The core of steroids is composed of twenty carbon atoms bonded together that take the form of four fused rings: three cyclohexane rings (designated as rings A, B, and C in the figure to the right) and one cyclopentane ring (the D ring). The steroids vary by the functional groups attached to this four ring core and by the oxidation state of the rings. Sterols are special forms of steroids, with a hydroxyl group at position-3 and a skeleton derived from cholestane.
Hundreds of distinct steroids are found in plants, animals, and fungi. All steroids are made in cells either from the sterols lanosterol (animals and fungi) or from cycloartenol (plants). Both lanosterol and cycloartenol are derived from the cyclization of the triterpene squalene.
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Gonane is the simplest possible steroid and is composed of seventeen carbon atoms, bonded together to form four fused rings. The three cyclohexane rings (designated as rings A, B, and C in the figure above right) form the skeleton of phenanthrene; ring D has a cyclopentane structure. Hence, together they are called cyclopentaphenanthrene.
Commonly, steroids have a methyl group at the carbons C-10 and C-13 and an alkyl side chain at carbon C-17. Further, they vary by the configuration of the side chain, the number of additional methyl groups and the functional groups attached to the rings. For example the hydroxyl group at position C-3 in sterols.
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Class | Examples | Number of carbon atoms |
''Gonane'' (or steroid nucleus) is the parent (17-carbon tetracyclic) hydrocarbon molecule without any alkyl sidechains.
===A. Steroid biosynthesis===
Steroid biosynthesis is an anabolic metabolic pathway that produces steroids from simple precursors. This pathway is carried out in different ways in animals than in many other organisms, making the pathway a common target for antibiotics and other anti-infective drugs. In addition, steroid metabolism in humans is the target of cholesterol-lowering drugs such as statins.
It starts in the mevalonate pathway in humans, with Acetyl-CoA as building blocks, which form DMAPP and IPP. In following steps, DMAPP and IPP form lanosterol, the first steroid. Further modification belongs to the succeeding steroidogenesis.
Here, the isoprene units are joined together to make squalene and then folded up and formed into a set of rings to make lanosterol. Lanosterol can then be converted into other steroids such as cholesterol and ergosterol.
===B. Steroidogenesis=== Steroidogenesis is the biological process by which steroids are generated from cholesterol and transformed into other steroids. The pathways of steroidogenesis differ between different species, but the pathways of human steroidogenesis are shown in the figure.
Products of steroidogenesis include:
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"The Man" is a slang phrase that may refer to the government or to some other authority in a position of power. In addition to this derogatory connotation, it may also serve as a term of respect and praise. Also, " The Man is coming" is a term used to frighten small children who are misbehaving.
The phrase "the Man is keeping me down" is commonly used to describe oppression. The phrase "stick it to the Man" encourages resistance to authority, and essentially means "fight back" or "resist", either openly or via sabotage.
It was also used as a term for a drug dealer in the 1950s and 1960s and can be seen in such media as Curtis Mayfield's "No Thing On Me"; Jonathan Larson's ''Rent'', William Burroughs's novel ''Naked Lunch'', and in the Velvet Underground song "I'm Waiting for the Man", in which Lou Reed sings about going to Uptown Manhattan, specifically Lexington Avenue and 125th Street, to buy heroin.
The use of this term was expanded to counterculture groups and their battles against authority, such as the Yippies, which, according to a May 19, 1969 article in ''U.S. News and World Report'', had the "avowed aim ... to destroy 'The Man', their term for the present system of government". The term eventually found its way into humorous usage, such as in a December 1979 motorcycle ad from the magazine ''Easyriders'' which featured the tagline, "California residents: Add 6% sales tax for The Man."
In present day, the phrase has been popularized in commercials and cinema.
In more modern usage, it can be a superlative compliment ("you da man!") indicating that the subject is currently standing out amongst his peers even though they have no special designation or rank, such as a basketball player who is performing better than the other players on the court. It can also be used as a genuine compliment with an implied, slightly exaggerated or sarcastic tone, usually indicating that the person has indeed impressed the speaker but by doing something relatively trivial.
