Progeria
Classification and external resources
ICD-10	E34.8 (ILDS E34.840)
ICD-9	259.8
OMIM	176670
DiseasesDB	10704
eMedicine	derm/731
MeSH	D011371

Progeria (also known as "Hutchinson–Gilford Progeria Syndrome",^[1] "Hutchinson–Gilford syndrome",^[2] and "Progeria syndrome"^[2]) is an extremely rare genetic condition wherein symptoms resembling aspects of aging are manifested at an early age. The word progeria comes from the Greek words "pro" (πρό), meaning "before", and "géras" (γῆρας), meaning "old age". The disorder has very low incidences and occurs in an estimated 1 per 8 million live births.^[3] Those born with progeria typically live to their mid teens and early twenties.^[4][5] It is a genetic condition that occurs as a new mutation (de novo), and is rarely inherited. Although the term progeria applies strictly speaking to all diseases characterized by premature aging symptoms, and is often used as such, it is often applied specifically in reference to Hutchinson-Gilford Progeria Syndrome (HGPS).

Scientists are particularly interested in progeria because it might reveal clues about the normal process of aging.^[6][7][8] Progeria was first described in 1886 by Jonathan Hutchinson.^[9] It was also described independently in 1897 by Hastings Gilford.^[10] The condition was later named Hutchinson-Gilford Progeria Syndrome (HGPS).

Signs and symptoms[link]

Children with progeria usually develop the first symptoms during infancy. The earliest symptoms include failure to thrive and a localized scleroderma-like skin condition. As a child ages past infancy, additional conditions usually become apparent around 18–24 months. Limited growth, full-body alopecia, and a distinctive appearance (small face and jaw, pinched nose) are all characteristics of progeria. Signs and symptoms of this progressive disease tend to get worse as the child ages. Later, the condition causes wrinkled skin, atherosclerosis, kidney failure, loss of eyesight, hair loss, and cardiovascular problems. Scleroderma, a hardening and tightening of the skin on trunk and extremities of the body, is prevalent. People diagnosed with this disorder usually have small, fragile bodies, like those of elderly people. The face is usually wrinkled, with a larger head in relation to the body, a narrow face and a beak nose. Prominent scalp veins are noticeable (made more obvious by hair loss), as well as prominent eyes. Musculoskeletal degeneration causes loss of body fat and muscle, stiff joints, hip dislocations, and other symptoms generally absent in the non-elderly population. Individuals usually retain normal mental and motor development.

Cause[link]

In normal conditions, the LMNA gene encodes a protein called prelamin A, which leads to the lamin A form. There is a farnesyl group attached to the carboxyl-terminus of its structure. Farnesyl molecule allows prelamin A to be anchored to nuclear rim, and then it is removed. Before the late 20th century, research on progeria yielded very little information about the syndrome. In 2003, the cause of progeria was discovered to be a point mutation in position 1824 of the LMNA gene, replacing cytosine with thymine, creating a truncated form, progerin, of the prelamin A protein whose further processing is abnormal. Normal lamin A is a major structural protein of the nuclear lamina of the nucleus (along with lamin C);when LMNA is mutated, farnesyl group can not be removed and progerin does not integrate into this structure and accumulates, disrupting it.^[11] This is when HGPS appears. Since the nuclear lamina participates in organizing chromatin and supporting the nuclear envelope; this disrupts the human cell nucleus as a whole, limiting the ability of the cell to divide.^[12] Then, the appearance of affected nuclei is like bubbles or a cluster of grapes. Progerin may also play a role in normal human aging, since its production is activated in senescent wild type cells.^[12]

Unlike "accelerated aging diseases" (such as Werner's syndrome, Cockayne's syndrome, or xeroderma pigmentosum), progeria is not caused by defective DNA repair. Because these diseases display what are considered different aspects of aging, but never every aspect, they are often called "segmental progerias".^[13]

Diagnosis[link]

Diagnosis is suspected according to signs and symptoms, such as skin changes, abnormal growth, and loss of hair. A genetic test for LMNA mutations can confirm the diagnosis of progeria.^[14][15]

Treatment[link]

No treatments have been proven effective. Most treatment focuses on reducing complications (such as cardiovascular disease) with heart bypass surgery or low-dose aspirin.^[16] Children may also benefit from a high-calorie diet.

Growth hormone treatment has been attempted.^[17] The use of morpholinos has also been attempted in order to reduce progerin production. Antisense morpholino oligonucleotides specifically directed against the mutated exon 11–exon 12 junction in the mutated premRNAs were used.^[18]

Potential therapeutic targets for the inhibition of progerin farnesylation.

A type of anticancer drug, the farnesyltransferase inhibitors (FTIs), has been proposed, but their use has been mostly limited to animal models.^[19] A Phase II clinical trial using the FTI lonafarnib began in May 2007.^[20] In studies on the cells another anti-cancer drug, rapamycin, caused removal of progerin from the nuclear membrane through autophagy.^[11][21] It has been proved that pravastatin and zoledronate are effective drugs when it comes to the blocking of farnesyl group production. However, it is important to remember that no treatment is able to cure progeria.

