name	Diabetes mellitus
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Diabetes mellitus, often simply referred to as diabetes, is a group of metabolic diseases in which a person has high blood sugar, either because the body does not produce enough insulin, or because cells do not respond to the insulin that is produced. This high blood sugar produces the classical symptoms of polyuria (frequent urination), polydipsia (increased thirst) and polyphagia (increased hunger).

There are three main types of diabetes:

Type 1 diabetes: results from the body's failure to produce insulin, and presently requires the person to inject insulin. (Also referred to as ''insulin-dependent'' diabetes mellitus, ''IDDM'' for short, and ''juvenile'' diabetes.)

Type 2 diabetes: results from insulin resistance, a condition in which cells fail to use insulin properly, sometimes combined with an absolute insulin deficiency. (Formerly referred to as ''non-insulin-dependent'' diabetes mellitus, ''NIDDM'' for short, and ''adult-onset'' diabetes.)

Gestational diabetes: is when pregnant women, who have never had diabetes before, have a high blood glucose level during pregnancy. It may precede development of type 2 DM.

Other forms of diabetes mellitus include congenital diabetes, which is due to genetic defects of insulin secretion, cystic fibrosis-related diabetes, steroid diabetes induced by high doses of glucocorticoids, and several forms of monogenic diabetes.

All forms of diabetes have been treatable since insulin became available in 1921, and type 2 diabetes may be controlled with medications. Both type 1 and 2 are chronic conditions that usually cannot be cured. Pancreas transplants have been tried with limited success in type 1 DM; gastric bypass surgery has been successful in many with morbid obesity and type 2 DM. Gestational diabetes usually resolves after delivery. Diabetes without proper treatments can cause many complications. Acute complications include hypoglycemia, diabetic ketoacidosis, or nonketotic hyperosmolar coma. Serious long-term complications include cardiovascular disease, chronic renal failure, retinal damage. Adequate treatment of diabetes is thus important, as well as blood pressure control and lifestyle factors such as smoking cessation and maintaining a healthy body weight.

As of 2000 at least 171 million people worldwide suffer from diabetes, or 2.8% of the population. Type 2 diabetes is by far the most common, affecting 90 to 95% of the U.S. diabetes population.

Classification

Most cases of diabetes mellitus fall into three broad categories: type 1, type 2, and gestational diabetes. A few other types are described. The term ''diabetes'', without qualification, usually refers to diabetes ''mellitus''. The rare disease diabetes insipidus has similar symptoms as diabetes mellitus, but without disturbances in the sugar metabolism (insipidus meaning "without taste" in Latin).

{|class="wikitable" align="right" !colspan=3 | Comparison of type 1 and 2 diabetes |- ! Feature !! Type 1 diabetes !! Type 2 diabetes |- ! Onset | Sudden || Gradual |- ! Age at onset | Any age (mostly young) || Mostly in adults |- ! Body habitus | Thin or normal || Often obese |- ! Ketoacidosis | Common || Rare |- ! Autoantibodies | Usually present || Absent |- ! Endogenous insulin | Low or absent || Normal, decreased or increased |- ! Concordance in identical twins | 50% || 90% |- ! Prevalence | Less prevalent || More prevalent - 90 to 95% of  U.S. diabetics |}

The term "type 1 diabetes" has replaced several former terms, including childhood-onset diabetes, juvenile diabetes, and insulin-dependent diabetes mellitus (IDDM). Likewise, the term "type 2 diabetes" has replaced several former terms, including adult-onset diabetes, obesity-related diabetes, and non-insulin-dependent diabetes mellitus (NIDDM). Beyond these two types, there is no agreed-upon standard nomenclature. Various sources have defined "type 3 diabetes" as: gestational diabetes, insulin-resistant type 1 diabetes (or "double diabetes"), type 2 diabetes which has progressed to require injected insulin, and latent autoimmune diabetes of adults (or LADA or "type 1.5" diabetes).

Type 1 diabetes

Type 1 diabetes mellitus is characterized by loss of the insulin-producing beta cells of the islets of Langerhans in the pancreas leading to insulin deficiency. This type of diabetes can be further classified as immune-mediated or idiopathic. The majority of type 1 diabetes is of the immune-mediated nature, where beta cell loss is a T-cell mediated autoimmune attack. There is no known preventive measure against type 1 diabetes, which causes approximately 10% of diabetes mellitus cases in North America and Europe. Most affected people are otherwise healthy and of a healthy weight when onset occurs. Sensitivity and responsiveness to insulin are usually normal, especially in the early stages. Type 1 diabetes can affect children or adults but was traditionally termed "juvenile diabetes" because it represents a majority of the diabetes cases in children.

Brittle diabetes, also known as unstable diabetes or labile diabetes, refers to a type of insulin-dependent diabetes characterized by dramatic and recurrent swings in glucose levels, often occurring for no apparent reason. The result can be irregular and unpredictable hyperglycemias, frequently with ketosis, and sometimes serious hypoglycemias. Brittle diabetes occurs no more frequently than in 1% to 2% of diabetics.

Type 2 diabetes

Type 2 diabetes mellitus is characterized by insulin resistance which may be combined with relatively reduced insulin secretion. The defective responsiveness of body tissues to insulin is believed to involve the insulin receptor. However, the specific defects are not known. Diabetes mellitus due to a known defect are classified separately. Type 2 diabetes is the most common type.

In the early stage of type 2 diabetes, the predominant abnormality is reduced insulin sensitivity. At this stage hyperglycemia can be reversed by a variety of measures and medications that improve insulin sensitivity or reduce glucose production by the liver.

Gestational diabetes

Gestational diabetes mellitus (GDM) resembles type 2 diabetes in several respects, involving a combination of relatively inadequate insulin secretion and responsiveness. It occurs in about 2%–5% of all pregnancies and may improve or disappear after delivery. Gestational diabetes is fully treatable but requires careful medical supervision throughout the pregnancy. About 20%–50% of affected women develop type 2 diabetes later in life.

Even though it may be transient, untreated gestational diabetes can damage the health of the fetus or mother. Risks to the baby include macrosomia (high birth weight), congenital cardiac and central nervous system anomalies, and skeletal muscle malformations. Increased fetal insulin may inhibit fetal surfactant production and cause respiratory distress syndrome. Hyperbilirubinemia may result from red blood cell destruction. In severe cases, perinatal death may occur, most commonly as a result of poor placental perfusion due to vascular impairment. Labor induction may be indicated with decreased placental function. A cesarean section may be performed if there is marked fetal distress or an increased risk of injury associated with macrosomia, such as shoulder dystocia.

A 2008 study completed in the U.S. found that the number of American women entering pregnancy with preexisting diabetes is increasing. In fact the rate of diabetes in expectant mothers has more than doubled in the past 6 years. This is particularly problematic as diabetes raises the risk of complications during pregnancy, as well as increasing the potential that the children of diabetic mothers will also become diabetic in the future.

Other types

Pre-diabetes indicates a condition that occurs when a person's blood glucose levels are higher than normal but not high enough for a diagnosis of type 2 diabetes. Many people destined to develop type 2 diabetes spend many years in a state of pre-diabetes which has been termed "America's largest healthcare epidemic."

Latent autoimmune diabetes of adults is a condition in which Type 1 diabetes develops in adults. Adults with LADA are frequently initially misdiagnosed as having Type 2 diabetes, based on age rather than etiology.

Some cases of diabetes are caused by the body's tissue receptors not responding to insulin (even when insulin levels are normal, which is what separates it from type 2 diabetes); this form is very uncommon. Genetic mutations (autosomal or mitochondrial) can lead to defects in beta cell function. Abnormal insulin action may also have been genetically determined in some cases. Any disease that causes extensive damage to the pancreas may lead to diabetes (for example, chronic pancreatitis and cystic fibrosis). Diseases associated with excessive secretion of insulin-antagonistic hormones can cause diabetes (which is typically resolved once the hormone excess is removed). Many drugs impair insulin secretion and some toxins damage pancreatic beta cells. The ICD-10 (1992) diagnostic entity, ''malnutrition-related diabetes mellitus'' (MRDM or MMDM, ICD-10 code E12), was deprecated by the World Health Organization when the current taxonomy was introduced in 1999.

Signs and symptoms

The classical symptoms of diabetes are polyuria (frequent urination), polydipsia (increased thirst) and polyphagia (increased hunger). Symptoms may develop rapidly (weeks or months) in type 1 diabetes while in type 2 diabetes they usually develop much more slowly and may be subtle or absent.

Prolonged high blood glucose causes glucose absorption, which leads to changes in the shape of the lenses of the eyes, resulting in vision changes; sustained sensible glucose control usually returns the lens to its original shape. Blurred vision is a common complaint leading to a diabetes diagnosis; type 1 should always be suspected in cases of rapid vision change, whereas with type 2 change is generally more gradual, but should still be suspected .

People (usually with type 1 diabetes) may also present with diabetic ketoacidosis, a state of metabolic dysregulation characterized by the smell of acetone; a rapid, deep breathing known as Kussmaul breathing; nausea; vomiting and abdominal pain; and altered states of consciousness.

A rarer but equally severe possibility is hyperosmolar nonketotic state, which is more common in type 2 diabetes and is mainly the result of dehydration. Often, the patient has been drinking extreme amounts of sugar-containing drinks, leading to a vicious circle in regard to the water loss.

A number of skin rashes can occur in diabetes that are collectively known as diabetic dermadromes.

Causes

The cause of diabetes depends on the type.

Type 1 diabetes is partly inherited and then triggered by certain infections, with some evidence pointing at Coxsackie B4 virus. There is a genetic element in individual susceptibility to some of these triggers which has been traced to particular HLA genotypes (i.e., the genetic "self" identifiers relied upon by the immune system). However, even in those who have inherited the susceptibility, type 1 diabetes mellitus seems to require an environmental trigger.

Type 2 diabetes is due primarily to lifestyle factors and genetics.

Following is a comprehensive list of other causes of diabetes:

Genetic defects of β-cell Function

*Maturity onset diabetes of the young (MODY)

*Mitochondrial DNA mutations

Genetic defects in insulin processing or insulin action

*Defects in proinsulin conversion

*Insulin gene mutations

*Insulin receptor mutations

Exocrine Pancreatic Defects

*Chronic pancreatitis

*Pancreatectomy

*Pancreatic neoplasia

*Cystic fibrosis

*Hemochromatosis

*Fibrocalculous pancreatopathy

Endocrinopathies

*Growth hormone excess (acromegaly)

*Cushing syndrome

*Hyperthyroidism

*Pheochromocytoma

*Glucagonoma

Infections

*Cytomegalovirus infection

*Coxsackievirus B

Drugs

*Glucocorticoids

*Thyroid hormone

*β-adrenergic agonists

Pathophysiology

Insulin is the principal hormone that regulates uptake of glucose from the blood into most cells (primarily muscle and fat cells, but not central nervous system cells). Therefore deficiency of insulin or the insensitivity of its receptors plays a central role in all forms of diabetes mellitus.

Humans are capable of digesting some carbohydrates, in particular those most common in food; starch, and some disaccharides such as sucrose, are converted within a few hours to simpler forms most notably the monosaccharide glucose, the principal carbohydrate energy source used by the body. The rest are passed on for processing by gut flora largely in the colon. Insulin is released into the blood by beta cells (β-cells), found in the Islets of Langerhans in the pancreas, in response to rising levels of blood glucose, typically after eating. Insulin is used by about two-thirds of the body's cells to absorb glucose from the blood for use as fuel, for conversion to other needed molecules, or for storage.

Insulin is also the principal control signal for conversion of glucose to glycogen for internal storage in liver and muscle cells. Lowered glucose levels result both in the reduced release of insulin from the beta cells and in the reverse conversion of glycogen to glucose when glucose levels fall. This is mainly controlled by the hormone glucagon which acts in the opposite manner to insulin. Glucose thus forcibly produced from internal liver cell stores (as glycogen) re-enters the bloodstream; muscle cells lack the necessary export mechanism. Normally liver cells do this when the level of insulin is low (which normally correlates with low levels of blood glucose).

