| Name | Vitiligo |
|---|---|
| Caption | Vitiligo of the hand in a dark-skinned individual |
| Diseasesdb | 13965 |
| Icd10 | |
| Icd9 | |
| Omim | 193200 |
| Medlineplus | 000831 |
| Emedicinesubj | derm |
| Emedicinetopic | 453 |
| Meshid | D014820 |
The transcriptional profile of melanocytes from vitiligo patients have been studied. Oligonucleotide microarrays containing approximately 16,000 unique genes were used to analyse mRNA expression in melanocytes from vitiligo patients and age-matched healthy controls. In total, 859 genes were identified as differentially expressed.
Vitiligo is sometime associated with autoimmune and inflammatory diseases, commonly thyroid overexpression and underexpression. A study comparing 656 people with and without vitiligo in 114 families found several mutations (single-nucleotide polymorphisms) in the NALP1 gene.The NALP1 gene, which is on chromosome 17 located at 17p13, is on a cascade that regulates inflammation and cell death, including myeloid and lymphoid cells, which are white cells that are part of the immune response. NALP1 is expressed at high levels in T cells and Langerhan cells, white blood cells that are involved in skin autoimmunity.
Among the inflammatory products of NALP1 are caspase 1 and caspase 5, which activate the inflammatory cytokine interleukin-1β. Interleukin-1β is expressed at high levels in patients with vitiligo. There are compounds which inhibit caspase and interleukin-1β, and so might be useful drugs for vitiligo and associated autoimmune diseases. In one of the mutations, the amino acid leucine in the NALP1 protein was replaced by histidine (Leu155->His). The original protein and sequence is highly conserved in evolution, and found in humans, chimpanzee, rhesus monkey, and bush baby, which means that it is an important protein and an alteration is likely to be harmful. Addison's disease (typically an autoimmune destruction of the adrenal glands) may cause vitiligo.
Studies have shown that immunomodulator creams such as Protopic and Elidel also cause repigmentation in some cases, when used with UVB narrowband treatments.
With one patient, repigmentation occurred significantly when another autoimmune disease, celiac disease, was treated. Eliminating gluten from the diet, a celiac patient who had Vitiligo reported repigmentation starting within 6 months of treatment. With the elimination of gluten, repigmentation continued to increase for 3–5 years, though not totally. This occurred with a patient who had Vitiligo for 25 years prior to learning of their diagnosis and treatment for Celiac Disease.
A 1997 report suggests that combining Vitamin B12 and folic acid supplements with sun exposure caused repigmentation in 52% of cases.
In October 1993, a scientific report was published of successfully transplanting melanocytes to vitiligo affected areas, effectively repigmenting the region. The procedure involved taking a thin layer of pigmented skin from the patient's gluteal region. Melanocytes were then separated out to a cellular suspension that was expanded in culture. The area to be treated was then denuded with a dermabrader and the melanocytes graft applied. Between 70 and 85 percent of patients experienced nearly complete repigmentation of their skin. The longevity of the repigmentation differed from person to person.
Ultraviolet light (UVA) treatments are normally carried out in a hospital clinic. Psoralen and Ultraviolet A light (PUVA) treatment involves taking a drug which makes the skin very sensitive to light. The skin is then exposed to ultraviolet A light (UVA). Treatment is required twice a week for 6–12 months or longer. PUVA may cause side effects such as 'sunburn' type reactions or skin freckling. It was also confirmed by Jackson during a leaked deposition tape in 1996, that he did not "bleach" his skin. The tape was leaked months after his death in June 2009. According to police reports, 19 tubes of hydroquinone and 18 tubes of benoquin (monobenzone) were found in Michael Jackson's home after his death. In July 2010, Michael Jackson's eldest son Prince Michael Jr is seen in a picture with a patch of de-pigmented skin on his right underarm leading to speculations that he may be affected by vitiligo like his father Michael Jackson. Graham Norton the Irish television personality. Lee Thomas, a news anchor and entertainment reporter for WJBK (Fox) Detroit. Yvette Fielding, British TV presenter, has had vitiligo from age 11; her mother developed it at age 24. John Wiley Price, the Dallas County Commissioner, also has vitiligo. Amitabh Bachchan, the famous Bollywood actor, also has vitiligo. Scott Jorgensen, the WEC fighter, also has vitiligo.
Category:Disturbances of human pigmentation Category:Autoimmune diseases Category:Genetic disorders by system
This text is licensed under the Creative Commons CC-BY-SA License. This text was originally published on Wikipedia and was developed by the Wikipedia community.
| Img alt | A mid-twenties African American man wearing a sequined military jacket and dark sunglasses. He is walking while waving his right hand, which is adorned with a white glove. His left hand is bare. |
|---|---|
| Landscape | no |
| Background | solo_singer |
| Birth name | Michael Joe Jackson |
| Alias | Michael Joseph Jackson, Michael Jackson, King of Pop |
| Born | August 29, 1958Gary, Indiana, U.S. |
| Died | June 25, 2009Los Angeles, California, U.S. |
| Instrument | Vocals, Piano, Drums, Beatbox, Guitar, Bass Guitar |
| Genre | R&B;, pop rock, electronic |
| Occupation | Singer-songwriter, record producer, composer, musician, dancer, choreographer, actor, author, businessman, philanthropist |
| Years active | 1964–2009 |
| Label | Motown, Epic, Legacy |
| Associated acts | The Jackson 5 |
| Url |
In the early 1980s, Jackson became a dominant figure in popular music. The music videos for his songs including "Beat It", "Billie Jean" and "Thriller", were credited with transforming the medium into an art form and a promotional tool, and the popularity of these videos helped to bring the relatively new television channel MTV to fame. Videos such as "Black or White" and "Scream" made him a staple on MTV in the 1990s. Through stage performances and music videos, Jackson popularized a number of dance techniques, such as the robot and the moonwalk. His distinctive musical sound and vocal style have influenced numerous hip hop, pop, contemporary R&B; and rock artists.
