Coordinates	43°19′54″N45°38′41″N
{{infobox disease | name	Diphtheria | Image Diphtheria bull neck.5325 lores.jpg | Caption Diphtheria causes a characteristic swollen neck, sometimes referred to as “bull neck”. | Width 150 | DiseasesDB 3122 | ICD10 | ICD9 | ICDO | OMIM | MedlinePlus 001608 | eMedicineSubj emerg | eMedicineTopic 138 | eMedicine_mult | MeshID D004165 }}

Diphtheria (Greek διφθέρα (''diphthera'') "pair of leather scrolls") is an upper respiratory tract illness caused by ''Corynebacterium diphtheriae'', a facultative anaerobic Gram-positive bacterium. It is characterized by sore throat, low fever, and an adherent membrane (a ''pseudomembrane'') on the tonsils, pharynx, and/or nasal cavity. A milder form of diphtheria can be restricted to the skin. Less common consequences include myocarditis (about 20% of cases) and peripheral neuropathy (about 10% of cases).

Diphtheria is a contagious disease spread by direct physical contact or breathing the aerosolized secretions of infected individuals. Historically quite common, diphtheria has largely been eradicated in industrialized nations through widespread vaccination. In the United States for example, there were 52 reported cases of diphtheria between 1980 and 2000; between 2000 and 2007 there were only three cases as the DPT (''Diphtheria–Pertussis–Tetanus'') vaccine is recommended for all school-age children. Boosters of the vaccine are recommended for adults since the benefits of the vaccine decrease with age without constant re-exposure; they are particularly recommended for those traveling to areas where the disease has not been eradicated.

Mechanism

Diphtheria toxin is a single protein composed of two fragments: one that allows entry into host cells and another that prevents the host cell from making proteins. The toxin binds to a cell-surface receptor to gain entry into the cell. Once inside the cell, the protein prevents the cell from making new proteins.

As mentioned, diphtheria toxin is composed of two components—fragment A and fragment B—held together by a disulfide bond. Fragment B is a recognition subunit that gains the toxin entry into the host cell by binding to a receptor on its plasma membrane (specifically, it binds to the EGF-like domain of heparin-binding EGF-like growth factor, or HB-EGF). This signals the cell to internalize the toxin within an endosome via receptor-mediated endocytosis. Inside the endosome, the toxin is split by a trypsin-like protease into its individual A and B fragments. The acidity of the endosome causes fragment B to create pores in the endosome membrane, thereby catalyzing the release fragment A into the cell's cytoplasm.

Fragment A inhibits the synthesis of new proteins in the affected cell. It does this by catalyzing ADP-ribosylation of elongation factor EF-2—a protein that is essential to the translation step of protein synthesis. Specifically, this ADP-ribosylation involves the transfer of an ADP-ribose from NAD+ to a diphthamide (a modified histidine) residue within the EF-2 protein. Since EF-2 is needed for the moving of tRNA from the A-site to the P-site of the ribosome during protein translation, ADP-ribosylation of EF-2 inhibits protein synthesis.

ADP-ribosylation of EF-2 is reversed by giving high doses of nicotinamide (a form of vitamin B3), since this is one of the reaction's end-products and high amounts will drive the reaction in the opposite direction.

Diphtheria toxin is produced by ''C. diphtheriae'' only when it is infected with a bacteriophage that integrates the toxin-encoding genetic elements into the bacteria.

Diagnosis

The current definition of diphtheria used by the Centers for Disease Control and Prevention (CDC) is based on both laboratory and clinical criteria.

Laboratory criteria

Isolation of ''Corynebacterium diphtheriae'' from a clinical specimen, or

Histopathologic diagnosis of diphtheria

Clinical criteria

Upper respiratory tract illness with sore throat

Low-grade fever (>103°F is rare)

An adherent pseudomembrane of the tonsil(s), pharynx, and/or nose.

