:''This entry focuses on the Ayahuasca brew; for information on the vine of the same name, see
Banisteriopsis caapi''
''Ayahuasca'' (
''ayawaska'' pronounced in the
Quechua language) is any of various
psychoactive infusions or
decoctions prepared from the ''
Banisteriopsis spp.'' vine, usually mixed with the leaves of
dimethyltryptamine-containing species of shrubs from the ''
Psychotria'' genus. The brew, first described academically in the early 1950s by
Harvard ethnobotanist
Richard Evans Schultes, who found it employed for divinatory and healing purposes by the native peoples of the
Amazonian Colombia, is known by a number of different names (see
below). A notable property of ayahuasca is that neither of the ingredients cause any significant psychedelic effects when imbibed alone; they must be consumed together in order to have the desired effect. How indigenous peoples discovered the psychedelic properties of the ayahuasca brew remains unknown.
Nomenclature
In
Ecuador,
Bolivia and
Peru,
Colombia and to a lesser extent in
Brazil, "ayahuasca" or "ayawaska" is
Quechua for "spirit vine" or "vine of the souls"; ''aya'' means "spirit" while ''huasca'' or ''waska'' means "vine". The spelling of ''ayahuasca'' is the hispanicized version of the name; many Quechua or
Aymara speakers would prefer the spelling ''ayawaska''. The name is properly that of the plant ''B. caapi'', one of the primary sources of beta-carbolines for the brew. Other terms include:
''cipó'' (generic vine, liana), "caapi", "hoasca", "vegetal", "daime" or "santo daime" in Brazil
''natem'' amongst the indigenous
Shuar and
Achuar people of Peru and Ecuador
''yagé'' or ''yajé'' (both pronounced jaˈhe) in
Tucanoan
''shori'' among the
Nahua people of Peru
Chemistry
Harmine compounds are of beta-carboline origin. The three most studied beta-carboline compounds found in the ''B. caapi'' vine are harmine, harmaline and tetrahydroharmine. Harmine and harmaline are selective and reversible inhibitors of
MAO-A, while tetrahydroharmine is a weak serotonin uptake inhibitor. This inhibition of MAO-A allows
DMT to diffuse unmetabolized past the membranes in the stomach and small intestine and eventually get through the
blood-brain barrier (which, by itself, requires no MAO-A inhibition) to activate receptor sites in the brain. Without
RIMAs or the MAOI of MAO-A,
DMT would be metabolized in the digestive tract and would not have an effect when taken orally.
Individual polymorphisms in the cytochrome P450-2D6 enzyme affect the ability of individuals to metabolize harmine. Some natural tolerance to habitual use of ayahuasca (roughly once weekly) may develop through upregulation of the serotonergic system. A phase 1 pharmacokinetic study on ayahuasca (as Hoasca) with 15 volunteers was conducted in 1993, during the Hoasca Project. A review of the Hoasca Project has been published.
Preparation
Sections of ''Banisteriopsis caapi'' vine are
macerated and boiled alone or with leaves from any of a number of other plants, including ''
Psychotria viridis'' (''chacruna'') or ''
Diplopterys cabrerana'' (also known as ''chaliponga''). The resulting brew contains the powerful
hallucinogenic alkaloid
N,N-dimethyltryptamine (
DMT), and
MAO inhibiting harmala alkaloids, which are necessary to make the DMT orally active.
Brews can also be made with no DMT-containing plants; ''Psychotria viridis'' being substituted by plants such as ''Justicia pectoralis'', Brugmansia, or sacred tobacco, also known as ''Mapacho'' (Nicotiana rustica), or sometimes left out with no replacement. The potency of this brew varies radically from one batch to the next, both in potency and psychoactive effect, based mainly on the skill of the shaman or brewer, as well as other admixtures sometimes added and the intent of the ceremony. Natural variations in plant alkaloid content and profiles also affect the final concentration of alkaloids in the brew, and the physical act of cooking may also serve to modify the alkaloid profile of harmala alkaloids.
Traditional brew
Traditional ayahuasca brews are often made with ''Banisteriopsis caapi'' as a
MAOI, although
Dimethyltryptamine sources and other admixtures vary from region to region. There are several
varieties of caapi, often known as different "colors", with varying effects, potencies, and uses.
DMT admixtures:
''Psychotria viridis'' (Chacruna) - leaves
''Diplopterys cabrerana'' (Chaliponga, ''Banisteriopsis rusbyana'') - leaves
''Psychotria carthagenensis'' (Amyruca) - leaves
''Acacia maidenii'' (Maiden's Wattle), ''Acacia phlebophylla'', and other Acacias, most commonly employed in Australia - bark
''Anadenanthera peregrina'', ''A. colubrina, A. excelsa, A. macrocarpa''
''Mimosa hostilis'' (Jurema) - root bark - not traditionally employed with ayahuasca by any existing cultures, though likely it was in the past. Popular in Europe and North America.