Higher insulin levels increase some anabolic ("building up") processes such as cell growth and duplication, protein synthesis, and fat storage. Insulin (or its lack) is the principal signal in converting many of the bidirectional processes of metabolism from a catabolic to an anabolic direction, and vice versa. In particular, a low insulin level is the trigger for entering or leaving ketosis (the fat burning metabolic phase).

If the amount of insulin available is insufficient, if cells respond poorly to the effects of insulin (insulin insensitivity or resistance), or if the insulin itself is defective, then glucose will not have its usual effect so that glucose will not be absorbed properly by those body cells that require it nor will it be stored appropriately in the liver and muscles. The net effect is persistent high levels of blood glucose, poor protein synthesis, and other metabolic derangements, such as acidosis.

When the glucose concentration in the blood is raised beyond its renal threshold (about 10 mmol/L, although this may be altered in certain conditions, such as pregnancy), reabsorption of glucose in the proximal renal tubuli is incomplete, and part of the glucose remains in the urine (glycosuria). This increases the osmotic pressure of the urine and inhibits reabsorption of water by the kidney, resulting in increased urine production (polyuria) and increased fluid loss. Lost blood volume will be replaced osmotically from water held in body cells and other body compartments, causing dehydration and increased thirst.

Diagnosis

Diabetes mellitus is characterized by recurrent or persistent hyperglycemia, and is diagnosed by demonstrating any one of the following:

Fasting plasma glucose level ≥ 7.0 mmol/L (126 mg/dL).

Plasma glucose ≥ 11.1 mmol/L (200 mg/dL) two hours after a 75 g oral glucose load as in a glucose tolerance test.

Symptoms of hyperglycemia and casual plasma glucose ≥ 11.1 mmol/L (200 mg/dL).

Glycated hemoglobin (Hb A1C) ≥ 6.5%.

A positive result, in the absence of unequivocal hyperglycemia, should be confirmed by a repeat of any of the above-listed methods on a different day. It is preferable to measure a fasting glucose level because of the ease of measurement and the considerable time commitment of formal glucose tolerance testing, which takes two hours to complete and offers no prognostic advantage over the fasting test. According to the current definition, two fasting glucose measurements above 126 mg/dL (7.0 mmol/L) is considered diagnostic for diabetes mellitus.

People with fasting glucose levels from 100 to 125 mg/dL (5.6 to 6.9 mmol/L) are considered to have impaired fasting glucose. Patients with plasma glucose at or above 140 mg/dL (7.8 mmol/L), but not over 200 mg/dL (11.1 mmol/L), two hours after a 75 g oral glucose load are considered to have impaired glucose tolerance. Of these two pre-diabetic states, the latter in particular is a major risk factor for progression to full-blown diabetes mellitus as well as cardiovascular disease.

Management

Diabetes mellitus is a chronic disease which cannot be cured except in very specific situations. Management concentrates on keeping blood sugar levels as close to normal ("euglycemia") as possible, without causing hypoglycemia. This can usually be accomplished with diet, exercise, and use of appropriate medications (insulin in the case of type 1 diabetes, oral medications as well as possibly insulin in type 2 diabetes).

Patient education, understanding, and participation is vital since the complications of diabetes are far less common and less severe in people who have well-managed blood sugar levels. The goal of treatment is an HbA1C level of 6.5%, but should not be lower than that, and may be set higher. Attention is also paid to other health problems that may accelerate the deleterious effects of diabetes. These include smoking, elevated cholesterol levels, obesity, high blood pressure, and lack of regular exercise.

Lifestyle

There are roles for patient education, dietetic support, sensible exercise, with the goal of keeping both short-term and long-term blood glucose levels within acceptable bounds. In addition, given the associated higher risks of cardiovascular disease, lifestyle modifications are recommended to control blood pressure.

Medications

;Oral medications Metformin is generally recommended as a first line treatment for type 2 diabetes as there is good evidence that it decreases mortality. Routine use of aspirin however has not been found to improve outcomes in uncomplicated diabetes.

;Insulin Type 1 diabetes is typically treated with a combinations of regular and NPH insulin, or synthetic insulin analogs. When insulin is used in type 2 diabetes, a long-acting formulation is usually added initially, while continuing oral medications. Doses of insulin are than increased to effect.

Support

In countries using a general practitioner system, such as the United Kingdom, care may take place mainly outside hospitals, with hospital-based specialist care used only in case of complications, difficult blood sugar control, or research projects. In other circumstances, general practitioners and specialists share care of a patient in a team approach. Optometrists, podiatrists/chiropodists, dietitians, physiotherapists, nursing specialists (e.g., DSNs (Diabetic Specialist Nurse)), nurse practitioners, or certified diabetes educators, may jointly provide multidisciplinary expertise.

Complications

Diabetes doubles the risk of vascular problems, including cardiovascular disease.

Glycated hemoglobin is better than fasting glucose for determining risks of cardiovascular disease and death from any cause.

Epidemiology

[[File:Diabetes world map - 2000.svg|thumb|Prevalence of diabetes worldwide in 2000 (per 1000 inhabitants). World average was 2.8%. ]] [[Image:Diabetes mellitus world map - DALY - WHO2004.svg|thumb|Disability-adjusted life year for diabetes mellitus per 100,000 inhabitants in 2004. ]]

In 2000, according to the World Health Organization, at least 171 million people worldwide suffer from diabetes, or 2.8% of the population. Its incidence is increasing rapidly, and it is estimated that by 2030, this number will almost double. Diabetes mellitus occurs throughout the world, but is more common (especially type 2) in the more developed countries. The greatest increase in prevalence is, however, expected to occur in Asia and Africa, where most patients will probably be found by 2030. The increase in incidence of diabetes in developing countries follows the trend of urbanization and lifestyle changes, perhaps most importantly a "Western-style" diet. This has suggested an environmental (i.e., dietary) effect, but there is little understanding of the mechanism(s) at present, though there is much speculation, some of it most compellingly presented.

For at least 20 years, diabetes rates in North America have been increasing substantially. In 2010 nearly 26 million people have diabetes in the United States alone, from those 7 million people remain undiagnosed. Another 57 million people are estimated to have pre-diabetes.

The Centers for Disease Control has termed the change an epidemic. The National Diabetes Information Clearinghouse estimates that diabetes costs $132 billion in the United States alone every year. About 5%–10% of diabetes cases in North America are type 1, with the rest being type 2. The fraction of type 1 in other parts of the world differs. Most of this difference is not currently understood. The American Diabetes Association cite the 2003 assessment of the National Center for Chronic Disease Prevention and Health Promotion (Centers for Disease Control and Prevention) that 1 in 3 Americans born after 2000 will develop diabetes in their lifetime.

According to the American Diabetes Association, approximately 18.3% (8.6 million) of Americans age 60 and older have diabetes. Diabetes mellitus prevalence increases with age, and the numbers of older persons with diabetes are expected to grow as the elderly population increases in number. The National Health and Nutrition Examination Survey (NHANES III) demonstrated that, in the population over 65 years old, 18% to 20% have diabetes, with 40% having either diabetes or its precursor form of impaired glucose tolerance.

Indigenous populations in first world countries have a higher prevalence and increasing incidence of diabetes than their corresponding non-indigenous populations. In Australia the age-standardised prevalence of self-reported diabetes in Indigenous Australians is almost 4 times that of non-indigenous Australians. Preventative community health programs such as Sugar Man (diabetes education) are showing some success in tackling this problem.

Etymology

The word “diabetes” ( or ) comes from Latin ''diabētēs'', which in turn comes from Ancient Greek διαβήτης (''diabētēs'') which literally means “a passer through; a siphon.” Ancient Greek physician Aretaeus of Cappadocia (fl. 1st century CE) used that word, with the intended meaning “excessive discharge of urine,” as the name for the disease. Ultimately, the word comes from Greek διαβαίνειν (''diabainein''), meaning “to pass through,” which is composed of δια- (''dia''-), meaning “through” and βαίνειν (''bainein''), meaning “to go”. The word “diabetes” is first recorded in English, in the form ''diabete'', in a medical text written around 1425.

The word “''mellitus''” ( or ) comes from the classical Latin word ''mellītus'', meaning “mellite” (i.e. sweetened with honey; honey-sweet). The Latin word comes from ''mell''-, which comes from ''mel'', meaning “honey; sweetness; pleasant thing,” and the suffix -''ītus'', whose meaning is the same as that of the English suffix “-ite.” It was Thomas Willis who in 1675 added “mellitus” to the word “diabetes” as a designation for the disease, when he noticed that the urine of a diabetic had a sweet taste (glycosuria). This sweet taste had been noticed in urine by the ancient Greeks, Chinese, Egyptians, Indians, and Persians.

History

Diabetes is one of the oldest known diseases. An Egyptian manuscript from c. 1550 BCE mentions the phrase “the passing of too much urine.” The great Indian physician Sushruta (fl. 6th century BCE) identified the disease and classified it as ''Medhumeha''. He further identified it with obesity and sedentary lifestyle, advising exercises to help "cure" it. The ancient Indians tested for diabetes by observing whether ants were attracted to a person's urine, and called the ailment "sweet urine disease" (Madhumeha).

Concerning the sweetness of urine, it is to be noted that the Chinese, Japanese and Korean words for diabetes are based on the same ideographs (糖尿病) which mean "sugar urine disease". It was in 1776 that Matthew Dobson confirmed that the sweet taste comes from an excess of a kind of sugar in the urine and blood.

The first complete clinical description of diabetes was given by the Ancient Greek physician Aretaeus of Cappadocia (fl. 1st century CE), who noted the excessive amount of urine which passed through the kidneys and gave the disease the name “diabetes.”

Diabetes mellitus appears to have been a death sentence in the ancient era. Hippocrates makes no mention of it, which may indicate that he felt the disease was incurable. Aretaeus did attempt to treat it but could not give a good prognosis; he commented that "life (with diabetes) is short, disgusting and painful."

In medieval Persia, Avicenna (980–1037) provided a detailed account on diabetes mellitus in ''The Canon of Medicine'', "describing the abnormal appetite and the collapse of sexual functions," and he documented the sweet taste of diabetic urine. Like Aretaeus before him, Avicenna recognized a primary and secondary diabetes. He also described diabetic gangrene, and treated diabetes using a mixture of lupine, trigonella (fenugreek), and zedoary seed, which produces a considerable reduction in the excretion of sugar, a treatment which is still prescribed in modern times. Avicenna also "described diabetes insipidus very precisely for the first time", though it was later Johann Peter Frank (1745–1821) who first differentiated between diabetes mellitus and diabetes insipidus.

Although diabetes has been recognized since antiquity, and treatments of various efficacy have been known in various regions since the Middle Ages, and in legend for much longer, pathogenesis of diabetes has only been understood experimentally since about 1900. The discovery of a role for the pancreas in diabetes is generally ascribed to Joseph von Mering and Oskar Minkowski, who in 1889 found that dogs whose pancreas was removed developed all the signs and symptoms of diabetes and died shortly afterwards. In 1910, Sir Edward Albert Sharpey-Schafer suggested that people with diabetes were deficient in a single chemical that was normally produced by the pancreas—he proposed calling this substance ''insulin'', from the Latin ''insula'', meaning island, in reference to the insulin-producing islets of Langerhans in the pancreas.

The endocrine role of the pancreas in metabolism, and indeed the existence of insulin, was not further clarified until 1921, when Sir Frederick Grant Banting and Charles Herbert Best repeated the work of Von Mering and Minkowski, and went further to demonstrate they could reverse induced diabetes in dogs by giving them an extract from the pancreatic islets of Langerhans of healthy dogs. Banting, Best, and colleagues (especially the chemist Collip) went on to purify the hormone insulin from bovine pancreases at the University of Toronto. This led to the availability of an effective treatment—insulin injections—and the first patient was treated in 1922. For this, Banting and laboratory director MacLeod received the Nobel Prize in Physiology or Medicine in 1923; both shared their Prize money with others in the team who were not recognized, in particular Best and Collip. Banting and Best made the patent available without charge and did not attempt to control commercial production. Insulin production and therapy rapidly spread around the world, largely as a result of this decision. Banting is honored by World Diabetes Day which is held on his birthday, November 14.

