Pituitary gland
Located at the base of the brain, the pituitary gland is protected by a bony structure called the sella turcica of the sphenoid bone.
Median sagittal through the hypophysis of an adult monkey. Semidiagrammatic.
Latin	hypophysis, glandula pituitaria
Gray's	subject #275 1275
Artery	superior hypophyseal artery, infundibular artery, prechiasmal artery, inferior hypophyseal artery, capsular artery, artery of the inferior cavernous sinus[1]
Precursor	neural and oral ectoderm, including Rathke's pouch
MeSH	Pituitary+Gland
Dorlands/Elsevier	Pituitary gland

In vertebrate anatomy the pituitary gland, or hypophysis, is an endocrine gland about the size of a pea and weighing 0.5 g (0.02 oz.) in humans. It is not a part of the brain. It is a protrusion off the bottom of the hypothalamus at the base of the brain, and rests in a small, bony cavity (sella turcica) covered by a dural fold (diaphragma sellae). The pituitary is functionally connected to the hypothalamus by the median eminence via a small tube called the infundibular stem (Pituitary stalk). The pituitary fossa, in which the pituitary gland sits, is situated in the sphenoid bone in the middle cranial fossa at the base of the brain. The pituitary gland secretes nine hormones that regulate homeostasis.

[edit] Sections

The pituitary gland consists of two components: the anterior pituitary (or adenohypophysis) and the posterior pituitary (or neurohypophysis), and is functionally linked to the hypothalamus by the pituitary stalk (also named the "infundibular stem", or simply the "infundibulum"). It is from the hypothalamus that hypothalamic tropic factors are released to descend down the pituitary stalk to the pituitary gland where they stimulate the release of pituitary hormones. While the pituitary gland is known as the 'master' endocrine gland, both of the lobes are under the control of the hypothalamus; the anterior pituitary receives its signals from the parvocellular neurons and the posterior pituitary receives its signals from magnocellular neurons.^[2]

[edit] Anterior pituitary (Adenohypophysis)

The anterior pituitary synthesizes and secretes the following important endocrine hormones:

Somatotrophins:

• Growth hormone (also referred to as 'Human Growth Hormone', 'HGH' or 'GH' or somatotropin), released under influence of hypothalamic Growth Hormone-Releasing Hormone (GHRH); inhibited by hypothalamic Somatostatin

Thyrotrophins:

• Thyroid-stimulating hormone (TSH), released under influence of hypothalamic Thyrotropin-Releasing Hormone (TRH)

Corticotropins:

• Adrenocorticotropic hormone (ACTH), released under influence of hypothalamic Corticotropin-Releasing Hormone (CRH)
• Beta-endorphin, released under influence of hypothalamic Corticotropin-Releasing Hormone (CRH)^[3]

Lactotrophins:

• Prolactin (PRL), also known as 'Luteotropic' hormone (LTH), whose release is inconsistently stimulated by hypothalamic TRH, oxytocin, vasopressin, vasoactive intestinal peptide, angiotensin II, neuropeptide Y, galanin, substance P, bombesin-like peptides (gastrin-releasing peptide, neuromedin B and C), and neurotensin, and inhibited by hypothalamic dopamine.^[4]

Gonadotropins:

• Luteinizing hormone (also referred to as 'Lutropin' or 'LH' or, in males, 'Interstitial Cell-Stimulating Hormone' (ICSH))
• Follicle-stimulating hormone (FSH), both released under influence of Gonadotropin-Releasing Hormone (GnRH)

Melanotrophins

• Melanocyte–stimulating hormones (MSHs) or "intermedins," as these are released by the pars intermedia, which is "the middle part"; adjacent to the posterior pituitary lobe, pars intermedia is a specific part developed from the anterior pituitary lobe.

These hormones are released from the anterior pituitary under the influence of the hypothalamus. Hypothalamic hormones are secreted to the anterior lobe by way of a special capillary system, called the hypothalamic-hypophysial portal system.

The anterior pituitary is divided into anatomical regions known as the pars tuberalis, pars intermedia, and pars distalis. It develops from a depression in the dorsal wall of the pharynx (stomodial part) known as Rathke's pouch.

[edit] Posterior pituitary (Neurohypophysis)

The posterior pituitary stores and secretes the following important endocrine hormones:

Magnocellular Neurons:

• Oxytocin, most of which is released from the paraventricular nucleus in the hypothalamus
• Antidiuretic hormone (ADH, also known as vasopressin and AVP, arginine vasopressin), the majority of which is released from the supraoptic nucleus in the hypothalamus

Oxytocin is one of the few hormones to create a positive feedback loop. For example, uterine contractions stimulate the release of oxytocin from the posterior pituitary, which, in turn, increases uterine contractions. This positive feedback loop continues throughout labor.

