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- Published: 2007-12-01
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X-rays from about 0.12 to 12 keV (10 to 0.10 nm wavelength) are classified as "soft" X-rays, and from about 12 to 120 keV (0.10 to 0.01 nm wavelength) as "hard" X-rays, due to their penetrating abilities.
Hard X-rays can penetrate solid objects, and their most common use is to take images of the inside of objects in diagnostic radiography and crystallography. As a result, the term X-ray is metonymically used to refer to a radiographic image produced using this method, in addition to the method itself. By contrast, soft X-rays can hardly be said to penetrate matter at all; for instance, the attenuation length of 600 eV (~ 2 nm) x-rays in water is less than 1 micrometer. X-rays are a form of ionizing radiation, and exposure to them can be a health hazard.
The distinction between X-rays and gamma rays has changed in recent decades. Originally, the electromagnetic radiation emitted by X-ray tubes had a longer wavelength than the radiation emitted by radioactive nuclei (gamma rays). Older literature distinguished between X- and gamma radiation on the basis of wavelength, with radiation shorter than some arbitrary wavelength, such as 10−11 m, defined as gamma rays. However, as shorter wavelength continuous spectrum "X-ray" sources such as linear accelerators and longer wavelength "gamma ray" emitters were discovered, the wavelength bands largely overlapped. The two types of radiation are now usually distinguished by their origin: X-rays are emitted by electrons outside the nucleus, while gamma rays are emitted by the nucleus.
However, the effect of ionizing radiation on matter (especially living tissue) is more closely related to the amount of energy deposited into them rather than the charge generated. This measure of energy absorbed is called the absorbed dose:
The equivalent dose is the measure of the biological effect of radiation on human tissue. For X-rays it is equal to the absorbed dose.
Medical X-rays are a significant source of manmade radiation exposure, accounting for 58% in the United States in 1987, but since most radiation exposure is natural (82%), medical X-rays only account for 10% of total American radiation exposure.
Reported dosage due to dental X-rays seems to vary significantly. Depending on the source, a typical dental X-ray of a human results in an exposure of perhaps, 3, 40, 300, or as many as 900 mrems (30 to 9,000 μSv).
! Target ! Kβ₁ ! Kβ₂ ! Kα₁ ! Kα₂ |- ! Fe | 0.17566 | 0.17442 | 0.193604 | 0.193998 |- ! Co | 0.162079 | 0.160891 | 0.178897 | 0.179285 |- ! Ni | 0.15001 | 0.14886 | 0.165791 | 0.166175 |- ! Cu | 0.139222 | 0.138109 | 0.154056 | 0.154439 |- ! Zr | 0.070173 | 0.068993 | 0.078593 | 0.079015 |- ! Mo | 0.063229 | 0.062099 | 0.070930 | 0.071359 |- |}
, on 1 January 1896]] X-rays are generated by an X-ray tube, a vacuum tube that uses a high voltage to accelerate the electrons released by a hot cathode to a high velocity. The high velocity electrons collide with a metal target, the anode, creating the X-rays. In medical X-ray tubes the target is usually tungsten or a more crack-resistant alloy of rhenium (5%) and tungsten (95%), but sometimes molybdenum for more specialized applications, such as when soft X-rays are needed as in mammography. In crystallography, a copper target is most common, with cobalt often being used when fluorescence from iron content in the sample might otherwise present a problem.
The maximum energy of the produced X-ray photon is limited by the energy of the incident electron, which is equal to the voltage on the tube, so an 80 kV tube cannot create X-rays with an energy greater than 80 keV. When the electrons hit the target, X-rays are created by two different atomic processes: #X-ray fluorescence: If the electron has enough energy it can knock an orbital electron out of the inner electron shell of a metal atom, and as a result electrons from higher energy levels then fill up the vacancy and X-ray photons are emitted. This process produces an emission spectrum of X-rays at a few discrete frequencies, sometimes referred to as the spectral lines. The spectral lines generated depend on the target (anode) element used and thus are called characteristic lines. Usually these are transitions from upper shells into K shell (called K lines), into L shell (called L lines) and so on. #Bremsstrahlung: This is radiation given off by the electrons as they are scattered by the strong electric field near the high-Z (proton number) nuclei. These X-rays have a continuous spectrum. The intensity of the X-rays increases linearly with decreasing frequency, from zero at the energy of the incident electrons, the voltage on the X-ray tube. So the resulting output of a tube consists of a continuous bremsstrahlung spectrum falling off to zero at the tube voltage, plus several spikes at the characteristic lines. The voltages used in diagnostic X-ray tubes, and thus the highest energies of the X-rays, range from roughly 20 to 150 kV.
