS Ranger (CV-61) in 1981, during the time she was cast off of Three's Company

At the beginning of the fifth season, Somers demanded a hefty raise from $30,000 to $150,000 an episode and 10% ownership of the show's profit. Those close to the situation suggested that Somers' rebellion was due to husband Hamel's influences. When ABC denied her request, Somers boycotted the second and fourth shows of the season, due to several excuses such as a broken rib (which was false). She finished the remaining season on her contract, but her role was decreased to 60 seconds per episode. After her contract was terminated, she sued ABC for $2 million, claiming that her credibility in show business had been damaged. It went to an arbitrator who decided that Somers was owed only $30,000 due to a single missed episode for which she had not been paid. Other rulings favored the producers. Somers has said she was fired because she asked to be paid as much as male actors like Alan Alda of M*A*S*H, and Carroll O'Connor of Archie Bunker's Place.^[13]

Before the feud with Three's Company producers and ABC ended, rival network CBS knew that Somers was ultimately going to be available. They signed her to a contract and a development deal for her own sitcom, which was going to be called The Suzanne Somers Show, in which she was to play an "over-the-top" airline stewardess. Once she was indeed available (after her firing from Three's Company), CBS gave Somers – and the public – a timeframe in which to expect the show to hit the air, but due to a change in administration at CBS' entertainment division in early 1982, the brass ended up passing on the project. Also, Somers claimed in her book After the Fall (1998), that the producers of Three's Company kept sending cease and desist forms to CBS stating that Somers could not use any of her Chrissy Snow characterization, and that chilled the creative process.

[edit] Playboy pictorials

Somers appeared in two Playboy cover-feature nude pictorials: in 1980 and 1984. The first set of photos was taken by Stan Malinowski in February 1970 when Somers was a struggling model and actress and did a test photoshoot for the magazine. She was accepted as a Playmate candidate in 1971, but declined to pose nude before the actual shoot. During a Tonight Show appearance, she denied ever posing nude (except for a High Society topless photo), which prompted Playboy into publishing the photos from the 1970 Malinowski shoot in February 1980.^[14] The second nude pictorial by Richard Fegley appeared in December 1984 in an attempt by Somers to regain her popularity after being terminated by Three's Company in 1982.

Spokeswoman for the Thighmaster[link]

During the 1980s, Somers became a Las Vegas entertainer. She was the spokeswoman for the Thighmaster, a piece of exercise equipment that is squeezed between one's thighs. Thighmaster was one of the first products responsible for launching the infomercial concept.^{[citation needed]} During this period of her career, she also performed for US servicemen overseas.^[15][16]

[edit] She's the Sheriff

At the height of her exposure as official spokesperson for Thighmaster infomercials, Somers made her first return to a series, although not on network television. In 1987, she starred in the sitcom She's the Sheriff, which ran in first-run syndication. Somers portrayed a widow with two young kids who decided to fill the shoes of her late husband, a sheriff of a southern town. The show ran for two seasons.

[edit] Step by Step

In 1990, Somers returned to network TV, appearing in numerous guest roles and made-for-TV movies, mostly for ABC. Her roles in these, including the movie Rich Men, Single Women, attracted the attention of Lorimar Television and Miller-Boyett Productions, who were developing a new sitcom. Somers had starred in the film with Heather Locklear, who inadvertently directed the focus of both production companies to Somers due to Locklear's starring role on Going Places (from Lorimar and Miller/Boyett). For Lorimar, this was asking Somers back, since they alone had produced She's the Sheriff.

In September 1991, Somers returned to TV starring in the sitcom Step By Step (with Patrick Duffy), which ran for seven seasons. Playing off her rejuvenated career, Somers also launched a daytime talk show in 1994, albeit briefly, titled Suzanne Somers. During Step By Step's final season, on CBS, she began co-hosting Candid Camera with Peter Funt.

[edit] Candid cohost

From 1997–99, Somers cohosted the revised Candid Camera show, when CBS chose to bring it back with Peter Funt. Somers stayed for two years before PAX TV renewed the series without her.

[edit] The Blonde in the Thunderbird

Somers receiving patriotic civilian service award for past USO tour performances after performing The Blonde in the Thunderbird for members of the US military and their families.