Jackson's 1982 album Thriller is the best-selling album of all time. His other records, including Off the Wall (1979), Bad (1987), Dangerous (1991) and (1995), also rank among the world's best-selling. Jackson is one of the few artists to have been inducted into the Rock and Roll Hall of Fame twice. He was also inducted into the Dance Hall of Fame as the first (and currently only) dancer from the world of pop and rock 'n' roll. Some of his other achievements include multiple Guinness World Records; 13 Grammy Awards (as well as the Grammy Legend Award and the Grammy Lifetime Achievement Award); 26 American Music Awards (more than any other artist, including the "Artist of the Century"); 13 number-one singles in the United States in his solo career (more than any other male artist in the Hot 100 era); and the estimated sale of over 750 million records worldwide. Jackson won hundreds of awards, which have made him one of the most-awarded recording artist in the history of music. He was also a notable humanitarian and philanthropist, donating and raising hundreds of millions of dollars for beneficial causes and supporting more than 39 charities.
Aspects of Jackson's personal life, including his changing appearance, personal relationships and behavior, have generated controversy. In 1993, he was accused of child sexual abuse, but the case was settled out of court and no formal charges were brought. In 2005, he was tried and acquitted of further sexual abuse allegations and several other charges after the jury ruled him not guilty on all counts. While preparing for his concert series This Is It, Jackson died on June 25, 2009, after suffering from cardiac arrest. Before his death, Jackson had reportedly been administered drugs such as propofol and lorazepam. The Los Angeles County Coroner declared his death a homicide, and his personal physician pleaded not guilty to charges of involuntary manslaughter. Jackson's death triggered a global outpouring of grief, and as many as one billion people around the world reportedly watched his public memorial service on live television. In March 2010, Sony Music Entertainment signed a US$250 million deal with Jackson's estate to retain distribution rights to his recordings until 2017, and to release seven posthumous albums over the decade following his death. His first posthumous album of new material, simply titled Michael, was released on December 14, 2010.
Jackson had a troubled relationship with his father, Joe. Jackson stated that he was physically and emotionally abused during incessant rehearsals, though he also credited his father's strict discipline with playing a large role in his success. Jackson first spoke openly about his childhood abuse in an interview with Oprah Winfrey, broadcast in February 1993. He admitted that he had often cried from loneliness and he would vomit on the sight of his father. Jackson's father was also said to have verbally abused Jackson, saying that he had a fat nose on numerous occasions. In fact, Michael Jackson's deep dissatisfaction with his appearance, his nightmares and chronic sleep problems, his tendency to remain hyper-compliant especially with his father, and to remain child-like throughout his adult life are in many ways consistent with the effects of this chronic maltreatment he endured as a young child. Childhood abuse is also known to impair neurobiological development (i.e. impairing the brain circuitry involved in addiction, motivation and incentive) causing increased susceptibility to drug addiction, which he struggled with; in addition to increased susceptibility by the psychological factor of emotional pain relief.
In an interview with Martin Bashir, later included in the 2003 broadcast of Living with Michael Jackson, Jackson acknowledged that his father hurt him when he was a child, but was nonetheless a "genius", as he admitted his father's strict discipline played a huge role in his success. When Bashir dismissed the positive remark and continued asking about beatings, Jackson put his hand over his face and objected to the questions. He recalled that Joseph sat in a chair with a belt in his hand as he and his siblings rehearsed, and that "if you didn't do it the right way, he would tear you up, really get you".
In 1964, Michael and Marlon joined the Jackson Brothers—a band formed by brothers Jackie, Tito, and Jermaine—as backup musicians playing congas and tambourine. Jackson later began performing backup vocals and dancing. When he was eight, Jackson began sharing the lead vocals with his older brother Jermaine, and the group's name was changed to The Jackson 5.
The Jackson 5 recorded several songs, including "Big Boy", for the local record label Steeltown in 1967, before signing with Motown Records in 1968. The group set a chart record when its first four singles ("I Want You Back", "ABC", "The Love You Save", and "I'll Be There") peaked at number one on the Billboard Hot 100.
