Sleeping child

Sleep is a naturally recurring state characterized by reduced or absent consciousness, relatively suspended sensory activity, and inactivity of nearly all voluntary muscles.^[1] It is distinguished from quiet wakefulness by a decreased ability to react to stimuli, and is more easily reversible than being in hibernation or a coma. Sleep is a heightened anabolic state, accentuating the growth and rejuvenation of the immune, nervous, skeletal and muscular systems. It is observed in all mammals, all birds, and many reptiles, amphibians, and fish.

The purposes and mechanisms of sleep are only partially clear and are the subject of intense research.^[2] Sleep is often thought to help conserve energy,^[3][4] but decreases metabolism only about 5–10%.^[3][4] Hibernating animals need to sleep despite the hypometabolism seen in hibernation, and must return from hypothermia to euthermia in order to sleep, making sleeping "energetically expensive."^[5]

Physiology[link]

Sleep stages[link]

In mammals and birds, sleep is divided into two broad types: rapid eye movement (REM) and non-rapid eye movement (NREM or non-REM) sleep. Each type has a distinct set of associated physiological, neurological, and psychological features. The American Academy of Sleep Medicine (AASM) further divides NREM into three stages: N1, N2, and N3, the last of which is also called delta sleep or slow-wave sleep (SWS).^[6]

Hypnogram showing sleep cycles from midnight to 6.30 am, with deep sleep early on. There is more REM (marked red) before waking.

Stage N3 sleep; EEG highlighted by red box. Thirty seconds of deep sleep, here with greater than 50% delta waves.

REM sleep; EEG highlighted by red box; eye movements highlighted by red line. Thirty seconds of sleep.

Sleep proceeds in cycles of REM and NREM, the order normally being N1 → N2 → N3 → N2 → REM. There is a greater amount of deep sleep (stage N3) earlier in the sleep cycle, while the proportion of REM sleep increases later in the sleep cycle and just before natural awakening.

The stages of sleep were first described in 1937 by Alfred Lee Loomis and his coworkers, who separated the different electroencephalography (EEG) features of sleep into five levels (A to E), which represented the spectrum from wakefulness to deep sleep.^[7] In 1953, REM sleep was discovered as distinct, and thus William Dement and Nathaniel Kleitman reclassified sleep into four NREM stages and REM.^[8] The staging criteria were standardized in 1968 by Allan Rechtschaffen and Anthony Kales in the "R&K sleep scoring manual."^[9] In the R&K standard, NREM sleep was divided into four stages, with slow-wave sleep comprising stages 3 and 4. In stage 3, delta waves made up less than 50% of the total wave patterns, while they made up more than 50% in stage 4. Furthermore, REM sleep was sometimes referred to as stage 5.

In 2004, the AASM commissioned the AASM Visual Scoring Task Force to review the R&K scoring system. The review resulted in several changes, the most significant being the combination of stages 3 and 4 into Stage N3. The revised scoring was published in 2007 as The AASM Manual for the Scoring of Sleep and Associated Events.^[10] Arousals and respiratory, cardiac, and movement events were also added.^[11][12]

Sleep stages and other characteristics of sleep are commonly assessed by polysomnography in a specialized sleep laboratory. Measurements taken include EEG of brain waves, electrooculography (EOG) of eye movements, and electromyography (EMG) of skeletal muscle activity. In humans, the average length of the first sleep cycle is approximately 90 minutes and 100 to 120 minutes from the second to the fourth cycle, which is usually the last one.^[13] Each stage may have a distinct physiological function and this can result in sleep that exhibits loss of consciousness but does not fulfill its physiological functions (i.e., one may still feel tired after apparently sufficient sleep).

Scientific studies on sleep have shown that sleep stage at awakening is an important factor in amplifying sleep inertia. Alarm clocks involving sleep stage monitoring appeared on the market in 2005.^[14] Using sensing technologies such as EEG electrodes or accelerometers, these alarm clocks are supposed to wake people only from light sleep.

NREM sleep[link]

According to the 2007 AASM standards, NREM consists of three stages. There is relatively little dreaming in NREM.

Stage N1 refers to the transition of the brain from alpha waves having a frequency of 8–13 Hz (common in the awake state) to theta waves having a frequency of 4–7 Hz. This stage is sometimes referred to as somnolence or drowsy sleep. Sudden twitches and hypnic jerks, also known as positive myoclonus, may be associated with the onset of sleep during N1. Some people may also experience hypnagogic hallucinations during this stage. During N1, the subject loses some muscle tone and most conscious awareness of the external environment.

Stage N2 is characterized by sleep spindles ranging from 11 to 16 Hz (most commonly 12–14 Hz) and K-complexes. During this stage, muscular activity as measured by EMG decreases, and conscious awareness of the external environment disappears. This stage occupies 45–55% of total sleep in adults.

Stage N3 (deep or slow-wave sleep) is characterized by the presence of a minimum of 20% delta waves ranging from 0.5–2 Hz and having a peak-to-peak amplitude >75 μV. (EEG standards define delta waves to be from 0 to 4 Hz, but sleep standards in both the original R&K, as well as the new 2007 AASM guidelines have a range of 0.5–2 Hz.) This is the stage in which parasomnias such as night terrors, nocturnal enuresis, sleepwalking, and somniloquy occur. Many illustrations and descriptions still show a stage N3 with 20–50% delta waves and a stage N4 with greater than 50% delta waves; these have been combined as stage N3.

REM sleep[link]

Rapid eye movement sleep, or REM sleep (also known as paradoxical sleep), accounts for 20–25% of total sleep time in most human adults. The criteria for REM sleep include rapid eye movements as well as a rapid low-voltage EEG. Most memorable dreaming occurs in this stage. At least in mammals, a descending muscular atonia is seen. Such paralysis may be necessary to protect organisms from self-damage through physically acting out scenes from the often-vivid dreams that occur during this stage.

Timing[link]

The human biological clock

Sleep timing is controlled by the circadian clock, sleep-wake homeostasis, and in humans, within certain bounds, willed behavior. The circadian clock—an inner timekeeping, temperature-fluctuating, enzyme-controlling device—works in tandem with adenosine, a neurotransmitter that inhibits many of the bodily processes associated with wakefulness. Adenosine is created over the course of the day; high levels of adenosine lead to sleepiness^{[citation needed]}. In diurnal animals, sleepiness occurs as the circadian element causes the release of the hormone melatonin and a gradual decrease in core body temperature. The timing is affected by one's chronotype. It is the circadian rhythm that determines the ideal timing of a correctly structured and restorative sleep episode.^[15]

Homeostatic sleep propensity (the need for sleep as a function of the amount of time elapsed since the last adequate sleep episode) must be balanced against the circadian element for satisfactory sleep.^[16] Along with corresponding messages from the circadian clock, this tells the body it needs to sleep.^[17] Sleep offset (awakening) is primarily determined by circadian rhythm. A person who regularly awakens at an early hour will generally not be able to sleep much later than his or her normal waking time, even if moderately sleep-deprived.

Sleep duration is affected by the gene DEC2. Some people have a mutation of this gene; they sleep two hours less than normal. Neurology professor Ying-Hui Fu and her colleagues bred mice that carried the DEC2 mutation and slept less than normal mice.^[18][19]

Optimal amount in humans[link]

Adult[link]

The optimal amount of sleep is not a meaningful concept unless the timing of that sleep is seen in relation to an individual's circadian rhythms. A person's major sleep episode is relatively inefficient and inadequate when it occurs at the "wrong" time of day; one should be asleep at least six hours before the lowest body temperature.^[20] The timing is correct when the following two circadian markers occur after the middle of the sleep episode and before awakening:^[21]

• maximum concentration of the hormone melatonin, and
• minimum core body temperature.

For more information on the human circadian rhythm and body temperature, see Biological markers (in the article Circadian rhythm).

Human sleep needs can vary by age and among individuals, and sleep is considered to be adequate when there is no daytime sleepiness or dysfunction. Moreover, self-reported sleep duration is only moderately correlated with actual sleep time as measured by actigraphy,^[22] and those affected with sleep state misperception may typically report having slept only four hours despite having slept a full eight hours.^[23]

A University of California, San Diego psychiatry study of more than one million adults found that people who live the longest self-report sleeping for six to seven hours each night.^[24] Another study of sleep duration and mortality risk in women showed similar results.^[25] Other studies show that "sleeping more than 7 to 8 hours per day has been consistently associated with increased mortality," though this study suggests the cause is probably other factors such as depression and socioeconomic status, which would correlate statistically.^[26] It has been suggested that the correlation between lower sleep hours and reduced morbidity only occurs with those who wake naturally, rather than those who use an alarm.