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birth name | Micah S. Katt Williams |
---|---|
birth date | September 02, 1971 |
birth place | Cincinnati, Ohio, U.S. |
othername | Katt Williams />Money Mike |
medium | Stand-up, Television, Film, Music |
nationality | American |
active | 1991–present |
genre | Black comedy, Blue comedy, Satire, Observational comedy, Physical comedy |
subject | African-American culture, Race relations, Racism, Recreational drug use, Human sexualityLife |
notable work | Various in ''Wild 'n Out''Bobby Shaw in ''My Wife and Kids''Money Mike in ''Friday After Next''''It's Pimpin' Pimpin''' |
website | http://www.kattwilliams.com/ }} |
As a means to get into a nightclub while underage, he noticed that they weren’t checking ID’s in the line for comics and proceeded to enter the club through that entrance. He was called on stage where he did a five-minute improv to an enthusiastic crowd. “I was so nervous but everyone laughed and thought I was funny. After that, I was opened up to the wonderful world of comedy... Improv is where a comic really gets to shine, if he is good. That’s as close as a comedian can get to the playoffs."
Williams has provided numerous skits and video appearances for artists such as Nick Cannon, DJ Drama, E-40, The Game, Lyfe Jennings, Lil Jon, Lil’ Kim, Lil' Scrappy, Ludacris, Outkast, T.I., Cyrano Williams, Oprah Winfrey, and others. He was a cast member on ''Wild 'n Out'' for several seasons; he voices "A Pimp Named Slickback" on the Adult Swim's ''The Boondocks''; he plays himself as an onstage comedian in ''Grand Theft Auto IV''; and Williams has appeared in several episodes of ''My Wife and Kids'' as character Bobby Shaw.
The following month, Williams was questioned and detained by police again in Coweta County, Georgia after an altercation in a Walmart parking lot. Police issued a warrant to search Williams' semi-truck for evidence, but found nothing. Williams maintains that police destroyed thousands of dollars worth of filming equipment for no reason. A mother and son who were involved in the altercation with Williams were charged with disorderly conduct, but Williams himself was not charged.
Williams maintains his innocence in both cases and said, after being detained, that he has begun to feel he is being persecuted by police.
Category:1971 births Category:Actors from Ohio Category:African American comedians Category:African American film actors Category:African American rappers Category:Living people Category:People from Cincinnati, Ohio Category:People from Dayton, Ohio Category:The Diplomats members Category:Rappers from Ohio
de:Katt Williams it:Katt Williams nl:Katt Williams pt:Katt Williams sv:Katt Williams bat-smg:Katt WilliamsThis text is licensed under the Creative Commons CC-BY-SA License. This text was originally published on Wikipedia and was developed by the Wikipedia community.
Witherspoon was a staunch Protestant, nationalist, and supporter of republicanism. Consequently, he was opposed to the Roman Catholic Legitimist Jacobite rising of 1745-1746. Following the Jacobite victory at the Battle of Falkirk (1746), he was briefly imprisoned at Doune Castle, which had a long-term affect on his health.
He became a Church of Scotland (Presbyterian) minister at Beith, Ayrshire (1745–1758), where he married Elizabeth Montgomery of Craighouse. They had ten children, with five surviving to adulthood.
From 1758-1768, he was minister of the Laigh kirk, Paisley (Low Kirk). Witherspoon became prominent within the Church as an Evangelical opponent of the Moderate Party. During his two pastorates he wrote three well-known works on theology, notably the satire "Ecclesiastical Characteristics" (1753), which opposed the philosophical influence of Francis Hutcheson. He was awarded a Master of Arts, Bachelor of Divinity, and Doctorate of Divinity from the University of St Andrews, Fife.
Some of the courses he taught personally were Eloquence or Belles Lettres, Chronology (history), and Divinity. Of his courses, none was more important than Moral Philosophy (a required course). An advocate of Natural Law within a Christian and republican Cosmology, which Witherspoon considered Moral Philosophy vital for ministers, lawyers, and those holding positions in government (magistrates). He was firm but good-humored in his leadership. Witherspoon instituted a number of reforms, including modeling the syllabus and university structure after that used at the University of St Andrews and other Scottish universities. Witherspoon was very popular among both faculty and students, among them James Madison and Aaron Burr.