Both of these X-ray production processes are very inefficient, with a production efficiency of only about one percent, and hence, to produce a usable flux of X-rays, most of the electric power consumed by the tube is released as waste heat. The X-ray tube must be designed to dissipate this excess heat.
In medical diagnostic applications, the low energy (soft) X-rays are unwanted, since they are totally absorbed by the body, increasing the dose. Hence, a thin metal sheet, often of aluminum, called an X-ray filter, is usually placed over the window of the X-ray tube, filtering out the low energy components in the spectrum. This is called hardening the beam. -->
Radiographs obtained using X-rays can be used to identify a wide spectrum of pathologies. Because the body structures being imaged in medical applications are large compared to the wavelength of the X-rays, the X-rays can be analyzed as particles rather than waves. (This is in contrast to X-ray crystallography, where their wave-like nature is more important because the wavelength is comparable to the sizes of the structures being imaged.)
To make an X-ray image of human or animal bones, short X-ray pulses illuminate the body or limb, with radiographic film placed behind it. Any bones that are present absorb most of the X-ray photons by photoelectric processes. This is because bones have a higher electron density than soft tissues. Note that bones contain a high percentage of calcium (20 electrons per atom), potassium (19 electrons per atom) magnesium (12 electrons per atom), and phosphorus (15 electrons per atom). The X-rays that pass through the flesh leave a latent image in the photographic film. When the film is developed, the parts of the image corresponding to higher X-ray exposure are dark, leaving a white shadow of bones on the film.
To generate an image of the cardiovascular system, including the arteries and veins (angiography) an initial image is taken of the anatomical region of interest. A second image is then taken of the same region after iodinated contrast material has been injected into the blood vessels within this area. These two images are then digitally subtracted, leaving an image of only the iodinated contrast outlining the blood vessels. The radiologist or surgeon then compares the image obtained to normal anatomical images to determine if there is any damage or blockage of the vessel.
A specialized source of X-rays which is becoming widely used in research is synchrotron radiation, which is generated by particle accelerators. Its unique features are X-ray outputs many orders of magnitude greater than those of X-ray tubes, wide X-ray spectra, excellent collimation, and linear polarization.
Before the advent of the digital computer and before the invention of digital imaging, photographic plates were used to produce most radiographic images. The images were produced right on the glass plates. Photographic film largely replaced these plates, and it was used in X-ray laboratories to produce medical images. In more recent years, computerized and digital radiography has been replacing photographic film in medical and dental applications, though film technology remains in widespread use in industrial radiography processes (e.g. to inspect welded seams). Photographic plates are mostly things of history, and their replacement, the "intensifying screen", is also fading into history. The metal silver (formerly necessary to the radiographic & photographic industries) is a non-renewable resource. Thus it is beneficial that this is now being replaced by digital (DR) and computed (CR) technology. Where photographic films required wet processing facilities, these new technologies do not. The digital archiving of images utilizing these new technologies also saves storage space.
Since photographic plates are sensitive to X-rays, they provide a means of recording the image, but they also required much X-ray exposure (to the patient), hence intensifying screens were devised. They allow a lower dose to the patient, because the screens take the X-ray information and intensify it so that it can be recorded on film positioned next to the intensifying screen.
The part of the patient to be X-rayed is placed between the X-ray source and the image receptor to produce a shadow of the internal structure of that particular part of the body. X-rays are partially blocked ("attenuated") by dense tissues such as bone, and pass more easily through soft tissues. Areas where the X-rays strike darken when developed, causing bones to appear lighter than the surrounding soft tissue.
Contrast compounds containing barium or iodine, which are radiopaque, can be ingested in the gastrointestinal tract (barium) or injected in the artery or veins to highlight these vessels. The contrast compounds have high atomic numbered elements in them that (like bone) essentially block the X-rays and hence the once hollow organ or vessel can be more readily seen. In the pursuit of a non-toxic contrast material, many types of high atomic number elements were evaluated. For example, the first time the forefathers used contrast it was chalk, and was used on a cadaver's vessels. Unfortunately, some elements chosen proved to be harmful – for example, thorium was once used as a contrast medium (Thorotrast) – which turned out to be toxic in some cases (causing injury and occasionally death from the effects of thorium poisoning). Modern contrast material has improved, and while there is no way to determine who may have a sensitivity to the contrast, the incidence of "allergic-type reactions" are low. (The risk is comparable to that associated with penicillin.)
