Interstate 83 (abbreviated I-83) is an Interstate Highway in the eastern United States. Its southern terminus is in Baltimore, Maryland at the Fayette Street exit; its northern terminus is in Harrisburg, Pennsylvania at Interstate 81.

Most of the route south of Lemoyne, Pennsylvania is a direct replacement of US 111, a former spur of US 11.

The Jones Falls Expressway, known to local residents as the JFX, is a 10.2-mile (16.4 km) long freeway that carries Interstate 83 from downtown Baltimore to the northern suburbs. It is the area's true north–south artery, because Interstate 95 runs mostly east–west through much of the city. Its southern terminus is at Fayette Street, and its northern terminus is at MD 25, just north of the Baltimore Beltway (I-695). Inside Baltimore, the road is maintained not by the Maryland State Highway Administration, which controls most freeways in the state, but by the city's Department of Transportation.

The freeway begins at an at-grade four-way intersection between the Jones Falls Expressway, Fayette Street, and President Street, located in close proximity to the Phoenix Shot Tower. The latter roadway continues south along the eastern edge of the central business district (CBD) to terminate at a traffic circle near the Inner Harbor. Fayette Street serves as an access route into the downtown area.