MAOI:
Harmal (''Peganum harmala'', Syrian Rue) - seeds
Passion flower
synthetic MAOIs
Other common admixtures:
''Justicia pectoralis''
Brugmansia (Toé)
''
Nicotiana rustica'' (Mapacho, variety of tobacco)
''
Ilex guayusa'', a relative of
yerba mate
Common admixtures with their associated ceremonial values and spirits:
Ayahuma bark
Dead Head Tree. Provides protection and is used in healing susto (soul loss from spiritual fright or trauma). Head spirit is a headless giant.
Capirona bark
Provides cleansing and protection. It is noted for its smooth bark, white flowers, and hard wood. Head spirits look Caucasian.
Chullachaki Caspi bark
Provides cleansing to the physical body. Used to transcend physical body ailments. Head spirits look Caucasian.
Lopuna Blanca bark
Provides protection. Head spirits take the form of giants.
Punga Amarilla bark
Yellow Punga. Provides protection. Used to pull or draw out negative spirits or energies. Head spirit is the yellow anaconda.
Remo Caspi bark
Oar Tree. Used to move dense or dark energies. Head spirit is a native warrior.
Wyra (huaira) Caspi bark
Air Tree. Used to create purging, transcend gastro/intestinal ailments, calm the mind, and bring tranquility. Head spirit looks African.
Shiwawaku bark
Brings purple medicine to the ceremony. Provides healing and protection.
Camu camu Gigante:
Head spirit comes in the form of a large dark skinned giant. He provides medicine and protection in the form of warding off dark and demonic spirits.
Tamamuri:
Head spirit looks like an old Asian warrior with a long white wispy beard. He carries a staff and manages thousands of spirits to protect the ceremony and send away energies that are purged from the participants.
Uchu Sanango
Head of the sanango plants. Provides power, strength, and protection. Head doctor spirit is a grandfather with a long, gray-white beard.
Huacapurana:
Giant tree of the amazon with very hard bark. Its head spirits come in the form of Amazonian giants and provide a strong grounding presence in the ceremony.
Usage
Ayahuasca is used largely as a religious
sacrament. Users of ayahuasca in non-traditional contexts often align themselves with the philosophies and cosmologies associated with ayahuasca
shamanism, as practiced among
indigenous peoples like the
Urarina of
Peruvian
Amazonia. While non-native users know of the spiritual applications of ayahuasca, a less well-known traditional usage focuses on the medicinal properties of ayahuasca. When used for its medicinal purposes ayahuasca affects the human consciousness for less than six hours beginning half an hour after consumption, and peaking after two hours. The remedy also has cardiovascular effects, moderately increasing both heart rate and diastolic blood pressure. The psychedelic effects of ayahuasca include visual and auditory stimulation, the mixing of sensory modaltities, and psychological introspection that may lead to great elation, fear, or illumination. Its purgative properties are important (known as ''la purga'' or "the purge"). The intense
vomiting and occasional
diarrhea it induces can clear the body of worms and other tropical
parasites, and harmala alkaloids themselves have been shown to be
anthelmintic Thus, this action is twofold; a direct action on the parasites by these harmala alkaloids (particularly harmine in ayahuasca) works to kill the parasites, and parasites are expelled through the increased intestinal motility that is caused by these alkaloids.
Dietary taboos are often associated with the use of ayahuasca. In the rainforest, these tend towards the purification of one's self - abstaining from spicy and heavily-seasoned foods, excess fat, salt, caffeine, acidic foods (such as citrus) and sex before, after, or during a ceremony. A diet low in foods containing tyramine has been recommended, as the speculative interaction of tyramine and MAOIs could lead to a hypertensive crisis. However, evidence indicates that harmala alkaloids act only on MAO-A, in a reversible way similar to moclobemide (an antidepressant that does not require dietary restrictions). Psychonautic experiments and the absence of dietary restrictions in the highly urban Brazilian ayahuasca church União do Vegetal also suggest that the risk is much lower than perceived, and probably non-existent. popularly termed Ayahuasca Open Style (AOS).
The work of Stanislav Grof has been an important inspiration for a non-religious approach to working with entheogen. Grof’s primary focus has been on the transpersonal dimensions of the psychedelic experience. According to Grof, the birth process plays a decisive role in determining the individual's relationship to life in general, and to spirituality in particular. Problems experienced during the intrauterine (pre-natal) phase, a time when the foetus is physically one with the mother, are reflected in developmental problems. As a consequence, authority issues inevitably play a significant role in this type of ayahuasca use. The personality of the person or persons administering ayahuasca, the purposes for which it is being used, the level of understanding and commitment as well as personal views and beliefs involved play a much more important role in determining the outcome of ayahuasca use than in the more conventional ceremonies of the Santo Daime and União do Vegetal where interactions between participants are strictly regulated.
Due to the legal status of ayahuasca, those who have been exploring its therapeutic potential are unable to do so openly. The therapeutic use of ayahuasca is not protected by covenants on religious freedom.