In order to gain energy spectrum information, a diffracting crystal may be used to first separate the different photons. The method is called wavelength dispersive X-ray spectroscopy (WDX or WDS). Position-sensitive detectors are often used in conjunction with dispersive elements. Other detection equipment that is inherently energy-resolving may be used, such as the aforementioned proportional counters. In either case, use of suitable pulse-processing (MCA) equipment allows digital spectra to be created for later analysis.
For many applications, counters are not sealed but are constantly fed with purified gas, thus reducing problems of contamination or gas aging. These are called "flow counters".
Practical application in medical imaging started in the 1990s. Currently amorphous selenium is used in commercial large area flat panel X-ray detectors for mammography and chest radiography. Current research and development is focused around pixel detectors, such as CERN's energy resolving Medipix detector.
Note: A standard semiconductor diode, such as a 1N4007, will produce a small amount of current when placed in an X-ray beam. A test device once used by Medical Imaging Service personnel was a small project box that contained several diodes of this type in series, which could be connected to an oscilloscope as a quick diagnostic.
Silicon drift detectors (SDDs), produced by conventional semiconductor fabrication, now provide a cost-effective and high resolving power radiation measurement. Unlike conventional X-ray detectors, such as Si(Li)s, they do not need to be cooled with liquid nitrogen.
The array technology is a variant on the amorphous silicon TFT arrays used in many flat panel displays, like the ones in computer laptops. The array consists of a sheet of glass covered with a thin layer of silicon that is in an amorphous or disordered state. At a microscopic scale, the silicon has been imprinted with millions of transistors arranged in a highly ordered array, like the grid on a sheet of graph paper. Each of these thin film transistors (TFTs) is attached to a light-absorbing photodiode making up an individual pixel (picture element). Photons striking the photodiode are converted into two carriers of electrical charge, called electron-hole pairs. Since the number of charge carriers produced will vary with the intensity of incoming light photons, an electrical pattern is created that can be swiftly converted to a voltage and then a digital signal, which is interpreted by a computer to produce a digital image. Although silicon has outstanding electronic properties, it is not a particularly good absorber of X-ray photons. For this reason, X-rays first impinge upon scintillators made from e.g. gadolinium oxysulfide or caesium iodide. The scintillator absorbs the X-rays and converts them into visible light photons that then pass onto the photodiode array.
Though X-rays are otherwise invisible it is possible to see the ionization of the air molecules if the intensity of the X-ray beam is high enough. The beamline from the wiggler at the ID11 at ESRF is one example of such high intensity.
Since 2005, X-rays are listed as a carcinogen by the U.S. government. The use of X-rays as a treatment is known as radiotherapy and is largely used for the management (including palliation) of cancer; it requires higher radiation energies than for imaging alone.
X-rays are a relatively safe method of investigation and the radiation exposure is relatively low, depending upon the study. Experimental and epidemiological data, however, do not support the proposition that there is a threshold dose of radiation below which there is no increased risk of cancer. Diagnostic X-rays account for 14% of the total annual radiation exposure from man-made and natural sources worldwide. It is estimated that the additional radiation will increase a person's cumulative risk of getting cancer by age 75 by 0.6–1.8%. The amount of absorbed radiation depends upon the type of X-ray test and the body part involved. CT and fluoroscopy entail higher doses of radiation than do plain X-rays.
To place the increased risk in perspective, a plain chest X-ray or dental X-ray will expose a person to the same amount from background radiation that we are exposed to (depending upon location) everyday over 10 days. Each such X-ray would add less than 1 per 1,000,000 to the lifetime cancer risk. An abdominal or chest CT would be the equivalent to 2–3 years of background radiation, increasing the lifetime cancer risk between 1 per 10,000 and 1 per 1,000.
Fathers exposed to diagnostic x-rays are more likely to have infants who contract leukemia, especially if exposure is closer to conception or includes two or more X-rays of the lower gastrointestinal (GI) tract or lower abdomen. The risk of radiation is greater to unborn babies, so in pregnant patients, the benefits of the investigation (X-ray) should be balanced with the potential hazards to the unborn fetus. In the US, there are an estimated 62,000,000 CT scans performed annually, including more than 4,000,000 on children.
The following table shows the recommended thickness of lead shielding in function of X-ray energy, from the Recommendations by the Second International Congress of Radiology.
