Androgenic alopecia
Classification and external resources
Androgenic alopecia in a male
ICD-10	L64
DiseasesDB	7773
eMedicine	derm/21
MeSH	D000505

Androgenic alopecia (also known as androgenetic alopecia or alopecia androgenetica) is the most common cause of hair loss and thinning in humans. Variants appear in both men and women. Androgenic alopecia also occurs in chimpanzee and orangutans.^[1] In humans, this condition is also commonly known as male pattern baldness. In classic pattern baldness, hair is lost in a well-defined pattern, beginning above both temples. Hair also thins at the crown of the head. Often a rim of hair around the sides and rear of the head is left. This type of pattern is dubbed "Hippocratic balding" and may rarely progress to complete baldness. Women do not suffer classic male pattern baldness, instead the hair becomes thinner around the whole scalp, and the hairline does not recede. This is dubbed "female pattern baldness" and may occur in males. This variety of androgenic alopecia in women rarely leads to total baldness.

Cause[link]

A variety of genetic (and possibly environmental) factors apparently play a role in androgenic alopecia. Although researchers have long studied the factors that may contribute to this condition, many remain unknown. Minimally, pattern hair loss is related to hormones called androgens, particularly dihydrotestosterone (DHT)^[2]. Androgens are important for normal male sexual development before birth and during puberty. Androgens also have other important functions in both males and females, such as regulating hair growth and sex drive.

Male pattern baldness is caused by a genetic sensitivity of hair follicles to DHT. This hormone causes follicles to shrink or "miniaturize". In turn, this shortens their lifespan and prevents them from producing hair normally.^[3]

Recently the existing theories have been challenged on the ground that while the androgens in question are responsible for hair growth on the face and all over the body of men, hair loss only occurs at the top of the scalp. For example, it has been suggested that androgenic alopecia is a consequence of the anabolic effect of androgens such as hormonal changes leading to structural changes in skin and scalp which in turn cause hair loss.^[4] There are as of yet no experiments testing this hypothesis. Recent research suggests that elevated levels of the enzyme prostaglandin D2 synthase and its product prostaglandin D2 (PGD2) in hair follicles causes androgenetic alopecia.^[5]

Hair loss and genetics[link]

Much research concerns the genetic component of male pattern baldness, or androgenic alopecia (AGA). Research indicates that some of the genes involved in the susceptibility to premature male pattern baldness are X-linked, which means linked to genes on an X-chromosome. Other genes that are not sex linked are also involved, however. Men whose fathers had experienced hairloss were 2.5 times more likely to experience hairloss themselves, regardless of the mother's side of the family.^[6][7]

Large studies in 2005 and 2007 stress the importance of the maternal line in the inheritance of male pattern baldness. German researchers name the androgen receptor gene as a necessary condition for balding.^[8] They conclude that a specific variant of the androgen receptor is needed for AGA to develop. This study has been confirmed by other researchers.^[9] This gene is recessive. Thus, a female would need two X chromosomes with the defect to show typical male pattern alopecia. Since androgens and their interaction with the androgen receptor are the cause of AGA, the androgen receptor gene plays an important part in its development.

Other research in 2007 suggests another gene on the X chromosome, that lies close to the androgen receptor gene, is an important gene in male pattern baldness. Researchers^[who?] found the region Xq11-q12 on the X-chromosome to be strongly associated with AGA in males. They point at the EDA2R gene as the gene that is mostly associated with AGA.^[10]

Other genes involved with hair loss have been found, one of them being an allele on chromosome 3. The allele is located at 3q26.^[11] This allele is recessive.

There are also genes that are involved in hair loss, although not male pattern baldness per se. In particular, three genes have been shown to both affect hair texture and also cause baldness in some people. One of these is P2RY5. Mutations in this gene affects hair structure "woolly hair".^[12] Certain variants can lead to baldness.^[13]

In May 2009, researchers in Japan identified a gene, SOX21, a Y-linked gene that may be responsible for some hair loss conditions in humans.^[14]

Hormone levels correlated with androgenic alopecia[link]

Men with androgenic alopecia typically have higher levels of 5-alpha-reductase, lower levels of total testosterone, higher levels of unbound/free testosterone, and higher levels of total free androgens including DHT.^[15][16]

5-alpha-reductase is responsible for converting free testosterone into DHT. The genes for 5-alpha-reductase are known.^[17] The enzymes are present predominantly in the scalp and prostate. Levels of 5-alpha-reductase are one factor in determining levels of DHT in the scalp. Drugs which interfere with 5-alpha-reductase (such as finasteride, which inhibits the predominant type 2 isoform) have been approved by the FDA as treatments for hair loss.

Sex hormone-binding globulin (SHBG), which is responsible for binding testosterone and preventing its bioavailability and conversion to DHT, is typically lower in individuals with high DHT. SHBG is downregulated by insulin.