History
In the 16th century, Christian missionaries from Spain and Portugal first encountered indigenous peoples using ayahuasca in South America; their earliest reports described it as the work of the devil. In the 20th century, the active chemical constituent of ''B. caapi'' was named ''
telepathine'', but it was found to be identical to a chemical already isolated from ''Peganum harmala'' and was given the name
harmaline. Beat writer William Burroughs read a paper by
Richard Evans Schultes on the subject and sought out ''yagé'' in the early 1950s while traveling through South America in the hopes that it could relieve or cure
opiate addiction (see ''
The Yage Letters''). Ayahuasca became more widely known when the McKenna brothers published their experience in the Amazon in ''True Hallucinations''. Dennis later studied the pharmacology,
botany, and
chemistry of ayahuasca and
oo-koo-he, which became the subject of his master's thesis.
In Brazil, a number of modern religious movements based on the use of ayahuasca have emerged, the most famous of them being Santo Daime and the União do Vegetal (or UDV), usually in an animistic context that may be shamanistic or, more often (as with Santo Daime and the UDV), integrated with Christianity. Both Santo Daime and União do Vegetal now have members and churches throughout the world. Similarly, the US and Europe have started to see new religious groups develop in relation to increased ayahuasca use. Some Westerners have teamed up with shamans in the Amazon rainforest regions, forming ayahuasca healing retreats that claim to be able to cure mental and physical illness and allow communication with the spirit world. Some reports and scientific studies affirm that ritualized use of ayahuasca may improve mental and physical health.
In recent years, the tea has been popularized by Wade Davis (''The Serpent and The Rainbow''), Chilean novelist Isabel Allende, writer Kira Salak,author Jeremy Narby (''The Cosmic Serpent''), and radio personality Robin Quivers.
Legal status
Internationally, DMT is a Schedule I drug under the
Convention on Psychotropic Substances. The Commentary on the Convention on Psychotropic Substances notes, however, that the plants containing it are not subject to international control:
The cultivation of plants from which psychotropic substances are obtained is not controlled by the Vienna Convention. . . . Neither the crown (fruit, mescal button) of the Peyote cactus nor the roots of the plant Mimosa hostilis nor Psilocybe mushrooms themselves are included in Schedule 1, but only their respective principles, mescaline, DMT and psilocin.
A fax from the Secretary of the International Narcotics Control Board to the Netherlands Ministry of Public Health sent in 2001 goes on to state that "Consequently, preparations (e.g.decoctions) made of these plants, including ayahuasca, are not under international control and, therefore, not subject to any of the articles of the 1971 Convention."
The legal status in the United States of DMT-containing plants is somewhat questionable. Ayahuasca plants and preparations are legal, as they contain no scheduled chemicals. However, brews made using DMT containing plants are illegal since DMT is a Schedule I drug. That said, some people are challenging this, using arguments similar to those used by peyotist religious sects, such as the Native American Church. A court case allowing União do Vegetal to use the tea for religious purposes in the United States, ''Gonzales v. O Centro Espirita Beneficente Uniao do Vegetal'', was heard by the U.S. Supreme Court on November 1, 2005; the decision, released February 21, 2006, allows the UDV to use the tea in its ceremonies pursuant to the Religious Freedom Restoration Act. In a similar case an Ashland, Oregon based Santo Daime church sued for their right to import and consume ayahuasca tea. In March 2009, U.S. District Court Judge Panner ruled in favor of the Santo Daime, acknowledging its protection from prosecution under the Religious Freedom Restoration Act.
Religious use in Brazil was legalized after two official inquiries into the tea in the mid-1980s, which concluded that ayahuasca is not a recreational drug and has valid spiritual uses.
In France, Santo Daime won a court case allowing them to use the tea in early 2005; however, they were not allowed an exception for religious purposes, but rather for the simple reason that they did not perform chemical extractions to end up with pure DMT and harmala and the plants used were not scheduled. Four months after the court victory, the common ingredients of ayahuasca as well as harmala were declared ''stupéfiants'', or narcotic schedule I substances, making the tea and its ingredients illegal to use or possess.
Research
Charles Grob directed the first major study of the effects of ayahuasca on humans with the Hoasca Project in 1993. The project studied members of the União do Vegetal (UDV) church in Brazil who use ayahuasca as a sacrament. which in May 2008 held a 3-day conference under the title ''The globalization of Ayahuasca - An Amazonian psychoactive and its users''. There are also the investigations of the human pharmacology of ayahuasca done by the team of Doctor Jordi Riba, in Barcelona, Spain and the work of Rafael G. dos Santos and collaborators, in Brazil.
References
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Burroughs, William S. and Allen Ginsberg. ''The Yage Letters''. San Francisco: City Lights, 1963. ISBN 0-87286-004-3
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Category:Herbal and fungal hallucinogens
Category:Psychedelic tryptamine carriers
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