The distinction between what is now known as type 1 diabetes and type 2 diabetes was first clearly made by Sir Harold Percival (Harry) Himsworth, and published in January 1936.

Despite the availability of treatment, diabetes has remained a major cause of death. For instance, statistics reveal that the cause-specific mortality rate during 1927 amounted to about 47.7 per 100,000 population in Malta.

Other landmark discoveries include:

Identification of the first of the sulfonylureas in 1942

Reintroduction of the use of biguanides for Type 2 diabetes in the late 1950s. The initial phenformin was withdrawn worldwide (in the U.S. in 1977) due to its potential for sometimes fatal lactic acidosis and metformin was first marketed in France in 1979, but not until 1994 in the US.

The determination of the amino acid sequence of insulin (by Sir Frederick Sanger, for which he received a Nobel Prize)

The radioimmunoassay for insulin, as discovered by Rosalyn Yalow and Solomon Berson (gaining Yalow the 1977 Nobel Prize in Physiology or Medicine) The three-dimensional structure of insulin ()

Dr Gerald Reaven's identification of the constellation of symptoms now called metabolic syndrome in 1988

Demonstration that intensive glycemic control in type 1 diabetes reduces chronic side effects more as glucose levels approach 'normal' in a large longitudinal study, and also in type 2 diabetics in other large studies

Identification of the first thiazolidinedione as an effective insulin sensitizer during the 1990s

In 1980, U.S. biotech company Genentech developed biosynthetic human insulin. The insulin was isolated from genetically altered bacteria (the bacteria contain the human gene for synthesizing synthetic human insulin), which produce large quantities of insulin. The purified insulin is distributed to pharmacies for use by diabetes patients. Initially, this development was not regarded by the medical profession as a clinically meaningful development. However, by 1996, the advent of insulin analogues which had vastly improved absorption, distribution, metabolism, and excretion (ADME) characteristics which were clinically meaningful based on this early biotechnology development.

Society and culture

The 1990 "St. Vincent Declaration" was the result of international efforts to improve the care accorded to those with diabetes. Doing so is important both in terms of quality of life and life expectancy but also economically—expenses due to diabetes have been shown to be a major drain on health-and productivity-related resources for healthcare systems and governments.

Several countries established more and less successful national diabetes programmes to improve treatment of the disease.

A study shows that diabetic patients with neuropathic symptoms such as numbness or tingling in feet or hands are twice as likely to be unemployed as those without the symptoms.

References

Further reading

Furdell, Elizabeth Lane. ''Fatal Thirst: Diabetes in Britain until Insulin'' (Leiden, Netherlands: Brill, 2009) 194 pp.

External links

Diabetes at the Open Directory Project

American Diabetes Association

IDF Diabetes Atlas

International Diabetes Federation

National Diabetes Education Program

Peers for Progress

World Diabetes Day

Category:Medical conditions related to obesity Category:Nutrition

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name	The Cure
background	group_or_band
origin	Crawley, England
genre	Alternative rock, gothic rock, New Wave, post-punk
years active	1976–present
label	Fiction, Suretone, Geffen, Polydor, Elektra, Asylum, Sire|, Warner
associated acts	Malice, Easy Cure, The Glove, Siouxsie and the Banshees
website
current members	Robert SmithSimon Gallup Porl Thompson Jason Cooper
past members	Michael DempseyMatthieu HartleyPhil ThornalleyAndy AndersonBoris WilliamsPerry Bamonte Lol Tolhurst Roger O'Donnell }}

The Cure are an English rock band formed in Crawley, West Sussex in 1976. The band has experienced several line-up changes, with frontman, vocalist, guitarist and principal songwriter Robert Smith being the only constant member. The Cure first began releasing music in the late 1970s with its debut album ''Three Imaginary Boys'' (1979); this, along with several early singles, placed the band as part of the post-punk and New Wave movements that had sprung up in the wake of the punk rock revolution in the United Kingdom. During the early 1980s, the band's increasingly dark and tormented music helped form the gothic rock genre.

After the release of ''Pornography'' (1982), the band's future was uncertain and Smith was keen to move past the gloomy reputation his band had acquired. With the 1982 single "Let's Go to Bed" Smith began to place a pop sensibility into the band's music (as well as a unique stage look). The Cure's popularity increased as the decade wore on, especially in the United States where the songs "Just Like Heaven", "Lovesong" and "Friday I'm in Love" entered the ''Billboard'' Hot 100 chart. By the start of the 1990s, The Cure were one of the most popular alternative rock bands in the world. The band is estimated to have sold 27 million albums as of 2004. The Cure have released thirteen studio albums and over thirty singles during the course of their career.

History

Formation and early years (1973–1979)

The first incarnation of what became The Cure was The Obelisk, a band formed by students at Notre Dame Middle School in Crawley, Sussex. The band made their public debut in a one-off performance in April 1973, and featured Robert Smith (piano), Michael "Mick" Dempsey (guitar), Laurence "Lol" Tolhurst (percussion), Marc Ceccagno (lead guitar) and Alan Hill (bass guitar). The first real incarnation though came in January 1976 when Ceccagno formed Malice with Smith and Dempsey along with two other classmates from St. Wilfrid's Catholic Comprehensive School, with Ceccagno on lead, Smith on guitar, and Dempsey switching to bass. Ceccagno soon left, however, to form a jazz-rock fusion band called Amulet. Increasingly influenced by the emergence of punk rock, Malice's remaining members became known as Easy Cure in January 1977. By this time, Smith and Dempsey had been joined by Lol Tolhurst from The Obelisk on drums, and new lead guitarist Porl Thompson. Both Malice and Easy Cure also trialled several unsuccessful vocalists before Smith finally assumed the role of Easy Cure's frontman in September 1977.

That year, Easy Cure won a talent competition with German label Hansa Records, and received a recording contract. Although the band recorded tracks for the company, none were ever released. Following disagreements in March 1978 over the direction the band should take, the contract with Hansa was dissolved. Smith later recalled, "We were very young. They just thought they could turn us into a teen group. They actually wanted us to do cover versions and we always refused." Thompson was dropped from the band in May, and the remaining trio (Smith/Tolhurst/Dempsey) were soon renamed The Cure by Smith. Later that month the band recorded their first sessions as a trio at Chestnut Studios in Sussex, which were distributed as a demo tape to a dozen major record labels. The demo found its way to Polydor Records scout Chris Parry, who signed The Cure to his newly formed Fiction label—distributed by Polydor—in September 1978. However, as a stopgap while Fiction finalised distribution arrangements with Polydor, in December 1978 The Cure released their debut single "Killing an Arab" on the Small Wonder label. "Killing an Arab" garnered both acclaim and controversy: while the single's provocative title led to accusations of racism, the song is actually based on French existentialist Albert Camus' novel ''The Stranger''. The band placed a sticker label that denied the racist connotations on the single's 1979 reissue on Fiction. An early ''NME'' article on the band wrote that The Cure "are like a breath of fresh suburban air on the capital's smog-ridden pub and club circuit" and noted "With a John Peel session and more extensive London gigging on their immediate agenda, it remains to be seen whether or not The Cure can retain their refreshing ''joie de vivre''."

The Cure released their debut album ''Three Imaginary Boys'' in May 1979. Due to the band's inexperience in the studio, Parry and engineer Mike Hedges took control of the recording. The band, particularly Smith, were unhappy with their debut; in a 1987 interview, he admitted, "a lot of it was very superficial – I didn't even like it at the time. There were criticisms made that it was very lightweight, and I thought they were justified. Even when we'd made it, I wanted to do something that I thought had more substance to it". The band's second single "Boys Don't Cry" was released in June. The Cure then embarked as the support band for Siouxsie & The Banshees' ''Join Hands'' promotional tour of England, Northern Ireland, and Wales between August and October. The tour saw Smith and Tolhurst pull double duty each night by performing with The Cure and as the guitarist / drummer with The Banshees when their guitarist John McKay and drummer Kenny Morris both walked out on the group just two days into the tour. That musical experience had a strong impact on him: "On stage that first night with the Banshees, I was blown away by how powerful I felt playing that kind of music. It was so different to what we were doing with The Cure. Before that, I'd wanted us to be like The Buzzcocks or Elvis Costello, the punk Beatles. Being a Banshee really changed my attitude to what I was doing."

The Cure's third single "Jumping Someone Else's Train" was released in early October 1979. Soon afterwards, Dempsey was dropped from the band due to his cold reception to material Smith had written for the upcoming album. Dempsey joined the Associates, while Simon Gallup (bass) and Matthieu Hartley (keyboards) from The Magspies joined The Cure. The Associates toured as support band for The Cure and The Passions on the ''Future Pastimes Tour'' of England between November and December—all three bands were on the Fiction Records roster—with the new Cure line-up already performing a number of new songs for the projected second album. Meanwhile, a spin-off band comprising Smith, Tolhurst, Dempsey, Gallup, Hartley and Thompson, with backing vocals from assorted family and friends, and lead vocals provided by their local postman Frankie Bell released a 7-inch single in December under the assumed name of Cult Hero.

Gothic phase (1980–1982)

Wary, due to the band's lack of creative control on the first album, Smith exerted a greater influence on the recording of The Cure's second album ''Seventeen Seconds'', which he co-produced with Mike Hedges. The album was released in 1980 and reached number 20 on the UK charts. A single from the album, "A Forest", became the band's first UK hit single, reaching number 31 on the singles chart. The album was a departure from The Cure's sound up to that point, with Hedges describing it as "morose, atmospheric, very different to ''Three Imaginary Boys''." In its review of ''Seventeen Seconds'' the ''NME'' said, "For a group as young as The Cure, it seems amazing that they have covered so much territory in such a brief time." At the same time, Smith was pressed concerning the concept of an alleged "anti-image". Smith told the press he was fed up with the anti-image association that some considered to be "elaborately disguising their plainness", stating, "We had to get away from that anti-image thing, which we didn't even create in the first place. And it seemed like we were trying to be more obscure. We just didn't like the standard rock thing. The whole thing really got out of hand." That same year ''Three Imaginary Boys'' was repackaged for the American market as ''Boys Don't Cry'', with new artwork and a modified tracklist. The Cure set out on their first world tour to promote both releases. At the end of the tour, Matthieu Hartley left the band. Hartley said, "I realised that the group was heading towards suicidal, sombre music—the sort of thing that didn't interest me at all."

The band reconvened with Hedges to produce their third album ''Faith'' (1981), which furthered the mood of misery present on ''Seventeen Seconds''. The album peaked at number 14 on the UK charts. Included with cassette copies of ''Faith'' was an instrumental soundtrack for ''Carnage Visors'', an animated film shown in place of an opening act for the band's 1981 Picture Tour. In late 1981, The Cure released the non-album single "Charlotte Sometimes". By this point, the sombre mood of the music had a profound effect on the attitude of the band. The band would refuse requests for older songs in concert, and sometimes Smith would be so absorbed by the persona he projected onstage he would leave at the end in tears.

In 1982, The Cure recorded and released ''Pornography'', the third and final album of an "oppressively dispirited" trio that cemented the Cure's stature as purveyors of the emerging gothic rock genre. Smith has said that during the recording of ''Pornography'' he was "undergoing a lot of mental stress. But it had nothing to do with the group, it just had to do with what I was like, my age and things. I think I got to my worst round about ''Pornography''. Looking back and getting other people's opinions of what went on, I was a pretty monstrous sort of person at that time". Gallup described the album by saying, "Nihilism took over [. . .] We sang 'It doesn't matter if we all die' and that is exactly what we thought at the time." Parry was concerned that the album did not have a hit song for radio play and instructed Smith and producer Phil Thornalley to polish the track "The Hanging Garden" for release as a single. Despite the concerns about the album's uncommercial sound, ''Pornography'' became the band's first UK Top 10 album, charting at number eight. The release of ''Pornography'' was followed by the Fourteen Explicit Moments tour, where the band finally dropped the anti-image angle and first adopted their signature look of big, towering hair and smeared lipstick on their faces. The tour also saw a series of incidents that prompted Simon Gallup to leave The Cure at the tour's conclusion. Gallup and Smith did not talk to each other for eighteen months following his departure.

