Spišská Nová Ves

Spišská Nová Ves ( pronunciation ; German: (Zipser) Neu(en)dorf; Hungarian: Igló; Polish: Nowa Wieś Spiska; is a town in the Košice Region of Slovakia. The town is located southeast of the High Tatras in the Spiš region, and lies on both banks of the Hornád River. It is the biggest town of the Spišská Nová Ves District (okres). As of 2006 the population was 38,357.

Tourist attractions nearby include the medieval town of Levoča, Spiš Castle and the Slovak Paradise National Park. A biennial music festival, Divertimento musicale, is held here, attracting amateur music ensembles from all over Slovakia.

History

Kingdom of Hungary 1268-1412
Kingdom of Poland 1412-1569
Polish-Lithuanian Commonwealth 1569-1769
Habsburg Monarchy 1769-1804
 Austrian Empire 1804-1867
 Austria-Hungary 1867-1918
 Czechoslovakia 1918-1939
Slovak Republic 1939-1945
 Czechoslovakia 1945-1990
Czech and Slovak Federative Republic 1990-1992
 Slovak Republic 1993–present

IGL

IGL may refer to:

IGL@

Immunoglobulin lambda locus, also known as IGL@, is a region on human chromosome 22 that contains genes for the lambda light chains of antibodies (or immunoglobulins).

Function

Immunoglobulins recognize foreign antigens and initiate immune responses such as phagocytosis and the complement system. Each immunoglobulin molecule consists of two identical heavy chains and two identical light chains. There are two classes of light chains, kappa and lambda. This region represents the germline organization of the lambda light chain locus. The locus includes V (variable), J (joining), and C (constant) segments. During B cell development, a recombination event at the DNA level joins a single V segment with a J segment; the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase, and by somatic hypermutation, which occurs during B cell maturation in the spleen and lymph nodes. Several V segments and three C segments are known to be incapable of encoding a protein and are considered pseudogenes. The locus also includes several non-immunoglobulin genes, many of which are pseudogenes or are predicted by automated computational analysis or homology to other species.