Nature Reviews Cancer
Volume 11, No 10 October 2011
Article series:
The next 10 years
Featured Article
A decade of exploring the cancer epigenome — biological and translational implications
Stephen B. Baylin & Peter A. Jones
Main pages for finding content:
Advance online publication
Review
RAS oncogenes: weaving a tumorigenic web
Yuliya Pylayeva-Gupta, Elda Grabocka & Dafna Bar-Sagi
The RAS oncogenes have far-reaching effects when they are oncogenically mutated. This Review discusses our current knowledge about the cell-autonomous and non-cell-autonomous effects of oncogenic RAS and how different RAS isoforms and substitutions seem to have different effects.
Advance online publication
Review
TRIM proteins and cancer
Shigetsugu Hatakeyama
Several members of the tripartite motif (TRIM) proteins (one of the subfamilies of the RING type E3 ubiquitin ligases) seem to function as important regulators for carcinogenesis. This Review focuses on TRIM proteins that are involved in tumour development and progression.
Current issue
Timeline
Article series:
The next 10 years
Unravelling the complexity of metastasis — molecular understanding and targeted therapies
Nilay Sethi & Yibin Kang
Will genomic and other systems level approaches help to overcome gaps in our understanding of metastasis?
Current Issue
Viewpoint
Article series:
The next 10 years
Cancer research: past, present and future
Ya Cao, Ronald A. DePinho, Matthias Ernst & Karen Vousden
Opinions on where we should progress next with cancer research are diverse. In this article, four top cancer researchers from across the globe discuss their thoughts on the current state of cancer research and what progress might be expected in the next 10 years.
Current Issue
Opinion
Rethinking ovarian cancer: recommendations for improving outcomes
Sebastian Vaughan, Jermaine I. Coward, Robert C. Bast, Jr, Andy Berchuck, Jonathan S. Berek, James D. Brenton, George Coukos, Christopher C. Crum, Ronny Drapkin, Dariush Etemadmoghadam, Michael Friedlander, Hani Gabra, Stan B. Kaye, Chris J. Lord, Ernst Lengyel, Douglas A. Levine, Iain A. McNeish, Usha Menon, Gordon B. Mills, Kenneth P. Nephew, Amit M. Oza, Anil K. Sood, Euan A. Stronach, Henning Walczak, David D. Bowtell & Frances R. Balkwill
This Opinion article outlines nine major recommendations for improving our understanding of ovarian cancer and the outcomes of women with this group of diseases.
Advance online publication
Research Highlights
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Tumorigenesis:
USP1 keeps ID proteins stable
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Gene expression:
Variety is the splice of strife
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Tumour suppressors:
HOTS makes antisense
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Pancreatic cancer:
Fibroblast co-conspirators
More Cancer
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Web Focus Collection
Selected articles from the Nature Publishing Group including focuses on microRNAs and cancer and on stem cells
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Recommended Links
Selected articles from Nature
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Conferences
A calendar of forthcoming meetings and workshops from across the field of cancer.
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Migration and metastasis
A selection of Research Highlights, News and Views, Progress, Reviews, Perspectives and Research Articles published by Nature Publishing Group journals on the topic of migration and metastasis.
Noticeboard
Hypoxia and metabolism
This Nature Reviews Cancer Collection on Hypoxia and metabolism includes a selection of recent Reviews, Perspectives and Research Highlights that provide insight into the roles of these processes in tumour biology and therapy.
Pathway Interaction Database
For a visual, up–to–date view of the proteins and genes that interact with and regulate p53.
Nature Reports Stem Cells
Nature Reports Stem Cells for the latest news, research, comment and analysis about stem cells and their implications.
MYC
Throughout 2008 and 2009, we will publish a series of specially commissioned articles that discuss the key issues and our current knowledge of MYC and cancer.
What is translational cancer research?
What does translational cancer research mean to you? Compare your views with those of our podcast panel from the new Cancer Research UK Cambridge Research Institute.
Bruce Ponder, Fiona Watt, Duncan Odom & David Neal
Mouse models
The evolution of genetically engineered mouse models of cancer
Kristopher K. Frese and David A. Tuveson
Tumour Microenvironment
The final two articles in our series on the tumour microenvironment are published in this month�s issue. All the articles that have appeared in this series can be found online at www.nature.com/nrc/series/tumourmicro
Milestones in Cancer
Milestones in Cancer is a collaborative project involving three journals - Nature, Nature Medicine and Nature Reviews Cancer - and celebrates more than 100 years of discoveries in the field of cancer.
2010 Journal Citation Report (Thomson Reuters, 2011)
