Coordinates	51°50′″N107°36′″N
name	Trey Parker
birth date	October 19, 1969
birth name	Randolph Severn Parker III
birth place
occupation	Actor, writer, director, producer, musician
active	1992 -
spouse	Emma Sugiyama (2005–2008) }}

Trey Parker (born Randolph Severn Parker III; October 19, 1969) is an American animator, screenwriter, director, producer, voice artist, musician and actor, best known for being the co-creator of the television series ''South Park'' along with his creative partner and best friend Matt Stone.

Parker started his film career in 1992, making a holiday short titled ''Jesus vs. Frosty''. His first success came from ''Cannibal! The Musical''. From there he made another short titled ''Jesus vs. Santa'', which led him and his college friend, Matt Stone, to create the animated television series ''South Park'', which began airing on television in 1997. He has won 4 Emmy Awards for his role in South Park, winning for both "Outstanding Programming More Than One Hour" and "Outstanding Programming Less Than One Hour".

He has co-written and co-directed the 2011 multi-Tony Award winning musical ''The Book of Mormon''.

Early life

Parker was born in Denver, Colorado, the son of Randy (a geologist) and Sharon (an insurance broker). The two share the first names and occupations of ''South Park'' characters Randy and Sharon Marsh. He has an older sister named Shelley, which is also the name of Stan Marsh's older sister. In the sixth grade, Parker wrote a sketch titled ''The Dentist'' and appeared in his school's talent show. He played the dentist and had a friend play the patient. The plot involved what can go wrong at the dentist; due to the amounts of fake blood involved, Parker's parents were called and were upset. "The kindergartners were all crying and freaking out," Parker recalled. As a teenager, Parker developed a love for musical theatre, and joined the Evergreen Players, a venerable mountain community theater outside of Denver. At 14, he performed his first role as chorus member in ''The Best Little Whorehouse in Texas'', ''Flower Drum Song'' and went on to also design sets for the community theater's production of ''Little Shop of Horrors''. Parker attended high school at Evergreen High, where he continued his musical endeavors through starring as Danny Zuko in ''Grease''. He also played piano for the chorus and was president of the choir counsel.

Parker worked hard in school and had a part-time student job in a pizza restaurant. Parker was also a "film geek and music buff". Parker grew up in the Conifer, Colorado area, and attended Berklee College of Music before transferring to the University of Colorado, where he majored in music and Japanese.

Career

In 1992, Parker and Stone created ''Jesus vs. Frosty''. It included four boys, Stan Marsh, Kyle Broflovski, Kenny McCormick and Eric Cartman. Both ''Jesus vs. Frosty'' and ''Cannibal! The Musical'' were made while they were students at the University of Colorado film school, studying under both ''Stan Brakhage'' and Jerry Aronson. Afterwards, the two friends set off for Hollywood in hopes of making more movies. Brian Graden, then an executive at Fox, put Parker to work making a pilot for a musical children's television series called ''Time Warped''. The pilot, called "Rom and Jul," was a love story about a Homo erectus and an Australopithecus. Fox passed on the series, but Graden paid Parker and Stone $1,200 to make a new version of ''The Spirit of Christmas'' he could send out as a video Christmas card.

They came up with two worthwhile ideas; one a sequel to ''Jesus vs. Frosty'', entitled ''Jesus vs. Santa'', and one about a character that would later be recurring in ''South Park'', Mr. Hankey. They chose to write about the four boys. The result was The Spirit of Christmas, an animated short film that centered on four crude-acting, blob-shaped third-grade boys forced to intervene in a nasty fistfight between Jesus Christ and Santa Claus. The tape was a smash, passed around and copied endlessly in media circles in Los Angeles and New York City. The video landed in the hands of Doug Herzog of Comedy Central. "It literally was the funniest thing I'd ever seen," he said in a 2006 interview. "We said, 'Develop a show.' So they went off and developed the show." Stone and Parker produced 13 episodes for season 1. South Park is currently still under contract to produce new episodes through 2011.

In 1997, they also released ''Orgazmo'', a movie rated NC-17. In 1998, they starred in (but did not write or direct) ''BASEketball'', another feature film, while being renewed for a second season of ''South Park''. In 1999, Parker and Stone made ''South Park: Bigger, Longer & Uncut'', which gave the series a new level of prominence. He was nominated for an Academy Award as the co-writer of one of the film's songs, "Blame Canada," but did not win. In 2001, the duo announced they would do 39 shorts between the lengths of 2 and 5 minutes. Although originally thought to be ''South Park'' related, they decided they would do something different. The result was the shorts ''Princess''. The content was so extreme that it was cancelled after two shows aired. In 2001, they also created ''That's My Bush!'', another television series. Despite great reviews, the show was cancelled after one season for the cost per episode. In 2004, they made a film, titled ''Team America: World Police''. The film was not considered a box-office success, grossing 51 million dollars in theaters, despite largely positive reviews (78% fresh rating on RottenTomatoes.com). As of 2011, ''South Park'' is in its fifteenth season.

Parker is also a member of the band DVDA with Stone, for which he plays keyboards and sings. DVDA's songs have appeared in many of the duo's productions. They include ''Orgazmo'', ''BASEketball'', ''South Park: Bigger, Longer & Uncut'', and ''Team America: World Police''.

Trey claimed to have been on acid with Matt Stone at the time of the 2000 Academy Awards, where they wore dresses popularized by Jennifer Lopez and Gwyneth Paltrow at previous awards shows.

On September 28, 2007, Parker and Stone acquired the rights to the Canadian-made ''Kenny vs. Spenny'', which premiered November 14, 2007 on Comedy Central with ten old and new episodes.

In April 2010, Trey Parker and Matt Stone received a "warning" for allegedly representing the Prophet Muhammad in a bear costume: "We have to warn Matt and Trey [South Park creators] that what they are doing is stupid and they will probably wind up like Theo Van Gogh for airing this show." It was revealed in the next episode that the person in the bear costume was really Santa Claus and not the Prophet Muhammad.

Theater productions

Parker and Stone have collaborated with ''Avenue Q'' composer Robert Lopez on a musical about Mormons; it is titled ''The Book of Mormon'', and stars Andrew Rannells and Josh Gad. It has been produced by Scott Rudin and Anne Garefino. It opened at the Eugene O'Neill Theatre on March 24, 2011, following previews from February 24, 2011. The Book of Mormon won nine Tony Awards in 2011, including that of Best Direction of a Musical for Parker and co-director Casey Nicholaw.

Voices on ''South Park''

{| |- style="vertical-align: top;" |

Eric Cartman

Stan Marsh

Randy Marsh

Marvin Marsh

Starvin' Marvin

Clyde Donovan

Mr. Garrison

Ned Gerblansky

Dr. Alphonse Mephisto

Mr. Hankey

Santa Claus

God

|

Sexual Harassment Panda

Mr. Mackey

Stephen Stotch

Officer Barbrady

Ms. Choksondik (2000-2002)

Timmy

Jimmy Vulmer

Tuong Lu Kim

Phillip

Satan

Various

|}

Personal life

In 2006, Parker married Emma Sugiyama. The officiant was 1970s sitcom producer Norman Lear. That marriage ended, and Parker is now living with a woman and her son.

On a September 2006 airing of the ABC news program ''Nightline'', Parker articulated his position on religion. He stated that he believes there is knowledge that humanity may not yet possess, and cautioned that it would take a long time to explain exactly what he meant by his belief in God. Parker further remarked, "Basically ... out of all the ridiculous religion stories which are greatly, wonderfully ridiculous — the silliest one I've ever heard is, 'Yeah ... there's this big giant universe and it's expanding, it's all gonna collapse on itself and we're all just here just 'cause ... just '''cause'''. That, to me, is the most ridiculous explanation ever."

Discography

''Baseketball (soundtrack)'' (1998)

''Orgazmo (soundtrack)'' (1998)

''Chef Aid: The South Park Album'' (1998)

''South Park: Bigger, Longer & Uncut (soundtrack)'' (1999)

''Mr. Hankey's Christmas Classics'' (1999)

''Team America: World Police (soundtrack)'' (2005)

Filmography

''Cannibal ''The Spirit of Christmas (short film) ''Orgazmo'' ''South Park'' (Television series; 1997–present) ''BASEketball'' ''South Park: Bigger, Longer & Uncut'' ''Even If You Don't'' ''Princess (Flash series) ''Team America: World Police'' ''The Aristocrats (film) ''Kenny vs. Spenny'' ''Saul of the Mole Men''

Year	! Production	! Role	! Other notes
rowspan="1"	1992	The Spirit of Christmas (short film)>Jesus vs. Frosty''	Actor, Producer, Writer
rowspan="1"	1993	The Musical''	Director, Actor, Producer, Writer
rowspan="3"	1995	Jesus vs. Santa'' ||	Actor, Producer, Writer
''Time Warped'' (un-aired television series)	Creator, Actor
''Your Studio and You''	Actor, Writer, Director
1996	|	Director, Actor, Writer, Producer
rowspan="1"	1997	|	Co-Creator, Voice Actor, Writer, Director, Executive Producer
1998	|	Actor
rowspan="2"	1999	|	Director, Voice Actor, Writer, Producer, Music Co-Composer	Nomination - Academy Award for Best Original Song
''Terror Firmer''	Actor
2000	|	Director	Music Video
rowspan="2"	2001	Princess'' ||	Director, Writer, Voice Actor, Producer	Animation Shorts
''That's My Bush! (Television Series; 2001'')	Co-creator, Writer, Executive Producer
rowspan="2"	2004	|	Director, Writer, Voice Actor, Producer
''Tales from the Crapper''	Actor
2005	The Aristocrats'' ||	Guest Appearance
2007	|	Executive Producer
2007	|	Voice actor	Television series, intro sung by him

Awards

Tony Awards

Trey Parker has won four Tony Awards.