Jones and Jackson produced the Off the Wall album together. Songwriters for the album included Jackson, Rod Temperton, Stevie Wonder, and Paul McCartney. Released in 1979, it was the first solo album to generate four U.S. top 10 hits, including the chart-topping singles "Don't Stop 'til You Get Enough" and "Rock with You". It reached number three on the Billboard 200 and eventually sold over copies worldwide. In 1980, Jackson won three awards at the American Music Awards for his solo efforts: Favorite Soul/R&B; Album, Favorite Soul/R&B; Male Artist, and Favorite Soul/R&B; Single for "Don't Stop 'Til You Get Enough". That year, he also won Billboard Year-End for Top Black Artist and Top Black Album and a Grammy Award for Best Male R&B; Vocal Performance, also for "Don't Stop 'Til You Get Enough". Jackson again won at the American Music Awards in 1981 for Favorite Soul/R&B; Album and Favorite Soul/R&B; Male Artist. Despite its commercial success, Jackson felt Off the Wall should have made a much bigger impact, and was determined to exceed expectations with his next release. In 1980, he secured the highest royalty rate in the music industry: 37 percent of wholesale album profit.
Time described Jackson's influence at that point as "Star of records, radio, rock video. A one-man rescue team for the music business. A songwriter who sets the beat for a decade. A dancer with the fanciest feet on the street. A singer who cuts across all boundaries of taste and style and color too".
In March 1983, Jackson reunited with his brothers for a legendary live performance which was taped for a television special. The show aired on May 16, 1983, to an audience of viewers, and featured the Jacksons and a number of other Motown stars. It is best remembered for Jackson's solo performance of "Billie Jean". Wearing a distinctive black sequin jacket and golf glove decorated with rhinestones, he debuted his signature dance move, the moonwalk, which former Soul Train dancer and Shalamar member, Jeffrey Daniel had taught him three years before. The Jacksons' performance drew comparisons to Elvis Presley's and The Beatles' appearances on The Ed Sullivan Show. Anna Kisselgoff of The New York Times later wrote, "The moonwalk that he made famous is an apt metaphor for his dance style. How does he do it? As a technician, he is a great illusionist, a genuine mime. His ability to keep one leg straight as he glides while the other bends and seems to walk requires perfect timing."
On January 27, 1984, Michael and other members of the Jacksons filmed a Pepsi Cola commercial, overseen by executive Phil Dusenberry, from ad agency BBDO and Pepsi's Worldwide Creative Director, Alan Pottasch at the Shrine Auditorium in Los Angeles. In front of a full house of fans during a simulated concert, pyrotechnics accidentally set Jackson's hair on fire. He suffered second-degree burns to his scalp. Jackson underwent treatment to hide the scars on his scalp, and he also had his third rhinoplasty shortly thereafter. Dusenberry later recounted the episode in his memoir, Then We Set His Hair on Fire: Insights and Accidents from a Hall of Fame Career in Advertising.
On May 14, 1984, Jackson was invited to the White House to receive an award from President Ronald Reagan for his support of charities that helped people overcome alcohol and drug abuse. Jackson won eight awards during the Grammys that year. Unlike later albums, Thriller did not have an official tour to promote it, but the 1984 Victory Tour, headlined by The Jacksons, showcased much of Jackson's new solo material to more than two million Americans. He donated all the funds (around ) raised from the Victory Tour to charity. He also co-wrote the charity single "We Are the World" in 1985 with Lionel Richie, which was released worldwide to aid the poor in the U.S. and Africa. It became one of the best-selling singles of all time, with nearly 30 million copies sold and millions of dollars donated to famine relief. In 1986, "We Are the World" won four Grammys (one for Jackson for Song of the Year). American Music Award directors removed the charity song from the competition because they felt it would be inappropriate, but recognised it with two special honors (one for the creation of the song and one for the USA for Africa idea). They are the only AMAs that Jackson won as non-solo artist.
In 1984, ATV Music Publishing, which had the copyrights to nearly 4000 songs, including the Northern Songs catalog that contained the majority of the Lennon/McCartney compositions recorded by The Beatles, was put up for sale by Robert Holmes à Court. Jackson had become interested in owning music catalogs after working with Paul McCartney in the early 1980s: Jackson had learned McCartney made approximately $40 million a year from other people's songs. In 1981, McCartney was offered the ATV music catalog for £20 million ($40 million USD). According to McCartney, he contacted Yoko Ono about making a joint purchase by splitting the cost equally at £10 million each, but Ono thought they could buy it for £5 million each. Also, an attorney for McCartney assured Jackson's attorney, John Branca, that McCartney was not interested in bidding: McCartney reportedly said "It's too pricey" According to J. Randy Taraborrelli's biography, in 1986, Jackson was diagnosed with vitiligo and lupus; the vitiligo partially lightened his skin, and the lupus was in remission; both illnesses made him sensitive to sunlight. The treatments he used for his condition further lightened his skin tone, and, with the application of pancake makeup to even out blotches, he could appear very pale. Jackson was also diagnosed with vitiligo in his autopsy. Several surgeons speculated that he had undergone various nasal surgeries, a forehead lift, thinned lips, and cheekbone surgery—although Jackson denied this and insisted that he only had surgery on his nose. Jackson claimed that he had only two rhinoplasties and no other surgery on his face, although at one point he mentioned having a dimple created in his chin. Jackson lost weight in the early 1980s because of a change in diet and a desire for "a dancer's body". Witnesses reported that he was often dizzy and speculated that he was suffering from anorexia nervosa; periods of weight loss would become a recurring problem later in life.
During the course of his treatment, Jackson made two close friends: his dermatologist, Dr. Arnold Klein, and Klein's nurse Debbie Rowe. Rowe eventually became Jackson's second wife and the mother of his two eldest children. Long before becoming romantically involved with her, Jackson relied heavily on Rowe for emotional support. He also relied heavily on Klein, for medical and business advice.