Increasing commercial success (1983–1986)

With Gallup's departure from The Cure and with Smith's work with Siouxsie & the Banshees, rumours spread that The Cure had broken up. In December 1982, Smith remarked to ''Melody Maker'', "Do The Cure really exist any more? I've been pondering that question myself [. . .] it has got to a point where I don't fancy working in that format again." He added, "Whatever happens, it won't be me, Laurence, and Simon together any more. I know that."

Parry was concerned at the state of his label's top band, and became convinced that the solution was for The Cure to reinvent its musical style. Parry managed to convince Smith and Tolhurst of the idea; Parry said, "It appealed to Robert because he wanted to destroy The Cure anyway." With Tolhurst now playing keyboards instead of drums, the duo released the single "Let's Go to Bed" in late 1982. While Smith wrote the single off as a throwaway, "stupid" pop song to the press, it became a minor hit in the UK, reaching number 44 on the singles chart. It was followed in 1983 by two more successful songs: the synthesiser-based "The Walk" (number 12), and the jazz-influenced "The Lovecats", which became the band's first British Top 10 hit, reaching number seven. The group released these studio singles and their B-sides as the compilation album ''Japanese Whispers'', designed by Smith for the Japanese market only, but released worldwide on the decision of the record company. The same year, Smith also recorded and toured with Siouxsie & the Banshees, contributing as guitarist on their ''Nocturne'' live video and their ''Hyaena'' studio album. Meanwhile, he recorded the ''Blue Sunshine'' album with Banshees bassist Steven Severin as The Glove, while Lol Tolhurst produced the first two singles and debut album of the English band And Also The Trees.

In 1984, The Cure released ''The Top'', a generally psychedelic album on which Smith played all the instruments except the drums—played by Andy Anderson—and the saxophone—played by returnee Porl Thompson. The album was a Top 10 hit in the UK, and was their first studio album to break the ''Billboard'' 200 in the U.S., reaching number 180. ''Melody Maker'' praised the album as "psychedelia that can't be dated", while pondering, "I've yet to meet anyone who can tell me why The Cure are having hits now of all times." The Cure then embarked on their worldwide "Top Tour" with Thompson, Anderson, and producer-turned-bassist Phil Thornalley on board. Released in late 1984, The Cure's first live album, ''Concert'' consisted of performances from this tour. Near the tour's end, Anderson was fired for destroying a hotel room and was replaced by Boris Williams. Thornalley also left due to the rigors of the road. However, the bassist slot was not vacant long, for a Cure roadie named Gary Biddles had brokered a reunion between Smith and former bassist Simon Gallup, who had been playing in the band Fools Dance. Soon after reconciling, Smith asked Gallup to rejoin the band. Smith was ecstatic about Gallup's return and declared to ''Melody Maker'', "It's a group again."

In 1985, the new line-up of Smith, Tolhurst, Gallup, Thompson, and Williams released ''The Head on the Door'', an album which managed to bind together the optimistic and pessimistic aspects of the band's music that they had previously shifted between. ''The Head on the Door'' reached number seven in the UK and was the band's first entry into American Top 75 at number 59, a success partly due to the international impact of the LP's two singles, "In Between Days" and "Close to Me". Following the album and world tour, the band released the singles compilation ''Standing on a Beach'' in three formats (each with a different track listing and a specific name) in 1986. This compilation made the US Top 50, and saw the re-issue of three previous singles: "Boys Don't Cry" (in a new form), "Let's Go To Bed" and later "Charlotte Sometimes". This release was accompanied by a VHS or LaserDisc called ''Staring at the Sea'', which featured videos for each track on the compilation. The Cure toured to support the compilation and released a live concert VHS of the show, filmed in the south of France called ''The Cure in Orange''. During this time, The Cure became a very popular band in Europe (particularly in France, Germany and the Benelux countries) and increasingly popular in the U.S.

''Kiss Me, Kiss Me, Kiss Me'' and worldwide success (1987–1993)

In 1987, The Cure released the double LP ''Kiss Me, Kiss Me, Kiss Me'', which reached number six in the UK, the Top 10 in several countries and was the band's first entry into the U.S. Top 40 at number 35 (where it was certified platinum), due to the combination of the band's rising popularity and the success of lead single, "Why Can't I Be You?". The album's third single, "Just Like Heaven" was the band's most successful single to date in the US, being their first to enter the ''Billboard'' Top 40. After the album's release, the band embarked on the successful Kissing Tour. During the European leg of the tour, Lol Tolhurst's alcohol consumption was interfering with his ability to perform so The Psychedelic Furs keyboardist Roger O'Donnell was frequently called upon to stand in for him. In 1989, The Cure released the album ''Disintegration'', which saw a return to the gothic atmospheres of earlier releases like ''Faith'' and ''Pornography''. It became their highest charting album in the UK to date, entering at number three and featuring three Top 30 singles in the UK and Germany ("Lullaby", "Lovesong" and "Pictures of You"). ''Disintegration'' also reached number twelve on the US charts. The first single stateside, "Fascination Street", reached number one on the American Modern Rock chart, but was quickly overshadowed when its third US single, "Lovesong", reached number two on the American pop charts (the only Cure single to reach the US Top 10). By 1992, ''Disintegration'' had sold over three million copies worldwide.

During the ''Disintegration'' sessions, the band gave Smith an ultimatum that either Tolhurst would have to leave the band or they would. In February 1989, Tolhurst's exit was made official and announced to the press; this resulted in Roger O'Donnell becoming a full-fledged member of the band and left Smith as The Cure's only remaining founder member. Smith attributed Tolhurst's dismissal to an inability to exert himself and issues with alcohol, concluding, "He was out of step with everything. It had just become detrimental to everything we'd do." Because Tolhurst was still on the payroll during the recording of ''Disintegration'', he was credited in the album's liner notes as playing "other instruments", however it has since been revealed that he contributed nothing to the album in either performance or song writing. The Cure then embarked on the Prayer Tour, which saw the band playing stadiums in America.

In May 1990, Roger O'Donnell quit and was replaced with the band's guitar technician Perry Bamonte. That November, The Cure released a collection of remixes called ''Mixed Up''. The album was not well received and quickly slid down the charts. The one new song on the collection, "Never Enough", was released as a single. In 1991 The Cure were awarded the BRIT Award for Best British Band. That same year Tolhurst filed a lawsuit against Smith and Fiction Records in 1991 over royalties payments, and claimed joint ownership of the name "The Cure" with Smith; the verdict was handed out in September 1994 in favour of Smith. In respite from the lawsuit, the band returned to the studio to record their next album. ''Wish'' reached number one in the UK and number two in the US and yielded the international hits "High" and "Friday I'm in Love". The Cure also embarked on the "Wish Tour" with Cranes, and released the live albums ''Show'' (September 1993) and ''Paris'' (October 1993). As a promotional exercise with the Our Price music chain in the UK, a limited edition EP was released consisting of instrumental outtakes from the ''Wish'' sessions. Entitled ''Lost Wishes'', the proceeds from the four-track cassette tape went to charity.

In the years between the release of ''Wish'' and the start of sessions for The Cure's next album, the band's line-up shifted again. Thompson left the band once more during 1993 to play with Robert Plant and Jimmy Page of Led Zeppelin, and Bamonte took over as lead guitarist. Boris Williams also left the band, and was replaced by Jason Cooper (formerly of My Life Story).

Period of transition (1994–1999)

The album sessions began in 1994 with only Smith and Bamonte present; the pair were later joined by Gallup (who was recovering from physical problems), and Roger O'Donnell, who had been asked to rejoin the band at the end of 1994. The Cure performed "Burn" in the movie The Crow and "Dredd Song," the theme song of the 1995 movie ''Judge Dredd'' starring Sylvester Stallone. It was not released on a Cure album until 2004 on ''Join the Dots: B-Sides & Rarities 1978–2001 (The Fiction Years)''.''Wild Mood Swings'', finally released in 1996, was poorly received compared with previous albums and marked the end of the band's commercial peak. Early in 1996, the Cure played festivals in South America, followed by a world tour in support of the album ''Galore''. ''Galore'' contained all of the Cure's singles released between 1987 and 1997, as well as the new single "Wrong Number", which featured longtime David Bowie guitarist Reeves Gabrels. Gabrels also accompanied the Cure on a brief American radio festival tour as an onstage guest guitarist for "Wrong Number". In 1998 The Cure contributed to the soundtrack album for ''The X-Files'' feature film as well as the Depeche Mode tribute album ''For the Masses'', with their cover of "World in My Eyes".

Recent years (2000–present)

With only one album left in their record contract and with commercial response to ''Wild Mood Swings'' and the ''Galore'' compilation lacklustre, Smith once again considered that the end of The Cure might be near and thus wanted to make an album that reflected the more serious side of the band. The Grammy-nominated album ''Bloodflowers'' was released in 2000 after being delayed since 1998. According to Smith, The album was the third of a trilogy along with ''Pornography'' and ''Disintegration''. The band also embarked on the nine-month Dream Tour, attended by over one million people worldwide. In 2001, The Cure left Fiction and released their ''Greatest Hits'' album and DVD, which featured the music videos for a number of classic Cure songs. In 2002, the band headlined twelve major summer music festivals, and played three extended concerts (one in Brussels, two in Berlin) in which they performed the albums ''Pornography'', ''Disintegration'' and ''Bloodflowers'' in their respective entireties each night. The Berlin performances were released on DVD as ''The Cure: Trilogy'' in 2003.

In 2003, The Cure signed with Geffen Records. In 2004, they released a new four-disc boxed set on Fiction Records titled ''Join the Dots: B-Sides and Rarities, 1978-2001 (The Fiction Years)''. The compilation includes seventy Cure songs, some previously unreleased, and a 76-page full-colour book of photographs, history and quotes, packaged in a hard cover. The album peaked at number 106 on the ''Billboard'' 200 album charts. The band released their twelfth album ''The Cure'' on Geffen in 2004, which was produced by Ross Robinson. It made a top ten debut on both sides of the Atlantic in July 2004. To promote the album, the band headlined the Coachella Valley Music and Arts Festival that May. From 24 July to 29 August, The Cure headlined the Curiosa concert tour of North America. While attendances were lower than expected, Curiosa was still one of the more successful American summer festivals of 2004. The same year the band was honoured with an MTV Icon television special.

In May 2005, Roger O'Donnell and Perry Bamonte were fired from the band. O'Donnell claims Smith informed him he was reducing the band to a three-piece. Previously O'Donnell said he had only found out about the band's upcoming tour dates via a fan site and added, "It was sad to find out after nearly 20 years the way I did but then I should have expected no less or more." The remaining members of the band—Smith, Gallup and Cooper—made several appearances as a trio before it was announced in June that Porl Thompson would be returning for the band's 2005 Festival summer shows, as well as their set at Live 8 in Paris on 2 July. Later that year, the band recorded a cover of John Lennon's "Love" for Amnesty International's charity album ''Make Some Noise''. It is available for download on the Amnesty website, while the album was released on CD in 2006. On 1 April 2006, The Cure appeared at the Royal Albert Hall on behalf of the Teenage Cancer Trust. It was their only show through to the end the year. In December a live DVD, entitled ''The Cure: Festival 2005'' including 30 songs of their 2005 Festival tour was released.