2011 – Best Musical for ''The Book of Mormon''

2011 – Tony Award for Best Book of a Musical for ''The Book of Mormon''

2011 – Tony Award for Best Direction of a Musical for ''The Book of Mormon''

2011 – Tony Award for Best Original Score for ''The Book of Mormon''

References

External links

Category:1969 births Category:American animators Category:American film directors Category:American libertarians Category:American screenwriters Category:American television producers Category:American voice actors Category:Berklee College of Music alumni Category:Critics of Scientology Category:Emmy Award winners Category:Living people Category:Peabody Award winners Category:People from Denver Metro Area Category:South Park Category:Tony Award winners Category:University of Colorado at Boulder alumni Category:American skeptics

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Coordinates	51°50′″N107°36′″N
Name	Trey Songz
Background	solo_singer
Birth name	Tremaine Aldon Neverson
Alias
Born	November 28, 1984Petersburg, Virginia, United States
Instrument	Vocals, keyboards, sampler
Genre	R&B;, Hip-hop
Occupation	Singer–songwriter, record producer, actor
Years active	2004–present
Label	Atlantic, Songbook
Associated acts	Drake, Troy Taylor, Twista, Juvenile, Bun B, Rick Ross, Plies
Website	www.treysongz.com }}

Tremaine "Trey" Aldon Neverson (born November 28, 1984), better known by his stage name Trey Songz, is an American singer-songwriter, rapper, record producer and actor. His debut album, ''I Gotta Make It'', was released in 2005, while his second album, ''Trey Day'', was released in 2007. His third album, ''Ready'', was released in 2009 while his fourth studio album, ''Passion, Pain & Pleasure'', was released on September 14, 2010.

Life and career

1984–2004: Early life

Songz was born Tremaine Aldon Neverson on November 28, 1984, in Petersburg, Virginia. Raised as a military brat, Songz did not have aspirations to have a musical career as a child due to his shyness, saying "Singing wasn't a reality for me, until other people started noticing I sounded good." He recognized his vocal abilities at the age of 14 in 1998. Reluctant to sing, he began performing with encouragement by friends and family in high school. Record producer Troy Taylor discovered Songz during a talent show in 2000, which led him to signing a recording contract with Atlantic Records in 2002. After graduating from high school in 2002, Songz moved to New Jersey to begin recording his debut album, though recording didn't actually begin until 2003.

2004–2006: ''I Gotta Make It''

While recording his debut album in 2004, Songz released multiple mixtapes under the alias ''Prince of Virginia''. One of the mixtapes featured an "answer track" to R. Kelly's "Trapped in the Closet", entitled "Open the Closet". The song gave Trey some notoriety. His debut album, ''I Gotta Make It'' was released on July 26, 2005. It debuted at #20 on the ''Billboard'' 200, selling 40,000 copies in its first week of sales. It has sold 300,000 records in the US, but was never certified by the RIAA. Songz's debut single, ''Gotta Make It'', featuring Twista, was released in March 2005 and reached #87 on the ''Billboard'' Hot 100 and #21 on the Hot R&B;/Hip-Hop Songs. It garnered success in the R&B;/urban community but failed to make a mark in mainstream music. The album's second and final single, ''Gotta Go'', was released in July 2005 and reached #67 on the Hot 100 and #11 on the Hot R&B;/Hip-Hop Songs chart, becoming even more successful than his debut single in the R&B;/urban community and in the mainstream community. After promotion for his debut concluded, he was featured on the lead single from Twista's fifth album, ''The Day After''. The single, "Girl Tonite", reached #14 on the Hot 100 and #3 on the Hot R&B;/Hip-Hop Songs chart, becoming a huge hit.

2007–2008: ''Trey Day''

In mid-2006, Songz began work on a follow-up album to his debut with longtime collaborator Troy Taylor and also employed hitmakers Bryan-Michael Cox, Danja, Stargate (production team) and R. Kelly to help create the album. Trey aimed for the album to be more mainstream-oriented than his debut album. His second studio album, ''Trey Day'', was released on October 2, 2007. The album reached #11 on the ''Billboard'' 200, selling 73,000 copies in its first week. It has since sold 400,000 records in the US, becoming his second album not to be certified by the RIAA. The album was going to be released on May 8, 2007, but was continually delayed in order for a successful single to precede the album, as the lead single failed to impact charts. His second album was preceded by the lead single, "Wonder Woman", which was released in February 2007. It reached #54 on the Hot R&B;/Hip-Hop Songs chart, but failed to impact the Hot 100. Because of the single's failure, his second album was delayed from May 2007 to October 2007. The album's second single, "Can't Help but Wait", was released in August 2007 and was released to promote his second album and the film ''Step Up 2 the Streets'' soundtrack as a single for it. The single reached #14 on the Hot 100, and #2 on the Hot R&B;/Hip-Hop Songs chart. It became Songz's first Top 20 hit on the Hot 100, and helped to boost his second album's sales. The single was also nominated for Best Male R&B; Vocal Performance at the 2008 50th Grammy Awards. The third single from the album, "Last Time", was released in January 2008 and reached #69 on the Hot 100, and #9 on the Hot R&B;/Hip-Hop Songs chart. The fourth and final single from the album, "Missin' You", was released in May 2008, but failed to chart completely. In mid-2008, Songz was nominated for a BET Award for Best Male R&B; Artist but didn't win the award.

2009–2010: ''Ready''

In late 2008, Trey began work on his third studio album with Bryan-Michael Cox, Sean Garrett, Stargate and Troy Taylor and aimed for the record to be more mature than his first two. Before releasing his third album, Songz released a mixtape titled ''Anticipation'' in June 2009 through his blog, which featured songs from his third album. Another mixtape from Trey was released in the summer of 2009, called ''Genesis''. ''Genesis'' was a collection of Trey Songz's first recordings when he was fifteen years old and was released to show his fans the dedication that he had to making a record when he was young. Trey released his third studio album, ''Ready'', on August 31, 2009. The album reached #3 on the ''Billboard'' 200, selling 131,000 copies in its first week. These are his best first week sales to date and the album was his first to reach the Top 10 on the Billboard 200. The album has since sold over 800,000 records in the US, earning a Gold certification from the RIAA in February 2010, becoming his first album to be certified by the RIAA. The lead single from the album, "I Need a Girl", was released in April 2009 and reached #5 on the Hot R&B;/Hip-Hop songs chart and #59 on the Hot 100, becoming an R&B;/urban hit but not a mainstream hit. A promotional single, "Successful", featuring rapper Drake, was released in June 2009 and reached #17 on the Hot 100, becoming Songz's third Top 20 hit. The single also served as the second and final single from Drake's EP, ''So Far Gone''. The second official single from his third album, "LOL Smiley Face", featuring Soulja Boy Tell 'Em and Gucci Mane, was released in August 2009 and reached #51 on the Hot 100 and #12 on the Hot R&B;/Hip-Hop Songs chart. The third single from the album, "I Invented Sex", featuring Drake, was released in October 2009 and reached #42 on the Hot 100 but #1 on the Hot R&B;/Hip-Hop Songs chart, becoming his first single to top that chart. Like the first two singles from the album, it achieved success in the R&B;/urban community but only some mainstream success. charted within the ''Billboard'' Hot 100, and topped the R&B; chart. The fourth single from the album, "Say Aah", featuring rapper Fabolous, was released in January 2010 and reached #9 on the Hot 100 and #3 on the Hot R&B;/Hip-Hop Songs chart. The single has become Trey's highest charting single on the Hot 100 and one of his most successful singles on the Hot R&B;/Hip-Hop Songs chart. The fifth and final single from the album, "Neighbors Know My Name", was released in February 2010 and reached #43 on the Hot 100 and #4 on the Hot R&B;/Hip-Hop Songs chart. A sixth single, "Yo Side of the Bed", was going to be released in June 2010, but its release was canceled due to unknown reasons. A music video, featuring singer Keri Hilson, was filmed and released, however. Songz was also the opening act for Jay-Z on his Jay-Z Fall Tour in late 2009. The album was nominated for Best Contemporary R&B; Album at the 52nd Grammy Awards in 2010, but lost to Beyoncé's ''I Am... Sasha Fierce''. On April 1, 2010, he recorded an episode of MTV Unplugged, which aired on April 26, 2010. A documentary-series about Trey, ''Trey Songz: My Moment'', began in June 2010 to positive reviews and high ratings. The 10-part series will end in August 2010 and follows Trey during his time as opening act on Jay-Z's Jay-Z Fall Tour in late 2009.