Case classification

Probable: a clinically compatible case that is not laboratory-confirmed and is not epidemiologically linked to a laboratory-confirmed case

Confirmed: a clinically compatible case that is either laboratory-confirmed or epidemiologically linked to a laboratory-confirmed case

Empirical treatment should generally be started in a patient in whom suspicion of diphtheria is high.

Treatment

The disease may remain manageable, but in more severe cases lymph nodes in the neck may swell, and breathing and swallowing will be more difficult. People in this stage should seek immediate medical attention, as obstruction in the throat may require intubation or a tracheotomy. Abnormal cardiac rhythms can occur early in the course of the illness or weeks later, and can lead to heart failure. Diphtheria can also cause paralysis in the eye, neck, throat, or respiratory muscles. Patients with severe cases will be put in a hospital intensive care unit (ICU) and be given a diphtheria antitoxin. Since antitoxin does not neutralize toxin that is already bound to tissues, delaying its administration is associated with an increase in mortality risk. Therefore, the decision to administer diphtheria antitoxin is based on clinical diagnosis, and should not await laboratory confirmation.

Antibiotics have not been demonstrated to affect healing of local infection in diphtheria patients treated with antitoxin. Antibiotics are used in patients or carriers to eradicate ''C. diphtheriae'' and prevent its transmission to others. The CDC recommends either:

Metronidazole

Erythromycin (orally or by injection) for 14 days (40 mg/kg per day with a maximum of 2 g/d), or

Procaine penicillin G given intramuscularly for 14 days (300,000 U/d for patients weighing <10 kg and 600,000 U/d for those weighing >10 kg). Patients with allergies to penicillin G or erythromycin can use rifampin or clindamycin.

In cases that progress beyond a throat infection, diphtheria toxin spreads through the bloodstream and can lead to potentially life-threatening complications that affect other organs of the body, such as the heart and kidneys. The toxin can cause damage to the heart that affects its ability to pump blood or the kidneys' ability to clear wastes. It can also cause nerve damage, eventually leading to paralysis. 40% to 50% of those left untreated can die.

Epidemiology

thumb|Disability-adjusted life year for diphtheria per 100,000 inhabitants.

Diphtheria is a serious disease, with fatality rates between 5% and 10%. In children under 5 years and adults over 40 years, the fatality rate may be as much as 20%. Outbreaks, though very rare, still occur worldwide, even in developed nations such as Germany and Canada. After the breakup of the former Soviet Union in the late 1980s, vaccination rates in its constituent countries fell so low that there was an explosion of diphtheria cases. In 1991 there were 2,000 cases of diphtheria in the USSR. By 1998, according to Red Cross estimates, there were as many as 200,000 cases in the Commonwealth of Independent States, with 5,000 deaths. This was so great an increase that diphtheria was cited in the Guinness Book of World Records as "most resurgent disease".

History

In 1878, Queen Victoria's daughter Princess Alice and her family became infected with it, causing two deaths, Princess Marie of Hesse and by Rhine and Princess Alice herself.

In the 1920s there were an estimated 100,000 to 200,000 cases of diphtheria per year in the United States, causing 13,000 to 15,000 deaths per year. Children represented a large majority of these cases and fatalities. One of the most famous outbreaks of diphtheria was in Nome, Alaska; the "Great Race of Mercy" to deliver diphtheria antitoxin is now celebrated by the Iditarod Trail Sled Dog Race.

One of the first effective treatments for diphtheria was discovered in the 1880s by U.S. physician Joseph O'Dwyer (1841–1898). O'Dwyer developed tubes that were inserted into the throat, and prevented victims from suffocating due to the membrane sheath that grows over and obstructs airways. In 1884 Friedrich Loeffler discovered the causative organism (''Corynebacterium diphtheriae''). In the 1890s, the German physician Emil von Behring developed an antitoxin that did not kill the bacterium, but neutralized the toxic poisons that the bacterium releases into the body. Von Behring discovered that animal blood has antitoxins in it and so he took the blood, removed the clotting agents and injected it into human patients. Von Behring was awarded the first Nobel Prize in Medicine for his role in the discovery, and development of a serum therapy for diphtheria. (Americans William H. Park and Anna Wessels Williams; and Pasteur Institute scientists Emile Roux and Auguste Chaillou also independently developed diphtheria antitoxin in the 1890s.) The first successful vaccine for diphtheria was developed in 1913 by Behring. However, antibiotics against diphtheria were not available until the discovery and development of sulfa drugs.

