Janssen's patent on Risperdal expired on December 29, 2003, opening the market for cheaper generic versions of the drug from other companies, and Janssen's exclusive marketing rights expired on June 29, 2004 (the result of a pediatric extension.)
Risperidone is available as a tablet, as an oral solution, and as a ampoule Risperdal Consta, which is a depot injection administered once every two weeks. It is also available as a wafer known in the United States and Canada as Risperdal M-Tabs and elsewhere as Risperdal Quicklets.
Risperidone became available as a generic drug in October 2008 from Teva Pharmaceuticals, Dr. Reddy's Laboratories, Inc. and Patriot Pharmaceutics. The Patriot generic is Janssen Pharmaceutical's "authorized generic pharmaceutical."
Many antipsychotics are known to cause hyperprolactinemia which may lead to hypogonadism-induced osteoporosis, galactorrhoea, gynaecomastia (male breast development), irregular menstruation and sexual dysfunction.
5-HT1A serotonin receptors (Ki = 420nM) 5-HT1D serotonin receptors (Ki = 100nM) 5-HT2A serotonin receptors (Ki = 0.16nM) D1 dopaminergic receptors (Ki = 536 nM) Doses range from 12.5 to 50 mg given as an intramuscular injection once every two weeks.
Category:Atypical antipsychotics Category:Piperidines Category:Benzisoxazoles Category:Organofluorides Category:Lactams Category:Pyridopyridazines
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