2010–2011: ''Passion, Pain & Pleasure''

Songz's fourth studio album, ''Passion, Pain & Pleasure'', was released on September 14, 2010. Trey began work on the album in early 2010 with Sean Garrett, Troy Taylor and Stargate and has stated that the album will be his most personal to date. The album was completed in July 2010. The album's lead single, "Bottoms Up", featuring female rapper Nicki Minaj, was released on July 27, 2010 and has reached number twenty-four on the Hot R&B;/Hip-Hop Songs chart and was shared enough on Facebook to appear as a trending video on ItsTrending. Its video was filmed on July 31, 2010 and is pending release. Trey also filmed the video for the album's second single, "Can't Be Friends", on August 1, 2010. "Can't Be Friends" was released as the album's second single in August 2010. Songz embarked on the ''Passion, Pain & Pleasure Tour'' on August 6, 2010 with singer Monica. The tour is his first headlining tour to date and consists of shows in venues that seat 3,000 to 5,000 people. Songz also contributed the song "Already Taken" to the ''Step Up 3D'' soundtrack, which was released on July 27, 2010. He filmed a video for the song, which was released in July 2010. The leading lady in the video is former girlfriend and professional dancer Helen Gedlu. Songz appeared at the 2010 MTV Video Music Awards on September 12, 2010. Songz performed at BET Awards 2011 which broadcasted on June 26, 2011.

In July 2011, he was cast in ''The Texas Chainsaw Massacre 3D'' as Ryan, the male lead role.

2011-Present: Chapter 5

On August 18th, 2011, It was announced Songz will be working on his fifth studio titled ''Chapter 5''. In a interview Trey said The album, which will act as the follow-up to ‘Passion, Pain, & Pleasure’, is said to be nearing completion. He also carried on to say "It’s my sixth year in the game so I’ve been here for a while now. You can expect the best me you’ve ever heard. I don’t have any release dates in mind right now but I’m just making music and enjoying myself in the studio and having fun. When I get to a place where I feel comfortable saying a date or all of that, people will definitely know. I have a few dream collaborations on that album that I want, but they say if you blow out your candle and make a wish you can’t tell people what you ask for or it won’t come true."

Discography

''I Gotta Make It'' (2005)

''Trey Day'' (2007)

''Ready'' (2009)

''Passion, Pain & Pleasure'' (2010)

''Chapter 5'' (TBA)

Filmography

{|class="wikitable" style="font-size: 95%;" !style="background:#B0C4DE;"|Year !style="background:#B0C4DE;"|Title !style="background:#B0C4DE;"|Role !style="background:#B0C4DE;"|Notes |- |2008 |''Queen of Media'' |DJ I.V. |film |- |2009 |''Lincoln Heights'' |Himself |Episode: "Relative Unknown" |- |2010 |''Preacher's Kid (film)'' |small role |- |2010 |''When I Was 17'' |Himself |Interview-like show, about what he did when he was 17 |- |2010 |''Trey Songz: My Moment'' |Himself |Interview-Documentary show, following him around on tour with Jay-Z. |}

Awards and nominations

{|class="wikitable" !Year !Award !Result |- |rowspan="3"|2008 |BET Award for Best Male R&B; Artist | |- |Grammy Award for Best Male R&B; Vocal Performance for "Can't Help but Wait" | |- |Ozone Award for Best R&B; Artist | |- |rowspan="1"|2009 |Soul Train Awards for Best Collaboration "Successful" | |- |rowspan="5"|2010 |Grammy Award for Best Contemporary R&B; Album for "Ready" | |- |BET Award for Best Male R&B; Artist | |- |BET Award for Best Collaboration for "Say Ahh" w/ Fabolous | |- |BET Award for Best Collaboration for "Successful" w/ Drake | |- |BET Award for Viewer's Choice for "Say Ahh" w/ Fabolous | |- |rowspan="2"|2011 |BET Award for Best Male R&B; Artist | |- |BET Award for Coca-Cola's Viewer's Choice for "Bottom's Up" | |}

References

External links

Official website

Category:1984 births Category:African American actors Category:African American musicians Category:African American singers Category:American actors Category:American rhythm and blues singers Category:American tenors Category:Atlantic Records artists Category:Living people Category:Military brats Category:People from Petersburg, Virginia Category:Musicians from Virginia

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Coordinates	51°50′″N107°36′″N
Name	Young Jeezy
Background	solo_singer
Birth name	Jay Wayne Jenkins
Alias	Lil J
Birth date	October 12, 1977
Birth place	Columbia, South Carolina
Death date	|origin Atlanta, Georgia, United States
Genre	Hip hop
Occupation	Rapper, songwriter
Years active	2001–present
Label	CTE World/Def Jam, Def Jam South
Associated acts	USDA, T.I., Gucci Mane
Website	http://youngjeezy.defjam.com

Jay Wayne Jenkins (born October 12, 1977), better known by his stage name Young Jeezy, is an American rapper. He is a member of the hip hop group United Streets Dopeboyz of America (USDA) and a former member of BMF (Black Mafia Family). He began his career in 2001 under an independent label and joined Boyz 'N Da Hood in 2005, the same year his solo major label debut ''Let's Get It: Thug Motivation 101'' was released. Its single "Soul Survivor", which featured Akon, became a top-ten hit in the US.

''The Inspiration'' followed in 2006, and ''The Recession'' followed in 2008; both albums yielded chart-topping singles. Jeezy has also appeared on numerous other rap and R&B; singles such as "Say I" by Christina Milian, "I'm So Paid" by Akon, "Hard" by Rihanna, and "Love in This Club" by Usher, the latter being a number one single on the US Billboard Hot 100 in 2008.

Early life

Jay Wayne Jenkins was born in Columbia, South Carolina and relocated to Atlanta, Georgia when he was a toddler. Because his parents were separated, custody of him transferred between family members frequently. At one point, he lived with his grandmother in Hawkinsville, Georgia. In an interview with ''XXL'' magazine, he described his childhood as "empty". In 1994, he spent nine months in YCA (Youth Challenge Academy), a boot camp in Fort Stewart, Georgia, for narcotics possession.

Music career

Independent debut

Jeezy released his first independent album, ''Thuggin' Under the Influence (T.U.I.)'', in 2001 under the name Lil J. It featured artists such as Freddy J.,Kinky B, Fidank, and Lil Jon, who also produced some of the tracks. In 2003, Jeezy released (also independently) ''Come Shop wit Me'', a two CD set featuring completely new tracks with some songs from ''T.U.I.'' Jeezy signed with Bad Boy Records in 2004 and joined the group Boyz n da Hood, whose self-titled album was released in June 2005 and peaked at #5 on the ''Billboard'' 200 albums charts.

''Let's Get It: Thug Motivation 101'' (2005)

In May 2004, Jazze Pha's manager Henry 'Noonie' Lee showed Young Jeezy's demo to his friend Shakir Stewart, Vice President Artist and Repertoire (VP A&R;) at Def Jam. Stewart "fell in love with it [the demo] the first time [he] heard it" and took it to L.A. Reid. Reid recognised the talent and gave Stewart the green light to sign him. As the "hottest thing on the street" at the time, various labels - including Warner and Interscope – were after his signature. However, Jeezy decided he wanted to be in business with Stewart and Reid. As a result, signed with Def Jam Records.

Jeezy's major label debut, ''Let's Get It: Thug Motivation 101'', was released on July 26, 2005. He debuted at #2, selling 172,000 copies in its first week. It spawned several hit singles such as "Soul Survivor" featuring Akon. It reached #4 on the ''Billboard'' Hot 100 and #1 on the Hot Rap Tracks charts. "And Then What" featuring Mannie Fresh, which reached #67 on the Hot 100 and #13 on the Hot Rap Tracks. "My Hood", #19 on the Rap chart. In an interview with HitQuarters, A&R; Shakir Stewart said that Jeezy had recorded over 60 songs for the album.

Jeezy partially wrote and performed on Gucci Mane's song, "Icy". Supposedly, Jeezy was never paid properly for his services. Those in Gucci Mane's camp have suggested that gang members from the Mechanicsville area attacked Gucci Mane to defend Jeezy's honor. Jeezy put out a track called "Stay Strapped" dissing Gucci Mane to the beat of "T.I.'s" song "A.S.A.P." Jeezy responded to Gucci Mane's, while rapping "even his own momma know, Radric Davis a bitch". In a recent Cutmaster C mixtape, ''The Hood News Page 3: Jay-Z Boycotts Cristal'', Gucci disses Jeezy along with Jay Z in his track, "745". Jeezy addresses Gucci back on the same mixtape. While on the track "Break It Down", featuring Cmillz. On "Streets On Lock", from The Inspiration, Jeezy addressed Gucci Mane again, saying "What type of real nigga name himself after a bag?/Nigga you's a hoe, a Louis Vuitton fag". Towards the end of 2009, DJ Drama brought Young Jeezy to the radio station and called Gucci Mane to settle the beef once and for all. The two stopped feuding but throughout early 2010, the crews of Jeezy & Gucci (CTE & Brick Squad) have been in and out altercations with each other despite the fact Jeezy & Gucci have nothing to do with that. In 2011, Jeezy plans to release a new single featuring DJ Spluge and the rest of the Gangster Brigade.