The Schick test, invented between 1910 and 1911, is a test used to determine whether or not a person is susceptible to diphtheria. It was named after its inventor, Béla Schick (1877–1967), a Hungarian-born American pediatrician. A massive five-year campaign was coordinated by Dr. Schick. As a part of the campaign, 85 million pieces of literature were distributed by the Metropolitan Life Insurance Company with an appeal to parents to "Save your child from diphtheria." A vaccine was developed in the next decade, and deaths began declining in earnest in 1924.

In early May 2010, a case of diphtheria was diagnosed in Port-au-Prince, Haiti after the devastating 2010 Haiti earthquake. The 15 year old male patient died while workers searched for anti-toxin.

References

Further reading

"Antitoxin dars 1735 and 1740." ''The William and Mary Quarterly'', 3rd Ser., Vol 6, No 2. p. 338.

Category:Bacterial diseases

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Coordinates	43°19′54″N45°38′41″N
birth date	August 17, 1960
birth place	Santa Monica, California, U.S.
birth name	Sean Justin Penn
occupation	Actor, screenwriter, director, producer
years active	1974–present
spouse	Madonna (1985–1989)Robin Wright (1996–2010)
parents	Leo Penn (deceased)Eileen Ryan
relatives	Aimee Mann (sister-in-law) }}

Sean Justin Penn (born August 17, 1960) is an American actor, screenwriter and film director, also known for his political and social activism. He is a two-time Academy Award winner for his roles in ''Mystic River'' (2003) and ''Milk'' (2008), as well as the recipient of a Golden Globe Award for the former and a Screen Actors Guild Award for the latter.

Penn began his acting career in television with a brief appearance in a 1974 episode of ''Little House on the Prairie'', directed by his father Leo Penn. Following his film debut in 1981's ''Taps'' and a diverse range of film roles in the 1980s, Penn emerged as a prominent leading actor with the 1995 drama film ''Dead Man Walking'', for which he earned his first Academy Award nomination and the Best Actor Award at the Berlin Film Festival. Penn subsequently received another two Oscar nominations for ''Sweet and Lowdown'' (1999) and ''I Am Sam'' (2001), before winning his first Academy Award for Best Actor in 2003 for ''Mystic River'' and a second one in 2008 for ''Milk''. He has also won a Best Actor Award of the Cannes Film Festival for ''She's So Lovely'' (1997), and two Best Actor Awards at the Venice Film Festival for ''Hurlyburly'' (1998) and ''21 Grams'' (2003).

Penn made his feature film directorial debut with 1991's ''The Indian Runner'', followed by the drama film ''The Crossing Guard'' (1995) and the mystery film ''The Pledge'' (2001). In 2002, Penn directed one of the 11 segments of ''11'09"01 September 11'', a compilation film made in response to the September 11 attacks. In 2007, Penn directed his fourth feature film ''Into the Wild'', which garnered critical acclaim and two Academy Award nominations.

In addition to his film work, Penn is known for his political and social activism, most notably his criticism of the George W. Bush administration, his contact with the Presidents of Venezuela and Cuba, and his humanitarian work in the aftermath of Hurricane Katrina and the 2010 Haiti earthquake. Penn also attracted media attention for his previous marriages to pop icon Madonna and actress Robin Wright.

Early life

Penn was born in Los Angeles County, California, the middle son of actor and director Leo Penn and actress Eileen Ryan (née Annucci). His older brother is musician Michael Penn. His younger brother, actor Chris Penn, died in 2006. His paternal grandparents were Jewish emigrants from Lithuania and Russia, while his mother is a Catholic of Italian and Irish descent. Penn was raised in a secular home and is an agnostic. He attended Santa Monica High School and began making short films with some of his childhood friends, including actors Emilio Estevez and Charlie Sheen, who lived near his home.