, here in the early stages of the disease]] Jackson became the subject of increasingly sensational reports. In 1986, the tabloids ran a story claiming that Jackson slept in a hyperbaric oxygen chamber to slow the aging process; he was pictured lying down in a glass box. Although the claim was untrue, according to tabloid reports that are widely cited, Jackson had disseminated the fabricated story himself. When Jackson bought a chimpanzee called Bubbles from a laboratory, he was reported to be increasingly detached from reality. It was reported that Jackson had offered to buy the bones of Joseph Merrick (the "elephant man") and although untrue, Jackson did not deny the story. These reports became embedded in the public consciousness, inspiring the nickname "Wacko Jacko," which Jackson came to despise. Responding to the gossip, Jackson remarked to Taraborrelli:
Jackson collaborated with Francis Ford Coppola on the 17-minute 3-D film Captain EO, which debuted in September 1986 at both the original Disneyland and at EPCOT in Florida, and in March 1987 at Tokyo Disneyland. The $30 million movie was a popular attraction at all three parks. A Captain EO attraction was later featured at Euro Disneyland after that park opened in 1992. All four parks' Captain EO installations stayed open well into the 1990s: Paris' installation was the last one to close, in 1998. The attraction would later return to Disneyland after Jackson's death in 2010.
In 1987, Jackson disassociated himself from the Jehovah's Witnesses, in response to their disapproval of the Thriller video. With the industry expecting another major hit, Jackson's first album in five years, Bad (1987), was highly anticipated. It did not top Thriller as a commercial or artistic triumph, but Bad was still a substantial success in its own right.
The Bad album spawned seven hit singles in the U.S., five of which ("I Just Can't Stop Loving You", "Bad", "The Way You Make Me Feel", "Man in the Mirror" and "Dirty Diana") reached number one on the Billboard Hot 100 charts. This was a record for most number one Hot 100 singles from any one album, including Thriller. Although the title track's video was arguably derivative of the video for the earlier single "Beat It", the "Bad" video still proved to be one of Jackson's iconic moments. It was a gritty but colorful epic set against the backdrop of the New York City Subway system, with costuming and choreography inspired by West Side Story. As of 2008, the album had sold 30 million copies worldwide. Thanks to the Bad album, Bruce Swedien and Humberto Gatica won one Grammy in 1988 for Best Engineered Recording – Non Classical and Michael Jackson won one Grammy for Best Music Video, Short Form for "Leave Me Alone" in 1989. In 1988, "Bad" won an American Music Award for Favorite Soul/R&B; Single.
The Bad World Tour began on September 12 that year, finishing on January 14, 1989. Jackson broke a Guinness World Record when 504,000 people attended seven sold-out shows at Wembley Stadium. He performed a total of 123 concerts to an audience of 4.4 million people. The Bad Tour turned out to be the last of Jackson's concert tours to include shows in the continental United States, although later tours did make it to Hawaii.
Following the illness and death of Ryan White, Jackson helped draw public attention to HIV/AIDS, something that was still controversial at the time. He publicly pleaded with the Clinton Administration at Bill Clinton's Inaugural Gala to give more money to HIV/AIDS charities and research. In a high-profile visit to Africa, Jackson visited several countries, among them Gabon and Egypt. His first stop to Gabon was greeted with a sizable and enthusiastic reception of more than 100,000 people, some of them carrying signs that read, "Welcome Home Michael."
Jackson gave a 90-minute interview to Oprah Winfrey in February 1993, his second television interview since 1979. He grimaced when speaking of his childhood abuse at the hands of his father; he believed he had missed out on much of his childhood years, admitting that he often cried from loneliness. He denied tabloid rumors that he had bought the bones of the Elephant Man, slept in a hyperbaric oxygen chamber, or bleached his skin, stating for the first time that he had vitiligo. The interview was watched by an American audience of 90 million. Dangerous re-entered the album chart in the top 10, more than a year after its original release. The Chandler family demanded payment from Jackson, and the singer initially refused. Jordan Chandler eventually told the police that Jackson had sexually abused him. Dr. Chandler was tape-recorded discussing his intention to pursue charges, saying, "If I go through with this, I win big-time. There's no way I lose. I will get everything I want and they will be destroyed forever ... Michael's career will be over". Jordan's mother was, however, adamant that there had been no wrongdoing on Jackson's part. a fact confirmed in his autopsy. His friends said he never recovered from the humiliation of the strip search. The investigation was inconclusive and no charges were ever filed. Jackson described the search in an emotional public statement, and proclaimed his innocence. On January 1, 1994, Jackson's insurance carrier settled with the Chandlers out of court for $22 million. A Santa Barbara County grand jury and a Los Angeles County grand jury disbanded on May 2, 1994 without indicting Jackson. After which time the Chandlers stopped co-operating with the criminal investigation around July 6, 1994. The out-of-court settlement's documentation specifically stated Jackson admitted no wrongdoing and no liability; the Chandlers and their family lawyer Larry Feldman signed it without contest. The Chandlers' lawyer Mr. Feldman also explicitly stated "nobody bought anybody's silence". A decade after the fact, during the second round of child abuse allegations, Jackson's lawyers would file a memo stating that the 1994 settlement was done without his consent. According to a friend of Presley's, "their adult friendship began in November 1992 in L.A." They stayed in contact every day over the telephone. As the child molestation accusations became public, Jackson became dependent on Presley for emotional support; she was concerned about his faltering health and addiction to drugs. Presley explained, "I believed he didn't do anything wrong and that he was wrongly accused and yes I started falling for him. I wanted to save him. I felt that I could do it." She eventually persuaded him to settle the allegations out of court and go into rehabilitation to recover. At the time, the tabloid media speculated that the wedding was a ploy to prop up Jackson's public image. The marriage lasted less than two years and ended with an amicable divorce settlement. In a 2010 interview with Oprah, Presley admitted that they spent four more years after the divorce "getting back together and breaking up", until she decided to stop.