Main health effects of sleep deprivation,^[27] indicating impairment of normal maintenance by sleep

Researchers at the University of Warwick and University College London have found that lack of sleep can more than double the risk of death from cardiovascular disease, but that too much sleep can also be associated with a doubling of the risk of death, though not primarily from cardiovascular disease.^[28][29] Professor Francesco Cappuccio said, "Short sleep has been shown to be a risk factor for weight gain, hypertension, and Type 2 diabetes, sometimes leading to mortality; but in contrast to the short sleep-mortality association, it appears that no potential mechanisms by which long sleep could be associated with increased mortality have yet been investigated. Some candidate causes for this include depression, low socioeconomic status, and cancer-related fatigue... In terms of prevention, our findings indicate that consistently sleeping around seven hours per night is optimal for health, and a sustained reduction may predispose to ill health."

Furthermore, sleep difficulties are closely associated with psychiatric disorders such as depression, alcoholism, and bipolar disorder.^[30] Up to 90% of adults with depression are found to have sleep difficulties. Dysregulation found on EEG includes disturbances in sleep continuity, decreased delta sleep and altered REM patterns with regard to latency, distribution across the night and density of eye movements.^[31]

Hours by age[link]

Children need more sleep per day in order to develop and function properly: up to 18 hours for newborn babies, with a declining rate as a child ages.^[17] A newborn baby spends almost 9 hours a day in REM sleep. By the age of five or so, only slightly over two hours is spent in REM. Studies say that school age children need about 10 to 11 hours of sleep.^[32]

Siesta or nap[link]

The siesta habit has recently been associated with a 37% reduction in coronary mortality, possibly due to reduced cardiovascular stress mediated by daytime sleep.^[35] Nevertheless, epidemiological studies on the relations between cardiovascular health and siesta have led to conflicting conclusions, possibly because of poor control of moderator variables, such as physical activity. It is possible that people who take a siesta have different physical activity habits, e.g., waking earlier and scheduling more activity during the morning. Such differences in physical activity may mediate different 24-hour profiles in cardiovascular function. Even if such effects of physical activity can be discounted for explaining the relationship between siesta and cardiovascular health, it is still unknown whether it is the daytime nap itself, a supine posture or the expectancy of a nap that is the most important factor. It was recently suggested that a short nap can reduce stress and blood pressure (BP), with the main changes in BP occurring between the time of lights off and the onset of stage 1.^[36][37] Dr. Zaregarizi and his team have conducted that the acute time of falling asleep was where beneficial cardiovascular changes take place. This study has indicated that a large decline in blood pressure occurs during the daytime sleep-onset period only when sleep is expected however when subjects rest in a supine position, the same reduction in blood pressure is not observed. This blood pressure reduction may be associated with the lower coronary mortality rates seen in Mediterranean and Latin American populations where siestas are common. Dr. Zaregarizi assessed cardiovascular function (blood pressure, heart rate, and measurements of blood vessel dilation) while nine healthy volunteers, 34 years of age on average, spent an hour standing quietly; reclining at rest but not sleeping; or reclining to nap. All participants were restricted to 4 hours of sleep on the night prior to each of the sleep laboratory tests. During the three phases of daytime sleep, he noted significant reductions in blood pressure and heart rate. By contrast, they did not observe changes in cardiovascular function while the participants were standing or reclining at rest. These findings also show that the greatest decline in blood pressure occurs between lights-off and onset of daytime sleep itself. During this sleep period, which lasted 9.7 minutes on average, blood pressure decreased, while blood vessel dilation increased by more than 9 percent. “There is little change in blood pressure once a subject is actually asleep," Dr. Zaregarizi noted, and he found minor changes in blood vessel dilation during sleep.^[36][37]

Sleep debt[link]

Sleep debt is the effect of not getting enough sleep; a large debt causes mental, emotional and physical fatigue.

Sleep debt results in diminished abilities to perform high-level cognitive functions. Neurophysiological and functional imaging studies have demonstrated that frontal regions of the brain are particularly responsive to homeostatic sleep pressure.^[38]

Scientists do not agree on how much sleep debt it is possible to accumulate; whether it is accumulated against an individual's average sleep or some other benchmark; nor on whether the prevalence of sleep debt among adults has changed appreciably in the industrialized world in recent decades. It is likely that children are sleeping less than previously in Western societies.^[39]

Genetics[link]

It is suspected that a considerable amount of sleep-related behavior, such as when and how long a person needs to sleep, is regulated by our genetics. Researchers have discovered some evidence that seems to support this assumption.^[40] ABCC9 is one gene found to be potentially significant.^{[citation needed]}

Functions[link]

A Kutchi woman sleeping

The multiple theories proposed to explain the function of sleep reflect the as-yet incomplete understanding of the subject. (When asked, after 50 years of research, what he knew about the reason people sleep William Dement, founder of Stanford University's Sleep Research Center, answered, "As far as I know, the only reason we need to sleep that is really, really solid is because we get sleepy."^[41]) It is likely that sleep evolved to fulfill some primeval function and took on multiple functions over time^{[citation needed]} (analogous to the larynx, which controls the passage of food and air, but descended over time to develop speech capabilities).

If sleep were not essential, one would expect to find:

• Animal species that do not sleep at all
• Animals that do not need recovery sleep when they stay awake longer than usual
• Animals that suffer no serious consequences as a result of lack of sleep

Outside of a few basal animals that have no brain or a very simple one, no animals have been found to date that satisfy any of these criteria.^[42] While some varieties of shark, such as great whites and hammerheads, must remain in motion at all times to move oxygenated water over their gills, it is possible they still sleep one cerebral hemisphere at a time as marine mammals do. However it remains to be shown definitively whether any fish is capable of unihemispheric sleep.

Some of the many proposed functions of sleep are as follows:

Restoration[link]

Wound healing has been shown to be affected by sleep. A study conducted by Gumustekin et al.^[43] in 2004 shows sleep deprivation hindering the healing of burns on rats.

It has been shown that sleep deprivation affects the immune system. In a study by Zager et al. in 2007,^[44] rats were deprived of sleep for 24 hours. When compared with a control group, the sleep-deprived rats' blood tests indicated a 20% decrease in white blood cell count, a significant change in the immune system. It is now possible to state that "sleep loss impairs immune function and immune challenge alters sleep," and it has been suggested that mammalian species which invest in longer sleep times are investing in the immune system, as species with the longer sleep times have higher white blood cell counts.^[45] Sleep has also been theorized to effectively combat the accumulation of free radicals in the brain, by increasing the efficiency of endogeneous antioxidant mechanisms.^[46]

It has yet to be proven that sleep duration affects somatic growth. One study by Jenni et al.^[47] in 2007 recorded growth, height, and weight, as correlated to parent-reported time in bed in 305 children over a period of nine years (age 1–10). It was found that "the variation of sleep duration among children does not seem to have an effect on growth." It has been shown that sleep—more specifically, slow-wave sleep (SWS)—does affect growth hormone levels in adult men. During eight hours' sleep, Van Cauter, Leproult, and Plat^[48] found that the men with a high percentage of SWS (average 24%) also had high growth hormone secretion, while subjects with a low percentage of SWS (average 9%) had low growth hormone secretion.

There are multiple arguments supporting the restorative function of sleep. The metabolic phase during sleep is anabolic; anabolic hormones such as growth hormones (as mentioned above) are secreted preferentially during sleep. The duration of sleep among species is, in general, inversely related to animal size^{[citation needed]} and directly related to basal metabolic rate. Rats with a very high basal metabolic rate sleep for up to 14 hours a day, whereas elephants and giraffes with lower BMRs sleep only 3–4 hours per day.

Energy conservation could as well have been accomplished by resting quiescent without shutting off the organism from the environment, potentially a dangerous situation. A sedentary nonsleeping animal is more likely to survive predators, while still preserving energy. Sleep, therefore, seems to serve another purpose, or other purposes, than simply conserving energy; for example, hibernating animals waking up from hibernation go into rebound sleep because of lack of sleep during the hibernation period. They are definitely well-rested and are conserving energy during hibernation, but need sleep for something else.^[5] Rats kept awake indefinitely develop skin lesions, hyperphagia, loss of body mass, hypothermia, and, eventually, fatal sepsis.^[49]

Ontogenesis[link]

According to the ontogenetic hypothesis of REM sleep, the activity occurring during neonatal REM sleep (or active sleep) seems to be particularly important to the developing organism (Marks et al., 1995). Studies investigating the effects of deprivation of active sleep have shown that deprivation early in life can result in behavioral problems, permanent sleep disruption, decreased brain mass (Mirmiran et al., 1983), and an abnormal amount of neuronal cell death.^[50]

REM sleep appears to be important for development of the brain. REM sleep occupies the majority of time of sleep of infants, who spend most of their time sleeping. Among different species, the more immature the baby is born, the more time it spends in REM sleep. Proponents also suggest that REM-induced muscle inhibition in the presence of brain activation exists to allow for brain development by activating the synapses, yet without any motor consequences that may get the infant in trouble. Additionally, REM deprivation results in developmental abnormalities later in life.

However, this does not explain why older adults still need REM sleep. Aquatic mammal infants do not have REM sleep in infancy;^[51] REM sleep in those animals increases as they age.