In interviews and on several records, Jeezy has affirmed his resistance to commercialism in his music. Maintaining his street credibility, according to Jeezy, is of the utmost concern to him as an artist. In 2005, Jeezy was featured in several popular hip hop songs including Gucci Mane's "Icy" and Boyz n da Hood's "Dem Boyz". Due to having a successful solo career, he left the group. From time to time he still keeps in contact with a few of the members, but in early 2010 Jeezy & Jody Breeze (who is still a member of Boyz N Da Hood) began to diss each other which started a new beef between the two.

''The Inspiration'', U.S.D.A. (2006–2007)

In 2006, he was featured in Christina Milian's single "Say I". Jeezy's second major label album was ''The Inspiration'', released in 2006. The album's first single "I Luv It" peaked at #14 on the ''Billboard'' Hot 100. "Bury Me A G" and "Go Getta" featuring R. Kelly, and "Dreamin’" featuring Keyshia Cole followed.

He also portrayed himself in the hip-hop fighting themed game ''Def Jam: Icon''. In 2007, Jeezy released ''Cold Summer'', an album by rap group USDA which consists of Jeezy, Blood Raw, Slick Pulla, 2Eleven and Boo Rossini.

Jeezy presented a week-long toy drive and charity event series with his CTE family with the first annual Toyz n da Hood toy drive. The series presented 1,000 toys for 1,000 kids at various locations in Macon and Atlanta, which began on December 17, 2007, with the CTE Christmas Kickoff from 10 pm to 5 am at Club Miami. The toy giveaway took place in the Unionville neighborhood of Macon and at the Old Fourth Ward Community in Atlanta.

''The Recession'' (2008)

His third album, ''The Recession'', was released in 2008. "Put On" featuring Kanye West was the lead single, which also led to a Grammy Nomination for Best Rap performance by a duo, but it came short. Put On was followed by "Vacation", "Crazy World", "My President" with Nas, and "Who Dat" to complete the Recession's singles. Jeezy appeared on the R&B; singles "Love in This Club" by Usher and "I'm So Paid" by Akon (also with Lil Wayne). "Love in This Club" peaked at #1 on the ''Billboard'' Hot 100. Later, he performed on Ciara's single "Never Ever", from her album ''Fantasy Ride''.

In the summer of 2008, Jeezy was at the center of a controversy over his choice for president. While he had previously endorsed Barack Obama, he spoke about meeting and supporting John McCain during an interview with ''Vibe'' magazine. The statement caused a stir, and Jeezy quickly clarified his choice, via a viral video. In the four-minute explanation, Jeezy made it clear, Obama was his main choice. "I represent the Democratic party. ... I've never been nor do I ever plan to be a John McCain supporter", the rapper said. "I support Barack Obama." Jeezy and Jay-Z performed in a concert to celebrate the inauguration of President Barack Obama on January 18, 2009. On ''The O'Reilly Factor'', commentator Bill O'Reilly criticized their performance as a "rant that offended people", but Jeezy responded: "I got white friends. It's nothing like that. I'm a taxpayer, I got a right to voice my opinion at any point in time. I don't think he really understands my struggle."

''Thug Motivation 103: Hustlerz Ambition'' (2011-present)

Jeezy is working on ''Thug Motivation 103'', his latest LP, as of November 2009. In March 2010, it was reported that Young Jeezy dropped "Young" from his stage name. Later, Young Jeezy denied the name change and claimed it was just a rumor: however, on the cover for his single "Lose My Mind", his name is printed as "Jeezy". On May 17, 2011, Jeezy released the first single for ''Thug Motivation 103'', "Ballin", which features Lil Wayne.

On March 4, 2010 Jeezy released the track "Illin", featuring the group Clipse; specifically Pusha T. On the track Pusha T raps, "No amount of record sales could derail this ...Stuffing dead prezzies in the wall like that Yale bitch..." The line was controversial and many felt the line was in bad taste and demeaned Yale student Annie Le, who was murdered in 2009, by making light of a crime that had grabbed a lot of media attention due to its extremely upsetting and tragic nature. On July 22, 2011, Young Jeezy released the second single off TM103, "Shake Life". On July 26, 2011, Young Jeezy announced a September 20, 2011 release date for TM103. However the album was pushed back yet again, this time to December 20, 2011. On September 29, 2011, Young Jeezy released the third single off TM103, named "F.A.M.E. (Fake Ass Mothafu*kas Envy)", featuring T.I. This is the first official song T.I. was featured on since his latest stint in prison.

Personal life

He is a personal friend of fellow Atlanta rapper Yung Joc. After Hurricane Katrina, Jeezy opened his house to the victims in an effort to help them have a place to stay. In October 2005, the mother of his 9 year old son used this as the basis to petition for child support. Early in the year, she had claimed that she had little income, no assets and did not even have a house.

On March 11, 2005, Jeezy was arrested after an alleged shooting involving some of his friends in Miami Beach, Florida. He was charged with two counts of carrying a concealed firearm without a permit; however, prosecutors dropped his charges two months later over lack of evidence. In the early hours of September 29, 2007, Jeezy totaled his Lamborghini when it was hit by a taxi crossing Peachtree Street, outside of Justin's, Sean Combs’ restaurant in Atlanta. The ''Atlanta Journal Constitution'' reported his claim that this gave him "a new appreciation for life". In Atlanta on June 18, 2008, police arrested him for DUI.

Discography

;Studio albums

2005: ''Let's Get It: Thug Motivation 101''

2006: ''The Inspiration''

2008: ''The Recession''

2011: ''Thug Motivation 103: Hustlerz Ambition''

Filmography

2009: ''Janky Promoters''

Awards

BET Awards

*2010, Viewer's Choice Award ("Hard") with Rihanna [Won]

*2009, Best Male Hip-Hop Artist [Nominated]

2008, Best Collaboration ("I'm So Hood [Remix]") with DJ Khaled, Ludacris, Busta Rhymes, Big Boi, Lil Wayne, Fat Joe, Birdman, & Rick Ross [Nominated]

BET Hip-Hop Awards

2008, Best Hip-Hop Video ("I'm So Hood [Remix]") with DJ Khaled, Ludacris, Busta Rhymes, Big Boi, Lil Wayne, Fat Joe, Birdman, & Rick Ross [Nominated]

2008, Best Hip-Hop Collabo ("I'm So Hood [Remix]") with DJ Khaled, Ludacris, Busta Rhymes, Big Boi, Lil Wayne, Fat Joe, Birdman, & Rick Ross [Won]

2008, People's Champ Award ("Put On") with Kanye West [Nominated]

2006, Hip-Hop CD of the Year ("Let's Get It: Thug Motivation 101") [Nominated]

2006, Hip-Hop MVP of the Year [Nominated]

Grammy Awards

2009, Best Rap Performance By a Duo or Group ("Put On") with Kanye West [Nominated]

*2010, Best Rap Performance By a Duo or Group ("Amazing") with Kanye West (Nominated)

*2011, Best Rap Performance by a Duo or Group ("Lose My Mind") with Plies (Nominated)

Ozone Awards

*2008, Best Rap Artist [Nominated]

*2008, Best Rap/R&B; Collaboration ("Love in This Club") with Usher (Won)

*2007, Best Rap Album ''The Inspiration'' (Won)

*2007, Best Rap/R&B; Collaboration ("Go Getta") with R. Kelly [Nominated]

*2007, Best Video ("Grew Up a Screw Up") with Ludacris [Nominated]

*2007, Best Group with Slick Pulla & Blood Raw as USDA [Nominated]

References

External links

Official website

Young Jeezy Interview at prefixmag

Young Jeezy Circulate Music Video

Young Jeezy Talks About Nas

Category:1977 births Category:Living people Category:Crips Category:African American rappers Category:American music industry executives Category:Def Jam Recordings artists Category:Rappers from South Carolina Category:Musicians from South Carolina Category:People convicted of drug offenses Category:People from Columbia, South Carolina Category:Rappers from Atlanta, Georgia Category:Southern hip hop musicians Category:Pseudonymous rappers

cs:Young Jeezy de:Jeezy es:Young Jeezy fr:Young Jeezy ko:영 지지 hr:Young Jeezy it:Young Jeezy nl:Young Jeezy ja:ヤング・ジージー no:Young Jeezy pl:Young Jeezy pt:Young Jeezy ru:Young Jeezy simple:Young Jeezy fi:Young Jeezy sv:Jeezy tr:Young Jeezy zh:杰伊·詹金斯

Coordinates	51°50′″N107°36′″N
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Myocardial infarction (MI) or acute myocardial infarction (AMI), commonly known as a heart attack, results from the interruption of blood supply to a part of the heart, causing heart cells to die. This is most commonly due to occlusion (blockage) of a coronary artery following the rupture of a vulnerable atherosclerotic plaque, which is an unstable collection of lipids (cholesterol and fatty acids) and white blood cells (especially macrophages) in the wall of an artery. The resulting ischemia (restriction in blood supply) and ensuing oxygen shortage, if left untreated for a sufficient period of time, can cause damage or death (''infarction'') of heart muscle tissue (''myocardium'').