The album was promoted with the successful HIStory World Tour. The tour began on September 7, 1996, and finished on October 15, 1997. Jackson performed 82 concerts in 58 cities to over 4.5 million fans, and grossed up a total of . The show, which visited five continents and 35 countries, became Jackson's most successful in terms of audience figures. During the tour, Jackson married his longtime friend Deborah Jeanne Rowe, a dermatology nurse, in an impromptu ceremony in Sydney, Australia. Rowe was approximately six months pregnant with the couple's first child at the time. Originally, Rowe and Jackson had no plans to marry, but Jackson's mother Katherine persuaded them to do so. Michael Joseph Jackson Jr (commonly known as Prince) was born on February 13, 1997; his sister Paris-Michael Katherine Jackson was born a year later on April 3, 1998. The couple divorced in 1999, and Jackson got full custody of the children. The divorce was relatively amicable, but a subsequent custody suit was not settled until 2006. It reached number one in the UK, as did the title track. In the US, the album was certified platinum, but only reached number 24. Later that month, Jackson organized a set of "Michael Jackson & Friends" benefit concerts in Germany and Korea. Other artists involved included Slash, The Scorpions, Boyz II Men, Luther Vandross, Mariah Carey, A. R. Rahman, Prabhu Deva Sundaram, Shobana, Andrea Bocelli and Luciano Pavarotti. The proceeds went to the "Nelson Mandela Children's Fund", the Red Cross and UNESCO.
In 2002, Michael Jackson won his 22nd American Music Award for Artist of the Century. In the same year, Jackson's third child, Prince Michael Jackson II (nicknamed "Blanket") was born. The mother's identity is unknown, but Jackson has said the child was the result of artificial insemination from a surrogate mother and his own sperm. On November 20 of that year, Jackson brought his newborn son onto the balcony of his room at the Hotel Adlon in Berlin, as fans stood below, holding him in his right arm, with a cloth loosely draped over the baby's face. The baby was briefly extended over a railing, four stories above ground level, causing widespread criticism in the media. Jackson later apologized for the incident, calling it "a terrible mistake". Sony released Number Ones, a compilation of Jackson's hits on CD and DVD. In the US, the album was certified triple platinum by the RIAA; in the UK it was certified six times platinum for shipments of at least units.
In a particularly controversial scene, Jackson was seen holding hands and discussing sleeping arrangements with a young boy. As soon as the documentary aired, the Santa Barbara county attorney's office began a criminal investigation. Jackson was arrested in November 2003, and was charged with seven counts of child molestation and two counts of administering an intoxicating agent in relation to the 13 year old boy shown in the film. After the trial, in a highly publicized relocation he moved to the Persian Gulf island of Bahrain, as a guest of Sheikh Abdullah.
In the spring of 2006, there was an announcement that Jackson had signed a contract with a Bahrain-based startup called Two Seas Records. However, nothing ever came of that deal, and the CEO of Two Seas, Guy Holmes, later stated that the deal had never been finalized. Throughout 2006, Sony repackaged 20 singles from the 1980s and 1990s as the series, which subsequently became a boxed set. Most of those singles returned to the charts as a result. In September 2006, Jackson and his ex-wife Debbie Rowe confirmed reports that they had settled their long-running child custody suit. The terms were never made public. Jackson continued to be the custodial parent of the couple's two children. In October 2006, Fox News entertainment reporter Roger Friedman said that Jackson had been recording at a studio in rural Westmeath, Ireland. It was not known at the time what Jackson might be working on, or who might be paying for the sessions, since his publicist had recently issued a statement claiming that he had left Two Seas.
In November 2006, Jackson invited an Access Hollywood camera crew into the studio in Westmeath, and MSNBC broke the story that he was working on a new album, produced by will.i.am of The Black Eyed Peas. Jackson returned to the United States after Christmas 2006 to attend James Brown's funeral in Augusta, Georgia. He gave one of the eulogies, saying that "James Brown is my greatest inspiration." In the spring of 2007, Jackson and Sony teamed up to buy yet another music publishing company: Famous Music LLC, formerly owned by Viacom. This deal gave him the rights to songs by Eminem, Shakira and Beck, among others. Jackson recorded extensively during this period in New York with songwriter and producer will.i.am and also in Las Vegas with producers Akon and RedOne. In March 2007, Jackson gave a brief interview to the Associated Press in Tokyo, where he said, "I've been in the entertainment industry since I was 6 years old, and as Charles Dickens would say, 'It's been the best of times, the worst of times.' But I would not change my career ... While some have made deliberate attempts to hurt me, I take it in stride because I have a loving family, a strong faith and wonderful friends and fans who have, and continue, to support me."