Memory processing[link]

Scientists have shown numerous ways in which sleep is related to memory. In a study conducted by Turner, Drummond, Salamat, and Brown,^[52] working memory was shown to be affected by sleep deprivation. Working memory is important because it keeps information active for further processing and supports higher-level cognitive functions such as decision making, reasoning, and episodic memory. The study allowed 18 women and 22 men to sleep only 26 minutes per night over a four-day period. Subjects were given initial cognitive tests while well-rested, and then were tested again twice a day during the four days of sleep deprivation. On the final test, the average working memory span of the sleep-deprived group had dropped by 38% in comparison to the control group.

Memory seems to be affected differently by certain stages of sleep such as REM and slow-wave sleep (SWS). In one study,^[53] multiple groups of human subjects were used: wake control groups and sleep test groups. Sleep and wake groups were taught a task and were then tested on it, both on early and late nights, with the order of nights balanced across participants. When the subjects' brains were scanned during sleep, hypnograms revealed that SWS was the dominant sleep stage during the early night, representing around 23% on average for sleep stage activity. The early-night test group performed 16% better on the declarative memory test than the control group. During late-night sleep, REM became the most active sleep stage at about 24%, and the late-night test group performed 25% better on the procedural memory test than the control group. This indicates that procedural memory benefits from late, REM-rich sleep, whereas declarative memory benefits from early, SWS-rich sleep.

A study conducted by Datta^[54] indirectly supports these results. The subjects chosen were 22 male rats. A box was constructed wherein a single rat could move freely from one end to the other. The bottom of the box was made of a steel grate. A light would shine in the box accompanied by a sound. After a five-second delay, an electrical shock would be applied. Once the shock commenced, the rat could move to the other end of the box, ending the shock immediately. The rat could also use the five-second delay to move to the other end of the box and avoid the shock entirely. The length of the shock never exceeded five seconds. This was repeated 30 times for half the rats. The other half, the control group, was placed in the same trial, but the rats were shocked regardless of their reaction. After each of the training sessions, the rat would be placed in a recording cage for six hours of polygraphic recordings. This process was repeated for three consecutive days. This study found that during the posttrial sleep recording session, rats spent 25.47% more time in REM sleep after learning trials than after control trials. These trials support the results of the Born et al. study, indicating an obvious correlation between REM sleep and procedural knowledge.

An observation of the Datta study is that the learning group spent 180% more time in SWS than did the control group during the post-trial sleep-recording session. This phenomenon is supported by a study performed by Kudrimoti, Barnes, and McNaughton.^[55] This study shows that after spatial exploration activity, patterns of hippocampal place cells are reactivated during SWS following the experiment. In a study by Kudrimoti et al., seven rats were run through a linear track using rewards on either end. The rats would then be placed in the track for 30 minutes to allow them to adjust (PRE), then they ran the track with reward-based training for 30 minutes (RUN), and then they were allowed to rest for 30 minutes. During each of these three periods, EEG data were collected for information on the rats' sleep stages. Kudrimoti et al. computed the mean firing rates of hippocampal place cells during prebehavior SWS (PRE) and three ten-minute intervals in postbehavior SWS (POST) by averaging across 22 track-running sessions from seven rats. The results showed that ten minutes after the trial RUN session, there was a 12% increase in the mean firing rate of hippocampal place cells from the PRE level; however, after 20 minutes, the mean firing rate returned rapidly toward the PRE level. The elevated firing of hippocampal place cells during SWS after spatial exploration could explain why there were elevated levels of SWS sleep in Datta's study, as it also dealt with a form of spatial exploration.

A study has also been done involving direct current stimulation to the prefrontal cortex to increase the amount of slow oscillations during SWSfe. The direct current stimulation greatly enhanced word-pair retention the following day, giving evidence that SWS plays a large role in the consolidation of episodic memories.^[56]

The different studies all suggest that there is a correlation between sleep and the complex functions of memory. Harvard sleep researchers Saper^[57] and Stickgold^[58] point out that an essential part of memory and learning consists of nerve cell dendrites' sending of information to the cell body to be organized into new neuronal connections. This process demands that no external information is presented to these dendrites, and it is suggested that this may be why it is during sleep that memories and knowledge are solidified and organized.

Preservation[link]

The "Preservation and Protection" theory holds that sleep serves an adaptive function. It protects the animal during that portion of the 24-hour day in which being awake, and hence roaming around, would place the individual at greatest risk.^[59] Organisms do not require 24 hours to feed themselves and meet other necessities. From this perspective of adaptation, organisms are safer by staying out of harm's way, where potentially they could be prey to other, stronger organisms. They sleep at times that maximize their safety, given their physical capacities and their habitats.

This theory fails to explain why the brain disengages from the external environment during normal sleep. However, the brain consumes a large proportion of the body's calories at any one time and preservation of energy could only occur by limiting its sensory inputs. Another argument against the theory is that sleep is not simply a passive consequence of removing the animal from the environment, but is a "drive"; animals alter their behaviors in order to obtain sleep. Therefore, circadian regulation is more than sufficient to explain periods of activity and quiescence that are adaptive to an organism, but the more peculiar specializations of sleep probably serve different and unknown functions. Moreover, the preservation theory needs to explain why carnivores like lions, which are on top of the food chain and thus have little to fear, sleep the most. It has been suggested that they need to minimize energy expenditure when not hunting.

Preservation also does not explain why aquatic mammals sleep while moving. Quiescence during these vulnerable hours would do the same and would be more advantageous, because the animal would still be able to respond to environmental challenges like predators, etc. Sleep rebound that occurs after a sleepless night will be maladaptive, but obviously must occur for a reason. A zebra falling asleep the day after it spent the sleeping time running from a lion is more, not less, vulnerable to predation.

Dreaming[link]

Bronze statue of Eros sleeping, 3rd century BC–early 1st century AD

Dreaming is the perceived experience of sensory images and sounds during sleep, in a sequence which the dreamer usually perceives more as an apparent participant than as an observer. Dreaming is stimulated by the pons and mostly occurs during the REM phase of sleep.

People have proposed many hypotheses about the functions of dreaming. Sigmund Freud postulated that dreams are the symbolic expression of frustrated desires that had been relegated to the unconscious mind, and he used dream interpretation in the form of psychoanalysis to uncover these desires. See Freud: The Interpretation of Dreams.

Freud's work concerns the psychological role of dreams, which does not exclude any physiological role they may have. Recent research^[60] claims that sleep has the overall role of consolidation and organization of synaptic connections formed during learning and experience. As such, Freud's work is not ruled out. Nevertheless, Freud's research has been expanded on, especially with regard to the organization and consolidation of recent memory.

Certain processes in the cerebral cortex have been studied by John Allan Hobson and Robert McCarley. In their activation synthesis theory, for example, they propose that dreams are caused by the random firing of neurons in the cerebral cortex during the REM period. Neatly, this theory helps explain the irrationality of the mind during REM periods, as, according to this theory, the forebrain then creates a story in an attempt to reconcile and make sense of the nonsensical sensory information presented to it.^[61] Ergo, the odd nature of many dreams.

Effect of food and drink on sleep[link]

This section needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed. (October 2008)

Hypnotics[link]

• Nonbenzodiazepine hypnotics such as eszopiclone (Lunesta), zaleplon (Sonata), and zolpidem (Ambien) are commonly used as sleep aids prescribed by doctors to treat forms of insomnia. Nonbenzodiazepines are the most commonly prescribed and OTC sleep aids used worldwide and have been greatly growing in use since the 1990s. They target the GABA_A receptor.
• Benzodiazepines target the GABA_A receptor also, and as such, they are commonly used sleep aids as well, though benzodiazepines have been found to decrease REM sleep.^[62]
• Antihistamines, such as diphenhydramine (Benadryl) and doxylamine (found in various OTC medicines, such as NyQuil)
• Alcohol – Often, people start drinking alcohol in order to get to sleep (alcohol is initially a sedative and will cause somnolence, encouraging sleep).^[63] However, being addicted to alcohol can lead to disrupted sleep, because alcohol has a rebound effect later in the night. As a result, there is strong evidence linking alcoholism and forms of insomnia.^[64] Alcohol also reduces REM sleep.^[62]
• Barbiturates cause drowsiness and have actions similar to alcohol in that they have a rebound effect and inhibit REM sleep, so they are not used as a long-term sleep aid.^[65]
• Melatonin is a naturally occurring hormone that regulates sleepiness. It is made in the brain, where tryptophan is converted into serotonin and then into melatonin, which is released at night by the pineal gland to induce and maintain sleep. Melatonin supplementation may be used as a sleep aid, both as a hypnotic and as a chronobiotic (see phase response curve, PRC).
• Siesta and the "post-lunch dip" – Many people have a temporary drop in alertness in the early afternoon, commonly known as the "post-lunch dip." While a large meal can make a person feel sleepy, the post-lunch dip is mostly an effect of the biological clock. People naturally feel most sleepy (have the greatest "drive for sleep") at two times of the day about 12 hours apart—for example, at 2:00 a.m. and 2:00 p.m. At those two times, the body clock "kicks in." At about 2 p.m. (14:00), it overrides the homeostatic buildup of sleep debt, allowing several more hours of wakefulness. At about 2 a.m. (02:00), with the daily sleep debt paid off, it "kicks in" again to ensure a few more hours of sleep.
• Tryptophan – The amino acid tryptophan is a building block of proteins. It has been claimed to contribute to sleepiness, since it is a precursor of the neurotransmitter serotonin, involved in sleep regulation. However, no solid data have ever linked modest dietary changes in tryptophan to changes in sleep.
• Marijuana – Some people use marijuana to induce sleepiness. Users often report relaxation and drowsiness. It has been shown that Tetrahydrocannabinol, the principal psychoactive constituent in marijuana, reduces the amount of REM sleep.^[66] Frequent users often report being unable to recall their dreams.