The Cure began writing and recording material for their thirteenth album in 2006. Smith initially stated it would be a double album. The Cure announced a last-minute postponement of their autumn 2007 North American 4Tour in August in order to continue working on the album, rescheduling the dates for spring 2008. Titled ''4:13 Dream'', the album was released in October 2008. The group released four singles and an EP—"The Only One", "Freakshow", "Sleep When I'm Dead", "The Perfect Boy" and ''Hypnagogic States'' respectively—on or near to the 13th of each month, in the months leading up to the album's release. In February 2009, The Cure received the 2009 Shockwaves NME Award for Godlike Genius.

In 2011, the band played their first 3 studio albums in their entirety during two shows in Sydney, Australia. These "Reflections" shows notably featured Roger O'Donnell and Laurence Tolhurst, both in a keyboard and percussion role. The shows are due to be released on DVD in 2011.

Musical style

The Cure are often identified with the gothic rock subgenre of alternative rock, and are viewed as one of the form's definitive bands. However, the band has routinely rejected classification, particularly as a gothic rock band. Robert Smith said in 2006, "It's so pitiful when 'goth' is still tagged onto the name The Cure", and added, "We're not categorisable. I suppose we were post-punk when we came out, but in total it's impossible [...] I just play Cure music, whatever that is." Smith has also expressed his distaste for gothic rock, describing it as "incredibly dull and monotonous. A dirge really." While typically viewed as producers of dark and gloomy music, The Cure have also yielded a number of upbeat songs. ''Spin'' has said "The Cure have always been an either/or sort of band: either [...] Robert Smith is wallowing in gothic sadness or he's licking sticky-sweet cotton-candy pop off his lipstick-stained fingers."

The Cure's primary musical traits have been listed as "dominant, melodic bass lines; whiny, strangulated vocals; and a lyric obsession with existential, almost literary despair." Most Cure songs start with Smith and Gallup writing the drum parts and bass lines. Both record demos at home and then bring them into the studio for fine-tuning. Smith said in 1992, "I think when people talk about the 'Cure sound,' they mean songs based on 6-string bass, acoustic guitar, and my voice, plus the string sound from the Solina." On top of this foundation is laid "towering layers of guitars and synthesisers". Keyboards have been a component of the band's sound since ''Seventeen Seconds'', and their importance increased with the instrument's extensive use on ''Disintegration''. With the Departure of Roger O'Donnell in 2005, keyboards have not been as prominent in the band's album 4:13 Dream and their live shows.

Music videos

The band's early music videos have been described as "dreadful affairs" and have been maligned for their poor quality, particularly by the band itself. Lol Tolhurst said, "Those videos were unmitigated disasters; we weren't actors and our personalities weren't coming across." It was with the video for "Let's Go to Bed", their first collaboration with director Tim Pope, that The Cure would become noted for their videos. Pope added a playful element to the band's videos; the director insisted in a 1987 ''Spin'' interview, "I think that side of them was always there, but was never brought out." Pope would go on to direct the majority of The Cure's videos, and his videos, which became synonymous with the band, helped expand The Cure's audience during the 1980s. Pope explained the appeal of working with The Cure by saying, "The Cure is the ultimate band for a filmmaker to work with because Robert Smith really understands the camera. His songs are so cinematic. I mean on one level there's this stupidity and humour, right, but beneath that there are all [Smith's] psychological obsessions and claustrophobia."

Legacy

The Cure were one of the first alternative bands to have chart and commercial success in an era before alternative rock had broken into the mainstream. In 1992 the ''NME'' declared The Cure had during the 1980s become "a goth hit machine (19 to date), an international phenomenon and, yep, the most successful alternative band that ever shuffled disconsolately about the earth". Smith has noted he looks at Cure-influenced bands like Interpol and My Chemical Romance with affection, adding, "I also think [Interpol bassist] Carlos D.'s obsession with Simon Gallup is sweet." Interpol lead singer, Paul Banks was quoted as saying ""The Cure is the band that all of us in Interpol can say influenced us. When I was younger I listened to them a lot. Carlos as well. Actually, he took a straight influence from this band on the way he played the bass and the keys. To me, Robert Smith is also one of these examples: you can't be Robert Smith if you're not Robert Smith. It's one of the bands with the deepest influence on Interpol, because we all like them. They're legendary."

Several references to The Cure and their music have been made in popular culture. A number of films have used the title of a Cure song as the film's title, including ''Boys Don't Cry'' (1999) and ''Just Like Heaven'' (2005). The Cure's gloomy image has been the subject of parody at times. In series two of ''The Mighty Boosh'', The Moon sings 'The Lovecats' over the credits. In the same episode, a powerful gothic hairspray, Goth Juice, is said to be "The most powerful hairspray known to man. Made from the tears of Robert Smith." ''The Mary Whitehouse Experience'' often featured brief clips of the stars of the show performing comical songs and nursery rhymes as The Cure in a morose style. Robert Smith appeared in the final episode of the first series of ''The Mary Whitehouse Experience'' singing "The Sun has got his hat on" before punching the character Ray (played by Robert Newman) whilst uttering Ray's catch phrase "Oh no what a personal disaster". Robert Smith was also portrayed on an episode of ''South Park'' (Season 1, Episode 12) where he transforms into the form of Mothra and battles Mecha-Streisand to save the day and Kyle shouts "''Disintegration'' is the best album ever!" In Craig Thompson's graphic novel ''Blankets'' the chapter seven is called "Just Like Heaven". The same chapter shows Raina singing some lyrics from this song to Craig.

Discography

''Three Imaginary Boys'' (1979)

''Seventeen Seconds'' (1980)

''Faith'' (1981)

''Pornography'' (1982)

''The Top'' (1984)

''The Head on the Door'' (1985)

''Kiss Me, Kiss Me, Kiss Me'' (1987)

''Disintegration'' (1989)

''Wish'' (1992)

''Wild Mood Swings'' (1996)

''Bloodflowers'' (2000)

''The Cure'' (2004)

''4:13 Dream'' (2008)

Members

;Current line-up

Robert Smith – lead vocals, guitars, keyboards (1976–present)

Porl Thompson – guitars, keyboards (1976–1978, 1983–1993, 2005–present)

Simon Gallup – bass guitar, keyboards (1979–1982, 1985–present)

Jason Cooper – drums, percussion (1995–present)

References

Sources

Apter, Jeff. (2006). ''Never Enough: The Story of the Cure''. Omnibus Press. ISBN 1-84449-827-1

Further reading

''Ten Imaginary Years'', by L. Barbarian, Steve Sutherland and Robert Smith (1988) Zomba Books ISBN 0-946391-87-4

''The Cure: A Visual Documentary'', by Dave Thompson and Jo-Ann Greene(1988) Omnibus Press ISBN 0-7119-1387-0

''The Cure: Songwords 1978–1989'' S. Hopkins, Robert Smith and T. Foo (1989) Omnibus Press ISBN 0-7119-1951-8

''In Between Days: An Armchair Guide To The Cure'' by Dave Thompson, Helter Skelter Publishing (October 2005) ISBN 1-905139-00-4

''The Cure – Greatest Hits'' (songbook containing 20 of their best, transcribed note-for-note with tab, chord symbols and complete lyrics), Hal Leonard Corporation (May 2002) ISBN 0-634-04667-5

''Robert Smith: "The Cure" and Wishful Thinking'' by Richard Carman (2005) Independent Music Press (UK) ISBN 9-78095-497041-3

''Jeremy Wulc : My dream comes true : Carnet de route avec The Cure. (2009) Editions : Camion Blanc

External links

'Chain of Flowers' – News about The Cure

Category:BRIT Award winners Category:English alternative rock groups Category:British New Wave musical groups Category:Gothic rock groups Category:Musical groups established in 1976 Category:British post-punk music groups Category:People from Crawley

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Name	Nick Jonas
Birth name	Nicholas Jerry Jonas
Background	solo_singer
Born	September 16, 1992Dallas, Texas, U.S.
Origin	Wyckoff, New Jersey,U.S.
Instrument	Vocals, guitar, drums, piano, glockenspiel
Genre	Teen pop, pop rock
Occupation	Vocalist, musician, actor, singer–songwriter
Years active	2002–present
Label	Hollywood, Columbia
Associated acts	Jonas Brothers, Nick Jonas & The Administration, Miley Cyrus
Notable instruments	Gibson SGFender TelecasterGibson ES-335 }}

Nicholas Jerry "Nick" Jonas (born September 16, 1992) is an American singer-songwriter, musician and actor best known as one of the Jonas Brothers, a pop-rock band he formed with his brothers Joe and Kevin. The Jonas Brothers originally started as an attempted solo singing career for Nick, but the record producer liked the sound when his brothers sang backup for him. He previously starred in the Disney Channel original series ''JONAS L.A.'' as Nick Lucas, alongside his brothers. He also starred in the Disney Channel original movie ''Camp Rock'' and ''Camp Rock 2: The Final Jam''. He formed the band Nick Jonas & The Administration, which released its first album in 2010.

Personal life

Jonas was born in Dallas, Texas. His mother, Denise (née Miller), is a former sign language teacher and singer, and his father, Paul Kevin Jonas, Sr., is a songwriter, musician, and former ordained minister at an Assemblies of God church. He was raised in Wyckoff, New Jersey and homeschooled by his mother. Nick is of Italian (from a great-grandfather), German, Irish, English, Cherokee, and French-Canadian descent.

Jonas was diagnosed with Type I diabetes at the age of thirteen and wears an OmniPod insulin pump to help him manage his condition. He has developed the Change for the Children Foundation. Partnering with five different charities, their goal is to raise money and awareness for diabetes. He also developed a public service announcement with the Washington Nationals to support diabetes care at Children's National Medical Center in Washington, D.C.

Since August 6, 2008, Bayer Diabetes Care has partnered with Jonas as a diabetes ambassador to promote the idea for young people to manage their diabetes. Jonas testified in the U.S. Senate to promote more research funding for the condition.

Singer and actress Miley Cyrus has stated that she dated Jonas from June 2006 to December 2007. Cyrus claimed they were "in love" and began dating soon after they first met. Nick is currently dating singer Delta Goodrem.

Acting

Theatre

Jonas's career started when he was discovered at the age of six in a barber shop, while his mother was getting her hair cut and was referred to a professional show business manager. At the age of 7, he began performing on Broadway. He had acted in several plays, including ''A Christmas Carol'' (in 2000 as Tiny Tim and Scrooge at eight), ''Annie Get Your Gun'' (in 2001 as Little Jake), ''Beauty and the Beast'' (in 2002 as Chip), and ''Les Misérables'' (in 2003 as Gavroche). After ''Les Misérables'' closed, he performed in ''The Sound of Music'' (as Kurt) at the Paper Mill Playhouse.

On June 21, 2010, Jonas made his West End debut performing in ''Les Misérables'' for the second time, but this time as the role of Marius Pontmercy. Jonas was originally supposed to play the role for only three weeks, but was able to extend his run until July 24, 2010, because of changes in the Jonas Brothers tour schedule. He also appeared in the 25th Anniversary Concert at The O2 Arena on October 3, 2010, again playing the role of Marius Pontmercy.

From August 5–7, 2011, Jonas performed in the musical ''Hairspray'' as Link Larkin. On September 7, 2011, Jonas announced through twitter he will be on Broadway again in 2012 in the musical "How to Succeed in Business Without Really Trying" starring as J. Pierrepont Finch.

Television

On August 17, 2007, Jonas, along with his brothers, guest starred in an episode of ''Hannah Montana'', which aired after the premiere of ''High School Musical 2'' and the Disney Channel show ''Phineas and Ferb''. The episode broke basic cable records with a record 10.7 million viewers and became basic cable's most watched series telecast ever.

Jonas and his brothers filmed a Disney Channel Original Movie called ''Camp Rock'' where they play a band called "Connect Three." Joe plays the lead male role as lead singer "Shane Gray"; Nick plays the role of "Nate," a guitarist; and Kevin plays the role of "Jason," also a guitarist. A soundtrack for the movie was released on June 17, 2008. The movie premiered on June 20, 2008, in the USA on Disney Channel, and Canada on Family. Production began on the sequel, Camp Rock 2: The Final Jam in September 2009 and it premiered during the summer of 2010.

