The Christian and Missionary Alliance (C&MA) is an evangelical Protestant denomination within Christianity.

Founded by Rev. Albert Benjamin Simpson in 1887, the Christian & Missionary Alliance did not start off as a denomination, but rather began as two distinct parachurch organizations: The Christian Alliance which focused on the pursuit and promotion of the Higher Christian life and The Evangelical Missionary Alliance, which focused on mobilizing "consecrated" Christians in the work of foreign missionary efforts. These two groups amalgamated in 1897 to form The Christian and Missionary Alliance. It was only much later during the mid-20th century that an official denomination was formed.^{[citation needed]}

As of 2006, there are 2,010 C&MA churches and approximately 417,000 members in the United States.^{[dead link]} Approximately 600 of those churches are described as intercultural. In Canada, there are 440 churches, 59 of which are multicultural, and approximately 120,000 members. In the C&MA 2004 annual report estimated that outside of the U.S. and Canada, C&MA membership exceeds 3 million.