Farnesyltransferase inhibitors (FTIs) are drugs which inhibit the activity of an enzyme needed in order to make a link between progerin proteins and farnesyl groups. This link generates the permanent attachment of the progerin to the nuclear rim. In progeria, cellular damage can be appreciated because that attachment takes place and the nucleus is not in a normal state. Lonafarnib is an FTI, which means it can avoid this link, so progerin can not remain attached to the nucleus rim and it has now a more normal state. The delivery of Lonafarnib is not approved by the US Food and Drug Administration (FDA). Therefore, it can only be used in certain clinical trials. Until the treatment of FTIs is implemented in progeria children we will not know its effects—which are positive in mice.^[22]

Pravastatin, traded as Pravachol or Selektine, is included in the family of statins. As well as zoledronate (also known as Zometa and Reclast, which is a bisphosphonate), its utility in Hutchinson-Gilford progeria syndrome (HGPS) is the prevention of farnesyl groups formation, which progerin needs to provoke the disease. Some animal trials have been realized using FTIs or a combination of pravastatin and zoledronate so as to observe whether they are capable of reversing abnormal nuclei. The results, obtained by blinded electron microscopic analysis and immunofluorescence microscopy, showed that nucleus abnormalities could be reversed in transgenic mice expressing progerin. The reversion was also observed in vivo—cultured cells from human subjects with progeria—due to the action of the pharmacs, which block protein prenylation (transfer of a farnesyl polypeptide to C-terminal cysteine). The authors of that trial add, when it comes to the results, that: “They further suggest that skin biopsy may be useful to determine if protein farnesylation inhibitors are exerting effects in subjects with HGPS in clinical trials”.^[23] Unlike FTIs, pravastatin and zoledronate were approved by the U.S. FDA (in 2006 and 2001 respectively), although they are not sold as a treatment for progeria. Pravastatin is used to decrease cholesterol levels and zoledronate to prevent hypercalcaemia.

Rapamycin, also known as Sirolimus, is a macrolide. There are recent studies concerning rapamycin which conclude that it can minimize the phenotypic effects of progeria fibroblasts. Other observed consequences of its use are: abolishment of nuclear blebbing, degradation of progerin in affected cells and reduction of insoluble progerin aggregates formation. All these results do not come from any clinical trial, although it is believed that the treatment might benefit HGPS kids.^[11]

It should always be taken in account that no treatment is delivered in order to cure Hutchinson-Gilford progeria syndrome; all potential drugs are in pre-clinical stages.

Prognosis[link]

As there is no known cure, few people with progeria exceed 13 years of age.^[24] At least 90% of patients die from complications of atherosclerosis, such as heart attack or stroke.^[25]

Mental development is not adversely affected; in fact, intelligence tends to be above average.^[26] With respect to the features of aging that progeria appears to manifest, the development of symptoms is comparable to aging at a rate eight to ten times faster than normal. With respect to features of aging that progeria does not exhibit, patients show no neurodegeneration or cancer predisposition. They also do not develop the so-called "wear and tear" conditions commonly associated with aging, such as cataracts (caused by UV exposure) and osteoarthritis (caused by mechanical wear).^[14]

Although there may not be any successful treatments for progeria itself, there are treatments for the problems it causes, such as arthritic, respiratory, and cardiovascular problems.

Epidemiology[link]

A study from the Netherlands has shown an incidence of 1 in 4 million births.^[27] Currently, there are 80 known cases in the world. Approximately 140 cases have been reported in medical history.^[28]

Classical Hutchinson-Gilford Progeria Syndrome is usually caused by a sporadic mutation taking place during the early stages of embryo development. It is almost never passed on from affected parent to child, as affected children rarely live long enough to have children themselves (very few children with progeria even live past the teen years to be 21).

There have been only two known cases in which it became evident that a healthy person can carry the LMNA mutation that causes progeria. These carriers were identified because they passed it on to their children.^[7] One family from India has five children with progeria, although this is not a classical HGPS ;^[29] they were the subject of a 2005 Bodyshock documentary entitled The 80 Year Old Children, while another from Belgium has two.^[30]

In September 2011, the first reported case of a black African child with progeria was reported, 12-year-old South African Ontlametse Phalatse.^[31] The Progeria Research Foundation at Children's Hospital Boston, affiliated with the Harvard University Medical School, is treating her and monitoring her case.