[edit] Intermediate lobe

Although rudimentary in humans (and often considered part of the anterior pituitary), the intermediate lobe located between the anterior and posterior pituitary is important to many animals. For instance, in fish, it is believed to control physiological color change. In adult humans, it is just a thin layer of cells between the anterior and posterior pituitary. The intermediate lobe produces melanocyte-stimulating hormone (MSH), although this function is often (imprecisely) attributed to the anterior pituitary.

[edit] Variations among vertebrates

The pituitary gland is found in all vertebrates, but its structure varies between different groups.

The division of the pituitary described above is typical of mammals, and is also true, to varying degrees, of all tetrapods. However, only in mammals does the posterior pituitary have a compact shape. In lungfishes, it is a relatively flat sheet of tissue lying above the anterior pituitary, and, in amphibians, reptiles, and birds, it becomes increasingly well developed. The intermediate lobe is, in general, not well developed in tetrapods, and is entirely absent in birds.^[5]

Apart from lungfishes, the structure of the pituitary in fish is generally different from that in tetrapods. In general, the intermediate lobe tends to be well developed, and may equal the remainder of the anterior pituitary in size. The posterior lobe typically forms a sheet of tissue at the base of the pituitary stalk, and in most cases sends irregular finger-like projection into the tissue of the anterior pituitary, which lies directly beneath it. The anterior pituitary is typically divided into two regions, a more anterior rostral portion and a posterior proximal portion, but the boundary between the two is often not clearly marked. In elasmobranchs there is an additional, ventral lobe beneath the anterior pituitary proper.^[5]

The arrangement in lampreys, which are among the most primitive of all fish, may indicate how the pituitary originally evolved in ancestral vertebrates. Here, the posterior pituitary is a simple flat sheet of tissue at the base of the brain, and there is no pituitary stalk. Rathke's pouch remains open to the outside, close to the nasal openings. Closely associated with the pouch are three distinct clusters of glandular tissue, corresponding to the intermediate lobe, and the rostral and proximal portions of the anterior pituitary. These various parts are separated by meningial membranes, suggesting that the pituitary of other vertebrates may have formed from the fusion of a number of separate, but closely associated, glands.^[5]

Most fish also possess a urophysis, a neural secretory gland very similar in form to the posterior pituitary, but located in the tail and associated with the spinal cord. This may have a function in osmoregulation.^[5]

There is an analogous structure in the octopus brain.^[6]

[edit] Functions

Hormones secreted from the pituitary gland help control the following body processes:

• Growth (Excess of HGH can lead to gigantism and acromegaly.)
• Blood pressure
• Some aspects of pregnancy and childbirth including stimulation of uterine contractions during childbirth
• Breast milk production
• Sex organ functions in both males and females
• Thyroid gland function
• The conversion of food into energy (metabolism)
• Water and osmolarity regulation in the body
• Water balance via the control of reabsorption of water by the kidneys
• Temperature regulation

Pituitary gland also makes endorphin to relieve pain and alter mood.

[edit] Additional images

• 

  Location of the pituitary gland in the human brain

• 

  Pituitary and pineal glands

• 

  The arteries of the base of the brain.

• 

  Mesal aspect of a brain sectioned in the median sagittal plane.

• 

  Pituitary

• 

  Pituitary gland

[edit] See also

• Pituitary disease
• Head and neck anatomy
• Dantian

[edit] References

Look up pituitary gland or hypophysis in Wiktionary, the free dictionary.

1. ^ Gibo H, Hokama M, Kyoshima K, Kobayashi S (1993). "[Arteries to the pituitary]". Nippon Rinsho 51 (10): 2550–4. PMID 8254920. 
2. ^ Dasen, J. S.; Rosenfeld, M. G. (1999). "Signaling mechanisms in pituitary morphogenesis and cell fate determination". Curr Opin Cell Biol. 11 (6): 669–677. doi:10.1016/S0955-0674(99)00034-4. PMID 10600709. 
3. ^ Knepel W, Homolka L, Vlaskovska M, Nutto D. (1984). Stimulation of adrenocorticotropin/beta-endorphin release by synthetic ovine corticotropin-releasing factor in vitro. Enhancement by various vasopressin analogs. Neuroendocrinology. 38(5):344-50.
4. ^ Shlomo Melmed (3 December 2010). The pituitary. Academic Press. p. 40. ISBN 978-0-12-380926-1. http://books.google.com/books?id=OFFW68kMpFIC&pg=PA40. 
5. ^ ^{a b c d} Romer, Alfred Sherwood; Parsons, Thomas S. (1977). The Vertebrate Body. Philadelphia, PA: Holt-Saunders International. pp. 549–550. ISBN 0-03-910284-X. 
6. ^ Wells, M. J.; Wells, J. (1969). "Pituitary Analogue in the Octopus". Nature 222 (5190): 293–294. doi:10.1038/222293a0. 

[edit] External links

• NeuroNames hier-382
• Histology at BU 14201loa
• The Pituitary Gland, from the UMM Endocrinology Health Guide
• Oklahoma State, Endocrine System
• Pituitary apoplexy mimicking pituitary abscess
• [1] The Pituitary Foundation