{| class=wikitable
|-
!X-Rays generated by peak voltages
not exceeding !! Minimum thickness
of Lead
|-
|75 kV || 1.0 mm
|-
|100 kV || 1.5 mm
|-
|125 kV || 2.0 mm
|-
|150 kV || 2.5 mm
|-
|175 kV || 3.0 mm
|-
|200 kV || 4.0 mm
|-
|225 kV || 5.0 mm
|-
|300 kV || 9.0 mm
|-
|400 kV || 15.0 mm
|-
|500 kV || 22.0 mm
|-
|600 kV || 34.0 mm
|-
|900 kV || 51.0 mm
|}
X-rays were found emanating from Crookes tubes, experimental discharge tubes invented around 1875, by scientists investigating the cathode rays, that is energetic electron beams, that were first created in the tubes. Crookes tubes created free electrons by ionization of the residual air in the tube by a high DC voltage of anywhere between a few kilovolts and 100 kV. This voltage accelerated the electrons coming from the cathode to a high enough velocity that they created X-rays when they struck the anode or the glass wall of the tube. Many of the early Crookes tubes undoubtedly radiated X-rays, because early researchers noticed effects that were attributable to them, as detailed below. Wilhelm Röntgen was the first to systematically study them, in 1895.
Among the important early researchers in X-rays were Ivan Pulyui, William Crookes, Johann Wilhelm Hittorf, Eugen Goldstein, Heinrich Hertz, Philipp Lenard, Hermann von Helmholtz, Nikola Tesla, Thomas Edison, Charles Glover Barkla, Max von Laue, and Wilhelm Conrad Röntgen.
There are conflicting accounts of his discovery because Röntgen had his lab notes burned after his death, but this is a likely reconstruction by his biographers: Röntgen was investigating cathode rays with a fluorescent screen painted with barium platinocyanide and a Crookes tube which he had wrapped in black cardboard so the visible light from the tube wouldn't interfere. He noticed a faint green glow from the screen, about 1 meter away. He realized some invisible rays coming from the tube were passing through the cardboard to make the screen glow. He found they could also pass through books and papers on his desk. Röntgen threw himself into investigating these unknown rays systematically. Two months after his initial discovery, he published his paper.
Röntgen discovered its medical use when he saw a picture of his wife's hand on a photographic plate formed due to X-rays. His wife's hand's photograph was the first ever photograph of a human body part using X-rays.
Crookes tubes were unreliable. They had to contain a small quantity of gas (invariably air) as a current will not flow in such a tube if they are fully evacuated. However as time passed the X-rays caused the glass to absorb the gas, causing the tube to generate "harder" X-rays until it soon stopped operating. Larger and more frequently used tubes were provided with devices for restoring the air, known as "softeners". These often took the form of a small side tube which contained a small piece of mica: a substance that traps comparatively large quantities of air within its structure. A small electrical heater heated the mica and caused it to release a small amount of air, thus restoring the tube's efficiency. However the mica had a limited life and the restore process was consequently difficult to control.
In 1904, John Ambrose Fleming invented the thermionic diode valve (vacuum tube). This used a hot cathode which permitted current to flow in a vacuum. This idea was quickly applied to X-ray tubes, and heated cathode X-ray tubes, called Coolidge tubes, replaced the troublesome cold cathode tubes by about 1920.
Two years later, physicist Charles Barkla discovered that X-rays could be scattered by gases, and that each element had a characteristic X-ray. He won the 1917 Nobel Prize in Physics for this discovery. Max von Laue, Paul Knipping and Walter Friedrich observed for the first time the diffraction of X-rays by crystals in 1912. This discovery, along with the early works of Paul Peter Ewald, William Henry Bragg and William Lawrence Bragg gave birth to the field of X-ray crystallography. The Coolidge tube was invented the following year by William D. Coolidge which permitted continuous production of X-rays; this type of tube is still in use today.
The use of X-rays for medical purposes (to develop into the field of radiation therapy) was pioneered by Major John Hall-Edwards in Birmingham, England. In 1908, he had to have his left arm amputated owing to the spread of X-ray dermatitis. The X-ray microscope was invented in the 1950s.
The Chandra X-ray Observatory, launched on July 23, 1999, has been allowing the exploration of the very violent processes in the universe which produce X-rays. Unlike visible light, which is a relatively stable view of the universe, the X-ray universe is unstable, it features stars being torn apart by black holes, galactic collisions, and novas, neutron stars that build up layers of plasma that then explode into space.
An X-ray laser device was proposed as part of the Reagan Administration's Strategic Defense Initiative in the 1980s, but the first and only test of the device (a sort of laser "blaster", or death ray, powered by a thermonuclear explosion) gave inconclusive results. For technical and political reasons, the overall project (including the X-ray laser) was de-funded (though was later revived by the second Bush Administration as National Missile Defense using different technologies).
Category:Radiography Category:Electromagnetic spectrum Category:IARC Group 1 carcinogens Category:Medical physics
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