Upon his arrival at then ''College of New Jersey at Princeton'', Witherspoon found the school in debt, instruction had become weak, and the library collection did not meet current student needs. At once he began fund-raising locally and back home in Scotland, added three hundred of his own books to the library, and began the purchase of scientific equipment: the Rittenhouse orrery, many maps and a "terrestial" globe. He also firmed up entrance requirements. These things helped the school be more on par with Harvard and Yale. According to Herbert Hovenkamp, his most lasting contribution was the initiation of the Scottish Common-Sense Realism, which he had learned by reading Thomas Reid and two of his expounders Dugald Stewart and James Beattie.
As the College's primary occupation at the time was training ministers, Witherspoon was a major leader of the early Presbyterian church in America. Witherspoon also helped to organize Nassau Presbyterian Church in Princeton, N.J.
Witherspoon served in Congress from June 1776 until November 1782 and became one of its most influential members and a workhorse of prodigious energy. He served on over 100 committees, most notably the powerful standing committees, the board of war and the committee on secret correspondence or foreign affairs. He spoke often in debate; helped draft the Articles of Confederation; helped organize the executive departments; played a major role in shaping foreign policy; and drew up the instructions for the peace commissioners. He fought against the flood of paper money, and opposed the issuance of bonds without provision for their amortization. "No business can be done, some say, because money is scarce," he wrote. He also served twice in the New Jersey Legislature, and strongly supported the adoption of the United States Constitution during the New Jersey ratification debates.
In November 1778, as British forces neared, Witherspoon closed and evacuated the College of New Jersey. The main building, Nassau Hall, was badly damaged and his papers and personal notes were lost. Witherspoon was responsible for its rebuilding after the war, which caused him great personal and financial difficulty.
In 1780 he was elected to a one-year term in the New Jersey Legislative Council representing Somerset County.
From among his students came 37 judges, three of whom made it to the U.S. Supreme Court; 10 Cabinet officers; 12 members of the Continental Congress, 28 U.S. senators, and 49 United States congressmen. His most prominent students were Aaron Burr and James Madison. When the General Assembly of the Presbyterian Church in America met in 1789, 52 of the 188 delegates had studied under Witherspoon.
The President's House in Princeton, New Jersey, his home from 1768 to 1779 is a U.S. National Historic Landmark. A bronze statue at Princeton University by Scottish sculptor Alexander Stoddart is the twin of one outside The University of the West of Scotland, Paisley, Scotland. In Princeton today, a University dormitory built in 1877, the street running north from the University's main gate, and the local public middle school all bear his name. Another statue stands near Dupont Circle in Washington, D.C., at the intersections of Connecticut Avenue, N and 18th Streets.
Paisley, Scotland honored Witherspoon's memory by naming a newly constructed street in the town center after him, in honor of his having lived in Paisley for a portion of his adult life.
A son-in-law was Congressman David Ramsay, who married Frances Witherspoon on 18 March 1783. Another daughter, Ann, married Samuel Stanhope Smith, who succeeded Witherspoon as president of Princeton in 1795.
The Witherspoon Society is a body of laypeople within the Presbyterian Church (USA) in existence since 1979 that is activist in liberal and progressive causes that takes its name from John Witherspoon.
A merchant ship, the SS John Witherspoon, saw service during the second world war. It was part of convoy PQ-17, and was sunk by a German U-boat in the North Atlantic on July 6, 1942
The Witherspoon Institute is an independent research center that works to enhance public understanding of the moral foundations of free and democratic societies. Located in Princeton, it promotes the application of fundamental principles of republican government and ordered liberty to contemporary problems through a variety of centers, research programs, seminars, consultations, and publications.
Witherspoon was portrayed in the musical ''1776'' by Edmund Lyndeck in the 1969 stage play and by James Noble in the 1972 film.
Category:Presidents of Princeton University Category:Continental Congressmen from New Jersey Category:Signers of the Articles of Confederation Category:Signers of the United States Declaration of Independence Category:Members of the New Jersey Legislative Council Category:Clergy in the American Revolution Category:Ministers of the Church of Scotland Category:American Presbyterians Category:Scottish scholars and academics Category:Scottish theologians Category:Scottish non-fiction writers Category:Alumni of the University of Edinburgh Category:People from East Lothian Category:Scottish emigrants to the United States Category:1723 births Category:1794 deaths Category:Presbyterian ministers Category:Burials at Princeton Cemetery Category:Blind people
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