The reality short series, ''Jonas Brothers: Living the Dream'', premiered on Disney Channel on May 16, 2008. The show, which ran until September 5, 2008, documents the brothers' lives on the Look Me In The Eyes Tour. The name was inspired by the band's hit song "When You Look Me in the Eyes". The series was renewed for a second season, which premiered on March 21, 2010. The second season follows the band on the European leg of their World Tour 2009.

Jonas and his brothers previously starred in the Disney Channel Original Series ''JONAS'' about a pop band trying to live a normal life, which premiered May 2, 2009 and concluded on March 14, 2010. Filming for the second season began in February 2010. The second season was renamed ''Jonas L.A.'', and premiered on June 20, 2010. On November 8, 2010, it was announced that the series had been cancelled.

Jonas appeared in the 2011 series ''Mr. Sunshine''; he played Eli White, an up-and-coming singer who wants everything his way before he performs at the Sunshine Center. He also plays the role of Ryan on the sitcom ''Last Man Standing''. In 2012 he appears in a brand new show called Smash were he plays the role of Lyle West, the episode appeares on February 27, 2012.

Singing

Solo artist

In 2002, while performing in ''Beauty and the Beast'', Nick had written a song with his father called "Joy to the World (A Christmas Prayer)." With background vocals from the ''Beauty and the Beast'' cast, Nick performed the song on the 2002 annual Broadway "Equity Fights AIDS" album, ''Broadway's Greatest Gifts: Carols for a Cure, Vol. 4''. In November 2003, INO Records received a demo copy of "Joy To The World (A Christmas Prayer)". The label released the song to Christian radio, where it quickly became popular on Record & Radio's Christian Adult Contemporary Chart. While Nick was working on his solo project, Joe followed in his footsteps to Broadway, appearing in Baz Luhrmann's production of ''La Boheme''.

By September 2004, an executive at Columbia Records found out about Nick's song. Nick was soon jointly signed to INO Records and Columbia Records and released the single "Dear God". A second single, "Joy to the World (A Christmas Prayer)" (a new solo recording), was released on November 16. It was supposed to be followed by a December release of a self-titled solo album ''Nicholas Jonas'', but the album was pushed back. It did, however, get a limited release. Nick, along with Kevin and Joe, had written several other songs for the album.

In early 2005, Columbia Records' new president, Steve Greenberg, listened to Nick's record. While Greenberg did not like the album, he did like Nick's voice.

Jonas is currently working on a side project from the Jonas Brothers called "Nick Jonas and the Administration". Their debut album ''Who I Am'' was released February 2, 2010. The band members consist of Tommy Barbarella on keyboard, Michael Bland on drums, John Fields on bass, and David Ryan Harris on guitar. Although David Ryan Harris recorded guitar in the studio for ''Who I Am'' he was unable to go on tour with the rest of band and was ultimately replaced by Sonny Thompson.

In January 2010, Jonas embarked on the Who I Am Tour with the Administration. This was Jonas' first tour without his brothers. The tour consisted of 22 dates that began on January 2, 2010, in Dallas, Texas and concluded on January 30, 2010, in Berkeley, California.

In September 2011 and October 2011, Nick Jonas & The Administration began touring through South America in support of their debut album, Who I Am.

Jonas Brothers

After meeting with Jonas and hearing the song, "Please Be Mine", written and performed by the brothers, Daylight/Columbia Records decided to sign the three as a group act. After being signed to Columbia, the brothers considered naming their group "Sons of Jonas" before settling on the name "Jonas Brothers."

''It's About Time'', the brothers' first album was released on August 8, 2006. According to the band's manager, it was only a "limited release" of a little over 50,000 copies. Because Sony was not interested in further promoting the band, the Jonas Brothers considered switching labels. The band was ultimately dropped by Columbia Records in early 2007.

After shortly being without a label, the Jonas Brothers signed with Hollywood Records in February 2007. Around the same time, brothers began appearing in commercials for Baby Bottle Pops, singing the jingle. Their self-titled second album, ''Jonas Brothers'', was released on August 7, 2007. It reached number five on the ''Billboard'' 200 chart in its first week. It has since sold over three million copies worldwide.

The Jonas Brothers' third studio album, ''A Little Bit Longer'', was released in the United States on August 12, 2008. It sold over 2 million copies worldwide. The Jonas Brothers were listed number 9 on the richest pop acts of 2008. The Jonas Brothers' Fourth studio album, ''Lines, Vines and Trying Times'', was released in the United States in June, 2009.

Discography

Studio albums

! Year	! Album details
2004	style="text-align:left;"	* Release date: December 16, 2004	* Label:
! Year	! Single	! Album

Featured Singles

Year	Single	Peak chart positions							Album
		! style="width:30px;"	! style="width:30px;"	! style="width:30px;"	! style="width:30px;"	! style="width:30px;"	! style="width:30px;"	! style="width:30px;"
	style="text-align:left;"	30	—	97	97	41	70	—	style="text-align:left;" rowspan="1"
	style="text-align:left;"	20	—	—	—	94	—	—
		2	—	18	50	7	—	9

1. The Jonas Brothers recorded the song with other artists; Nick was the only one of the three who had a solo part in the song.

   Promotional Singles

   Year	Single	Peak chart positions						Album
   		! style="width:30px;"	! style="width:30px;"	! style="width:30px;"	! style="width:30px;"	! style="width:30px;"	! style="width:30px;"
   		18	20	56	57	22	42	style="text-align:left;" rowspan="1"
   	11	20	—	—	10	—

   Other charted songs

   Year	Song	Chart positions								Album
   		! style="width:30px;"	! style="width:30px;"	! style="width:30px;"	! style="width:30px;"	! style="width:30px;"	! style="width:30px;"	! style="width:30px;"	! style="width:30px;"
   		92	—	53	51	44	68	73	32	style="text-align:left;"

   Awards and nominations

   !Year	!Title	!Award	!Nominated work	!Result
   2009	[[Los Premios MTV Latinoamérica">INO Records

   Singles

   ! Year	! Single	! Album

   Featured Singles

   Year	Single	Peak chart positions							Album
   		! style="width:30px;"	! style="width:30px;"	! style="width:30px;"	! style="width:30px;"	! style="width:30px;"	! style="width:30px;"	! style="width:30px;"
   	style="text-align:left;"	30	—	97	97	41	70	—	style="text-align:left;" rowspan="1"
   	style="text-align:left;"	20	—	—	—	94	—	—
   		2	—	18	50	7	—	9

   1. The Jonas Brothers recorded the song with other artists; Nick was the only one of the three who had a solo part in the song.

      Promotional Singles

      Year	Single	Peak chart positions						Album
      		! style="width:30px;"	! style="width:30px;"	! style="width:30px;"	! style="width:30px;"	! style="width:30px;"	! style="width:30px;"
      		18	20	56	57	22	42	style="text-align:left;" rowspan="1"
      	11	20	—	—	10	—

      Other charted songs

      Year	Song	Chart positions								Album
      		! style="width:30px;"	! style="width:30px;"	! style="width:30px;"	! style="width:30px;"	! style="width:30px;"	! style="width:30px;"	! style="width:30px;"	! style="width:30px;"
      		92	—	53	51	44	68	73	32	style="text-align:left;"

      Awards and nominations

      !Year	!Title	!Award	!Nominated work	!Result
      2009	[[Los Premios MTV Latinoamérica	"Best Fashionista (Most Fashionable)"	Himself
      	Nickelodeon Kids' Choice Awards	"Favorite TV Actor"	Himself
      rowspan="2"	Choice Music: Love Song
      Choice Breakout Artist: Male	Nick Jonas & The Administration
      	Iconic TV Actor	Himself, Jonas L.A
      Iconic Male Star	Himself
      Iconic Of The Year	Himself
      Young Hollywood Awards	"Young hollywood Artist of the year"	Himself
      	Nickelodeon Kids' Choice Awards	"Favorite TV Actor"	Himself
      	Iconic Couple [Couples dating or have dated in 2011]	Nick Jonas & Delta Goodrem
      Iconic Male Star	Himself
      Iconic Triple Threat[Acting, singing, and dancing]	Himself
      DRLC	DREAM Award	Himself

      Tours

      In January 2010, Nick Jonas & The Administration began touring in support of their debut album, Who I Am. Apart from guest appearances at specific events, it marks the first time Nick has toured without his brothers, Kevin and Joe.

      In September 2011 and October 2011, Nick Jonas & The Administration began touring through South America in support of their debut album, Who I Am.

      Filmography

      Film
      ! Year	! Film	! Role	! Notes
      		Himself	3D Concert film
      ''Camp Rock''	Nate	Made for television
      	''Jonas Brothers: The 3D Concert Experience''	Himself	3D Concert film
      ''Band in a Bus''	Himself	Reality DVD
      ''Night at the Museum: Battle of the Smithsonian	Cherub	Film
      	''Camp Rock 2: The Final Jam''	Nate	Made for television; Completed
      	Marius Pontmercy	Limited theatrical release; Released on DVD and Blu-ray in the UK November 29, 2010
      2011	Jonas Brothers: The Journey	Himself	(Unauthorized Documentary)
      TV Series
      ! Year !! Title !! Role !! Notes
      2007	''Hannah Montana''	Himself	"Me and Mr. Jonas and Mr. Jonas and Mr. Jonas" (Season 2, Episode 16)
      2008,2010	''Jonas Brothers: Living the Dream''	Himself	Reality series
      2009–2010	''JONAS L.A.''	Nick Lucas	Disney Channel Original Series
      		Eli White	"Employee Of The Year" (Season 1, Episode 2)
      	Ryan	"Last Christmas Standing" (Season 1, Episode 10)
      2012		Lyle West	"The Cost Of Art" (Season 1, Episode 4)
      Guest appearances
      ! Year !! Title !! Role !! Notes
      	''Studio DC: Almost Live''	Himself	Second show
      ''Extreme Makeover: Home Edition''	Himself	"The Akers Family" (Season 6, Episode 2)
      	''Saturday Night Live''	Himself	February 14, 2009 episode
      ''The Grammy Nominations Concert Live!''	Himself	December 2, 2009 episode
      	''Live with Regis and Kelly''	Himself (Co-Host)	January 8, 2010 episode
      ''Minute to Win It''	Himself	May 12, 2010 episode
      ''Good Morning America''	Himself	May 13, 2010 episode
      ''I Get That a Lot''	Himself	May 19, 2010 episode
      ''Extreme Makeover: Home Edition''	Himself	"The Heathcock Family" (Season 7, Episode 17)
      		Himself	February 15, 2011 episode
      	Himself	June 8, 2011 episode
      ''Dancing With The Stars''	Himself	Audience Member
      ''The Chew''	Himself	November 11, 2011 episode
      	''Live With Kelly''	Himself	January 26, 2012 episode
      ''Good Morning America''	Himself	January 26, 2012 episode
      Music video
      Year	Title	Artist	Role
      2011	''My Time''	Gabrielle Giguere	Producer, cameo
      Musicals
      ! Year !! Title !! Role !! Notes
      2000		Tiny Tim
      2001		Little Jake
      2002		Chip
      		Gavroche
      ''The Sound of Music''	Kurt
      2010		Marius Pontmercy	June 21, 2010 - July 24, 2010 ; October 3, 2010 (25th Anniversary Concert)
      2011		Link Larkin	August 5, 2011 - August 7, 2011
      2012	''How to Succeed in Business Without Really Trying''	J. Pierrepont Finch	January 24, 2012 - July 1, 2012