Career

Acting

Penn appeared in a 1974 episode of the ''Little House on the Prairie'' television series as a then blond-haired extra when his father, Leo, directed some of the episodes.

Penn launched his film career with the 1981 action-drama ''Taps,'' where he played a key role, as a military high school cadet, opposite protagonist Timothy Hutton. Tom Cruise also made one of his first film appearances, as another cadet. A year later, Penn appeared in the hit comedy ''Fast Times at Ridgemont High'', in the role of surfer-stoner Jeff Spicoli, with his character helping popularize the word "dude" in popular culture. In 1983, Penn appeared as Mick O'Brien, a troubled youth, in the drama ''Bad Boys''. The role earned Penn favorable reviews and jump-started his career as a serious actor.

In 1985, Penn played Andrew Daulton Lee in the film ''The Falcon and the Snowman'', which closely followed an actual criminal case. Lee was a former drug dealer by trade, convicted of espionage for the Soviet Union and originally sentenced to life in prison, later being paroled in 1998. Penn later hired Lee as his personal assistant, partly because he wanted to reward Lee for allowing him to play Lee in the film; also, he was a firm believer in rehabilitation and thought Andrew Lee should be successfully reintegrated into society, since he was a free man again.

In 1986, he starred in the drama ''At Close Range'', opposite Christopher Walken. The film featured his then-wife Madonna's single "Live to Tell". The music video for the song, which featured clips from the film, played heavily on MTV and helped promote the film. Penn stopped acting for a few years in the early 1990s, having been dissatisfied with the industry, and focused on making his directing debut.

Penn, nominated for the Academy Award for Best Actor five times, has won the award twice. The Academy first recognized his work in nominating him for playing a racist murderer on death row in Tim Robbins' 1995 drama ''Dead Man Walking''. Penn was nominated again for his comedic performance as an egotistical jazz guitarist in Woody Allen's 1999 release ''Sweet and Lowdown''. He received his third nomination after portraying a mentally-handicapped father in 2001's ''I am Sam''. Penn finally won for his role in Clint Eastwood's 2003 Boston crime-drama ''Mystic River''. In 2004, he played a disturbed man bent on killing the president in ''The Assassination of Richard Nixon''. He was invited to join the Academy of Motion Picture Arts and Sciences in 2004.

In 2006, he portrayed populist governor Willie Stark (based on Huey Long) in an adaptation of the classic American novel ''All the King's Men'', though the film was a critical and commercial failure. In November 2008, Penn earned rave reviews for his portrayal of real-life gay-rights icon and politician Harvey Milk in the biopic ''Milk'' and was nominated for best actor for the 2008 Independent Spirit Awards. The film also earned Penn his fifth nomination and second win for the Academy Award for Best Actor. In 2010 he starred as Joseph Wilson in ''Fair Game'', a film adaptation of Valerie Plame's 2007 memoir. Penn co-starred with Brad Pitt and Jessica Chastain in the drama ''The Tree of Life'' which won the Palme d'Or at the 2011 Cannes Film Festival.

Directing

In 1991, Penn made his directorial debut with ''The Indian Runner'', a film based on Bruce Springsteen's song "Highway Patrolman", from the ''Nebraska'' album. He also directed music videos, such as Shania Twain's "Dance with the One That Brought You" and Lyle Lovett's "North Dakota" in 1993, and Peter Gabriel's "The Barry Williams Show" in 2002. He has since directed three more films, all of which were well-received by critics: ''The Crossing Guard'' in 1995, ''The Pledge'' in 2001, and ''Into the Wild'' in 2007.

