It can be used in a treatment plan in combination with other agents, such as quinine.
It is also effective against Yersinia pestis (the infectious agent of bubonic plague), and is prescribed for the treatment of Lyme disease, ehrlichiosis and Rocky Mountain spotted fever. In fact, because doxycycline is one of the few medications shown to be effective in treating Rocky Mountain spotted fever (with the next-best alternative being chloramphenicol), doxycycline is indicated even for use in children for this illness. Otherwise, doxycycline is not indicated for use in children under the age of eight years. Doxycycline, like other antibiotics, will not work for colds, influenza, or other viral infections. When bacteriologic testing indicates appropriate susceptibility to the drug, doxycycline may be used to treat and prevent:
Unlike some other members of the tetracycline group, it may be used in those with renal impairment.
Previously, doxycycline was believed to impair the effectiveness of many types of hormonal contraception due to CYP450 induction. Recent research has shown no significant loss of effectiveness in oral contraceptives while using most tetracycline antibiotics (including doxycycline), although many physicians still recommend the use of barrier contraception for people taking the drug to prevent unwanted pregnancy.
Individuals eating yogurt for beneficial bacteria (to counter antibiotic-induced diarrhea) should not eat it within three hours before or after taking a dose of doxycycline, as calcium content in dairy products can interfere with its absorption by being chelated by it. For the same reason, antacids containing calcium and/or magnesium salts are to be avoided for at least three hours after taking the drug.
Doxycycline, like all tetracyclines, is not approved for general use in children, but specific exceptions are made for potentially fatal illnesses where the benefits outweigh the risks and there are few or no other alternatives, such as with Rocky Mountain spotted fever and anthrax.
Expired tetracyclines or tetracyclines allowed to stand at a pH less than 2 are reported to be nephrotoxic due to the formation of a degradation product, anhydro-4-epitetracycline causing Fanconi's syndrome. In the case of doxycycline, the absence of an hydroxyl group in C-6 prevent the formation of the nephrotoxic compound. Nevertheless, tetracyclines and doxycycline itself have to be taken with precaution in patients with kidney injury, as they can worsen azotemia due to catabolic effects.
Other experimental applications include: Vancomycin-resistant enterococcus (VRE) Infected animal bite wounds (Pasteurella multocida, Pasteurella pneumotropica) Rheumatoid arthritis and reactive arthritis Chronic inflammatory lung diseases (panbronchiolitis, asthma, cystic fibrosis, bronchitis) Sarcoidosis Prevention of aortic aneurysm in people with Marfan syndrome and Vascular Ehlers-Danlos syndrome Multiple sclerosis
Category:Antimalarial agents Category:Tetracycline antibiotics Category:World Health Organization essential medicines
af:Doxisiklien ar:دوكسيسايكلين zh-min-nan:Doxycycline cs:Doxycyklin de:Doxycyclin dv:ޑޮކްސީސައިކްލިން es:Doxiciclina fa:داکسی سایکلین fr:Doxycycline it:Doxiciclina ht:Doksisiklin nl:Doxycycline ja:ドキシサイクリン pl:Doksycyklina pt:Doxiciclina ru:Доксициклин sr:Доксициклин fi:Doksisykliini sv:Doxycyklin th:ดอกซีไซคลีน tr:Doksisiklin zh:多西环素This text is licensed under the Creative Commons CC-BY-SA License. This text was originally published on Wikipedia and was developed by the Wikipedia community.
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