Research[link]

Several discoveries have been made that have led to greater understanding and perhaps eventual treatment.^[32]

A 2003 report in Nature^[33] said that progeria may be a de novo dominant trait. It develops during cell division in a newly conceived zygote or in the gametes of one of the parents. It is caused by mutations in the LMNA (lamin A protein) gene on chromosome 1; the mutated form of lamin A is commonly known as progerin. One of the authors, Leslie Gordon, was a physician who did not know anything about progeria until her own son, Sam, was diagnosed at 21 months. Gordon and her husband, pediatrician Scott Berns, founded the Progeria Research Foundation.^[34]

Lamin A[link]

A range of putative disease-causing mechanisms for the case of HGPS, in which lamin A is permanently farnesylated in the form of progerin. We predict that progerin becomes entrapped in the nuclear membrane as a result of permanent farnesylation, resulting in a multitude of downstream effects. Disruption of the normal lamina architecture leads to fragility, vulnerability to mechanical stresses and nuclear blebbing. Other consequences include disrupted interactions with other nuclear envelope proteins – such as nesprin, emerin and laminaassociated protein 2 (LAP2) – which leads to their mislocalization (that is, emerin is relocalized to the cytoplasm in Lmna -/- mice)74 and clustering of nuclear pores. Disorganization and loss of peripheral heterochromatin is also seen, with heterochromatin becoming detached from the nuclear envelope, and disrupted interactions with RNA polymerase II, RNA splicing factors and transcription factors such as the retinoblastoma transcriptional regulator (RB) and sterol response element binding protein (SREBP1), which leads to misregulation of gene expression. GCL, germ cell-less. Capell and Collins, Nature Reviews Genetics 2006.^{[35][caption too long]}

Lamin A is a major component of a protein scaffold on the inner edge of the nucleus called the nuclear lamina that helps organize nuclear processes such as RNA and DNA synthesis.

Prelamin A contains a CAAX box at the C-terminus of the protein (where C is a cysteine and A is any aliphatic amino acids). This ensures that the cysteine is farnesylated and allows prelamin A to bind membranes, specifically the nuclear membrane. After prelamin A has been localized to the cell nuclear membrane, the C-terminal amino acids, including the farnesylated cysteine, are cleaved off by a specific protease. The resulting protein, now lamin A, is no longer membrane-bound, and carries out functions inside the nucleus.

In HGPS, the recognition site that the enzyme requires for cleavage of prelamin A to lamin A is mutated. Lamin A cannot be produced, and prelamin A builds up on the nuclear membrane, causing a characteristic nuclear blebbing.^[36] This results in the symptoms of progeria, although the relationship between the misshapen nucleus and the symptoms is not known.

A study that compared HGPS patient cells with the skin cells from young and elderly normal human subjects found similar defects in the HGPS and elderly cells, including down-regulation of certain nuclear proteins, increased DNA damage, and demethylation of histone, leading to reduced heterochromatin.^[37] Nematodes over their lifespan show progressive lamin changes comparable to HGPS in all cells but neurons and gametes.^[38] These studies suggest that lamin A defects are associated with normal aging.

Mouse model of progeria[link]

Confocal microscopy photographs of the descending aortas of two 15-month-old progeria mice, one untreated (left picture) and the other treated with the farnsyltransferase inhibitor drug tipifarnib (right picture). The microphotographs show prevention of the vascular smooth muscle cell loss that is otherwise rampant by this age. Staining was smooth muscle alpha-actin (green), lamins A/C (red) and DAPI (blue). (Original magnification, x 40)^{[caption too long]}

Untreated cells from children with the genetic disease progeria (left) compared to similar cells treated with farnesyltransferase inhibitors (FTIs). In the test tube, FTIs reverse the nuclear damage caused by the disease.

A mouse model of progeria exists, though in the mouse, the LMNA prelamin A is not mutated. Instead, ZMPSTE24, the specific protease that is required to remove the C-terminus of prelamin A, is missing. Both cases result in the buildup of farnesylated prelamin A on the nuclear membrane and in the characteristic nuclear LMNA blebbing. Fong et al. use a farnesyl transferase inhibitor (FTI) in this mouse model to inhibit protein farnesylation of prelamin A. Treated mice had greater grip strength and lower likelihood of rib fracture and may live longer than untreated mice.^[39]

This method does not directly "cure" the underlying cause of progeria. This method prevents prelamin A from going to the nucleus in the first place so that no prelamin A can build up on the nuclear membrane, but equally, there is no production of normal lamin A in the nucleus. Lamin A does not appear to be necessary for life; mice in which the Lmna gene is knocked out show no embryological symptoms (they develop an Emery–Dreifuss muscular dystrophy-like condition postnatally).^[40] This implies that it is the buildup of prelamin A in the wrong place, rather than the loss of the normal function of lamin A, that causes the disease.