Personal life

Penn was engaged to actress Elizabeth McGovern, his co-star in 1984's ''Racing with the Moon''. Penn's personal life began to attract media attention when he married pop star Madonna in 1985. The two starred in the panned and much-derided ''Shanghai Surprise'', directed by Jim Goddard, and Madonna dedicated her third studio album ''True Blue'' to Penn, referring to him in the liner notes as "the coolest guy in the universe". The relationship was marred by violent outbursts against the press, including one incident for which he was arrested for assaulting a photographer on a film set; Penn was sentenced to 60 days in jail in mid-1987, of which he served 33 days. It is also alleged that when Penn discovered the paparazzo in his hotel room, he hung him by his ankles from the ninth-floor balcony. Later in the marriage, Penn was charged with felony domestic assault, a charge for which he pleaded to a misdemeanor. Penn and Madonna divorced in 1989.

He soon began a relationship with actress Robin Wright, and their first child – a daughter named Dylan Frances – was born in 1991. Their second child, a son whom they named Hopper Jack, was born in 1993. Penn and Wright married in 1996 and lived in Ross, California. The relationship went through on-and-off periods in the late 2000s (decade). The couple filed for divorce in December 2007, but reconciled several months later, requesting a court dismissal of their divorce case. In April 2009, Penn filed for legal separation, only to withdraw the case once again when the couple reconciled in May. On August 12, 2009, Wright Penn filed for divorce again. The couple's divorce was finalized on July 22, 2010, with the couple reaching a private agreement on child and spousal support, division of assets, and custody over their underage son.

During a separation from Wright in the mid 1990s, Penn dated singer and songwriter Jewel. He was also the director of the original video for Jewel's hit song "You Were Meant for Me".

Political and social causes

Penn has been active in supporting several political and social causes. On June 10, 2005, Penn made a visit to Iran. Acting as a journalist on an assignment for the ''San Francisco Chronicle'', he attended a Friday prayer at Tehran University.

On January 7, 2006, Penn was a special guest at the Progressive Democrats of America, where he was joined by author and media critic Norman Solomon, Democratic congressional candidate Charles Brown, and activist Cindy Sheehan. The "Out of Iraq Forum", which took place in Sacramento, California, was organized to promote the anti-war movement calling for an end to the War in Iraq.

In August 2008, Penn made an appearance at one of Ralph Nader's "Open the Debates" Super Rallies. He protested the political exclusion of Nader and other third parties.

In October 2008, Penn traveled to Cuba, where he met with and interviewed President Raúl Castro.

Criticism of President Bush

On October 18, 2002, Penn placed a US$56,000 advertisement in the ''Washington Post'' asking then President George W. Bush to end a cycle of violence. It was written as an open letter and referred to the planned attack on Iraq and the War on Terror. In the letter, Penn also criticized the Bush administration for its "deconstruction of civil liberties" and its "simplistic and inflammatory view of good and evil." Penn visited Iraq briefly in December 2002.

This advertisement was cited as a primary reason for the development of his relationship with Venezuelan president Hugo Chávez. In one of his televised speeches, Chávez used and read aloud an open letter Penn wrote to Bush. The letter condemned the Iraq War, called for Bush to be impeached, and also called Bush, Vice President Dick Cheney, and Secretary of State Condoleezza Rice "villainously and criminally obscene people.". In August 2007, Penn met with Chávez in Caracas for two hours, after which Chávez praised him for urging Americans to impeach Bush. Penn also visited a new film studio on the outskirts of Caracas, though he did not speak publicly.

On April 19, 2007, Penn appeared on ''The Colbert Report'' and had a "Meta-Free-Phor-All" versus Stephen Colbert that was judged by Robert Pinsky. This stemmed from some of Penn's criticisms of Bush. His exact quote was "We cower as you point your fingers telling us to support our troops. You and the smarmy pundits in your pocket– those who bathe in the moisture of your soiled and blood-soaked underwear– can take that noise and shove it." He won the contest with 10,000,000 points to Colbert's 1.

On December 7, 2007, Penn said he supported Ohio Congressman Dennis J. Kucinich for U.S. President in 2008, and criticized Bush's handling of the Iraq war. Penn questioned whether Bush's twin daughters supported the war in Iraq.