Classical symptoms of acute myocardial infarction include sudden chest pain (typically radiating to the left arm or left side of the neck), shortness of breath, nausea, vomiting, palpitations, sweating, and anxiety (often described as a sense of impending doom). Women may experience fewer typical symptoms than men, most commonly shortness of breath, weakness, a feeling of indigestion, and fatigue. Approximately one-quarter of all myocardial infarctions are "silent", that is without chest pain or other symptoms.

Among the diagnostic tests available to detect heart muscle damage are an electrocardiogram (ECG), echocardiography, cardiac MRI and various blood tests. The most often used blood markers are the creatine kinase-MB (CK-MB) fraction and the troponin levels. Immediate treatment for suspected acute myocardial infarction includes oxygen, aspirin, and sublingual nitroglycerin.

Most cases of STEMI (ST elevation MI) are treated with thrombolysis or percutaneous coronary intervention (PCI). NSTEMI (non-ST elevation MI) should be managed with medication, although PCI is often performed during hospital admission. In people who have multiple blockages and who are relatively stable, or in a few emergency cases, bypass surgery may be an option, especially in diabetics.

Ischemic heart disease (which includes myocardial infarction, angina pectoris and heart failure when preceded by myocardial infarction) was the leading cause of death for both men and women worldwide in 2004. Important risk factors are previous cardiovascular disease, older age, tobacco smoking, high blood levels of certain lipids (triglycerides, low-density lipoprotein) and low levels of high density lipoprotein (HDL), diabetes, high blood pressure, obesity, chronic kidney disease, heart failure, excessive alcohol consumption, the abuse of certain drugs (such as cocaine and methamphetamine), and chronic high stress levels.

Classification

There are two basic types of acute myocardial infarction: Transmural: associated with atherosclerosis involving major coronary artery. It can be subclassified into anterior, posterior, inferior, lateral or septal. Transmural infarcts extend through the whole thickness of the heart muscle and are usually a result of complete occlusion of the area's blood supply. Subendocardial: involving a small area in the subendocardial wall of the left ventricle, ventricular septum, or papillary muscles. The subendocardial area is particularly susceptible to ischemia.

In the clinical context, a myocardial infarction can be further subclassified into a ST elevation MI (STEMI) versus a non-ST elevation MI (non-STEMI) based on ECG changes.

The phrase ''heart attack'' is sometimes used incorrectly to describe sudden cardiac death, which may or may not be the result of acute myocardial infarction. A heart attack is different from, but can be the cause of cardiac arrest, which is the stopping of the heartbeat, and cardiac arrhythmia, an abnormal heartbeat. It is also distinct from heart failure, in which the pumping action of the heart is impaired; however severe myocardial infarction may lead to heart failure.

A 2007 consensus document classifies myocardial infarction into five main types:

Type 1 – Spontaneous myocardial infarction related to ischaemia due to a primary coronary event such as plaque erosion and/or rupture, fissuring, or dissection

Type 2 – Myocardial infarction secondary to ischaemia due to either increased oxygen demand or decreased supply, e.g. coronary artery spasm, coronary embolism, anaemia, arrhythmias, hypertension, or hypotension

Type 3 – Sudden unexpected cardiac death, including cardiac arrest, often with symptoms suggestive of myocardial ischaemia, accompanied by new ST elevation, or new LBBB, or evidence of fresh thrombus in a coronary artery by angiography and/or at autopsy, but death occurring before blood samples could be obtained, or at a time before the appearance of cardiac biomarkers in the blood

Type 4 – Associated with coronary angioplasty or stents:

* Type 4a – Myocardial infarction associated with PCI

* Type 4b – Myocardial infarction associated with stent thrombosis as documented by angiography or at autopsy

Type 5 – Myocardial infarction associated with CABG

Signs and symptoms

The onset of symptoms in myocardial infarction (MI) is usually gradual, over several minutes, and rarely instantaneous. Chest pain is the most common symptom of acute myocardial infarction and is often described as a sensation of tightness, pressure, or squeezing. Chest pain due to ischemia (a lack of blood and hence oxygen supply) of the heart muscle is termed angina pectoris. Pain radiates most often to the left arm, but may also radiate to the lower jaw, neck, right arm, back, and epigastrium, where it may mimic heartburn. Levine's sign, in which the patient localizes the chest pain by clenching their fist over the sternum, has classically been thought to be predictive of cardiac chest pain, although a prospective observational study showed that it had a poor positive predictive value.

Shortness of breath (dyspnea) occurs when the damage to the heart limits the output of the left ventricle, causing left ventricular failure and consequent pulmonary edema. Other symptoms include diaphoresis (an excessive form of sweating), weakness, light-headedness, nausea, vomiting, and palpitations. These symptoms are likely induced by a massive surge of catecholamines from the sympathetic nervous system which occurs in response to pain and the hemodynamic abnormalities that result from cardiac dysfunction. Loss of consciousness (due to inadequate cerebral perfusion and cardiogenic shock) and sudden death (frequently due to the development of ventricular fibrillation) can occur in myocardial infarctions.

Women and older patients report atypical symptoms more frequently than their male and younger counterparts. Women also report more numerous symptoms compared with men (2.6 on average vs 1.8 symptoms in men). The most common symptoms of MI in women include dyspnea (shortness of breath), weakness, and fatigue. Fatigue, sleep disturbances, and dyspnea have been reported as frequently occurring symptoms that may manifest as long as one month before the actual clinically manifested ischemic event. In women, chest pain may be less predictive of coronary ischemia than in men.

Approximately one-fourth of all myocardial infarctions are silent, without chest pain or other symptoms. These cases can be discovered later on electrocardiograms, using blood enzyme tests or at autopsy without a prior history of related complaints. A silent course is more common in the elderly, in patients with diabetes mellitus and after heart transplantation, probably because the donor heart is not fully innervated by the nervous system of the recipient. In diabetics, differences in pain threshold, autonomic neuropathy, and psychological factors have been cited as possible explanations for the lack of symptoms.

Any group of symptoms compatible with a sudden interruption of the blood flow to the heart are called an acute coronary syndrome.

The differential diagnosis includes other catastrophic causes of chest pain, such as pulmonary embolism, aortic dissection, pericardial effusion causing cardiac tamponade, tension pneumothorax, and esophageal rupture. Other non-catastrophic differentials include gastroesophageal reflux and Tietze's syndrome.

Causes

Heart attack rates are higher in association with intense exertion, be it psychological stress or physical exertion, especially if the exertion is more intense than the individual usually performs. The period of intense exercise and subsequent recovery is associated with about a 6-fold higher myocardial infarction rate (compared with other more relaxed time frames) for people who are physically very fit. For those in poor physical condition, the rate differential is over 35-fold higher. One observed mechanism for this phenomenon is the increased arterial pulse pressure stretching and relaxation of arteries with each heart beat, which, as has been observed with intravascular ultrasound, increases mechanical "shear stress" on atheromas and the likelihood of plaque rupture.

Acute severe infection, such as pneumonia, can trigger myocardial infarction. A more controversial link is that between ''Chlamydophila pneumoniae'' infection and atherosclerosis. While this intracellular organism has been demonstrated in atherosclerotic plaques, evidence is inconclusive as to whether it can be considered a causative factor. Treatment with antibiotics in patients with proven atherosclerosis has not demonstrated a decreased risk of heart attacks or other coronary vascular diseases.

There is an association of an increased incidence of a heart attack in the morning hours, more specifically around 9 a.m. Some investigators have noticed that the ability of platelets to aggregate varies according to a circadian rhythm, although they have not proven causation.

Risk factors

In general, risk factors for atherosclerosis are risk factors for myocardial infarction:

Age — Men acquire an independent risk factor at age 45, Women acquire an independent risk factor at age 55; in addition, individuals acquire another independent risk factor if they have a first-degree male relative (brother, father) who suffered a coronary vascular event at or before age 55. Another independent risk factor is acquired if one has a first-degree female relative (mother, sister) who suffered a coronary vascular event at age 65 or younger.

Males are more at risk than females.

Diabetes (with or without insulin resistance)

High blood pressure

Dyslipidemia/hypercholesterolemia (abnormal levels of lipoproteins in the blood), particularly high low-density lipoprotein, low high-density lipoprotein and high Triglycerides

Tobacco smoking including secondhand smoke

Air pollution

Family history of ischaemic heart disease (IHD)

Obesity (defined by a body mass index of more than 30 kg/m², or alternatively by waist circumference or waist-hip ratio).