It was hypothesized that part of the reason that treatment with an FTI such as alendronate is inefficient is due to prenylation by geranylgeranyltransferase. Since statins inhibit geranylgeranyltransferase, the combination of an FTI and statins was tried, and markedly improved "the aging-like phenotypes of mice deficient in the metalloproteinase Zmpste24, including growth retardation, loss of weight, lipodystrophy, hair loss, and bone defects".^[41]

Popular culture[link]

Perhaps one of the earliest influences of progeria on popular culture occurred in the 1922 short story The Curious Case of Benjamin Button by F. Scott Fitzgerald (and later released as a feature film in 2008). The main character, Benjamin Button, is born as a seventy-year-old man and ages backwards; it has been suggested that this was inspired by progeria.^[42]

Charles Dickens may have described a case of progeria in the family of Smallweed of Bleak House, specifically in the grandfather and his grandchildren Judy and twin brother Bart.^[43] Orlando Gardiner of the science fiction book series Otherland suffers from this disease.

The Chuck Palahniuk novel Haunted includes one character, Brandon Whittier, who is dying of progeria at 13.

David Lindsay-Abaire's play Kimberly Akimbo dramatizes the experience of central character Kimberly Levaco's experience with progeria.

In film, a number of well-known films have featured progeria or progeria-like diseases. The 2009 Bollywood film Paa, released in December 2009, has its storyline around progeria (starring Amitabh Bachchan, playing a 13-year old boy Auro).^[44] The 1996 film Jack, starring Robin Williams, portrays a character who has a condition which causes him to age at 4 times the normal rate. This was possibly based on progeria though is otherwise not an accurate portrayal of the syndrome. In the film Blade Runner the character J.F. Sebastian is a genetic designer who is not allowed to emigrate off-world because of his progeria.

The extraterrestrial space traveler in the 1986 film The Aurora Encounter was played by Mickey Hays, a teenage boy who suffered from progeria.

In the episode of the series Dark Angel titled "Designate This", Max's "younger version" has the disease. Progeria was featured in the X-Files episode "Young at Heart," where a scientist studying the disease found a way to reverse the aging process.

Rabbi Harold Kushner, author of the well known book When Bad Things Happen to Good People, had a son who suffered from this disease, and his son's illness was probably the impetus for this book on suffering.^{[citation needed]}

Leon Botha, a South African visual artist and DJ who appeared in a video for the conceptual rave-rap group Die Antwoord, was one of the oldest people in the world who lived with progeria, dying one day after his 26th birthday on June 5, 2011.

See also[link]

• Werner syndrome, also called Adult progeria
• Biogerontology
• Degenerative disease
• Laminopathies
• Lipodystrophy
• Hayley Okines, an English girl with progeria who is known for spreading progeria awareness
• Brooke Greenberg, an American girl with the opposite condition (permanently a baby), known as Syndrome X.
• List of cutaneous conditions

References[link]

External links[link]

• Progeria : Aging starts in childhood
• Media related to progeria at Wikimedia Commons
• Progeria Research Foundation
• Progeria News and Media Collection
• GeneReview/NIH/UW entry on Hutchinson-Gilford Progeria Syndrome
• Segmental progeria
• "A Time to Live" – Seattle Post-Intelligencer feature about Seth Cook, a child with progeria.
• "ABC 20/20 special news program about Progeria, with Barbara Walters"

Selena Gomez
Gomez attending "The 6th Annual Hollywood Style Awards", Beverly Hills, CA on Oct. 10, 2009
Background information
Birth name	Selena Marie Gomez
Born	(1992-07-22) July 22, 1992 (age 19) Grand Prairie, Texas, U.S.
Genres	Pop, dance, pop rock[1]
Occupations	Actress, singer, Fashion Designer
Instruments	Vocals, piano, guitar, drums
Years active	2002–present
Labels	Hollywood
Associated acts	Selena Gomez & the Scene, Demi Lovato, Taylor Swift
Website	SelenaGomez.com

Selena Marie Gomez (born July 22, 1992)^[2] is an American actress and singer best known for portraying Alex Russo in the Emmy Award-winning Disney Channel television series Wizards of Waverly Place. She subsequently ventured into feature films and has starred in the television movies Another Cinderella Story, Wizards of Waverly Place: The Movie, and Princess Protection Program. She made her starring theatrical film debut in Ramona and Beezus.

Her career has expanded into the music industry; Gomez is the lead singer and founder of the pop band Selena Gomez & the Scene, which has released three RIAA Gold certified studio albums, Kiss & Tell, A Year Without Rain, and When the Sun Goes Down, spawned three RIAA Platinum certified singles, "Naturally", "Who Says" and "Love You Like a Love Song" and charted four No. 1 Billboard Hot Dance Club Songs.^[3] Gomez has also contributed to the soundtracks of Tinker Bell, Another Cinderella Story, Wizards of Waverly Place, and Shake It Up after signing a record deal with Hollywood Records.