      References

      External links

      Category:1992 births Category:Actors from New Jersey Category:American child actors Category:American child singers Category:American Christians Category:American drummers Category:American film actors Category:American male singers Category:American multi-instrumentalists Category:American musicians of Italian descent Category:American people of German descent Category:American people of Irish descent Category:American people of Italian descent Category:American people of Cherokee descent Category:American pop guitarists Category:American singer-songwriters Category:American stage actors Category:American television actors Category:Jonas Brothers members Category:Living people Category:Musicians from New Jersey Category:People from Wyckoff, New Jersey

      ar:نيك جوناس az:Nik Conas bg:Ник Джонас ca:Nick Jonas cs:Nick Jonas da:Nick Jonas de:Nick Jonas et:Nick Jonas es:Nick Jonas eu:Nick Jonas fr:Nick Jonas id:Nick Jonas it:Nick Jonas he:ניק ג'ונאס jv:Nick Jonas hu:Nick Jonas nl:Nick Jonas ja:ニック・ジョナス no:Nick Jonas nn:Nick Jonas pl:Nick Jonas pt:Nick Jonas ro:Nick Jonas ru:Джонас, Ник sl:Nick Jonas sh:Nick Jonas fi:Nick Jonas sv:Nick Jonas tl:Nick Jonas th:นิก โจนาส tr:Nick Jonas uk:Нік Джонас vi:Nick Jonas

name	Larry King
birth name	Lawrence Harvey Zeiger
birth date	November 19, 1933
birth place	Brooklyn, New York City, U.S.
religion	Jewish (1933–1966)Agnostic (1966–present)
occupation	Television/Radio personality
years active	1957–present
spouse	Freda Miller (1952–1953, annulled); Annette Kaye (1961, divorced); Alene Akins (1961–1963; divorced)Mickey Sutphin (1963–1967, divorced); Alene Akins (1967–1972, divorced); Sharon Lepore (1976–1983, divorced); Julie Alexander (1989–1992, divorced); Shawn Southwick (1997–present)}}

Larry King (born November 19, 1933) is an American television and radio host whose work has been recognized with awards including two Peabodys and ten Cable ACE Awards. He began as a local Florida journalist and radio interviewer in the 1950s and 1960s and became prominent as an all-night national radio broadcaster starting in 1978. From 1985-2010, he hosted the nightly interview TV program ''Larry King Live'' on CNN, a network for which he continues to host specials.

Early life

King was born Lawrence Harvey Zeiger in Brooklyn, New York City, to an Austrian immigrant Edward Zeiger, a restaurant owner and defense plant worker, and his wife Jennie Gitlitz, a garment worker, who emigrated from Belarus. King grew up in a religiously observant Jewish home, but in adulthood became an agnostic.

King's father died at 44 of heart disease, and his mother had to go on welfare to support her two sons. His father's death greatly affected King, and he lost interest in school. After graduating from high school, he worked to help support his mother. From an early age, however, he had wanted to go into radio. King is a fan of the Los Angeles Dodgers.

Career

Miami radio and television

A CBS staff announcer, whom King met by chance, told him to go to Florida, a growing media market where openings still existed for inexperienced broadcasters. King rode a bus to Miami. After initial setbacks, King persisted and got his first job in radio. The manager of a small station, WAHR (now WMBM) in Miami Beach, hired him to clean up and perform miscellaneous tasks. When one of their announcers quit, they put King on the air. His first broadcast was on May 1, 1957, when he worked as the disc jockey from 9 a.m. to noon. He also did two afternoon newscasts and a sportscast. He was paid $55 a week. He acquired the name Larry King when the general manager Martial Cemen said that Zeiger was too ethnic and difficult to remember, so Larry chose the surname ''King'', which he got from an ad in ''The Miami Herald'' for King's Wholesale Liquor, minutes before air. He started interviewing on a midmorning show for WIOD, at Pumpernik's Restaurant in Miami Beach. He would interview anyone who walked in. His first interview was with a waiter at the restaurant. Two days later, singer Bobby Darin, in Miami for a concert later that day, walked into Pumpernik's as a result of coming across King's show on his radio; Darin became King's first celebrity interview guest.

His Miami radio show launched him to local stardom. A few years later, in May 1960, he hosted ''Miami Undercover,'' airing Sunday nights at 11:30 p.m. on WPST-TV Channel 10 (now WPLG). On the show, he moderated debates on important issues of the time. King credits his success on local TV to the assistance of another showbiz legend, comedian Jackie Gleason, whose national TV variety show was being filmed in Miami Beach during this period. "That show really took off because Gleason came to Miami," King said in a 1996 interview he gave when inducted into the Broadcasters' Hall of Fame. "He did that show and stayed all night with me. We stayed till five in the morning. He didn't like the set, so we broke into the general manager's office and changed the set. Gleason changed the set, he changed the lighting, and he became like a mentor of mine." Jackie Gleason was instrumental in getting Larry a hard-to-get on air interview with Frank Sinatra during this time.

During this period, WIOD gave King further exposure as a color commentator for the Miami Dolphins of the National Football League, during their 1970 season and most of their 1971 season. However, he was dismissed by both WIOD and television station WTVJ as a late-night radio host and sports commentator as of December 20, 1971, when he was arrested after being accused of grand larceny by a former business partner. Other staffers covered the Dolphins' games into their 24–3 loss to Dallas in Super Bowl VI. King also lost his weekly column at the ''Miami Beach Sun'' newspaper. The charges were dropped on March 10, 1972, and King spent the next several years in reviving his career, including a stint as the color announcer in Louisiana for the Shreveport Steamer of the World Football League in 1974–75 on KWKH. Eventually, King was rehired by WIOD in Miami. For several years during the 1970s in South Florida, he hosted a sports talk-show called "Sports-a-la-King" that featured guests and callers. He is known for voice Doris in Shrek 2, Shrek The Third, and Shrek forever After,

National radio

In 1978, he went national, inheriting the nightly talk show slot on the Mutual Broadcasting System, broadcast coast-to-coast, that had been "Long John" Nebel's until his death, and had been pioneered by Herb Jepko. One reason King got the Mutual job is that he had once been an announcer at WGMA-AM in Hollywood, Florida, which was then owned by C. Edward Little. Little went on to become president of Mutual and was the one who hired King when Nebel died. King's Mutual show developed a devoted audience.

It was broadcast live Monday through Friday from midnight to 5:30 a.m. Eastern Time. King would interview a guest for the first 90 minutes, with callers asking questions that continued the interview for another 90 minutes. At 3 a.m., he would allow callers to discuss any topic they pleased with him, until the end of the program, when he expressed his own political opinions. That segment was called "Open Phone America". Some of the regular callers used the pseudonyms "The Portland Laugher", "The Miami Derelict", "The Todd Cruz Caller", "The Scandal Scooper", "Mr. Radio" and "The Water Is Warm Caller". "Mr. Radio" made over 200 calls to King during Open Phone America. The show was successful, starting with relatively few affiliates and eventually growing to more than 500. It ran until 1994.

For its final year, the show was moved to afternoons, but, because most talk radio stations at the time had an established policy of local origination in the time-slot (3 to 6 p.m. Eastern Time) that Mutual offered the show, a very low percentage of King's overnight affiliates agreed to carry his daytime show and it was unable to generate the same audience size. The afternoon show was eventually given to David Brenner and radio affiliates were given the option of carrying the audio of King's new CNN evening television program. The Westwood One radio simulcast of the CNN show continued until December 31, 2009.

CNN

He started his ''Larry King Live'' CNN show in June 1985, hosting a broad range of guests from controversial figures of UFO conspiracy theories and alleged psychics, to prominent politicians and leading figures in the entertainment industry, often doing their first or only interview on breaking news stories on his show.

Unlike many interviewers, King has a direct, non-confrontational approach. His reputation for asking easy, open-ended questions has made him attractive to important figures who want to state their position while avoiding being challenged on contentious topics. His interview style is characteristically frank, but with occasional bursts of irreverence and humor. His approach attracts some guests who would not otherwise appear. King, who is known for his general lack of pre-interview preparation, once bragged that he never read the books of authors before making an appearance on his program.

In a show dedicated to the surviving Beatles, King asked George Harrison's widow about the song "Something", which was written about George Harrison's first wife. He seemed surprised when she did not know very much about the song.

Throughout his career King has interviewed many of the leading figures of his time. CNN claimed during his final episode that he had performed 60,000 interviews in his career.

King also wrote a regular newspaper column in USA Today for almost 20 years, from shortly after that newspaper's origin in 1982 until September 2001. The column consisted of short "plugs, superlatives and dropped names" but was dropped when the newspaper redesigned its "Life" section. The column was resurrected in blog form in November 2008 and on Twitter in April 2009.

Departure

On June 29, 2010, King announced that after 25 years, he would be stepping down from his nightly job hosting ''Larry King Live''. However, he stated that he would remain with CNN to host occasional specials. The announcement came in the wake of speculation that CNN had approached Piers Morgan, the British television personality and journalist, as King's primetime replacement, speculation confirmed in September.

The final edition of ''Larry King Live'' aired on December 16, 2010. The show concluded with his last thoughts and a thank you to his audience for watching and supporting him over the years.

Other ventures

King was the moderator of the 6th KAZENERGY Eurasian Forum in Astana, Kazakhstan, an annual forum for Kazakhstan's energy sector occurring in October 2011.

Charitable works

As a result of heart attacks, he established the Larry King Cardiac Foundation, an organization to which David Letterman, through his American Foundation for Courtesy and Grooming, has also contributed. King gave $1 million to George Washington University's School of Media and Public Affairs for scholarships to students from disadvantaged backgrounds. King serves as a member of the Board of Directors on the Police Athletic League of New York City, a nonprofit youth development agency serving inner-city children and teenagers.

On September 3, 2005, following Hurricane Katrina, King aired "How You Can Help", a three-hour special designed to provide a forum and information clearinghouse for viewers to understand and join nationwide and global relief efforts. On January 18, 2010, in the wake the 2010 Haiti earthquake, King aired "Haiti: How You Can Help", a special two-hour edition designed to show viewers how to take action and be a part of the global outreach. Following the Deepwater Horizon explosion, King aired "Disaster in the Gulf: How You Can Help", a special two-hour edition designed to show viewers how to take action in the clean-up efforts on the Gulf Coast.

On August 30, 2010, King served as the host of Chabad's 30th annual "To Life" telethon, in Los Angeles.

Controversial positions

On September 10, 1990, while on ''The Joan Rivers Show,'' Rivers asked King which contestant in the Miss America pageant was "the ugliest". King responded, "Miss Pennsylvania. She was one of the 10 finalists and she did a great ventriloquist bit [...] The dummy was prettier." King was a judge for the September 8, 1990 pageant. King later sent Miss Pennsylvania, Marla Wynne, a dozen long-stemmed roses and a telegram apologizing for saying she was the ugliest contestant in the pageant that year.

In 1997, King was one of 34 celebrities to sign an open letter to then-German Chancellor Helmut Kohl, published as a newspaper advertisement in the ''International Herald Tribune'', which protested the treatment of Scientologists in Germany, comparing it to the Nazis' oppression of Jews in the 1930s. Other signatories included Dustin Hoffman and Goldie Hawn.

Personal life

King has been married eight times, to seven different women. He married high-school sweetheart Freda Miller in 1951 at age 18. The union ended the following year at the behest of their parents, who reportedly had the marriage annulled. King was later briefly married to Annette Kaye who gave birth to his son, Larry Jr., in November 1961. King did not meet Larry Jr. until the son was in his thirties. Larry Jr. and his wife, Shannon, have three children.

In 1961, King married his third wife, Alene Akins, a ''Playboy'' bunny at one of the magazine's eponymous nightclubs. The couple had son Andy in 1962, and divorced the following year. In 1963, King married his fourth wife, Mary Francis "Mickey" Sutphin, who divorced King. He remarried Akins, with whom he had a second child, Chaia, in 1969. The couple divorced a second time in 1972. In 1997, Dove Books published a book written by King and Chaia, ''Daddy Day, Daughter Day''. Aimed at young children, it tells each of their accounts of his divorce from Akins.

On September 25, 1976, King married his fifth wife, math teacher and production assistant Sharon Lepore. The couple divorced in 1983.