Hyperhomocysteinemia (high homocysteine)

Stress — Occupations with high stress index are known to have susceptibility for atherosclerosis

Alcohol — Studies show that prolonged exposure to high quantities of alcohol can increase the risk of heart attack

Many of these risk factors are modifiable, so many heart attacks can be prevented by maintaining a healthier lifestyle. Physical activity, for example, is associated with a lower risk profile. Non-modifiable risk factors include age, sex, and family history of an early heart attack (before the age of 60), which is thought of as reflecting a genetic predisposition.

Socioeconomic factors such as a shorter education and lower income (particularly in women), and unmarried cohabitation are also correlated with a higher risk of MI. To understand epidemiological study results, it is important to note that many factors associated with MI mediate their risk via other factors. For example, the effect of education is partially based on its effect on income and marital status.

Women who use combined oral contraceptive pills have a modestly increased risk of myocardial infarction, especially in the presence of other risk factors, such as smoking.

Inflammation is known to be an important step in the process of atherosclerotic plaque formation. C-reactive protein (CRP) is a sensitive but non-specific marker for inflammation. Elevated CRP blood levels, especially measured with high-sensitivity assays, can predict the risk of MI, as well as stroke and development of diabetes. Moreover, some drugs for MI might also reduce CRP levels. The use of high-sensitivity CRP assays as a means of screening the general population is advised against, but it may be used optionally at the physician's discretion in patients who already present with other risk factors or known coronary artery disease. Whether CRP plays a direct role in atherosclerosis remains uncertain.

Inflammation in periodontal disease may be linked to coronary heart disease, and, since periodontitis is very common, this could have great consequences for public health. Serological studies measuring antibody levels against typical periodontitis-causing bacteria found that such antibodies were more present in subjects with coronary heart disease. Periodontitis tends to increase blood levels of CRP, fibrinogen and cytokines; thus, periodontitis may mediate its effect on MI risk via other risk factors. Preclinical research suggests that periodontal bacteria can promote aggregation of platelets and promote the formation of foam cells. A role for specific periodontal bacteria has been suggested but remains to be established. There is some evidence that influenza may trigger an acute myocardial infarction.

Baldness, hair greying, a diagonal earlobe crease (Frank's sign) and possibly other skin features have been suggested as independent risk factors for MI. Their role remains controversial; a common denominator of these signs and the risk of MI is supposed, possibly genetic.

Calcium deposition is another part of atherosclerotic plaque formation. Calcium deposits in the coronary arteries can be detected with CT scans. Several studies have shown that coronary calcium can provide predictive information beyond that of classical risk factors.

The European Society of Cardiology and the European Association for Cardiovascular Prevention and Rehabilitation have developed an interactive tool for prediction and managing the risk of heart attack and stroke in Europe. HeartScore is aimed at supporting clinicians in optimising individual cardiovascular risk reduction. The Heartscore Programme is available in 12 languages and offers web-based or PC version.

Pathophysiology

Acute myocardial infarction refers to two subtypes of acute coronary syndrome, namely non-ST-elevated myocardial infarction and ST-elevated myocardial infarction, which are most frequently (but not always) a manifestation of coronary artery disease. The most common triggering event is the disruption of an atherosclerotic plaque in an epicardial coronary artery, which leads to a clotting cascade, sometimes resulting in total occlusion of the artery. Atherosclerosis is the gradual buildup of cholesterol and fibrous tissue in plaques in the wall of arteries (in this case, the coronary arteries), typically over decades. Blood stream column irregularities visible on angiography reflect artery lumen narrowing as a result of decades of advancing atherosclerosis. Plaques can become unstable, rupture, and additionally promote a thrombus (blood clot) that occludes the artery; this can occur in minutes. When a severe enough plaque rupture occurs in the coronary vasculature, it leads to myocardial infarction (necrosis of downstream myocardium).

If impaired blood flow to the heart lasts long enough, it triggers a process called the ischemic cascade; the heart cells in the territory of the occluded coronary artery die (chiefly through necrosis) and do not grow back. A collagen scar forms in its place. Recent studies indicate that another form of cell death called apoptosis also plays a role in the process of tissue damage subsequent to myocardial infarction. As a result, the patient's heart will be permanently damaged. This myocardial scarring also puts the patient at risk for potentially life threatening arrhythmias, and may result in the formation of a ventricular aneurysm that can rupture with catastrophic consequences.

Injured heart tissue conducts electrical impulses more slowly than normal heart tissue. The difference in conduction velocity between injured and uninjured tissue can trigger re-entry or a feedback loop that is believed to be the cause of many lethal arrhythmias. The most serious of these arrhythmias is ventricular fibrillation (''V-Fib''/VF), an extremely fast and chaotic heart rhythm that is the leading cause of sudden cardiac death. Another life-threatening arrhythmia is ventricular tachycardia (''V-Tach''/VT), which may or may not cause sudden cardiac death. However, ventricular tachycardia usually results in rapid heart rates that prevent the heart from pumping blood effectively. Cardiac output and blood pressure may fall to dangerous levels, which can lead to further coronary ischemia and extension of the infarct.

The cardiac defibrillator is a device that was specifically designed to terminate these potentially fatal arrhythmias. The device works by delivering an electrical shock to the patient in order to depolarize a critical mass of the heart muscle, in effect "rebooting" the heart. This therapy is time dependent, and the odds of successful defibrillation decline rapidly after the onset of cardiopulmonary arrest.

Diagnosis

The diagnosis of myocardial infarction can be made after assessing patient's complaints and physical status. ECG changes, coronary angiogram and levels of cardiac markers help to confirm the diagnosis. ECG gives valuable clues to identify the site of myocardial damage while coronary angiogram allows visualization of narrowing or obstructions in the heart vessels. At autopsy, a pathologist can diagnose a myocardial infarction based on anatomopathological findings.

A chest radiograph and routine blood tests may indicate complications or precipitating causes and are often performed upon arrival to an emergency department. New regional wall motion abnormalities on an echocardiogram are also suggestive of a myocardial infarction. Echo may be performed in equivocal cases by the on-call cardiologist. In stable patients whose symptoms have resolved by the time of evaluation, Technetium (99mTc) sestamibi (i.e. a "MIBI scan") or thallium-201 chloride can be used in nuclear medicine to visualize areas of reduced blood flow in conjunction with physiologic or pharmocologic stress. Thallium may also be used to determine viability of tissue, distinguishing whether non-functional myocardium is actually dead or merely in a state of hibernation or of being stunned.

WHO criteria formulated in 1979 have classically been used to diagnose MI; a patient is diagnosed with myocardial infarction if two (probable) or three (definite) of the following criteria are satisfied: # Clinical history of ischaemic type chest pain lasting for more than 20 minutes # Changes in serial ECG tracings # Rise and fall of serum cardiac biomarkers such as creatine kinase-MB fraction and troponin

The WHO criteria were refined in 2000 to give more prominence to cardiac biomarkers. According to the new guidelines, a cardiac troponin rise accompanied by either typical symptoms, pathological Q waves, ST elevation or depression, or coronary intervention is diagnostic of MI.

Prevention

The risk of a recurrent myocardial infarction decreases with strict blood pressure management and lifestyle changes, chiefly smoking cessation, regular exercise, a sensible diet for those with heart disease, and limitation of alcohol intake. People are usually commenced on several long-term medications post-MI, with the aim of preventing secondary cardiovascular events such as further myocardial infarctions, congestive heart failure or cerebrovascular accident (CVA). Unless contraindicated, such medications may include:

Antiplatelet drug therapy such as aspirin and/or clopidogrel should be continued to reduce the risk of plaque rupture and recurrent myocardial infarction. Aspirin is first-line, owing to its low cost and comparable efficacy, with clopidogrel reserved for patients intolerant of aspirin. The combination of clopidogrel and aspirin may further reduce risk of cardiovascular events, however the risk of hemorrhage is increased. Beta blocker therapy such as metoprolol or carvedilol should be commenced. These have been particularly beneficial in high-risk patients such as those with left ventricular dysfunction and/or continuing cardiac ischaemia. β-Blockers decrease mortality and morbidity. They also improve symptoms of cardiac ischemia in NSTEMI. ACE inhibitor therapy should be commenced 24–48 hours post-MI in hemodynamically-stable patients, particularly in patients with a history of MI, diabetes mellitus, hypertension, anterior location of infarct (as assessed by ECG), and/or evidence of left ventricular dysfunction. ACE inhibitors reduce mortality, the development of heart failure, and decrease ventricular remodelling post-MI. Statin therapy has been shown to reduce mortality and morbidity post-MI. The effects of statins may be more than their LDL lowering effects. The general consensus is that statins have plaque stabilization and multiple other ("pleiotropic") effects that may prevent myocardial infarction in addition to their effects on blood lipids. The aldosterone antagonist agent eplerenone has been shown to further reduce risk of cardiovascular death post-MI in patients with heart failure and left ventricular dysfunction, when used in conjunction with standard therapies above. Spironolactone is another option that is sometimes preferable to eplerenone due to cost. Evidence supports the consumption of polyunsaturated fats instead of saturated fats as a measure of decreasing coronary heart disease. Omega-3 fatty acids, commonly found in fish, have been shown to reduce mortality post-MI. While the mechanism by which these fatty acids decrease mortality is unknown, it has been postulated that the survival benefit is due to electrical stabilization and the prevention of ventricular fibrillation. However, further studies in a high-risk subset have not shown a clear-cut decrease in potentially fatal arrhythmias due to omega-3 fatty acids.