In 2008, Gomez was designated a UNICEF Goodwill Ambassador.^[4]

Early life[link]

Gomez was born in Grand Prairie, Texas.^[2] She is the daughter of former stage actress Amanda Dawn "Mandy" Teefey (née Cornett) and Ricardo Joel Gomez.^[5][6][7] Her father is of Mexican ancestry, and her mother is of part Italian descent.^[8][9] Regarding her Hispanic heritage, Gomez said: "My family does have Quinceañeras, and we go to the communion church. We do everything that's Catholic, but we don't really have anything traditional except [that we] go to the park and have barbecues on Sundays after church."^[10] Her birth parents divorced when she was five years old, and she was raised as an only child by her working mother.^[5][11] In 2006, Mandy remarried Brian Teefey.^[12] She was named after Tejano singer Selena, who died almost three years after Gomez was born.^[13] In a 2009 interview with People, Gomez mentioned that she developed an early interest in acting from watching her mother prepare for and act in theater productions.^[11] She earned a high school diploma through homeschooling in May 2010.^[14]

Career[link]

[edit] 2002–06: Barney & Friends and early work

Gomez began her acting career at age seven, playing Gianna on Barney & Friends.^[15] She later had minor roles in Spy Kids 3-D: Game Over and the TV film Walker, Texas Ranger: Trial By Fire. Gomez also starred in the television movie Brain Zapped. (Selena Gomez also found out that she wanted to be an actress because in E Special she states that "I would also watch my mom on stage do her lines".)

In 2004, Gomez was discovered by the Disney Channel in a USA-wide scouting.^[16] Gomez appeared as a guest star on The Suite Life of Zack & Cody and had a guest appearance – that later turned into a recurring role – on Hannah Montana from seasons two to three. Gomez previously taped two different pilots that were spin-offs to two previous Disney series.^[17] The first one, What's Stevie Thinking?, was the spin-off to Lizzie McGuire. Gomez played Stevie Sanchez, Miranda Sanchez's little sister. The other show was titled Arwin!, the spin-off to The Suite Life of Zack & Cody, in which she played Alexa. Neither series was picked up.

[edit] 2007–09: Wizards of Waverly Place and Selena Gomez & The Scene

Gomez on the studio set of Wizards of Waverly Place before filming an episode for the show's first season in April 2007

In early 2007 Gomez was cast in the Disney Channel series Wizards of Waverly Place as one of the three main characters, Alex Russo. The show premiered to an audience of 5.9 million, becoming a hit. Many news outlets began dubbing Gomez the next 'Miley Cyrus' causing some controversy and a reported 'feud'. Gomez clarified that there was no feud and that she was flattered by the comparison, saying: "It's a little overwhelming, but I think really, it's a compliment. She's obviously extremely successful, and I think she's a wonderful performer ... So being compared to her, I was very, very flattered."^[18] Gomez recorded four songs, one of which was a cover, for theWizards of Waverly Place soundtrack, only one single (Magic) from the album was released.

In 2008, Gomez recorded a cover of "Cruella de Vil"—which included a music video—for the compilation albumDisneyMania 6. Gomez also recorded "Fly to Your Heart" for the 2008 animated film Tinker Bell. In July 2008, before Gomez' sixteenth birthday, she signed a recording deal with Hollywood Records, a music label owned by Disney.^[19] In May, of the same year, Gomez was featured, with Forever the Sickest Kids, on a duet version of the non-album song "Whoa Oh!".^[20] The same year Gomez appeared in Another Cinderella Story, the direct-to-DVD sequel to the 2004 Hilary Duff film, opposite Drew Seeley. She also had a minor voiceover role as one the Mayor's ninety-six daughters in Horton Hears a Who! which released in March of that year. In April, Lacey Rose, of Forbes ranked Gomez as being fifth on their "Eight Hot Kid Stars To Watch" list; and Rose described Gomez as having been "a multitalented teen".^[21] Gomez recorded three songs for the movie's soundtrack.

In 2009, Gomez formed the teen pop band Selena Gomez & the Scene. Kiss & Tell, the band's debut studio album and was released on September 29, 2009 by Hollywood Records. On March 5, 2010, the album was certified Gold by RIAA.^[3] The album's single, "Naturally", was certified Platinum by the RIAA on July 15, 2010.^[3] In February 2009, Gomez signed on to star as one of the two female leads in Ramona and Beezus, a film adaption of the children's novel series by Beverly Cleary.^[22][23] Gomez stated that she felt no pressure in taking more adult roles: "I think I’m fully aware of my audience and I’m still just a kid myself. I wouldn’t do a role I don’t feel comfortable doing or that my audience wouldn’t feel comfortable seeing."^[24]

In June 2009, Gomez did a guest appearance as herself in one episode of best friend Demi Lovato's Disney Channel television show, Sonny with a Chance, entitled "Battle of The Network Stars". That same month Gomez appeared alongside Lovato in the made-for-television Disney Channel movie, Princess Protection Program.^[25] The telecast garnered 8.5 million viewers becoming, at the time, the third most watched Disney Channel Original Movie.^[26] One month later, Gomez, along with two cast members of Wizards of Waverly Place appeared in a television three-way cross-over episode with Hannah Montana and The Suite Life on Deck, entitled Wizards on Deck with Hannah Montana.