In summer 2005, Somers made her Broadway debut in a one-woman show, The Blonde in the Thunderbird, a collection of stories about her life and career. The show was supposed to run until September, but was cancelled in less than a week after poor reviews and disappointing ticket sales.^[17] Somers blamed the harsh reviews (The New York Times referred to it as "...a drab and embarrassing display of emotional exhibitionism masquerading as entertainment"^[18]) and told the New York Post: "These men [New York critics] are curmudgeons, and maybe I went too close to the bone for them. I was lying there naked, and they decided to kick me and step on me, just like these visions you see in Iraq."^[19]

[edit] Breaking Through

In 2012, Somers began an online talk show, Suzanne Somers Breaking Through, at CafeMom. Three of the episodes featured a reunion with Joyce DeWitt, the two speaking with each other for the first time in thirty years.^[20]

Views on medical subjects[link]

Somers supports bioidentical hormone replacement therapy. Her book, Ageless,^[21] includes interviews with 16 practitioners of bioidentical hormone therapy, but gives extra discussion to one specific approach, the 'Wiley Protocol'. Somers and T. S. Wiley, the originator of the Wiley Protocol, have been criticized for their advocacy of the Wiley Protocol. A group of seven doctors, all of whom utilize bioidentical hormone therapies to address health issues in women, issued a public letter to Somers and her publisher, Crown, in which they state that the protocol is "scientifically unproven and dangerous" and cite Wiley's lack of medical and clinical qualifications.^[2] The use of bioidentical hormone therapies is a very controversial area of medicine;^[3] its efficacy has never been tested and numerous groups have expressed concern over its safety and the misleading claims made by practitioners.^[22]

Her promotion of them, and Oprah Winfrey's support of her, has been the subject of an Associated Press article:^[4]

The problem, for many doctors: These custom-compounded products are not approved by the Food and Drug Administration.

Somers, whose hormone regimen involves creams, injections and some 60 supplements daily, got a huge boost earlier this year from Oprah Winfrey. "Many people write Suzanne off as a quackadoo," Winfrey said when Somers appeared on her show. "But she just might be a pioneer."

Yet Winfrey's tacit support of Somers gave her some of the worst press of her career. "Crazy Talk," Newsweek headlined an article on the talk show host earlier this year. Another headline, on Salon.com: "Oprah's Bad Medicine."^[4]

In 2001, Somers was diagnosed with breast cancer. She had a lumpectomy, and radiation, but declined to undergo chemotherapy.^[3] In November, 2008, Suzanne Somers announced she was diagnosed with inoperable cancer by six doctors, but Somers learned a week later that she was misdiagnosed. During this time, she interviewed doctors about cancer treatments and these interviews became the basis of her book, Knockout, about alternative treatments to chemotherapy.^[23] In her book Knockout, Somers promotes alternative cancer treatments, for which she has received criticism from the American Cancer Society:

The American Cancer Society is concerned.
"I am very afraid that people are going to listen to her message and follow what she says and be harmed by it," says Dr. Otis Brawley, the organization's chief medical officer. "We use current treatments because they've been proven to prolong life. They've gone through a logical, scientific method of evaluation. I don't know if Suzanne Somers even knows there IS a logical, scientific method."
More broadly, Brawley is concerned that in the United States, celebrities or sports stars feel they can use their fame to dispense medical advice. "There's a tendency to oversimplify medical messages," he says. "Well, oversimplification can kill."^[4]

She is also opposed to water fluoridation.^[24]

In the movie "Sex and the City 2" Samantha, one of the characters, advocates Suzanne Somers' book and method of bioidentical hormone replacement therapy ^[25]

Television work[link]

• Anniversary Game (1969–1970)
• Mantrap (1971–1973)
• Lotsa Luck (c1973)
• The Big Ripoff (The Rockford Files) (Aired Oct, 1974)
• Sky Heist (1975)
• Match Game ('77/PM) (1977)
• It Happened at Lakewood Manor (1977)
• Three's Company (cast member from 1977–1981)
• Happily Ever After (1978)
• Zuma Beach (1978)
• Hollywood Wives (1985) (miniseries)
• Goodbye Charlie (1985)
• She's the Sheriff (1987–1989)
• Rich Men, Single Women (1990)
• Step by Step (1991–1998)
• Keeping Secrets (1991)
• Exclusive (1992) (also co-executive producer)
• The Suzanne Somers Show (1994–1995)
• Seduced by Evil (1994)
• 8-Track Flashback (1995-1998)
• Devil's Food (1996)
• Love-Struck (1997)
• No Laughing Matter (1998)
• Candid Camera (co-host from 1998–2000)
• The Darklings (1999)
• Kathy Griffin: My Life on the D-List (2009) (Guest appearance)
• ShopNBC