Stimulants[link]

• Amphetamine (dextroamphetamine, and a related, slightly more powerful drug methamphetamine, etc.) are used to treat narcolepsy. Their most common effects are anxiety, insomnia, stimulation, increased alertness, and decreased hunger.
• Caffeine is a stimulant that works by slowing the action of the hormones in the brain that cause somnolence, particularly by acting as an antagonist at adenosine receptors. Effective dosage is individual, in part dependent on prior usage. It can cause a rapid reduction in alertness as it wears off.
• Cocaine and crack cocaine – Studies on cocaine have shown its effects to be mediated through the circadian rhythm system.^[67] This may be related to the onset of hypersomnia (oversleeping) in regard to "cocaine-induced sleep disorder."^[68]
• MDMA, including similar drugs like MDA, MMDA, or bk-MDMA – The class of drugs called empathogen-entactogens keep users awake with intense euphoria. Commonly known as "ecstasy."
• Methylphenidate – Commonly known by the brand names Ritalin and Concerta, methylphenidate is similar in action to amphetamine and cocaine; its chemical composition more closely resembles that of cocaine.
• Tobacco – Tobacco has been found not only to disrupt but also to reduce total sleep time. In studies, users have described more daytime drowsiness than nonsmokers.^[69]
• Other analeptic drugs like Modafinil and Armodafinil are prescribed to treat narcolepsy, hypersomnia, shift work sleep disorder, and other conditions causing Excessive Daytime Sleepiness. The precise mechanism of these CNS stimulants is not known, but they have been shown to increase both the release of monoamines and levels of hypothalamic histamine, thereby promoting wakefulness.

Insomnia[link]

Insomnia is a general term describing difficulty falling asleep and staying asleep. Insomnia can have many different causes, including psychological stress, a poor sleep environment, an inconsistent sleep schedule, or excessive mental or physical stimulation in the hours before bedtime. Insomnia is often treated through behavioral changes like keeping a regular sleep schedule, avoiding stimulating or stressful activities before bedtime, and cutting down on stimulants such as caffeine. Patients are often counseled to improve their sleep environment by installing heavy drapes to shut out all sunlight, and keeping computers, televisions and work materials out of the sleeping area.

A 2010 review of published scientific research suggested that exercise generally improves sleep for most people, and helps sleep disorders such as insomnia. The optimum time to exercise may be 4 to 8 hours before bedtime, though exercise at any time of day is beneficial, with the exception of heavy exercise taken shortly before bedtime, which may disturb sleep. However there is insufficient evidence to draw detailed conclusions about the relationship between exercise and sleep.^[70]

Sleeping medications such as Ambien and Lunesta are an increasingly popular treatment for insomnia, and have become a major source of revenue for drug companies. Although these nonbenzodiazepine medications are generally believed to be better and safer than earlier generations of sedatives, they have still generated some controversy and discussion regarding side-effects.

White noise appears to be a promising treatment for insomnia.^[71]

Obstructive sleep apnea[link]

Obstructive sleep apnea is a condition in which major pauses in breathing occur during sleep, disrupting the normal progression of sleep and often causing other more severe health problems. Apneas occur when the muscles around the patient's airway relax during sleep, causing the airway to collapse and block the intake of oxygen. As oxygen levels in the blood drop, the patient then comes out of deep sleep in order to resume breathing. When several of these episodes occur per hour, sleep apnea rises to a level of seriousness that may require treatment.

Diagnosing sleep apnea usually requires a professional sleep study performed in a sleep clinic, because the episodes of wakefulness caused by the disorder are extremely brief and patients usually do not remember experiencing them. Instead, many patients simply feel tired after getting several hours of sleep and have no idea why. Major risk factors for sleep apnea include chronic fatigue, old age, obesity and snoring.

Other sleep disorders[link]

People sleeping on a train at night

Sleep disorders include narcolepsy, periodic limb movement disorder (PLMD), restless leg syndrome (RLS), and the circadian rhythm sleep disorders. Fatal familial insomnia, or FFI, is an extremely rare genetic disease with no known treatment or cure, is characterized by increasing insomnia as one of its symptoms; ultimately sufferers of the disease stop sleeping entirely, before dying of the disease.^[41]

Older people are more easily awakened by disturbances in the environment^[72] and may to some degree lose the ability to consolidate sleep.

Anthropology of sleep[link]

Research suggests that sleep patterns vary significantly across cultures.^[73][74] The most striking differences are between societies that have plentiful sources of artificial light and ones that do not.^[73] The primary difference appears to be that pre-light cultures have more broken-up sleep patterns.^[73] For example, people might go to sleep far sooner after the sun sets, but then wake up several times throughout the night, punctuating their sleep with periods of wakefulness, perhaps lasting several hours.^[73] The boundaries between sleeping and waking are blurred in these societies.^[73] Some observers believe that nighttime sleep in these societies is most often split into two main periods, the first characterized primarily by deep sleep and the second by REM sleep.^[73]

Some societies display a fragmented sleep pattern in which people sleep at all times of the day and night for shorter periods. In many nomadic or hunter-gatherer societies, people will sleep on and off throughout the day or night depending on what is happening.^[73] Plentiful artificial light has been available in the industrialized West since at least the mid-19th century, and sleep patterns have changed significantly everywhere that lighting has been introduced.^[73] In general, people sleep in a more concentrated burst through the night, going to sleep much later, although this is not always true.^[73] Historian Roger Ekrich thinks that the traditional pattern of "segmented sleep" as it is called began to disappear among the urban upper class in Europe in the late 17th century and the change spread over the next 200 years; by the 1920s "the idea of a first and second sleep had receded entirely from our social consciousness."^[75] Ekrich attributes the change to increases in "street lighting, domestic lighting and a surge in coffee houses," which slowly made nighttime a legitimate time for activity, decreasing the time available for rest.^[75]

In some societies, people generally sleep with at least one other person (sometimes many) or with animals. In other cultures, people rarely sleep with anyone but a most intimate relation, such as a spouse. In almost all societies, sleeping partners are strongly regulated by social standards. For example, people might only sleep with their immediate family, extended family, spouses, their children, children of a certain age, children of specific gender, peers of a certain gender, friends, peers of equal social rank, or with no one at all. Sleep may be an actively social time, depending on the sleep groupings, with no constraints on noise or activity.^[73]

People sleep in a variety of locations. Some sleep directly on the ground; others on a skin or blanket; others sleep on platforms or beds. Some sleep with blankets, some with pillows, some with simple headrests, some with no head support. These choices are shaped by a variety of factors, such as climate, protection from predators, housing type, technology, personal preference, and the incidence of pests.^[73]

Sleep in non-humans[link]

Sleeping Japanese Macaques

Neurological sleep states can be difficult to detect in some animals. In these cases, sleep may be defined using behavioral characteristics such as minimal movement, postures typical for the species, and reduced responsiveness to external stimulation. Sleep is quickly reversible, as opposed to hibernation or coma, and sleep deprivation is followed by longer or deeper rebound sleep. Herbivores, who require a long waking period to gather and consume their diet, typically sleep less each day than similarly sized carnivores, who might well consume several days' supply of meat in a sitting.

Horses and other herbivorous ungulates can sleep while standing, but must necessarily lie down for REM sleep (which causes muscular atony) for short periods. Giraffes, for example, only need to lie down for REM sleep for a few minutes at a time. Bats sleep while hanging upside down. Some aquatic mammals and some birds can sleep with one half of the brain while the other half is awake, so-called unihemispheric slow-wave sleep.^[76] Birds and mammals have cycles of non-REM and REM sleep (as described above for humans), though birds' cycles are much shorter and they do not lose muscle tone (go limp) to the extent that most mammals do.

Many mammals sleep for a large proportion of each 24-hour period when they are very young.^[77] However, killer whales and some dolphins do not sleep during the first month of life.^[78] Such differences may be explained by the ability of land-mammal newborns to be easily protected by parents while sleeping, while marine animals must, even while very young, be more continuously vigilant for predators.

See also[link]

• Cortisol awakening response
• Microsleep
• Morvan's syndrome
• Polyphasic sleep
• Power nap
• Segmented sleep
• Sleep architecture
• Sleep medicine
• Somnology
• Sudden infant death syndrome
• Sudden unexpected death syndrome

Positions, practices, and rituals[link]

• Sleeping positions
• Co-sleeping
• Hypnosis
• Meditation
• Neutral spine
• Sleep hygiene
• Yoga-nidra
• World Sleep Day

References[link]

External links[link]

Wikimedia Commons has media related to: Sleep

Look up sleep in Wiktionary, the free dictionary.