In September 2007 Jackson was reportedly still working with will.i.am, but the album was apparently never completed. However, in 2008, Jackson and Sony released Thriller 25 to mark the 25th anniversary of the original Thriller. This album featured the previously unreleased song "For All Time" (an outtake from the original sessions) as well as remixes, where Jackson collaborated with younger artists who had been inspired by his work. Two of the remixes were released as singles with only modest success: "The Girl Is Mine 2008" (with will.i.am) and "Wanna Be Startin' Somethin' 2008" (with Akon). The first single was based on an early demo version, without Paul McCartney. The album itself was a hit, however. In anticipation of Jackson's 50th birthday, Sony BMG released a series of greatest-hits albums called King of Pop. Slightly different versions were released in various countries, based on polls of local fans. King of Pop reached the top 10 in most countries where it was issued, and also sold well as an import in other countries (such as the United States.)
In the fall of 2008, Fortress Investments threatened to foreclose on Neverland Ranch, which Jackson used as collateral for loans running into many tens of millions of dollars. However, Fortress opted to sell Jackson's debts to Colony Capital LLC. In November, Jackson transferred Neverland Ranch's title to Sycamore Valley Ranch Company LLC, which was a joint venture between Jackson and Colony Capital LLC. This deal cleared Jackson's debt, and he reportedly even gained an extra from the venture. At the time of his death, Jackson still owned a stake in Neverland/Sycamore Valley, but it is unknown how large that stake was. In September 2008, Jackson entered negotiations with Julien's Auction House to display and auction a large collection of memorabilia amounting to approximately 1,390 lots. The auction was scheduled to take place between April 22 and April 25. An exhibition of the lots opened as scheduled on April 14, but the actual auction was eventually cancelled at Jackson's request.
In March 2009, Jackson held a press conference at London's O2 Arena and announced a series of comeback concerts titled This Is It. The shows would be Jackson's first major series of concerts since the HIStory World Tour finished in 1997. Jackson suggested possible retirement after the shows; he said it would be his "final curtain call". The initial plan was for 10 concerts in London, followed by shows in Paris, New York City and Mumbai. Randy Phillips, president and chief executive of AEG Live, stated that the first 10 dates alone would earn the singer approximately . The London residency was increased to 50 dates after record breaking ticket sales: over one million were sold in less than two hours. Jackson rehearsed in Los Angeles in the weeks leading up to the tour under the direction of choreographer Kenny Ortega. Most of these rehearsals took place at the Staples Center, which was owned by AEG. The concerts would have commenced on July 13, 2009, and finished on March 6, 2010. Less than three weeks before the first show was due to begin in London and with all concerts being sold out, Jackson died after suffering cardiac arrest. Sometime before his death, it was widely stated that he was starting a clothing line with Christian Audigier. However, due to Jackson's untimely death, the current status of the label remains unknown.
Jackson's first posthumous single was a song entitled "This Is It" which Jackson cowrote in the 1980s with Paul Anka. It was not on the set lists for the concerts, and the recording was based on an old demo tape. The surviving brothers reunited in the studio for the first time since 1989 to record backing vocals. On October 28, 2009, a documentary film about the rehearsals entitled Michael Jackson's This Is It was released. Even though it ran for a limited two-week engagement, it became the highest grossing documentary or concert movie of all time, with earnings of more than worldwide. Jackson's estate received 90% of the profits. The film was accompanied by a compilation album of the same name. Two versions of the new song appear on the album, which also featured original masters of Jackson's hits in the order in which they appear in the movie, along with a bonus disc with previously unreleased versions of more Jackson hits as well as a spoken word poem entitled "Planet Earth". At the 2009 American Music Awards Jackson won four posthumous awards, two for him and two for his album Number Ones, bringing his total American Music Awards total to 26. Los Angeles Fire Department paramedics received a 911 call at 12:22 (PDT, 19:22 UTC), arriving three minutes later at Jackson's location. He was reportedly not breathing and CPR was performed. Resuscitation efforts continued en route to the Ronald Reagan UCLA Medical Center, and for an hour after arriving there at 1:13 (20:13 UTC). He was pronounced dead at 2:26 local time (21:26 UTC). Jackson's death triggered a global outpouring of grief. Google initially believed that the input from millions of people searching for "Michael Jackson" meant that the search engine was under attack. Twitter reported a crash, as did Wikipedia at PDT ( EDT). The Wikimedia Foundation reported nearly a million visitors to Jackson's biography within one hour, probably the most visitors in a one-hour period to any article in Wikipedia's history. AOL Instant Messenger collapsed for 40 minutes. AOL called it a "seminal moment in Internet history", adding, "We've never seen anything like it in terms of scope or depth."
Around 15% of Twitter posts—or 5,000 per minute—reportedly mentioned Jackson after the news broke, compared to the 5% recalled as having mentioned the Iranian elections or the flu pandemic that had made headlines earlier in the year. MTV and Black Entertainment Television (BET) aired marathons of Jackson's music videos. Jackson specials aired on multiple television stations around the world. The British soap opera EastEnders added a last-minute scene, in which one character tells another about the news, to the June 26 episode. Jackson was the topic of every front-page headline in the daily British tabloid The Sun for about two weeks following his death. During the same period, the three major U.S. networks' evening newscasts—ABC World News, CBS Evening News, and NBC Nightly News—devoted 34% of their broadcast time to him. Magazines including Time published commemorative editions. A scene that had featured Jackson's sister La Toya was cut from the film Brüno out of respect toward Jackson's family.