King met businesswoman Julie Alexander in summer 1989, and proposed to her on the couple's first date, on August 1, 1989. Alexander became King's sixth wife on October 7, 1989, when the two were married in Washington, D.C. The couple lived in different cities, however, with Alexander in Philadelphia, Pennsylvania, and King in Washington, D.C., where he worked. The couple separated in 1990 and divorced in 1992. He became engaged to actress Deanna Lund in 1995, after five weeks of dating, but they never married.

He married his seventh wife, Shawn Southwick, born in 1959 as Shawn Oro Engemann, a former singer and TV host, in King's Los Angeles, California, hospital room three days before King underwent heart surgery to clear a clogged blood vessel. The couple have two children: Chance, born March 1999, and Cannon, born May 2000. He is stepfather to Danny Southwick. On King and Southwick's 10th anniversary in September 2007, Southwick boasted she was "the only [wife] to have lasted into the two digits". On April 14, 2010, both Larry and Shawn King filed for divorce. but have since stopped the proceedings, claiming "We love our children, we love each other, we love being a family. That is all that matters to us".

On February 24, 1987, King suffered a major heart attack and then had quintuple-bypass surgery. Since then, King has written two books about living with heart disease. ''Mr. King, You're Having a Heart Attack: How a Heart Attack and Bypass Surgery Changed My Life'' (1989, ISBN 0-440-50039-7) was written with New York's ''Newsday'' science editor B. D. Colen. ''Taking On Heart Disease: Famous Personalities Recall How They Triumphed over the Nation's #1 Killer and How You Can, Too'' (2004, ISBN 1-57954-820-2) features the experience of various celebrities with cardiovascular disease including Peggy Fleming and Regis Philbin.

In July 2009, King appeared on ''The Tonight Show with Conan O'Brien'', where he told host O'Brien about his wishes to be cryonically preserved upon death, as he had revealed in his book ''My Remarkable Journey''. In December of 2011, preceding a CNN Special on the topic, the Kings had a special dinner with friends Conan O'Brien, Tyra Banks, Shaquille O'Neal, Seth MacFarlane, Jack Dorsey, Quincy Jones and Russell Brand where his intent to do so was reiterated, among other topics that were discussed.

On February 12, 2010, Larry King revealed that he had undergone surgery five weeks earlier to place stents in his coronary artery to remove plaque from his heart. During the segment on Larry King Live which discussed Bill Clinton's similar procedure, King said he was "feeling great" and had been in hospital for just one day.

Awards

King has received many broadcasting awards. He won the Peabody Award for Excellence in broadcasting for both his radio (1982) and television (1992) shows. He has also won 10 CableACE awards for Best Interviewer and for Best Talk Show Series.

In 1989, King was inducted into the National Radio Hall of Fame, and in 1996 to the Broadcasters' Hall of Fame. In 2002, the industry magazine ''Talkers'' named King both the fourth-greatest radio talk show host of all time and the top television talk show host of all time.

in June 1998, King received an Honorary Degree from Brooklyn College, City University of New York, for his life achievements.

King was given the Golden Mike Award for Lifetime Achievement in January 2009, by the Radio & Television News Association of Southern California.

King is an honorary member of the Rotary Club of Beverly Hills. He is also a recipient of the President's Award honoring his impact on media from the Los Angeles Press Club in 2006.

King is the first recipient of the Arizona State University Hugh Downs Award for Communication Excellence, presented April 11, 2007, via satellite by Downs himself. Downs sported red suspenders for the event and turned the tables on King by asking "very tough questions" about King's best, worst and most influential interviews during King's 50 years in broadcasting.

References

External links

CNN profile

Larry King Cardiac Foundation - Foundation to fund treatments cardiac patients with little or no insurance

Clark lawsuit

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name	Paula Deen
birth date	January 19, 1947
birth place	Albany, Georgia
style	Southern
restaurants	The Lady & Sons Restaurant, Uncle Bubba's Oyster House
television	''Paula's Home Cooking'' (2002–present)''Paula's Party'' (2006–present)''Paula's Best Dishes'' (2008–present)
awards	2007 Emmy for Outstanding Lifestyle Host
website	}}

Paula Deen (born January 19, 1947) American cook, cooking show host, restaurateur, author, actress and Emmy Award-winning television personality.

Deen resides in Savannah, Georgia, where she owns and operates The Lady & Sons restaurant with her sons, Jamie and Bobby Deen. She has also published five cookbooks. Though married in 2004 to Michael Anthony Groover, she continues to use the surname Deen from her first marriage.

Early life

Paula Deen was born in Albany, Georgia. As documented in the Food Network special ''Chefography'' and on her official Web site, both her parents died before she was 23 and an early marriage ended in divorce. Deen suffered from agoraphobia and would not leave her house. She relied on cooking to help deal with her condition. In 1986, she felt well enough to take a job as a bank teller. After that she and her sons moved to Savannah. In 1989, she divorced Jimmy Deen, to whom she had been married since 1965, and expanded her cooking experience into a catering service. She made sandwiches and other meals, which her sons Jamie and Bobby delivered. The Bag Lady, as the business was named, was successful and soon outgrew her kitchen. On January 8, 1996, Deen opened her own restaurant, The Lady & Sons, in downtown Savannah, on West Congress Street. Within a few years, the restaurant moved to a larger building in Savannah's historic district. ''USA Today'' named The Lady & Sons the "International Meal of the Year," in 1999. The specialty is the buffet, which may include sweet potatoes, macaroni and cheese, deep-fried Twinkies, fried chicken, cheesy meatloaf, greens, beans, and creamed corn. Every meal comes with a garlic cheese biscuit and one of Deen's famous hoecakes. The restaurant is run by her sons when they are in town. The restaurant is a perennial favorite with tourists to Savannah.

Deen parlayed her fame into another restaurant, the "Paula Deen Buffet" at Harrah's Tunica Casino in Tunica, Mississippi. The entrance facade of the restaurant, which opened in May 2008, is modeled on Deen's home in Savannah and features Southern fare.

On September 1, 2009, Deen announced plans to unveil her own dessert line at Walmart featuring signature pies (Apple Crunch Top, Dark Rum Pecan, Old Fashioned Fudge and Gooey Butter Cake bars).

Books

In 1997, Deen self-published ''The Lady & Sons Savannah Country Cooking'' and ''The Lady & Sons Savannah Country Cooking 2''. Both cookbooks were filled with traditional Southern recipes, such as "Gooey Butter Cake" (also known as Chess Cake, a variation of a chess pie recipe). The cookbooks were very successful, and she has since published two more, written with help from Martha Nesbit. Deen has appeared on QVC and on ''The Oprah Winfrey Show'' (first in 2002, twice in 2007 and once in 2010). Her story is featured in ''Extraordinary Comebacks: 201 Inspiring Stories of Courage, Triumph, and Success'' (2007, Sourcebooks). In April 2007, Simon & Schuster published Deen's memoir, ''It Ain't All About the Cookin'''. She launched a lifestyle magazine called ''Cooking with Paula Deen'' in November 2005. which claimed a circulation of 7.5 million in March, 2009.

Food Network

Deen's relationship with Food Network began in 1999, when her friend Erin Lewis introduced her to Gordon Elliott, who then introduced her to her current agent, Artist's Agency owner Barry Weiner. Elliott took her through the city for a series of ''Doorknock Dinners'' episodes. She also appeared on ''Ready, Set, Cook!''. Deen was invited to shoot a pilot named ''Afternoon Tea'' in early 2001. The network liked it, and eventually gave Deen her own show, ''Paula's Home Cooking'', which premiered in November 2002. ''Paula's Home Cooking'' was originally taped in Millbrook, New York at the home of Gordon Elliott, the show's executive producer. Deen mentioned in an interview aired on the March 13, 2006, edition of ''The Daily Buzz'' that the next batch of episodes of her show would be taped at her home in Savannah, Georgia. According to the first of those episodes, actual production at her new Savannah home began in November 2005. Since then, Deen has been given two more Food Network shows, ''Paula's Party'' and ''Paula's Best Dishes''. ''Paula's Party'' premiered on the Food Network in 2006 and ''Paula's Best Dishes'' debuted on June 8, 2008.

A televised biography of Deen was aired on an episode of the Food Network's ''Chefography'' program, in March 2006.

In December 2007, Deen teamed with Cat Cora and faced Chefs Tyler Florence and Robert Irvine in battle Sugar on the holiday special of ''Iron Chef America''. At the end, Deen and Cora won.

Deen also helped Pat and Gina Neely get their first Food Network show, ''Down Home with the Neelys''. During the summer of 2006, her sons, Bobby and Jamie Deen, featured the Neely's Bar-B-Que Nashville location on their Food Network show ''Road Tasted''. In September 2006, Paula ate at the Neely's downtown Memphis restaurant and was impressed. In January 2007, the Neelys were invited to appear on ''Paula's Party'', which eventually led to the ''Down Home'' show. In July 2008, the Neelys would also take over ''Road Tasted'' from the Deen brothers.

In May 2008, Deen announced at the Metropolitan Cooking and Entertaining Show that she had signed a deal to host a talk show beginning in September 2009.

Deen has appeared in public service announcements for Civitan International.

On February 23, 2011, Deen appeared on the show ''Top Chef'', and sat at the Judges Table.

Personal life

In her 20s, Deen suffered from panic attacks with agoraphobia, eventually becoming virtually housebound.

Deen remarried, on March 6, 2004, to Michael Groover (born 1956), a tugboat captain in the port of Savannah. Michael has two children, Michelle and Anthony, from a previous marriage. The wedding and preparation were documented by Food Network for a show aired in 2004. Their wedding also took place at the Bethesda Home for Boys in Savannah, Georgia. Paula is also an avid supporter of the Bethesda Home for Boys and asked Old Savannah Tours to donate $1 to the organization for each ticket purchased for the Paula Deen Store ticket sale.

Film debut

Deen made her film debut in ''Elizabethtown'', starring Orlando Bloom and Kirsten Dunst. She played the aunt of Bloom's character, and her cooking was showcased heavily. The film premiered on October 8, 2005. A Food Network special, ''Paula Goes Hollywood'', aired in conjunction with the film's premiere.

Awards and honors

In June 2007, Deen won a Daytime Emmy Awards (Outstanding Lifestyle Host) for ''Paula's Home Cooking''.

On October 26, 2010, Deen was selected as the Grand Marshal of the Tournament of Roses Parade. She and the Queen and Court presided over the Rose Parade and Rose Bowl Game on New Year's Day January 1, 2011.

Criticism

Deen has faced some criticism for the high amounts of fat, salt, and sugar in her recipes. She faced even more objections after she released ''Lunch-Box Set'', a cookbook aimed at children, with Barbara Walters saying of the book, "You tell kids to have cheesecake for breakfast. You tell them to have chocolate cake and meatloaf for lunch. And french fries. Doesn't it bother you that you're adding to this?"

Deen is also a spokesperson for Smithfield Foods, a company that has faced allegations of animal cruelty.

Filmography

Year !! Title !! Role
2002–present	''Paula's Home Cooking'' (television)	Host
2005	Elizabethtown (film)>Elizabethtown''
2006–2008	''Paula's Party'' (television)
2006	''Chefography'' (television)
2008–present	''Paula's Best Dishes'' (television)
2009	''Kathy Griffin: My Life on the D-List'' (television)
2009	''Extreme Makeover: Home Edition'' (television)
2011	''Top Chef'' (television)

References

External links

Deen Home Furniture'

The Lady & Sons restaurant

Uncle Bubba's Oyster House

''Cooking with Paula Deen'' magazine

Paula Deen ... Answers Your Questions Archive at People.com

Category:American chefs Category:American food writers Category:American film actors Category:American television chefs Category:Food Network chefs Category:People from Albany, Georgia Category:1947 births Category:Living people Category:Actors from Georgia (U.S. state) Category:People from Savannah, Georgia

fi:Paula Deen