On August 28, 2009 two months after appearing in Princess Protection Program, Gomez starred in Wizards of Waverly Place: The Movie, a made-for-television film based on the show.^[27] The film premiered to an audience of 11.4 million viewers becoming cable's No. 1 scripted telecast of 2009 and Disney Channel's second most-viewed film premiere after High School Musical 2.^[28] In September 2009, Wizards of Waverly Place won "Outstanding Children's Program" at the 61st Primetime Emmy Awards.^[29] In 2010, the film adaptation won the series its second consecutive Emmy for "Outstanding Children's Program" at the 62nd Primetime Emmy Awards.^[29]

[edit] 2010–2011:Theatrical film debut, A Year Without Rain and When The Sun Goes Down

Gomez on location in Paris, France filming Monte Carlo in June 2010

Gomez's first theatrical film Ramona & Beezus premiered on July 23, 2010 and met with generally positive reviews.^[30] In March 2010, Variety reported that Gomez was set to star as one of the three lead roles in Monte Carlo, alongside Leighton Meester and Katie Cassidy.^[31] In the film Gomez plays Grace, a girl who’s “mistaken for a socialite while on a trip to Paris.”^[32] To prepare for the role Gomez learned how to play polo and also took two weeks of vocal training to learn two different British accents.^[33][34] The same year Gomez confirmed that the fourth season of her hit Disney Channel show, Wizards of Waverly Place, would be its last.

Gomez performing at the 2011 MuchMusic Video Awards.

On September 17, 2010 , Selena Gomez and The Scene released their second studio album, A Year Without Rain The record debuted on the Billboard 200 at number 4, selling 66,000 copies. On January 19, 2011, the album was certified Gold by RIAA.^[3] As of April 2011, the band has sold 1,354,000 albums in the United States.^[35] To support the album, the band embarked on the mini-tour A Year Without Rain Tour. In February 2011, Deadline.com reported that Universal Pictures and Strike Entertainment had acquired the novel Thirteen Reasons Why by Jay Asher with Gomez attached to the lead.^[36] That same month TV Guide reported that Gomez would make a cameo in the Muppets film.^[37] On March 23, 2011, Hollywood Records announced through a press release that Selena Gomez & The Scene would be embarking on their third concert tour in the United States, the We Own the Night Tour ran during the summer of 2011.^[38] Production for the final season of Wizards of Waverly Place came to a wrap on May 14, 2011.^[39] Gomez co-hosted the 2011 MuchMusic Video Awards on June 19.^[40] She also hosted the 2011 MTV EMAs on November 6, 2011, in Belfast, Northern Ireland, where she performed her band's single "Hit the Lights". Near the end of 2011, it was reported Gomez was in talks to star in two upcoming films. Deadline.com announced in October that Gomez would take part in the comedy Hot Mess.^[41]

In early November, Variety reported that Gomez was in talks to star in the upcoming film Spring Breakers alongside James Franco and Vanessa Hudgens.^[42] Gomez confirmed to MTV that she had signed on for the project and that production will begin in early 2012.^[43] On June 28, 2011, Selena Gomez & the scene released their third studio album, When the Sun Goes Down, previously titledOtherside,^[44] The album debuted at number 4 on the Billboard 200, selling 78,000 copies its first week and the following week, the album rose to number 3 on the Billboard chart, becoming the band's highest charting album to date.^[45][46] On November 17, 2011, the album was certified platinum.^[3] The album's lead single, "Who Says" was certified Platinum by RIAA on June 23, 2011 and has become the band's highest charting song on the Billboard Hot 100 to date, peaking at number 21.^[3][47] The second single, "Love You Like a Love Song", was certified Platinum by RIAA on December 2, 2011, and became the act's first to sell over two-million copies.^[3][48]

2012–present: Focus on film[link]

In January 2012, Gomez announced that she would put her music career on hold.^[49] This was later reaffirmed as Gomez wrote on her Facebook page that she was taking a break from music in order to focus on her acting career, "my band and I are going our separate ways for a while. This year is all about films and acting and I want my band to play music wherever with whoever. We will be back but, it will be a good while."^[50] In February 2012, Gomez announced that the band would be taking a hiatus, so that she could focus on film for the year. She encouraged her band mates to work with other artists during the hiatus.^[51] The same month, it was announced that Gomez will replace Miley Cyrus in the animated comedy Hotel Transylvania playing Mavis, the daughter of Dracula who will be voiced by Adam Sandler.^[52] As of March 2012, Gomez has been cast in four upcoming films; in which three of them she has been cast as a lead role. She will first appear in Hotel Transylvania, an animated film, voicing the character of Mavis, who was originally supposed to be voiced by Miley Cyrus, however Cyrus dropped out of the film in early 2012 in order to focus on her music career.^[53] The film is scheduled to be released on September 21, 2012.^[54] Next, Gomez will appear in Spring Breakers, which is currently being filmed on location in Sarasota, Florida. The film is being written and directed by Harmony Korine.^[55] Gomez has also been cast as the main role of Hannah Baker in the film adaptation of young-adult fiction novel, 13 Reasons Why. The novel was written by Jay Asher.^[56] She will also play the lead role in a film called Hot Mess, a comedy film directed by Dave Meyers.^[56] On April 7, 2012, Gomez posted a video for fans in which she revealed that she will be filming a new movie called "The Getaway" in Bulgaria. ^[57]