Jackson's memorial was held on July 7, 2009, at the Staples Center in Los Angeles, preceded by a private family service at Forest Lawn Memorial Park's Hall of Liberty. Jackson's casket was present during the memorial but no information was released about the final disposition of the body. While some unofficial reports claimed a worldwide audience as high as one billion people, the U.S. audience was estimated by Nielsen to be 31.1 million, an amount comparable to the estimated that watched the 2004 burial of former president Ronald Reagan, and the estimated Americans who watched the 1997 funeral for Princess Diana.
Mariah Carey, Stevie Wonder, Lionel Richie, John Mayer, Jennifer Hudson, Usher, Jermaine Jackson, and Shaheen Jafargholi performed at the event. Berry Gordy and Smokey Robinson gave eulogies, while Queen Latifah read, "We had him," a poem written for the occasion by Maya Angelou. The Reverend Al Sharpton received a standing ovation with cheers when he told Jackson's children, "Wasn't nothing strange about your daddy. It was strange what your daddy had to deal with. But he dealt with it anyway." Jackson's 11-year-old daughter, Paris Katherine, cried as she told the crowd, "Ever since I was born, Daddy has been the best father you could ever imagine ... I just wanted to say I love him ... so much." Reverend Lucious Smith provided a closing prayer. On August 24, several news outlets quoted anonymous sources as stating that the Los Angeles coroner had decided to treat Jackson's death as a homicide; this was later confirmed by the coroner on August 28. At the time of death, Jackson had been administered propofol, lorazepam and midazolam. Law enforcement officials conducted a manslaughter investigation of his personal physician, Conrad Murray. On February 8, 2010, Murray was charged with involuntary manslaughter by prosecutors in Los Angeles. Jackson was entombed on September 3, 2009, at Forest Lawn Memorial Park in Glendale, California.
On June 25, 2010, the first anniversary of Jackson's death, fans came to Los Angeles to pay their tribute to him. They visited Jackson’s star on the Hollywood Walk of Fame and his family’s home, as well as Forest Lawn Memorial Park. Many of the fans were carrying sunflowers and other tribute items to drop off at the sites. Members of the Jackson family and close friends arrived to pay their respects. Katherine returned to Gary, Indiana to unveil a granite monument constructed in the front yard of the family home. The memorial continued with a candlelight vigil and a special performance of "We Are the World." On June 26, there was a protest march in front of the Los Angeles Police Department's Robbery-Homicide Division at the old Parker Center building and a petition with thousands of signatures demanding justice was delivered. The Jackson Family Foundation in conjunction with Voiceplate presented "Forever Michael", an event bringing together Jackson family members, celebrities, fans, supporters and the community to celebrate and honor his legacy. A portion of the proceeds ere presented to some of Jackson's favorite charities. Katherine also introduced her new book "Never Can Say Goodbye."
The young Michael Jackson owed his vocal technique in large part to Diana Ross. In October 1969, it was decided that Jackson would live with Ross. Not only a mother figure to him, she was often observed in rehearsal as an accomplished performer. He later expressed: "I got to know her well. She taught me so much. I used to just sit in the corner and watch the way she moved. She was art in motion. I studied the way she moved, the way she sang – just the way she was." He told her: "I want to be just like you, Diana." She said: "You just be yourself." But Jackson owed part of his enduring style—especially his use of the oooh interjection—to Ross. From a young age, Jackson often punctuated his verses with a sudden exclamation of oooh. Diana Ross had used this effect on many of the songs recorded with The Supremes.
HIStory creates an atmosphere of paranoia. Its content focuses on the hardships and public struggles Jackson went through just prior to its production. In the new jack swing-funk-rock efforts "Scream" and "Tabloid Junkie", along with the R&B; ballad "You Are Not Alone", Jackson retaliates against the injustice and isolation he feels, and directs much of his anger at the media. In the introspective ballad "Stranger in Moscow", Jackson laments over his "fall from grace", while songs like "Earth Song", "Childhood", "Little Susie" and "Smile" are all operatic pop pieces. Invincible found Jackson working heavily with producer Rodney Jerkins. It is a record made up of urban soul like "Cry" and "The Lost Children", ballads such as "Speechless", "Break of Dawn" and "Butterflies" and mixes Hip-Hop, Pop and R&B; in "2000 Watts", "Heartbreaker" and "Invincible".
A distinctive deliberate mispronunciation of "come on", used frequently by Jackson, occasionally spelt "cha'mone" or "shamone", is also a staple in impressions and caricatures of him. The turn of the 1990s saw the release of the introspective album Dangerous. The New York Times noted that on some tracks, "he gulps for breath, his voice quivers with anxiety or drops to a desperate whisper, hissing through clenched teeth" and he had a "wretched tone". Nelson George summed up Jackson's vocals by stating "The grace, the aggression, the growling, the natural boyishness, the falsetto, the smoothness—that combination of elements mark him as a major vocalist".