• NIH.gov, National Center on Sleep Disorders Research
• National Sleep Foundation, information on School Start Time and Sleep at National Sleep Foundation
• HealthySleep.med.harvard.edu, from the Division of Sleep Medicine at Harvard Medical School and WGBH Educational Foundation
• PLOSjournals.org, Is Sleep Essential? by Chiara Cirelli and Giulio Tononi, from the Public Library of Science, Biology

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Eric Whitacre
Whitacre conducting in 2007
Background information
Born	(1970-01-02) 2 January 1970 (age 42)
Occupations	Composer Conductor Lecturer Model
Website	EricWhitacre.com

Eric Whitacre (born 2 January 1970 in Reno, Nevada) is an American Grammy award winning composer, conductor and lecturer. He is one of the most popular and performed composers of his generation.^[1][2] In 2008, the all-Whitacre choral CD Cloudburst (released by the British ensemble Polyphony on Hyperion Records) became an international best-seller, topping the classical charts and earning a Grammy nomination. Robert Hollingworth commented: "what hits you straight between the eyes is the honesty, optimism and sheer belief that passes any pretension. This is music that can actually make you smile."^[3] In addition to Whitacre's litany of choral and wind ensemble compositions, he is also known for his "Virtual Choir" projects on YouTube, bringing individual voices from around the globe together in a cyber internet choir. His virtual choirs have exposed his music to a new audience and have helped it gain an unprecedented popularity.^[4][5] Whitacre signed a long-term recording deal with Decca in 2010 and continues to develop his award winning musical Paradise Lost. A concert version was given at Carnegie Hall in 2010.^[6] Plans for the stage show and soundtrack extend into 2013.

Biography[link]

Coming to classical music relatively late in life when he joined a college choir at the University of Nevada Las Vegas (UNLV), where he earned a BA in Music in 1995. The first work that Eric Whitacre sang – Mozart's Requiem – changed his life. Inspired to compose, his first piece Go, Lovely Rose was completed at the age of 21. At the age of 23 he completed his first piece for Wind Orchestra, Ghost Train, which has been recorded over 40 times and has continued to sell phenomenally well. He went on to the Juilliard School (New York), where he studied with Pulitzer Prize and Oscar-winning composer, John Corigliano and earned his Master of Music degree.

Countless recordings feature music written by Eric Whitacre, but his first album as both composer and conductor on Decca/Universal, Light & Gold, won a Grammy in 2012, reaped unanimous five star reviews, and became the no. 1 Classical Album in the US and UK charts within a week of a release. Eric's second album, Water Night, was released on Decca in 3 April 2012 and will feature seven world premiere recordings and include performances from his professional choir Eric Whitacre Singers, the London Symphony Orchestra, Julian Lloyd Webber and Hila Plitmann.

He has written for the London Symphony Orchestra and Chorus, Chanticleer, Julian Lloyd Webber, the Philharmonia Orchestra, Rundfunkchor Berlin, and The King's Singers, among others. His musical, Paradise Lost: Shadows and Wings, won both the ASCAP Harold Arlen award and the Richard Rodgers Award, and earned 10 nominations at the Los Angeles Stage Alliance Ovation Awards. A versatile musician, he has also worked with prolific film composer, Hans Zimmer, co-writing the Mermaid Theme for Pirates of the Caribbean: On Stranger Tides. In 2011, Eric conducted the winning entries of the Abbey Road 80th Anniversary Anthem Competition, recording the London Symphony Orchestra and his professional choir, the Eric Whitacre Singers, in Abbey Road Studio 1.

Eric's ground-breaking Virtual Choir, Lux Aurumque, received over a million views on YouTube in just 2 months (now approaching 3 million), featuring 185 singers from 12 different countries. Eric Whitacre's Virtual Choir 2.0, Sleep, was released in April 2011 and involved over 2,000 voices from 58 countries. Virtual Choir 3, Water Night, combined 3746 submissions from 73 countries and was released in April 2012.

As a conductor, Eric Whitacre has performed across the world with orchestras, choirs and bands, and he gives regular guest workshops. His Soaring Leap initiative is a dynamic one-day workshop where singers, conductors and composers read, rehearse and perform several of Eric's works, digging deep into the poetry and exploring the compositional tools. An exceptional orator, he was honoured to address the U.N. Leaders programme and give a TED Talk in March 2011, which earned the first full standing ovation of the conference. He has addressed audiences at Duke, Harvard, The Economist, Seoul Digital Forum and JCDA Conference in Tokyo. Eric was appointed Composer in Residence at Sidney Sussex College, Cambridge University, UK, in September 2011.

Many of Eric Whitacre's works have entered the standard choral and symphonic repertories and have become the subject of scholarly works and doctoral dissertations. Whitacre has received composition awards from the Barlow International Composition Competition, the ACDA and the American Composers Forum. In 2001, he became the youngest recipient ever awarded the coveted Raymond C. Brock commission by the ACDA. Eric Whitacre currently lives in London with his wife (Grammy award winning soprano, Hila Plitmann) and their son.

Style[link]

Whitacre writes music that incorporates contemporary sounds and influences while demanding precision, intonation and ensemble. He is probably best known for his choral works; however, both his choral and instrumental styles use his signature "Whitacre chords," or pan-diatonic clusters usually arranged in successive increasing or decreasing density. Whitacre achieves this growth and decay by splitting voices divisi—in one case up to 18 parts. These sonorities can often be read as seventh or ninth chords, with or without suspended seconds and fourths. Perhaps his most famous chord is a root-position major triad with an added major second and/or perfect fourth. Whitacre makes frequent use of quartal, quintal and secundal harmonies, and is also known for his use of unconventional chord progressions. His use of rhythm often involves mixed, complex, and/or compound meters. His pieces sometimes include frequent meter changes and unusual rhythmic patterns. Another trademark of Whitacre's pieces is the use of aleatoric and indeterminate sections, as well as unusual score instructions involving, in some cases, hand actions and/or props.^[7]

Projects[link]

Virtual Choir[link]

Whitacre's Virtual Choir projects were inspired by a video sent to him of a young girl singing one of his choral pieces.^[8] He began with a test run of Sleep, then Lux Aurumque in 2009^[4][9] and then Sleep again in 2010. The video for Lux Aurumque, featuring a virtual choir of 185 voices from 12 countries, was described as a "musical experience that works better than anyone might have expected."^[10] It received over a million hits in the first two months of its release.

The 2010 version of the Virtual Choir 2.0 "Sleep" began in October 2010, and the video submission process was completed on 10 January 2011. Whitacre spoke at The 2011 TED Conference^[11] and this video was released on 1 April 2011, accompanied with a short 2 minute example of the "Sleep" project. The YouTube release was on 7 April 2011. One year later,it had been viewed over 900,000 times.

On 27 September 2011, Eric announced on his blog his plans for a "Virtual Choir 3". On 21 December 2011, it was revealed that the piece will be "Water Night", an a cappella piece he wrote in 1995.^[12] By the entry close date of 1 February 2012, 3,746 videos had been uploaded by 2,945 people in 73 countries, singing one or more parts of Water Night. NBC Network's Nightly News, and ABC National News television reported on the Virtual Choir. This heightened awareness of the project in the mainstream. The completed work was released as a YouTube video 2 April 2012, and received 100,000 views in the first week. On 15 April, on the exact 100 year anniversary moment of the sinking of the Titanic, the Water Night Virtual Choir video was shown in the new Titanic Belfast commemorative building, in remembrance of those lost in the disaster.

Recording projects[link]

Whitacre's first album with Decca, Light & Gold, was released in October 2010. This album won the Grammy for Best Choral Performance in 2012.^[13] From October to December 2010, Whitacre was a visiting Fellow at Sidney Sussex College, Cambridge during Michaelmas (Autumn) Term.^[14]

Whitacre's second album with Decca, Water Night, was released on 3 April 2012 in the United States, and features some of his newest compositions for chorus and for orchestra.^[15]

Performance projects[link]

Whitacre has worked collaboratively with Distinguished Concerts International New York^[16] (DCINY), and is due to collaborate with them again in 2011 in New York, Vancouver and Los Angeles. With regard to his musical "Paradise Lost: Shadows and Wings", he was described by the New York Times as a "younger, hipper Andrew Lloyd Webber, with fleeting hints of Bernstein and Sondheim".^[6]

On 24 October 2010, he conducted an all-American programme with the London Symphony Orchestra and Chorus at the Barbican London in a performance that featured his commission for the London Symphony Chorus entitled Songs of Immortality. On 28 November 2010, he sat on the panel of judges for the final episode of Choir of the Year, broadcast on BBC Four and BBC Radio 3. In December 2010, Whitacre conducted the I Vocalisti choir in Hamburg, and was a guest conductor of the Christmas performance of the Berlin Rundfunkchor.