Other projects[link]

Philanthropy[link]

Selena Gomez performs at the KISS 108 Jingle Ball in December 2010

Gomez was involved in the UR Votes Count campaign which encouraged teenagers to learn more about 2008 presidential candidates Barack Obama and John McCain.^[58] In October 2008, Gomez participated in St. Jude's Children's Hospital "Runway For Life" benefit.^[59] Gomez is a spokesperson for Borden Milk; she is featured in the campaign's print and television ads.^[60] She is the ambassador of DoSomething.org after being involved with the charity Island Dog, which help dogs in Puerto Rico.^[61] She got involved while filming Wizards of Waverly Place: The Movie in Puerto Rico.^[62] Gomez is a spokesperson for State Farm Insurance, and is featured in their TV commercials; which air on the Disney Channel, to raise awareness of being a safe driver.^[63] Gomez is also involved with the charity RAISE Hope For Congo, an initiative of the Enough Project, which helps raise awareness about conflict minerals and violence against Congolese women.^[64]

In October 2008, Gomez was named UNICEF's spokesperson for the Trick-or-Treat for UNICEF campaign, which encouraged children to raise money on Halloween to help children around the world.^[4] She said that she was "extremely excited" to "encourage other kids to make a difference in the world."^[4]

In August 2009, a 17-year-old Gomez became the youngest UNICEF ambassador ever, passing fellow songstress Hayley Westenra, who was 18 when she was chosen. In her first official field mission, Gomez traveled to Ghana on September 4, 2009 for a week to witness first-hand the stark conditions of vulnerable children that lack vital necessities including clean water, nourishment, education and healthcare.^[65][66] Gomez explained during an interview with Associated Press that she wanted to use her star power to bring awareness to Ghana: “That’s why I feel very honored to have a voice that kids listen to and take into consideration [...] I had people on my tour asking me where IS Ghana, and they Googled it [...] and because I went there, they now know where Ghana is. So it’s pretty incredible.”^[66][67] Gomez said of her role as ambassador that: "Every day 25,000 children die from preventable causes. I stand with UNICEF in the belief that we can change that number from 25,000 to zero. I know we can achieve this because every moment, UNICEF is on the ground providing children with the lifesaving assistance needed to ensure zero becomes a reality."^[65]

Gomez was named spokesperson for UNICEF's 2009 Trick-or-Treat campaign, for the second year in a row.^[68] Gomez, who raised over $700,000 for the charity in 2008, stated that she hopes to be able to raise 1 million dollars in 2009.^[66] Gomez participated in a celebrity auction^[69] and hosted a live web cast series on Facebook in support of the Trick-or-Treat for UNICEF campaign.^[70] Gomez returned as the UNICEF spokesperson for the 60th anniversary of Trick-or-Treat for UNICEF campaign in 2010.^[71] In celebration of the 60th anniversary, Gomez and her band, The Scene, held a benefit concert donating all proceeds to the campaign.^[72]. On January 22nd 2010, Gomez participated in the Hope for Haiti Now Telethon with a number of other celebrities^[73].

In February 2011, Gomez traveled to Chile to witness and meet with the families of UNICEF's supported program, "Programa Puente" which helps families better understand and develops skills to deal effectively with early childhood education, development and other issues related to raising children. From her field trip experience, Gomez said "UNICEF is helping Chilean families get out of poverty, prevent violence within the home and promote education. To witness first hand these families' struggles, and also their hope and perseverance, was truly inspiring."^[74] In March 2011, Gomez participated in the UNICEF Tap Project's "Celebrity Tap Pack," limited-edition, custom-made water bottles featuring tap water from the homes of each celebrity advocate, in order to raise funds and increase profile for the clean water and sanitation programs.^[75] She is also featured in videos promoting the campaign.^[76][77]

Gomez is involved in Disney's Friends for Change, an organization which promotes "environmently-friendly behavior", and appears in its public service announcements.^[78] Gomez, Demi Lovato, Miley Cyrus, and the Jonas Brothers recorded "Send It On", a charity single with all of its proceeds to the Disney Worldwide Conservation Fund.^[79][80] It debuted on the Billboard Hot 100 at number 20.^[79] Also in 2009, Gomez made a surprise visit to a Los Angeles elementary school as part of the "A Day Made Better" program that was sponsored by OfficeMax. During her visit, Gomez gave the school an award and $1,000 worth of school supplies, and talked to students about the importance of giving back to the community.^[81][82]

Gomez is also the owner of six rescue dogs and describes herself as a "huge animal-lover".^[83]

In April 2012, Gomez was named ambassador to the Ryan Seacrest Foudation^[84].