Blood donation may reduce the risk of heart disease for men, but the link has not been firmly established.

A Cochrane review found that giving heparin to people with heart conditions like unstable angina and some forms of heart attacks reduces the risk of having another heart attack. However, heparin also increases the chance of suffering from minor bleeding.

Management

An MI is a medical emergency that requires immediate medical attention. Treatment attempts to salvage as much myocardium as possible and to prevent further complications, hence the phrase "time is muscle". Oxygen, aspirin, and nitroglycerin may be administered. Morphine was classically used if nitroglycerin was not effective; however, it may increase mortality in the setting of NSTEMI. A 2009 and 2010 review of high flow oxygen in myocardial infarction found increased mortality and infarct size, calling into question the recommendation about its routine use. Other analgesics such as nitrous oxide are of unknown benefit. Percutaneous coronary intervention (PCI) or fibrinolysis are recommended in those with an STEMI.

Prognosis

The prognosis post myocardial infarction varies greatly, depending on a person's health, the extent of the heart damage and the treatment given. For the period 2005–2008 in the United States, the median mortality at 30 days was 16.6% with a range from 10.9% to 24.9% depending on the hospital. Using variables available in the emergency room, people with a higher risk of adverse outcome can be identified. One study found that 0.4% of patients with a low-risk profile died after 90 days, whereas in high-risk people it was 21.1%.

Some of the more reproduced risk-stratifying factors include: age, hemodynamic parameters (such as heart failure, cardiac arrest on admission, systolic blood pressure, or Killip class of two or greater), ST-segment deviation, diabetes, serum creatinine, peripheral vascular disease and elevation of cardiac markers. Assessment of left ventricular ejection fraction may increase the predictive power. The prognostic importance of Q-waves is debated. Prognosis is significantly worsened if a mechanical complication such as papillary muscle or myocardial free wall rupture occur. Morbidity and mortality from myocardial infarction has improved over the years due to better treatment.

Complications

Complications may occur immediately following the heart attack (in the acute phase), or may need time to develop (a chronic problem). Acute complications may include heart failure if the damaged heart is no longer able to adequately pump blood around the body; aneurysm or rupture of the myocardium; mitral regurgitation, in particular if the infarction causes dysfunction of the papillary muscle; and arrhythmias, such as ventricular fibrillation, ventricular tachycardia, atrial fibrillation and heart block. Longer-term complications include heart failure, atrial fibrillation, and the increased risk of a second myocardial infarction.

Epidemiology

Myocardial infarction is a common presentation of ischemic heart disease. The WHO estimated in 2002, that 12.6 percent of worldwide deaths were from ischemic heart disease with it the leading cause of death in developed countries, and third to AIDS and lower respiratory infections in developing countries. Worldwide more than 3 million people have STEMIs and 4 million have NSTEMIs a year.

Coronary heart disease is responsible for 1 in 5 deaths in the United States. It is becoming more common in the developing world such that, in India, cardiovascular disease (CVD) is the leading cause of death. The deaths due to CVD in India were 32% of all deaths in 2007 and are expected to rise from 1.17 million in 1990 and 1.59 million in 2000 to 2.03 million in 2010. Although a relatively new epidemic in India, it has quickly become a major health issue with deaths due to CVD expected to double during 1985–2015. Mortality estimates due to CVD vary widely by state, ranging from 10% in Meghalaya to 49% in Punjab (percentage of all deaths). Punjab (49%), Goa (42%), Tamil Nadu (36%) and Andhra Pradesh (31%) have the highest CVD related mortality estimates. State-wise differences are correlated with prevalence of specific dietary risk factors in the states. Moderate physical exercise is associated with reduced incidence of CVD in India (those that exercise have less than half the risk of those that do not).

Legal implications

At common law, in general a myocardial infarction is a disease, but may sometimes be an injury. This has implications for no-fault insurance schemes such as workers' compensation. In general, a heart attack is not covered; however, it may be a work-related injury if it results, for example, from unusual emotional stress or unusual exertion. In addition, in some jurisdictions, heart attacks suffered by persons in particular occupations such as police officers may be classified as line-of-duty injuries by statute or policy. In some countries or states, a person having suffered from a myocardial infarction may be prevented from participating in activity that puts other people's lives at risk, for example driving a car or flying an airplane.

Research

Patients who receive stem cell treatment by coronary artery injections of stem cells derived from their own bone marrow after a myocardial infarction (MI) show improvements in left ventricular ejection fraction and end-diastolic volume not seen with placebo. The larger the initial infarct size, the greater the effect of the infusion. Clinical trials of progenitor cell infusion as a treatment approach to ST elevation MI are proceeding.

There are currently 3 biomaterial and tissue engineering approaches for the treatment of MI, but these are in an even earlier stage of medical research, so many questions and issues must be addressed before they can be applied to patients. The first involves polymeric left ventricular restraints in the prevention of heart failure. The second utilizes ''in vitro'' engineered cardiac tissue, which is subsequently implanted ''in vivo''. The final approach entails injecting cells and/or a scaffold into the myocardium to create ''in situ'' engineered cardiac tissue.

References

External links

American Heart Association's Heart Attack web site – Information and resources for preventing, recognizing and treating heart attack.

Heart Attack – overview of resources from MedlinePlus

Category:Aging-associated diseases Category:Causes of death Category:Ischemic heart diseases Category:Medical emergencies

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Coordinates	51°50′″N107°36′″N
Name	Nicki Minaj
Background	solo_singer
Birth name	Onika Tanya Maraj
Birth date	December 08, 1982
Birth place	Saint James, Trinidad and Tobago
Origin	South Jamaica, Queens, New York, U.S.
Genre	Hip hop, R&B;, pop
Occupation	Rapper, singer-songwriter
Years active	2002–present
Label	Cash Money Records, Young Money Entertainment, Universal Republic Records, Universal Motown
Associated acts	Young Money
website	}}

Onika Tanya Maraj (born December 8, 1982), known by her stage name Nicki Minaj (), is a Trinidadian-born American musician. She was born in Saint James, Trinidad and Tobago and moved to the New York City borough of Queens when she was five.

After releasing three mixtapes between 2007 and 2009 and being signed to Young Money Entertainment in August 2009, Minaj released her debut album, ''Pink Friday'', in November 2010. It quickly became a commercial success, peaking at number one on the U.S. ''Billboard'' 200 and being certified Platinum by the Recording Industry Association of America (RIAA) a month after its release. She became the first female solo artist to have seven singles on the ''Billboard'' Hot 100 at the same time. Her second single, "Your Love", reached #1 on the ''Billboard'' Hot Rap Songs chart, making Minaj the first female artist to top the chart unaccompanied since 2002. She also became the first female artist to be included on MTV's Annual Hottest MC List. Minaj was named the 2011 ''Rising Star'' by ''Billboard''. Her second studio album, ''Pink Friday: Roman Reloaded'' was released on April 3, 2012.

Early life

Maraj was born in 1982 in Saint James, a suburb of Trinidad and Tobago's capital city Port of Spain. Her parents are of mixed Indian and Afro-Trinidadian ancestry and she lived in Saint James with her grandmother until age five, because her parents were looking for a place to live in the Queens borough of New York City at the time. Her mother would occasionally visit, and one day, when Minaj was five, her mother picked her up to move to Queens. According to Minaj, her father drank heavily, took drugs, and once tried to kill her mother by setting the house on fire.

She attended Elizabeth Blackwell Middle School 210, where she played the clarinet. She graduated from LaGuardia High School. At LaGuardia, a school specializing in music and the visual and performing arts, Minaj participated in the drama program. She had initially planned to sing at LaGuardia, but lost her voice on the day of the audition.

Career

2007–09: Mixtapes and Young Money

Minaj released her first mixtape in 2007 after releasing ''Playtime Is Over'' with ''Dirty Money Records''. She released another mixtape on July 7, 2008, titled ''Sucka Free'', under the label ''Be''. On April 18, 2009, Minaj released a third mixtape and appeared in ''XXL'' magazine. She won the Female Artist of the Year award at the 2008 Underground Music Awards. Minaj released ''Beam Me Up Scotty'', another mixtape, in April 2009 under the label of ''Trapaholics Records''; it received positive coverage on both BET and MTV.