Hurricane Katrina

In September 2005, Penn traveled to New Orleans, Louisiana, to aid Hurricane Katrina victims. He was physically involved in rescuing people, although there was criticism that his involvement was a PR stunt as he hired a photographer to come along with his entourage. Penn denied such accusation in an article he wrote for ''The Huffington Post''.

Director Spike Lee interviewed Penn for his documentary ''When the Levees Broke: A Requiem in Four Acts'', about Hurricane Katrina.

LGBT civil rights

On February 22, 2009, Penn received the Academy Award for Best Actor for the film ''Milk''. In his acceptance speech, Penn said "...I think that it is a good time for those who voted for the ban against gay marriage to sit and reflect and anticipate their great shame and the shame in their grandchildren's eyes if they continue that way of support. We've got to have equal rights for everyone!"

2010 Haiti earthquake: Manager of Relief Organization and Tent Camp

After the 2010 Haiti earthquake, Sean Penn co-founded the J/P Haitian Relief Organization and has been running a 55,000 person tent camp.

Filmography and awards

On December 18, 2006, Penn received the Christopher Reeve First Amendment Award from the Creative Coalition.

Actor

Year	Film	Role	Notes
1981		Cadet Captain Alex Dwyer	film debut
1982	''Fast Times at Ridgemont High''	Jeff Spicoli
	''Summerspell''	Buddy
	Michael O'Brien
		Dillard
''Racing with the Moon''	Henry 'Hopper' Nash/Lou
1985	''The Falcon and the Snowman''	Daulton Lee
	''At Close Range''	Brad Whitewood Jr.
''Shanghai Surprise''	Glendon Wasey
1987	''Dear America: Letters Home from Vietnam''	Narrator
	''Cool Blue''	Phil the Plumber	uncredited
	Officer Danny McGavin
''Judgment in Berlin''	Guenther X
	''Casualties of War''	Sgt. Tony Meserve
	Jim
1990		Terry Noonan
1991	''Schneeweißrosenrot''	Himself	documentary
1992	''Cruise Control''	Jeffrey	short subject
		Himself	documentary
''Carlito's Way''	David Kleinfeld	Nominated – Chicago Film Critics Association Award for Best Supporting ActorNominated – Golden Globe Award for Best Supporting Actor – Motion Picture
1995		Matthew Poncelet
	''Loved''	Man on the Hill (Michael)
''She's So Lovely''	Eddie Quinn
	Bobby Cooper
	Conrad Van Orton
''Hugo Pool''	Strange Hitchhiker
		Eddie	Volpi CupNominated – Independent Spirit Award for Best Male Lead
	1st Sgt. Welsh
	''Being John Malkovich''	Himself	uncredited
''Sweet and Lowdown''	Emmett Ray	Nominated – Academy Award for Best ActorNominated – Chlotrudis Award for Best ActorNominated – Golden Globe Award for Best Actor – Motion Picture Musical or ComedyNominated – Satellite Award for Best Actor - Motion Picture Musical or Comedy
	''A Constant Forge''	Himself	documentary
''Up at the Villa''	Rowley Flint
	Cuco Sánchez
	Thomas Janes
	''Dogtown and Z-Boys''	Narrator	documentary
''The Beaver Trilogy''	Groovin' Larry (segment Beaver Kid 2)
''Scene Smoking: Cigarettes, Cinema & the Myth of Cool''	Himself	documentary
''See How They Run''	Himself	documentary
''I Am Sam''	Sam Dawson	Nominated – Academy Award for Best ActorNominated – Broadcast Film Critics Association Award for Best ActorNominated – Satellite Award for Best Actor - Motion Picture DramaNominated – Screen Actors Guild Award for Outstanding Performance by a Male Actor in a Leading Role
	''It's All About Love''	Marciello
	Jimmy Markum
''21 Grams''	Paul Rivers	Florida Film Critics Circle Award for Best Actor (also for ''Mystic River'')Las Vegas Film Critics Society Award for Best Actor (also for ''Mystic River'')National Board of Review Award for Best Actor (also for ''Mystic River'')Phoenix Film Critics Society Award for Best CastSatellite Award for Best Actor - Motion Picture Drama (also for ''Mystic River'')Volpi CupNominated – BAFTA Award for Best Actor in a Leading RoleNominated – Phoenix Film Critics Society Award for Best Actor
2004	''The Assassination of Richard Nixon''	Samuel J. Bicke	Nominated – Satellite Award for Best Actor - Motion Picture Drama
2005	''The Interpreter''	Tobin Keller
2006		Willie Stark
		Marjane's father	English dub; voice only
''War Made Easy''	Narrator	documentary
		Harvey Milk	Academy Award for Best ActorBoston Society of Film Critics Award for Best Actor (tied with Mickey Rourke for The Wrestler)Broadcast Film Critics Association Award for Best ActorBroadcast Film Critics Association Award for Best CastLos Angeles Film Critics Award for Best ActorNew York Film Critics Circle Award for Best ActorPalm Springs International Film Festival Award for Best ActorPhoenix Film Critics Society Award for Best ActorScreen Actors Guild Award for Outstanding Performance by a Male Actor in a Leading RoleSoutheastern Film Critics Award for Best ActorNominated – BAFTA Award for Best Actor in a Leading RoleNominated – Chicago Film Critics Association Award for Best ActorNominated – Golden Globe Award for Best Actor – Motion Picture DramaNominated – Independent Spirit Award for Best Lead MaleNominated – Irish Film Award People's Choice Award for Best International ActorNominated – London Film Critics Circle Award for Best ActorNominated – MTV Movie Award for Best KissNominated – Satellite Award for Best Actor - Motion Picture DramaNominated – Screen Actors Guild Award for Outstanding Performance by a Cast in a Motion Picture
	Narrator and Executive Producer	documentary
2010
		Adult Jack
	Cheyenne
2013	''The Gangster Squad''	Mickey Cohen	Filming