On 6 November 2010, Whitacre conducted Côrdydd, a Cardiff-based mixed choir, and friends in a concert of his work at the BBC Hoddinott Hall in the Wales Millennium Centre.

He composed a piece for the Sidney Sussex college choir, and worked with students in masterclasses and workshops. The concert version of his musical Paradise Lost: Shadows and Wings was performed to a sold out audience at Carnegie Hall in June 2010.

Whitacre is a founding member of BCM International, a quartet of composers consisting of himself, Steven Bryant, Jonathan Newman and James Bonney, which aspires to "enrich the wind ensemble repertoire with music unbound by traditional thought or idiomatic cliché."^[17]

Awards and honors[link]

This biographical section of an article needs additional citations for verification. Please help by adding reliable sources. Contentious material about living persons that is unsourced or poorly sourced must be removed immediately, especially if potentially libelous or harmful. (January 2011)

Whitacre has won awards from the Barlow international composition competition, American Choral Directors Association, American Composers' Forum and in 2001 became the youngest recipient ever of The Raymond C Brock Commission given by the American Choral Directors Association. His musical Paradise Lost: Shadows and Wings earned him a Richard Rodgers Award and received 10 nominations at the 2007 Los Angeles Stage Alliance Ovation Awards. The album Cloudburst and Other Choral Works received a Grammy nomination in 2007 for Best Choral Performance. Later, his album "Light and Gold" won a Grammy for Best Choral Performance in 2012.^[18]

Works[link]

Wind symphony[link]

• Equus
• Ghost Train Triptych
  • Ghost Train
  • At the Station
  • Motive Revolution
• Godzilla Eats Las Vegas!
• Noisy Wheels of Joy
• October
• Sleep (choral transcription)
• The Seal Lullaby (choral transcription for wind symphony and piano)
• Lux Aurumque (transcription of the choral work, transposed a semitone lower from C-Sharp Minor to C Minor)
• Cloudburst (choral transcription)
• Libertas Imperio (From Paradise Lost: Shadows and Wings)

SATB choral[link]

• A Boy and A Girl (poem by Octavio Paz)
• Alleluia (adapted from his October)
• Animal Crackers, Volume 1 (Poems by Ogden Nash)
  • The Panther
  • The Cow
  • The Firefly
• Animal Crackers, Volume 2 (Poems by Ogden Nash)
  • The Canary
  • The Eel
  • The Kangaroo
• The City and the Sea (poems by e. e. cummings)
  • i walked the boulevard
  • the moon is hiding in her hair
  • maggie and millie and molly and may
  • as is the sea marvelous
  • little man in a hurry
• Cloudburst (poem by Octavio Paz)
• Five Hebrew Love Songs (poem by Hila Plitmann)
  • Temuna
  • Kala Kalla (Light Bride)
  • Larov (Mostly)
  • Eyze Sheleg! (What snow!)
  • Rakut (Tenderness)
• Goodnight Moon (chorus and piano)
• Her Sacred Spirit Soars (poem by Charles Anthony Silvestri)
• Leonardo Dreams of His Flying Machine (libretto by Charles Anthony Silvestri)
• Little Birds (poem by Octavio Paz)
• little tree (poem by E. E. Cummings)
• Lux Aurumque (poem by Edward Esch; translated into Latin by Charles Anthony Silvestri) (also set for male chorus)
• Nox Aurumque (poem by Charles Anthony Silvestri)
• Oculi Omnium
• The Seal Lullaby (poem by Rudyard Kipling)
• She Weeps Over Rahoon (poem by James Joyce)
• Sleep (originally a setting of Robert Frost's poem, "Stopping by Woods on a Snowy Evening"; for copyright reasons^[19] the published version uses a specially-written text by Charles Anthony Silvestri)
• Sleep, My Child (Choral transcription from Paradise Lost: Shadows and Wings)
• The Stolen Child (setting of a poem by William Butler Yeats, commissioned in 2008 by the National Youth Choir of Great Britain and The King's Singers for their respective 25th and 40th anniversaries)
• This Marriage (poem by Jalal al-Din Rumi)
• Three Flower Songs
  • I Hide Myself (poem by Emily Dickinson)
  • With a Lily in Your Hand (poem by Federico García Lorca)
  • Go, Lovely Rose (poem by Edmund Waller)
• Three Songs of Faith (poems by E. E. Cummings)
  • i will wade out
  • hope, faith, life, love
  • i thank You God for most this amazing day^[20]
• Water Night (poem by Octavio Paz; translated by Muriel Rukeyser)
• When David Heard (from II Samuel 18:33)
• Winter (poem by Edward Esch)
• What If (lyrics by David Norona and Eric Whitacre)

SSA choral[link]

• She Weeps Over Rahoon (text by James Joyce)
• Five Hebrew Love Songs (poem by Hila Plitmann)
• The Seal Lullaby (text by Rudyard Kipling)
• I Thank You God (text by E. E. Cummings)

TTBB choral[link]

• Lux Aurumque (poem by Edward Esch, translated into Latin by Charles Anthony Silvestri)
• The Seal Lullaby (text by Rudyard Kipling)

Choral works not yet published[link]

• Goodnight Moon
• Songs of Immortality
  • Lie still, sleep becalmed (poem by Dylan Thomas)
  • After Great Pain (poem by Emily Dickinson)^[21]

Orchestral[link]

• A Boy and a Girl
• Equus
• Goodnight Moon (strings, harp, soprano)
• Lux Aurumque
• October
• The River Cam
• Water Night
• Winter
• Winter (for strings, choir and sitar)

Solo voice[link]

• The City and the Sea (poems by E. E. Cummings)
• Five Hebrew Love Songs (poem by Hila Plitmann)

Music theatre[link]

• Paradise Lost: Shadows and Wings, a musical featuring electronic, world, and orchestral instruments; classical singers; and many different styles of music.

Other arrangements[link]

• Rak HaHatchala (Only the Beginning) [aka Five Hebrew Love Songs]; for soprano voice, solo violin, piano

Film and Television[link]

• Pirates of the Caribbean: On Stranger Tides, co-composer (with Hans Zimmer) of the Mermaid Theme and choral segments

Publishers[link]

Whitacre is published by Chester Music; G. Schirmer; Walton Music; Santa Barbara Music; Shadow Water Music; and Carpe Ranam Music.

Biography portal

References[link]

External links[link]

• Official website
• Eric_Whitacre on WikiMusicGuide
• Biography on Hyperion Records
• NPR Review of Cloudburst and choral audio. 28 September 2006
• Music Productions Ltd (Management company of Eric Whitacre)
• Eric Whitacre write-up on ChesterNovello web site
• Eric talking at TED about the virtual choir
• Eric Whitacre's Virtual Choir 2.0, 'Sleep'
• Classical Archives Interview

John Lennon MBE
Lennon rehearses "Give Peace a Chance" in Montreal, Canada, in 1969
Background information
Birth name	John Winston Lennon
Born	(1940-10-09)9 October 1940 Liverpool, England, UK
Died	8 December 1980(1980-12-08) (aged 40) New York, New York, US
Genres	Rock, pop
Occupations	Musician, singer-songwriter, record producer, artist, writer
Instruments	Vocals, guitar, piano, harmonica, harmonium, electronic organ, six-string bass
Years active	1957–75, 1980
Labels	Parlophone, Capitol, Apple, EMI, Geffen, Polydor
Associated acts	The Quarrymen, The Beatles, Plastic Ono Band, The Dirty Mac, Yoko Ono
Website	www.johnlennon.com
Notable instruments
Rickenbacker 325 Epiphone Casino Gibson J-160E

Lennon's signature

John Winston Ono Lennon, MBE (9 October 1940 – 8 December 1980) was an English musician and singer-songwriter who rose to worldwide fame as one of the founder members of The Beatles, one of the most commercially successful and critically acclaimed acts in the history of popular music. Together with Paul McCartney, he formed one of the most celebrated songwriting partnerships of the 20th century.

Born and raised in Liverpool, Lennon became involved as a teenager in the skiffle craze; his first band, The Quarrymen, evolved into The Beatles in 1960. As the group disintegrated towards the end of the decade, Lennon embarked on a solo career that produced the critically acclaimed albums John Lennon/Plastic Ono Band and Imagine, and iconic songs such as "Give Peace a Chance" and "Imagine". After his marriage to Yoko Ono in 1969, he changed his name to John Ono Lennon. Lennon disengaged himself from the music business in 1975 to devote time to raising his infant son Sean, but re-emerged with Ono in 1980 with the new album Double Fantasy. He was murdered three weeks after its release.

Lennon revealed a rebellious nature and acerbic wit in his music, writing, drawings, on film, and in interviews. Controversial through his political and peace activism, he moved to New York City in 1971, where his criticism of the Vietnam War resulted in a lengthy attempt by Richard Nixon's administration to deport him, while some of his songs were adopted as anthems by the anti-war movement.