In August 2009, Minaj signed a record deal with Young Money Entertainment, with distribution from Universal Motown Records, after fellow American rapper Lil Wayne discovered her and secured the record deal. She then had a solo rap verse in their single "BedRock," which became a commercial success, reaching #2 on the ''Billboard'' Hot 100. Minaj also appeared on "Roger That", which charted at #56. The song, and in particular Minaj, received positive reviews from critics. Both songs were included in Young Money Entertainment's debut collaborative studio album ''We Are Young Money'', which was released in December 2009. The album charted in the top ten on the ''Billboard'' 200, reaching #9 and later receiving a Gold Certification by the RIAA. She was then chosen by Mariah Carey to be featured on her single and music video for "Up Out My Face". Critics praised her collaboration for helping to maintain Carey's feminine image and providing a polite track for the female R&B; singer.

2010–11: ''Pink Friday''

After a major record label bidding war, Young Money Entertainment announced on August 31, 2009 that Minaj had been released from a 360 deal with the label in which she retains and owns all of her 360 rights – including merchandising, sponsorships, endorsements, touring and publishing. In an interview with 95.8 Capital FM, Rihanna stated that after the two collaborated on "Raining Men" from her album ''Loud'' that the duo would be teaming up together for a possible second collaboration on Minaj's ''Pink Friday''. Hip-hop rap artist and producer Kanye West was also confirmed for the album. On August 3, 2010 Minaj revealed on a Ustream.tv channel that the album's name would be ''Pink Friday'', in reference to Black Friday.

''Pink Friday'' was released on November 19, 2010 in both standard and deluxe versions. A buzz single, "Massive Attack", was released in April. In August, Minaj released "Your Love" as the first official single from her debut album. The single peaked at 14 on the ''Billboard'' Hot 100, 7 on the Hot R&B;/Hip-Hop Songs chart and topped the Rap Songs chart. Minaj became the first female artist to be included on MTV's Annual Hottest MC List and the first female artist to top the chart unaccompanied since 2002. In October 2010, Minaj became the first artist to have seven songs on the ''Billboard'' Hot 100 chart simultaneously. Minaj released a joint single with The Black Eyed Peas front man, will.i.am titled, "Check It Out", which is Minaj's most successful single to date in Europe. "Right thru Me" was released September 24, 2010; the music video was released in late October. "Moment 4 Life" was released as the fourth single. The track featured Canadian rapper Drake and was released on December 7, 2010, becoming a success on the ''Billboard'' Hot 100. The single peaked at number 5 on the Hot Rap Songs. The album gained a Platinum certification in the United States a month after the release. It was hinted by Simon Cowell that Minaj would join the judging panel of the American version of the ''The X Factor.'' Starting in June 2011, Minaj will be supporting ''Pink Friday'' by serving as an opening act along with Jessie and the Toy Boys and Nervo on Britney Spears' sixth concert tour, the Femme Fatale Tour, in support of her seventh studio album, ''Femme Fatale''. She also was featured on the official remix of Spears' track "Till the World Ends" along with Spears and singer Kesha, which charted at number 3 in the US in April 2011. "Super Bass" was released from ''Pink Friday'' in May 2011, the single charted within the top 10 in many countries including; United Kingdom, United States, Australia, Canada and more. The song gained positive reviews from critics. Minaj will voice a character in the 3D animated film, ''Ice Age: Continental Drift'', as an unknown character. Minaj is also featured on French DJ David Guetta's 2011 album, ''Nothing but the Beat'' on "Where Them Girls At" and "Turn Me On".

2011–present: ''Pink Friday: Roman Reloaded''

Minaj's second studio album, ''Pink Friday: Roman Reloaded'', was announced through Twitter in November 2011 and was released on April 2, 2012. It has spawned four promotional singles as of April 2012: Roman in Moscow (which didn't make the final cut of the album), "Stupid Hoe," "Roman Reloaded," and "Beez in the Trap." The album's first single, "Starships", was released on February 14. The album also had another single, Right by My Side. On February 12, 2012, Minaj debuted her song "Roman Holiday" at the 54th Grammy Awards. The exorcism-themed perfomance drew a mixed response online.

She was featured on Madonna's twelfth studio album, titled ''MDNA'', alongside M.I.A. on its lead single "Give Me All Your Luvin'", for which a music video has been directed by Megaforce. The trio performed the song for the Super Bowl XLVI halftime show. She was also featured on a song called "I Don't Give A", another track from the album.

Musical style and image

Image

In an interview with ''Vibe'' Minaj discussed her sexual image stating, "[w]hen I grew up I saw females doing certain things, and I thought I had to do that exactly. The female rappers of my day spoke about sex a lot... and I thought that to have the success they got, I would have to represent the same thing. When in fact I didn’t have to represent the same thing." In an interview with ''Interview'', Minaj commented on her sexual image again stating, "I made a conscious decision to try to tone down the sexiness, I want people—especially young girls—to know that in life, nothing is going to be based on sex appeal. You’ve got to have something else to go with that.” Minaj has a tattoo in Chinese characters that reads "" (''shangdi yu ni chang zai'') on her left arm, meaning, "God is always with you."

Alter egos

While growing up, Minaj's home life was often chaotic, with her parents constantly fighting. As a means of escape, she would create characters and live her life through them. In an interview with ''New York'' she stated, "To get away from all their fighting, I would imagine being a new person. 'Cookie' was my first identity – that stayed with me for a while. I went on to 'Harajuku Barbie,' then 'Nicki Minaj'. Fantasy was my reality."

On November 18, 2010, Minaj assumed a different alter-ego named "Nicki Teresa". Wearing a colorful scarf around her head, she went around as the "healer to her fans" as she visited them at The Garden of Dreams Foundation at Fuse studios in New York City. Minaj made an appearance on ''Lopez Tonight'' on December 6, 2010 and presented a different alter-ego for the Spanish-inspired occasion, named "Rosa" (pronounced Rrrrrosa).

Roman Zolanski

For her debut album, Minaj created another alter-ego named "Roman Zolanski". She stated that in songs like "Bottoms Up" with Trey Songz it is not Minaj rapping, but instead Roman Zolanski, and claims that Roman is her "twin brother". She claims that he was born inside her, out of rage, and becomes him when she is angry. She has also said 'He is a demon inside her'. Roman has been compared to Eminem's alter ego Slim Shady, and on the song "Roman's Revenge" from ''Pink Friday'', Minaj and Eminem collaborate, using these alter egos. On the collaboration, she said "The new album is going to have a lot of Roman on it ... And if you're not familiar with Roman, then you will be familiar with him very soon. He’s the boy that lives inside of me. He's a lunatic and he's gay and he'll be on there a lot." Roman also has a "mother" called "Martha Zolanski", who also appeared on the song Roman's Revenge, with a British accent. Martha appears in the video for "Moment 4 Life" where she appears to be Minaj's magical Godmother. In songs such as "All I Do Is Win (Remix)" it is Minaj rapping. Minaj stated that on her debut album, fans will get to "meet" Nicki, Roman and Onika.

Influences

Minaj has stated that artists who have influenced her musical style include Lisa "Left Eye" Lopes, Lil Wayne, Lauryn Hill, Jadakiss, Natasha Bedingfield, Foxy Brown, Lil' Kim and Missy Elliott. She was also inspired by Janet Jackson, Madonna, Britney Spears, Marilyn Monroe, Grace Jones, M.I.A. and Cyndi Lauper.

Personal life

While some songs and interviews have implied that Minaj is bisexual, she has said that she does not date nor have sex with women, but added in an interview with ''Out'' magazine, "I don’t date men either." In an interview with ''Vibe'' she commented, "I just embrace all people of all lifestyles and I don’t tell them they are bad people. And I say girls are beautiful and girls are sexy and they need to be told that, and if they don’t have anyone to tell them that and mean it, I’m gonna tell them that. But I feel like people always wanna define me and I don’t wanna be defined." She reiterated her dislike of being labeled in an interview with ''Out'', saying: "The point is, everyone is not black and white. There are so many shades in the middle, and you’ve got to let people feel comfortable with saying what they want to say when they want to say it."

During an interview in the May 2010 issue of ''Details'', Minaj was asked if she felt hip-hop was becoming more gay-friendly. She responded, "I think the world is getting more gay-friendly, so hip-hop is too. But it's harder to imagine an openly gay male rapper being embraced, people view gay men as having no street credibility. But I think we'll see one in my lifetime."

In July 2011, Minaj's cousin Nicholas Telemaque was murdered near his home in Brooklyn, New York City.

Discography

''Pink Friday'' (2010)

''Pink Friday: Roman Reloaded'' (2012)

See also

List of awards and nominations received by Nicki Minaj

Notes

References

External links

Category:Nicki Minaj Category:1982 births Category:Living people Category:African American female singers Category:African American rappers Category:American musicians of Indian descent Category:American people of Trinidad and Tobago descent Category:Female rappers Category:Fiorello H. LaGuardia High School alumni Category:Hip hop singers Category:Naturalized citizens of the United States Category:People from Queens Category:People from Port of Spain Category:Rappers from New York City Category:Singers from New York City Category:Trinidad and Tobago emigrants to the United States Category:Trinidad and Tobago musicians Category:Trinidad and Tobago people of Dougla descent Category:Young Money Entertainment artists

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