Director

Year	Film	Notes
1991	''The Indian Runner''
1995	''The Crossing Guard''	Also writer, Nominated – Golden Lion
2001		Nominated – Golden BearNominated – Bodil Award for Best Non-European FilmNominated – Palme d'Or
2002	''11'9"01 September 11''	anthology short, segment "U.S.A."UNESCO AwardNominated – César Award for Best Film from the European Union
2007		Also writer, Palm Springs International Film Festival Award for Best DirectorRome Film Fest Premiere PrizeSão Paulo International Film Festival Best Foreign Language FilmNominated – Broadcast Film Critics Association Award for Best DirectorNominated – BFCA Critics' Choice Award for Best WriterNominated – Chicago Film Critics Association Award for Best Adapted ScreenplayNominated – Directors Guild of America Award for Best Director – Motion PictureNominated – Film Critics Circle of Australia Award for Best Foreign Film – English LanguageNominated – Writers Guild of America Award for Best Adapted Screenplay

References

External links

''Guardian'' Interview, April 8, 2005

''Esquire'' magazine interview/profile

Sean Penn's visit to Iran at the San Francisco Chronicle

Smiles for Smirks by Sean Penn, ''The Huffington Post'', April 21, 2009

Sean Penn on Managing a Tent Camp of 55,000 Displaced Haitians – video report by ''Democracy Now!''

Category:1960 births Category:Actors from California Category:American agnostics Category:American anti–Iraq War activists Category:American film actors Category:American film directors Category:American people convicted of assault Category:American people of Irish descent Category:American people of Italian descent Category:American people of Jewish descent Category:American people of Russian descent Category:American screenwriters Category:American stage actors Category:American television actors Category:Best Actor Academy Award winners Category:Best Drama Actor Golden Globe (film) winners Category:Independent Spirit Award winners Category:Living people Category:People associated with Charles Bukowski Category:People from Burbank, California Category:People from Marin County, California Category:People from Santa Monica, California

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