As of 2012 Lennon's solo album sales in the United States exceed 14 million units, and as writer, co-writer or performer, he is responsible for 25 number-one singles on the US Hot 100 chart. In 2002 a BBC poll on the 100 Greatest Britons voted him eighth, and in 2008, Rolling Stone ranked him the fifth-greatest singer of all-time. He was posthumously inducted into the Songwriters Hall of Fame in 1987 and into the Rock and Roll Hall of Fame in 1994.

History[link]

1940–57: Early years[link]

Lennon was born in war-time England, on 9 October 1940 at Liverpool Maternity Hospital to Julia and Alfred Lennon, a merchant seaman who was away at the time of his son's birth.^[1] He was named John Winston Lennon after his paternal grandfather, John "Jack" Lennon, and then-Prime Minister Winston Churchill.^[2] His father was often away from home but sent regular pay cheques to 9 Newcastle Road, Liverpool, where Lennon lived with his mother,^[3] but the cheques stopped when he went absent without leave in February 1944.^[4][5] When he eventually came home six months later, he offered to look after the family, but Julia—by then pregnant with another man's child—rejected the idea.^[6] After her sister, Mimi Smith, twice complained to Liverpool's Social Services, Julia handed the care of Lennon over to her. In July 1946 Lennon's father visited Smith and took his son to Blackpool, secretly intending to emigrate to New Zealand with him.^[7] Julia followed them—with her partner at the time, 'Bobby' Dykins—and after a heated argument his father forced the five-year-old to choose between them. Lennon twice chose his father, but as his mother walked away, he began to cry and followed her.^[8] It would be 20 years before he had contact with his father again.^[9]

251 Menlove Avenue, the home of George and Mimi Smith, where Lennon lived for most of his childhood and adolescence

Throughout the rest of his childhood and adolescence he lived with his aunt and uncle, Mimi and George Smith, who had no children of their own, at Mendips, 251 Menlove Avenue, Woolton.^[10] His aunt bought him volumes of short stories, and his uncle, a dairyman at his family's farm, bought him a mouth organ and engaged him in solving crossword puzzles.^[11] Julia visited Mendips on a regular basis, and when he was 11 years old he often visited her at 1 Blomfield Road, Liverpool, where she played him Elvis Presley records, and taught him the banjo, learning how to play "Ain't That a Shame" by Fats Domino.^[12]

In September 1980 he talked about his family and his rebellious nature:

Part of me would like to be accepted by all facets of society and not be this loudmouthed lunatic musician. But I cannot be what I am not. Because of my attitude, all the other boys' parents ... instinctively recognised what I was, which was a troublemaker, meaning I did not conform and I would influence their kids, which I did ... I did my best to disrupt every friend's home ... Partly, maybe, it was out of envy that I didn't have this so-called home, but I really did ... There were five women who were my family. Five strong, intelligent women. Five sisters. Those women were fantastic ... that was my first feminist education ... One happened to be my mother ... she just couldn't deal with life. She had a husband who ran away to sea and the war was on and she couldn't cope with me, and when I was four-and-a-half, I ended up living with her elder sister ... the fact that I wasn't with my parents made me see that parents are not gods.^[13]

He regularly visited his cousin, Stanley Parkes, who lived in Fleetwood. Seven years Lennon's senior, Parkes took him on trips, and to local cinemas.^[14] During the school holidays, Parkes often visited Lennon with Leila Harvey, another cousin, often travelling to Blackpool two or three times a week to watch shows. They would visit the Blackpool Tower Circus and see artists such as Dickie Valentine, Arthur Askey, Max Bygraves and Joe Loss, with Parkes recalling that Lennon particularly liked George Formby.^[15] After Parkes's family moved to Scotland, the three cousins often spent their school holidays together there. Parkes recalled, "John, cousin Leila and I were very close. From Edinburgh we would drive up to the family croft at Durness, which was from about the time John was nine years old until he was about 16."^[16] He was 14 years old when his uncle George died of a liver haemorrhage on 5 June 1955 (aged 52).^[17]

Lennon was raised as an Anglican and attended Dovedale Primary School.^[18] From September 1952 to 1957, after passing his Eleven-Plus exam, he attended Quarry Bank High School in Liverpool, and was described by Harvey at the time as, "A happy-go-lucky, good-humoured, easy going, lively lad."^[19] He often drew comical cartoons which appeared in his own self-made school magazine called The Daily Howl,^[20] but despite his artistic talent, his school reports were damning: "Certainly on the road to failure ... hopeless ... rather a clown in class ... wasting other pupils' time."^[21]

His mother bought him his first guitar in 1956, an inexpensive Gallotone Champion acoustic for which she "lent" her son five pounds and ten shillings on the condition that the guitar be delivered to her own house, and not Mimi's, knowing well that her sister was not supportive of her son's musical aspirations.^[22] As Mimi was sceptical of his claim that he would be famous one day, she hoped he would grow bored with music, often telling him, "The guitar's all very well, John, but you'll never make a living out of it".^[23] On 15 July 1958, when Lennon was 17 years old, his mother, walking home after visiting the Smiths' house, was struck by a car and killed.^[24]

Lennon failed all his GCE O-level examinations, and was accepted into the Liverpool College of Art only after his aunt and headmaster intervened.^[25] Once at the college, he started wearing Teddy Boy clothes and acquired a reputation for disrupting classes and ridiculing teachers. As a result, he was excluded from the painting class, then the graphic arts course, and was threatened with expulsion for his behaviour, which included sitting on a nude model's lap during a life drawing class.^[26] He failed an annual exam, despite help from fellow student and future wife Cynthia Powell, and was "thrown out of the college before his final year."^[27]

1957–70: The Quarrymen to The Beatles[link]

1957–65: Formation, commercial break-out, and touring years[link]

Lennon playing with The Beatles in 1964 at the height of Beatlemania

The Beatles evolved from Lennon's first band, the Quarrymen. Named after Quarry Bank High School, the group was established by him in September 1956 when he was 15, and began as a skiffle group.^[28] By the summer of 1957 the Quarrymen played a "spirited set of songs" made up of half skiffle, and half rock and roll.^[29] Lennon first met Paul McCartney at the Quarrymen's second performance, held in Woolton on 6 July at the St. Peter's Church garden fête, after which McCartney was asked to join the band.^[30]

McCartney says that Aunt Mimi: "was very aware that John's friends were lower class", and would often patronise him when he arrived to visit Lennon.^[31] According to Paul's brother Mike, McCartney's father was also disapproving, declaring Lennon would get his son "into trouble";^[32] although he later allowed the fledgling band to rehearse in the McCartneys' front room at 20 Forthlin Road.^[33][34] During this time, the 18-year-old Lennon wrote his first song, "Hello Little Girl", a UK top 10 hit for The Fourmost nearly five years later.^[35]

George Harrison joined the band as lead guitarist,^[36] even though Lennon thought Harrison (at 14 years old) was too young to join the band, so McCartney engineered a second audition on the upper deck of a Liverpool bus, where Harrison played "Raunchy" for Lennon.^[37] Stuart Sutcliffe, Lennon's friend from art school, later joined as bassist.^[38] Lennon, McCartney, Harrison and Sutcliffe became "The Beatles" in early 1960. In August that year The Beatles, engaged for a 48-night residency in Hamburg, Germany, and desperately in need of a drummer, asked Pete Best to join them.^[39] Lennon was now 19, and his aunt, horrified when he told her about the trip, pleaded with him to continue his art studies instead.^[40] After the first Hamburg residency, the band accepted another in April 1961, and a third in April 1962. Like the other band members, Lennon was introduced to Preludin while in Hamburg,^[41] and regularly took the drug, as well as amphetamines, as a stimulant during their long, overnight performances.^[42]

Brian Epstein, The Beatles' manager from 1962, had no prior experience of artist management, but nevertheless had a strong influence on their early dress code and attitude on stage.^[43] Lennon initially resisted his attempts to encourage the band to present a professional appearance, but eventually complied, saying, "I'll wear a bloody balloon if somebody's going to pay me".^[44] McCartney took over on bass after Sutcliffe decided to stay in Hamburg, and drummer Ringo Starr replaced Best, completing the four-piece line-up that would endure until the group's break-up in 1970. The band's first single, "Love Me Do", was released in October 1962 and reached #17 on the British charts. They recorded their debut album, Please Please Me, in under 10 hours on 11 February 1963,^[45] a day when Lennon was suffering the effects of a cold,^[46] which is evident in the vocal on the last song to be recorded that day, Twist and Shout.^[47] The Lennon–McCartney songwriting partnership yielded eight of its fourteen tracks. With few exceptions—one being the album title itself—Lennon had yet to bring his love of wordplay to bear on his song lyrics, saying: "We were just writing songs ... pop songs with no more thought of them than that–to create a sound. And the words were almost irrelevant".^[45] In a 1987 interview, McCartney said that the other Beatles idolised John: "He was like our own little Elvis ... We all looked up to John. He was older and he was very much the leader; he was the quickest wit and the smartest".^[48]