Entrepreneurship and sponsorships[link]

Gomez was part of Sears back-to-school fashion ad campaign.^[85] As part of the campaign Gomez was featured in the television commercials. In August 2009, Gomez also hosted the "Sears Arrive Air Band Casting Call" – to select five people for the first-ever "Sears Air Band", which performed at the 2009 MTV Video Music Awards.^[86]

In October 2008, Gomez launched her own production company, July Moon Productions, and partnered with XYZ Films to create star vehicles for Gomez. As part of the agreement Gomez will have the opportunity to be able option articles, hire writers and create talent packages to shop to studios.^[87][88] Also, as part of the deal, "XYZ Films will allow Gomez to star in and produce at least two films.^[81] Variety reported that: "In August, XYZ [Films] inked a similar deal with Time Inc. and management-production company the Collective to finance the development of the print media giant's content for the bigscreen [...] As part of the July Moon-XYZ deal, [Selena] Gomez will have the ability to cherry-pick projects from the vast Time Inc. library, which includes Time, Sports Illustrated, Fortune and Life."^[88]

In October 2009, Gomez announced her plan to launch her own fashion line, called "Dream Out Loud by Selena Gomez". The clothing line launched in the fall of 2010.^[89][90] The collection consists of and features bohemian dresses, floral tops, jeans, skirts, jackets, scarves and hats, all made from recycled or eco-friendly materials.^[91][92] Gomez said that the line will reflect her own personal style and described the clothing as being "pretty, feminine, and bohemian," and: "With my line, I really want to give the customer options on how they can put their own looks together [...] I want the pieces that can be easy to dress up or down, and the fabrics being eco-friendly and organic is super important [...] Also, the tags will all have some of my inspirational quotes on them. I'm just looking to send a good message."^[89][92] Gomez, who has no background in fashion, teamed up with designers Tony Melillo and Sandra Campos, both who have worked with big-name fashion houses.^[90] Gomez said of the partnering: "When I met Tony and Sandra, I was instantly comfortable with them and now they are just like family to me ... They are so creative and I love how I can just call them up whenever and talk to them about everything, even if it's just about changing a button ... They've been so cool about everything."^{[89][90][91][92]} The brand will be manufactured by, Melillo and Campos teamed with New York-based Adjmi Apparel and formed by Adjmi CH Brands LLC; which is the holding company for the brand.^[93]

It was announced on July 14, 2011, that Gomez had signed a license agreement with Adrenalina, an extreme sports and adventure-themed lifestyle brand, to develop, manufacture, and distribute the actress' fragrance. It is expected to debut in May of 2012. Chairman and C.E.O. of Adrenalina, Ilia Lekach, said, "We are incredibly enthused to be working with Ms. Gomez and will reveal more details pertaining to the fragrance as we get closer to the launch date."^[94]

Personal life and Image[link]

With a solid fan and media following, Selena Gomez is considered a teen idol. She has appeared on several magazine covers, including People Magazine,^[95] Cosmopolitan,^[96] Billboard,^[97] TVGuide,^[98] Teen Vogue,^[99] Seventeen,^[100] Elle^[101].

Wax statues of Gomez are on display at Madame Tussauds wax museums in New York^[102], London^[103], Washington D.C^[104] and Hollywood.

Relationships[link]

Gomez has had several high-profile relationships. She had an on-off relationship with singer Nick Jonas of the Jonas Brothers from 2008 to 2010.^[105] In 2009, she met actor Taylor Lautner in Vancouver, while she was filming Ramona and Beezus and he was shooting New Moon^[106], and the two dated for almost a year. However the pressure of the media became too much for them and caused the two to break-up.^[107] On February 27 2011, Gomez attended the 2011 Vanity Fair Oscar Party with Canadian singer Justin Bieber,^[108] confirming several months of media speculation about a romantic relationship between the pair.^{[109][110][111][112][113][114]} The relationship has since continued to garner significant media attention.^{[115][116][117][118][119]}

Filmography[link]

Film[link]

Television[link]

Discography[link]

Albums

• 2009: Kiss & Tell
• 2010: A Year Without Rain
• 2011: When the Sun Goes Down

Soundtrack albums[link]

Singles[link]

Featured singles[link]

Other charted songs[link]

Music videos[link]

Tours[link]

Rankings[link]

Awards and nominations[link]

Main article: List of awards and nominations received by Selena Gomez

References[link]

External links[link]

Wikimedia Commons has media related to: Selena Gomez

• Official website
• Selena Gomez at the Internet Movie Database
• Selena Gomez on Facebook
• Selena Gomez at Disney.com