The MTV Video Vanguard Artist of the Decade Award was given to Jackson to celebrate his accomplishments in the art form in the 1980s; the following year the award was renamed in his honor. "Black or White" was accompanied by a controversial music video, which, on November 14, 1991, simultaneously premiered in 27 countries with an estimated audience of 500 million people, the largest viewing ever for a music video. Along with Jackson, it featured Macaulay Culkin, Peggy Lipton and George Wendt. It helped usher in morphing as an important technology in music videos.
"Remember the Time" was an elaborate production, and became one of his longest videos at over nine minutes. Set in ancient Egypt, it featured groundbreaking visual effects and appearances by Eddie Murphy, Iman and Magic Johnson, along with a distinct complex dance routine. The video for "In the Closet" was Jackson's most sexually provocative piece. It featured supermodel Naomi Campbell in a courtship dance with Jackson. The video was banned in South Africa because of its imagery. The song and its accompanying video are a response to the backlash Jackson received from the media after being accused of child molestation in 1993. A year later, it won a Grammy for Best Music Video, Short Form; shortly afterwards Guinness World Records listed it as the most expensive music video ever made at a cost of $7 million.
"Earth Song" was accompanied by an expensive and well-received music video that gained a Grammy nomination for Best Music Video, Short Form in 1997. The video had an environmental theme, showing images of animal cruelty, deforestation, pollution and war. Using special effects, time is reversed so that life returns, wars end, and the forests re-grow. Released in 1997 and premiering at the 1996 Cannes Film Festival, Michael Jackson's Ghosts was a short film written by Jackson and Stephen King and directed by Stan Winston. The video for Ghosts is over 38 minutes long and holds the Guinness World Record as the world's longest music video.
, set in 1984]] Jackson throughout his career transformed the art of the music video and paved the way for modern pop music. Daily Telegraph writer Tom Utley described Jackson in 2003 as "extremely important" and a "genius." For much of his career, he had an "unparalleled" level of worldwide influence over the younger generation through his musical and humanitarian contributions. Mariah Carey, Usher, Green Day, Britney Spears, Justin Timberlake,
Allmusic's Steve Huey describes Jackson as "an unstoppable juggernaut, possessed of all the skills to dominate the charts seemingly at will: an instantly identifiable voice, eye-popping dance moves, stunning musical versatility and loads of sheer star power".
Shortly after Jackson's death, on June 25, 2009, MTV briefly returned to its original music video format to celebrate and pay tribute to his work. The channel aired many hours of Jackson's music videos, accompanied by live news specials featuring reactions from MTV personalities and other celebrities. The temporary shift in MTV's programming culminated the following week in the channel's live coverage of Jackson's memorial service. At the memorial service on July 7, 2009, founder of Motown Records Berry Gordy proclaimed Jackson as "the greatest entertainer that ever lived."
In 2010, two university librarians found that Jackson's influence extended into academia, and was detectable in scholarly literature pertaining to a range of subject matter. The two researchers combed through various scholars' writings, and compiled an annotated bibliography of those writings that appeared to meet at least one of several criteria. Among these criteria were appearance in a peer-reviewed journal, and the provision of insight into the nature of "popular icons including Jackson". The bibliography located references to Jackson in research reports concerning music, popular culture, and an array of other topics. The bibliographers identified as their most peculiar finding an argument that certain aspects of chemistry can be effectively taught by altering and imitating elements of Jackson's singing. One of the research librarians later reflected that "the fact that someone would take a Michael Jackson song and co-opt it as a means to convey chemistry concepts just shows the pervasiveness of Jackson's influence".
Michael Jackson was inducted onto the Hollywood Walk of Fame in 1980 as member of the The Jacksons and in 1984 as solo artist. Throughout his career he received numerous honors and awards, including the World Music Awards' Best-Selling Pop Male Artist of the Millennium, the American Music Award's Artist of the Century Award and the Bambi Pop Artist of the Millennium Award. He was a double-inductee of the Rock and Roll Hall of Fame, once as a member of The Jackson 5 in 1997 and later as a solo artist in 2001. Jackson was also inducted in several other hall of fames, including Vocal Group Hall of Fame (as The Jackson 5 member) in 1999, Songwriters Hall of Fame in 2002 and Hit Parade Hall of Fame (with his brothers) in 2009. In 2010, Jackson was inducted into the Dance Hall of Fame as the first (and currently only) dancer from the world of pop and rock 'n' roll. His awards include many Guinness World Records (eight in 2006 alone), 13 Grammy Awards (as well as the Grammy Legend Award and the Grammy Lifetime Achievement Award), 26 American Music Awards (24 only as a solo artist, including the "Artist of the Century", but not the poll of "Artist of the '80s")—more than any artist—, 13 number one singles in the US in his solo career—more than any other male artist in the Hot 100 era—and estimated sales of up to 750 million records worldwide, making him the world's best selling male solo pop artist. On December 29, 2009, the American Film Institute recognized Jackson's passing as a "moment of significance" saying, "Michael Jackson's sudden death in June at age 50 was notable for the worldwide outpouring of grief and the unprecedented global eulogy of his posthumous concert rehearsal movie This Is It." Michael Jackson also received a Doctor of Humane Letters Degree from the United Negro College Fund and also an Honorary Doctorate of Humane Letters from Fisk University.
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