The Beatles achieved mainstream success in the UK during the beginning of 1963. Lennon was on tour when his first son, Julian, was born in April. During their Royal Variety Show performance, attended by the Queen Mother and other British royalty, Lennon poked fun at his audience: "For our next song, I'd like to ask for your help. For the people in the cheaper seats, clap your hands ... and the rest of you, if you'll just rattle your jewellery."^[49] After a year of Beatlemania in the UK, the group's historic February 1964 US debut appearance on The Ed Sullivan Show marked their breakthrough to international stardom. A two-year period of constant touring, moviemaking, and songwriting followed, during which Lennon wrote two books, In His Own Write and A Spaniard in the Works.^[50] The Beatles received recognition from the British Establishment when they were appointed Members of the Order of the British Empire in the Queen's Birthday Honours of 1965.^[51]

Lennon grew concerned that fans attending Beatles' concerts were unable to hear the music above the screaming of fans, and that the band's musicianship was beginning to suffer as a result.^[52] Lennon's "Help!" expressed his own feelings in 1965: "I meant it ... It was me singing 'help'".^[53] He had put on weight (he would later refer to this as his "Fat Elvis" period),^[54] and felt he was subconsciously seeking change.^[55] The following January he was unknowingly introduced to LSD when a dentist, hosting a dinner party attended by Lennon, Harrison and their wives, spiked the guests' coffee with the drug.^[56] When they wanted to leave, their host revealed what they had taken, and strongly advised them not to leave the house because of the likely effects. Later, in an elevator at a nightclub, they all believed it was on fire: "We were all screaming ... hot and hysterical."^[56] A few months later in March, during an interview with Evening Standard reporter Maureen Cleave, Lennon remarked, "Christianity will go. It will vanish and shrink ... We're more popular than Jesus now—I don't know which will go first, rock and roll or Christianity."^[57] The comment went virtually unnoticed in England but caused great offence in the US when quoted by a magazine there five months later. The furore that followed—burning of Beatles' records, Ku Klux Klan activity, and threats against Lennon—contributed to the band's decision to stop touring.^[58]

1966–70: Studio years, break-up and solo work[link]

Deprived of the routine of live performances after their final commercial concert on 29 August 1966, Lennon felt lost and considered leaving the band.^[59] Since his involuntary introduction to LSD in January, he had made increasing use of the drug, and was almost constantly under its influence for much of the year."^[60] According to biographer Ian MacDonald, Lennon's continuous experience with LSD during the year brought him "close to erasing his identity".^[61] 1967 saw the release of "Strawberry Fields Forever", hailed by TIME magazine for its "astonishing inventiveness",^[62] and the group's landmark album Sgt. Pepper's Lonely Hearts Club Band, which revealed Lennon's lyrics contrasting strongly with the simple love songs of the Lennon–McCartney's early years.

In August, after having been introduced to the Maharishi Mahesh Yogi, the group attended a weekend of personal instruction at his Transcendental Meditation seminar in Bangor, Wales,^[63] and were informed of Epstein's death during the seminar. "I knew we were in trouble then", Lennon said later. "I didn't have any misconceptions about our ability to do anything other than play music, and I was scared".^[64] They later travelled to Maharishi's ashram in India for further guidance, where they composed most of the songs for The Beatles and Abbey Road.^[65]

The anti-war, black comedy How I Won the War, featuring Lennon's only appearance in a non–Beatles' full-length film, was shown in cinemas in October 1967.^[66] McCartney organised the group's first post-Epstein project,^[67] the self-written, -produced and -directed television film Magical Mystery Tour, released in December that year. While the film itself proved to be their first critical flop, its soundtrack release, featuring Lennon's acclaimed, Lewis Carroll-inspired "I am the Walrus", was a success.^[68][69] With Epstein gone, the band members became increasingly involved in business activities, and in February 1968 they formed Apple Corps, a multimedia corporation comprising Apple Records and several other subsidiary companies. Lennon described the venture as an attempt to achieve, "artistic freedom within a business structure",^[70] but his increased drug experimentation and growing preoccupation with Yoko Ono, and McCartney's own marriage plans, left Apple in need of professional management. Lennon asked Lord Beeching to take on the role, but he declined, advising Lennon to go back to making records. Lennon approached Allen Klein, who had managed The Rolling Stones and other bands during the British Invasion. Klein was appointed as Apple's chief executive by Lennon, Harrison and Starr,^[71] but McCartney never signed the management contract.^[72]

	"Give Peace a Chance" noicon Sample of "Give Peace a Chance", recorded in 1969 during Lennon and Ono's second Bed-In for Peace. As described by biographer Bill Harry, Lennon wanted to "write a peace anthem that would take over from the song 'We Shall Overcome'—and he succeeded ... it became the main anti-Vietnam protest song."[73]
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At the end of 1968, Lennon featured in the film The Rolling Stones Rock and Roll Circus (not released until 1996) in the role of a Dirty Mac band member. The supergroup, comprising Lennon, Eric Clapton, Keith Richards and Mitch Mitchell, also backed a vocal performance by Ono in the film.^[74] Lennon and Ono were married on 20 March 1969, and soon released a series of 14 lithographs called "Bag One" depicting scenes from their honeymoon,^[75] eight of which were deemed indecent and most of which were banned and confiscated.^[76] Lennon's creative focus continued to move beyond The Beatles and between 1968 and 1969 he and Ono recorded three albums of experimental music together: Unfinished Music No.1: Two Virgins^[77] (known more for its cover than for its music), Unfinished Music No.2: Life with the Lions and Wedding Album. In 1969 they formed The Plastic Ono Band, releasing Live Peace in Toronto 1969. In protest at Britain's involvement in the Nigerian Civil War,^[78] Lennon returned his MBE medal to the Queen, though this had no effect on his MBE status, which could not be renounced.^[79] Between 1969 and 1970 Lennon released the singles "Give Peace a Chance" (widely adopted as an anti-Vietnam-War anthem in 1969),^[80] "Cold Turkey" (documenting his withdrawal symptoms after he became addicted to heroin^[81]) and "Instant Karma!".

Lennon left the group in September 1969,^[82] and agreed not to inform the media while the band renegotiated their recording contract, but he was outraged that McCartney publicised his own departure on releasing his debut solo album in April 1970. Lennon's reaction was, "Jesus Christ! He gets all the credit for it!"^[83] He later wrote, "I started the band. I disbanded it. It's as simple as that."^[84] In later interviews with Rolling Stone magazine, he revealed his bitterness towards McCartney, saying, "I was a fool not to do what Paul did, which was use it to sell a record."^[85] He spoke too of the hostility he perceived the other members had towards Ono, and of how he, Harrison, and Starr "got fed up with being sidemen for Paul ... After Brian Epstein died we collapsed. Paul took over and supposedly led us. But what is leading us when we went round in circles?"^[86]

1970–80: Solo career[link]

1970–72: Initial solo success and activism[link]

Advertisement for "Imagine" from Billboard, 18 September 1971.

In 1970, Lennon and Ono went through primal therapy with Dr. Arthur Janov in Los Angeles, California. Designed to release emotional pain from early childhood, the therapy entailed two half-days a week with Janov for four months; he had wanted to treat the couple for longer, but they felt no need to continue and returned to London.^[87] Lennon's emotional debut solo album, John Lennon/Plastic Ono Band (1970), was received with high praise. Critic Greil Marcus remarked, "John's singing in the last verse of 'God' may be the finest in all of rock."^[88] The album featured the songs "Mother", in which Lennon confronted his feelings of childhood rejection,^[89] and the Dylanesque "Working Class Hero", a bitter attack against the bourgeois social system which, due to the lyric "you're still fucking peasants", fell foul of broadcasters.^[90][91] The same year, Tariq Ali's revolutionary political views, expressed when he interviewed Lennon, inspired the singer to write "Power to the People". Lennon also became involved with Ali during a protest against Oz magazine's prosecution for alleged obscenity. Lennon denounced the proceedings as "disgusting fascism", and he and Ono (as Elastic Oz Band) released the single "God Save Us/Do the Oz" and joined marches in support of the magazine.^[92]

	"Imagine" noicon Sample of "Imagine", Lennon's "most famous post-Beatles' track."[93] Like "Give Peace a Chance", the song became an anti-war anthem, but its lyrics offended religious groups. Lennon's explanation was, "If you can imagine a world at peace, with no denominations of religion—not without religion, but without this 'my God is bigger than your God' thing—then it can be true."[94]
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With Lennon's next album, Imagine (1971), critical response was more guarded. Rolling Stone reported that "it contains a substantial portion of good music" but warned of the possibility that "his posturings will soon seem not merely dull but irrelevant".^[95] The album's title track would become an anthem for anti-war movements,^[96] while another, "How Do You Sleep?", was a musical attack on McCartney in response to lyrics from Ram that Lennon felt, and McCartney later confirmed,^[97] were directed at him and Ono. However, Lennon softened his stance in the mid-1970s and said he had written "How Do You Sleep?" about himself.^[98] He said in 1980: "I used my resentment against Paul ... to create a song ... not a terrible vicious horrible vendetta ... I used my resentment and withdrawing from Paul and The Beatles, and the relationship with Paul, to write 'How Do You Sleep'. I don't really go 'round with those thoughts in my head all the time".^[99]