Filmography[link]

• Bullitt (1968)
• Daddy's Gone A-Hunting (1969)
• American Graffiti (1973)
• Magnum Force (1973) (uncredited)
• Ants (1977)
• Billy Jack Goes to Washington (1977)
• Yesterday's Hero (1979)
• Nothing Personal (1980)
• Totally Minnie (1987)
• Serial Mom (1994) (cameo)
• Rusty: A Dog's Tale (1998) (voice)
• Say It Isn't So (2001) (cameo)

Bibliography[link]

Suzanne Somers at the Ina Soltani

• Somers, S (1980). Touch Me: The Poems of Suzanne Somers. Workman Pub Co. ISBN 0-89480-141-4. 
• Somers, S (1987). Keeping Secrets. Warner Books. ISBN 978-0-446-51395-1. 
• Somers, S (1992). Wednesday's Children: Adult Survivors of Abuse Speak Out. Putnam Adult. ISBN 0-399-13743-2. 
• Somers, S (1998). After the Fall: How I Picked Myself Up, Dusted Myself Off, and Started All Over Again. Crown Publishing Group. ISBN 0-609-60312-4. 
• Somers, S (1999). Suzanne Somers' Get Skinny on Fabulous Food. Crown Publishing Group. ISBN 978-0-609-60162-4. 
• Somers, S (1999). Suzanne Somers' 365 Ways to Change Your Life. Crown Publishing Group. ISBN 978-0-609-60161-7. 
• Somers, S (2001). Suzanne Somers' Eat, Cheat, and Melt the Fat Away. Crown Publishing Group. ISBN 978-0-609-60722-0. 
• Somers, S (2001). Suzanne Somers' Eat Great, Lose Weight (Miniature Editions). Running Press. ISBN 978-0-7624-1160-3. 
• Somers, S (2001). Somersize Desserts. Clarkson Potter. ISBN 978-0-609-60977-4. 
• Somers, S (2002). Suzanne Somers' Fast and Easy: Lose Weight the Somersize Way with Quick, Delicious Meals for the Entire Family!. Crown Publishing Group. ISBN 978-1-4000-4643-0. 
• Somers, S (2004). The Sexy Years: Discover the Hormone Connection - The Secret to Fabulous Sex, Great Health, and Vitality, for Women and Men. Crown Publishing Group. ISBN 0-609-60721-9. 
• Somers, S (2004). Somersize Chocolate. Crown Publishing Group. ISBN 978-1-4000-5329-2. 
• Somers, S (2005). Suzanne Somers' Slim and Sexy Forever: The Hormone Solution for Permanent Weight Loss and Optimal Living. Crown Publishing Group. ISBN 978-1-4000-5325-4. 
• Somers, S (2005). Somersize Cocktails: 30 Sexy Libations from Cool Classics to Unique Concoctions to Stir Up Any Occasion. Crown Publishing Group. ISBN 978-1-4000-5330-8. 
• Somers, S (2005). Somersize Appetizers: 30 Scintillating Starters to Tantalize Your Tastebuds at Every Occasion. Crown Publishing Group. ISBN 978-1-4000-5331-5. 
• Somers, S (2006). Ageless: The Naked Truth About Bioidentical Hormones. Crown Publishing Group. ISBN 0-307-23724-9. 
• Somers, S (2008). Breakthrough: Eight Steps to Wellness. Crown Publishing Group. ISBN 1-4000-5327-7. 
• Somers, S (2009). Knockout: Interviews with Doctors Who Are Curing Cancer--And How to Prevent Getting It in the First Place. Crown Publishing Group. ISBN 978-0-307-58746-6. 
• Somers, S (2009). Stay Young & Sexy with Bio-Identical Hormone Replacement: The Science Explained. Smart Publications. ISBN 978-1-890572-22-8. 
• Somers, S (2010). Sexy Forever: How to Fight Fat after Forty. Crown Publishing Group. ISBN 978-0-307-58851-7. 

References[link]

External links[link]

Wikimedia Commons has media related to: Suzanne Somers

• Official website
• Suzanne Somers at the Internet Movie Database
• Suzanne Somers at AllRovi