Increased levels of Insulin Growth Factor-1 (IGF-1) have been correlated to vertex balding.^[18]

High insulin levels seem the likely link between metabolic syndrome and baldness. Low levels of SHBG in men and non-pregnant women are also correlated with glucose intolerance and diabetes risk, though this correlation disappears during pregnancy.^[19]

Hair loss, Age and Hormones Paradox[link]

As people age, the risk of having noticeable hair loss increases so that by age 20, 20% of people have at least some visible hair loss and by age 50, 50% of people have at least some noticeable hair loss. Counterintuitively, the same aging process is followed by an equally linear decrease in 1) serum Testosterone, 2) DHT, and 3) 3AAG(a peripheral marker of DHT metabolism) and an equally similar linear increase in SHBG. The two events are paradoxical to the increase in hair loss with age as Testosterone and peripheral DHT metabolism are thought to accelerate hair loss and SHBG is thought to protect against hair loss. The Ratio of T/SHBG, DHT/SHBG decreases by as much as about 80% by age 80 so the effect of age on hormones is as dramatic as it is on hair loss. Reconciliation of this paradox has not been done and may require a better understanding of the androgen receptor in the skin, and disentangling the mechanisms of hair loss and obtaining a better understanding of the sources of hormones in the blood ie., skin, liver, adipose tissue etc. Of interest, even though free testosterone decreases dramatically by age 80, the levels are still double those of women age 20 and it is possible that the minimum required dose of testosterone to maintain hair loss is under this. The fact that dutasteride and finasteride prevent hair loss in an environment of high testosterone is also insightful into the downstream effects of testosterone and local pathophysiology.

Hair loss and lifestyle[link]

One study did show that free testosterone is lower 24 hours after intense aerobic exercise in men who already have high endurance^[20] but it was not investigated whether that level remains lowered beyond that point, or whether that lowering affects male pattern baldness in any way. It has been suggested^{[citation needed]} that weight training may have a detrimental effect on hair by increasing testosterone levels; however, there is at least one study that indicates a decline in free testosterone as a result of weight training.^[21] Several large scale studies have not found a consistent significant effect of physical activity on hair loss either in making hair loss worse or improving it . eg., in the Physician's Study which measured hair loss and physical activity in tens of thousands of subjects through self report.

Theories on male pattern baldness[link]

One theory, advanced by Muscarella and Cunningham, suggests baldness came about in males through sexual selection as an enhanced signal of aging and social maturity, whereby aggression and risk-taking decrease and nurturing behaviours increase. This may have conveyed a male with enhanced social status but reduced physical threat, which could enhance ability to secure reproductive partners and raise offspring to adulthood.

In a study by Muscarella and Cunnhingham,^[22] males and females viewed six male models with different levels of facial hair (beard and mustache or none) and cranial hair (full head of hair, receding and bald). Participants rated each combination on 32 adjectives related to social perceptions. Males with facial hair and those with bald or receding hair were rated as being older than those who were clean shaven or had a full head of hair. Beards and a full head of hair were seen as being more aggressive and less socially mature, and baldness was associated with more social maturity. A review of social perceptions of male pattern baldness has been provided by Henss (2001).^{[citation needed]}

A study done among South Koreans has shown most people rate balding men as less attractive,^[23] if these results generalize to other cultures, any mating benefit must target purely maternal instincts. In the same vein, it should be noted that ancestral primates had shorter life-spans and earlier mating ages, so there was little significant baldness at mating age. Balding is likely more prevalent in the modern day as a result of extended life expectancy.

Other hypotheses include genetic linkage to beneficial traits unrelated to hair loss and genetic drift.

Diagnosis[link]

The diagnosis of androgenic alopecia can be usually established based on clinical presentation in men. In women, the diagnosis usually requires more complex diagnostic evaluation.

Differential diagnosis involves eliminating other causes of hair loss (such as poisoning) and comparing the pattern of hair loss to a typical male pattern baldness progression.^[24]

In most cases androgenic alopecia may be confirmed by trichoscopy.^[25]

It can be hard to know the diagnosis for sure without a biopsy.^[26]

Treatments[link]

While many people with male pattern baldness choose to accept the condition as they accepted their hair color or shape, there are baldness treatments which can manage and reduce or halt hair loss.

Regrowth of lost hair in the early stages of male pattern baldness can be fully restored with treatment. However, bald spots where hair follicles have been destroyed cannot be restored with non-invasive treatments and require a hair transplant to achieve coverage.^[27].

See also[link]

• Dihydrotestosterone
• Noncicatricial alopecia
• Management of baldness
• Ludwig scale - The scale which rates the severity of androgenic alopecia in females
• Hamilton-Norwood scale - The scale which rates the severity of androgenic alopecia in males

References[link]

External links[link]

• NLM- Genetics Home Reference
• Scow, Dean Thomas; Nolte, Robert S.; Shaugnessy, Allen F. (April 1999). "Medical treatments for balding in men". American family physician 59 (8): 2189–2194, 2196. PMID 10221304. http://www.aafp.org/afp/990415ap/2189.html. 
• Kabai, P (2008). "Androgenic alopecia may have come about to protect men from prostate cancer by increasing skin exposure to ultraviolet radiation". Medical Hypotheses 70 (5): 1038–1040. DOI:10.1016/j.mehy.2007.07.044. PMID 17910907. 
• How Hair Replacement Works Covers oral medications, hair transplant surgery, and topical treatments.
• [2] Male Pattern Baldness Genetics
• [3] USA Today article examining the impact of baldness on career success.

Amy Gibson is a former daytime television Emmy-nominated actress turned businesswoman. Her credits include “Love of Life” (Lynn Henderson), “Young and the Restless” (Alana Anthony Jackson), and “General Hospital” (Colette Francoise) in the 1980s. She is the younger sister of Jody (Babydol) Gibson and niece of singer Georgia Gibbs, a recording artist with a star on the Hollywood Walk of Fame. Her mother Tobe Gibson is the talent agent who discovered Tom Cruise.

Secretly bald for over 20 years due to the medical condition Alopecia Areata Gibson built a post-acting career in wig manufacturing and consulting services to those in need of guidance and support who are dealing with hair loss.^[1][2]

References[link]

External links[link]

• [1]